Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes

Journal of Molecular Endocrinology

Volumn 42, Issue 1, 2009, Pages 57-66

  Zhang, Tingting ^a,b   He, Jinhan ^a,c   Xu, Chong ^a   Zu, Luxia ^a   Jiang, Hongfeng ^a   Pu, Shenshen ^a   Guo, Xiaohui ^b   Xu, Guoheng ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FAT DROPLET; FATTY ACID; GLYCEROL; ISOPRENALINE; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERILIPIN; TRIACYLGLYCEROL LIPASE; ANTIDIABETIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVITY; DRUG MECHANISM; ENZYME INHIBITION; INHIBITION KINETICS; INSULIN SENSITIVITY; LIPOLYSIS; LIPOLYSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADIPOCYTES; ADRENERGIC BETA-AGONISTS; ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; FATTY ACIDS, NONESTERIFIED; GLYCEROL; HYPOGLYCEMIC AGENTS; ISOPROTERENOL; LIPASE; LIPOLYSIS; METFORMIN; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 58849137050     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-08-0130     Document Type: Article

References (40)

1. Abbasi F, Carantoni M, Chen YD & Reaven GM 1998 Further evidence for a central role of adipose tissue in the antihyperglycemic effect of metformin. Diabetes Care 21 1301-1305.
2. Aboulaich N, Vener AV & Stralfors P 2006 Hormonal control of reversible translocation of perilipin B to the plasma membrane in primary human adipocytes. Journal of Biological Chemistry 281 11446-11449.
3. Arner P, Hellstrom L, Wahrenberg H & Bronnegard M 1990 Beta-adrenoceptor expression in human fat cells from different regions. Journal of Clinical Investigation 86 1595-1600.
4. Bailey CJ 1992 Biguanides and NIDDM. Diabetes Care 15 755-772.
5. Bailey CJ & Turner RC 1996 Metformin. New England Journal of Medicine 334 574-579.
6. Bergman RN & Ader M 2000 Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends in Endocrinology and Metabolism 11 351-356.
7. Cigolini M, Bosello O, Zancanaro C, Orlandi PG, Fezzi O & Smith U 1984 Influence of metformin on metabolic effect of insulin in human adipose tissue in vitro. Diabetes & Metabolism 10 311-315.
8. Daval M, Diot-Dupuy F, Bazin R, Hainault I, Viollet B, Vaulont S, Hajduch E, Ferre P & Foufelle F 2005 Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. Journal of Biological Chemistry 280 25250-25257.
9. Egan JJ, Greenberg AS, Chang MK & Londos C 1990 Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. Journal of Biological Chemistry 265 18769-18775.
10. Flechtner-Mors M, Ditschuneit HH, Jenkinson CP, Alt A & Adler G 1999 Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. Diabetic Medicine 16 1000-1006.
11. Granneman JG, Moore HP, Granneman RL, Greenberg AS, Obin MS & Zhu Z 2007 Analysis of lipolytic protein trafficking and interactions in adipocytes. Journal of Biological Chemistry 282 5726-5735.
12. Greenberg AS, Shen WJ, Muliro K, Patel S, Souza SC, Roth RA & Kraemer FB 2001 Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. Journal of Biological Chemistry 276 45456-45461.
13. Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E & DeFronzo RA 1989 Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. Journal of Clinical Investigation 84 205-213.
14. He J, Jiang H, Tansey JT, Tang C, Pu S & Xu G 2006 Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes. Biochimica et Biophysica Acta 1761 247-255.
15. Honnor RC, Dhillon GS & Londos C 1985a cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior. Journal of Biological Chemistry 260 15122-15129.
16. Honnor RC, Dhillon GS & Londos C 1985b cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady-state relationship with lipolytic and antilipolytic modulators. Journal of Biological Chemistry 260 15130-15138.
17. Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, Inzucchi SE, Schumann WC, Petersen KF, Landau BR et al. 2000 Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49 2063-2069.
18. Jansson PA, Gudbjornsdottir HS, Andersson OK & Lonnroth PN 1996 The effect of metformin on adipose tissue metabolism and peripheral blood flow in subjects with NIDDM. Diabetes Care 19 160-164.
19. Jiang H, He J, Pu S, Tang C & Xu G 2007 Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Biochimica et Biophysica Acta 1771 66-74.
20. Lenhard JM, Kliewer SA, Paulik MA, Plunket KD, Lehmann JM & Weiel JE 1997 Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways. Biochemical Pharmacology 54 801-808.
21. Londos C, Brasaemle DL, Schultz CJ, Adler-Wailes DC, Levin DM, Kimmel AR & Rondinone CM 1999 On the control of lipolysis in adipocytes. Annals of the New York Academy of Sciences 892 155-168.
22. Londos C, Sztalryd C, Tansey JT & Kimmel AR 2005 Role of PAT proteins in lipid metabolism. Biochimie 87 45-49.
23. Miyoshi H, Perfield JW II, Souza SC, Shen WJ, Zhang HH, Stancheva ZS, Kraemer FB, Obin MS & Greenberg AS 2007 Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes. Journal of Biological Chemistry 282 996-1002.
24. Pentikainen PJ 1986 Bioavailability of metformin. Comparison of solution, rapidly dissolving tablet, and three sustained release products. International Journal of Clinical Pharmacology, Therapy, and Toxicology 24 213-220.
25. Perriello G, Misericordia P, Volpi E, Santucci A, Santucci C, Ferrannini E, Ventura MM, Santeusanio F, Brunetti P & Bolli GB 1994 Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes 43 920-928.
26. Ren T, He J, Jiang H, Zu L, Pu S, Guo X & Xu G 2006 Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol. Journal of Molecular Endocrinology 37 175-183.
27. Riccio A, Del Prato S, Vigili de Kreutzenberg S & Tiengo A 1991 Glucose and lipid metabolism in non-insulin-dependent diabetes. Effect of metformin. Diabetes and Metabolism 17 180-184.
28. Robidoux J, Kumar N, Daniel KW, Moukdar F, Cyr M, Medvedev AV & Collins S 2006 Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation. Journal of Biological Chemistry 281 37794-37802.
29. Schweiger M, Schreiber R, Haemmerle G, Lass A, Fledelius C, Jacobsen P, Tornqvist H, Zechner R & Zimmermann R 2006 Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. Journal of Biological Chemistry 281 40236-40241.
30. Sengenes C, Bouloumie A, Hauner H, Berlan M, Busse R, Lafontan M & Galitzky J 2003 Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes. Journal of Biological Chemistry 278 48617-48626.
31. Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D & Beri RK 1994 Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Letters 353 33-36.
32. Sztalryd C, Xu G, Dorward H, Tansey JT, Contreras JA, Kimmel AR & Londos C 2003 Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. Journal of Cell Biology 161 1093-1103.
33. Wang DS, Kusuhara H, Kato Y, Jonker JW, Schinkel AH & Sugiyama Y 2003 Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Molecular Pharmacology 63 844-848.
34. Wei E, Gao W & Lehner R 2007 Attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux. Journal of Biological Chemistry 282 8027-8035.
35. Xu G, Sztalryd C, Lu X, Tansey JT, Gan JW, Dorward H, Kimmel AR & Londos C 2005 Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. Journal of Biological Chemistry 280 42841-42847.
36. Xu G, Sztalryd C & Londos C 2006 Degradation of perilipin is mediated through ubiquitination-proteasome pathway. Biochimica et Biophysica Acta 1761 83-90.
37. Yin W, Mu J & Birnbaum MJ 2003 Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes. Journal of Biological Chemistry 278 43074-43080.
38. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N et al. 2001 Role of AMP-activated protein kinase in mechanism of metformin action. Journal of Clinical Investigation 108 1167-1174.
39. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A et al. 2004 Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 1383-1386.
40. Zu L, Jiang H, He J, Xu C, Pu S, Liu M & Xu G 2008 Salicylate blocks lipolytic actions of tumor necrosis factor-α in primary rat adipocytes. Molecular Pharmacology 73 215-223.