Contribution of TRPV1 receptor-expressing fibers to spinal ventral root after-discharges and mechanical hyperalgesia in a spared nerve injury (SNI) rat model

Journal of Pharmacological Sciences

Volumn 121, Issue 1, 2013, Pages 9-16

  Yamamoto, Shohei ^a   Ohsawa, Masahiro ^a   Ono, Hideki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

After discharge; Hyperalgesia; Spared nerve injury model; Spinal cord; Transient receptor potential V1

Indexed keywords

RESINIFERATOXIN; VANILLOID RECEPTOR 1;

AFTERDISCHARGE; ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CENTRAL NERVOUS SYSTEM SENSITIZATION; CONTROLLED STUDY; DRUG EFFECT; EVOKED RESPONSE; HYPERALGESIA; HYPERSENSITIVITY; MALE; MECHANICAL STIMULATION; NERVE INJURY; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TACTILE STIMULATION; THERMAL STIMULATION; VENTRAL ROOT;

EID: 84873808796     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12213FP     Document Type: Article

References (36)

1. Sandkühler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev. 2009;89:707-758.
2. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33:87-107.
3. Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 1990;43:205-218.
4. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 1992;50:355-363.
5. Decosterd I, Woolf CJ. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain. 2000;87:149-158.
6. Yamamoto S, Honda M, Tanabe M, Ono H. Spinal ventral root after-discharges as a pain index: involvement of NK-1 and NMDA receptors. Brain Res. 2006;1082:115-123.
7. Yamamoto S, Tanabe M, Ono H. N- and L-type voltage-dependent Ca2+ channels contribute to the generation of after-discharges in the spinal ventral root after cessation of noxious mechanical stimulation. J Pharmacol Sci. 2012;119:82-90.
8. Tal M, Bennett GJ. Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve. Pain. 1994;57:375-382.
9. Pitcher GM, Henry JL. NSAID-induced cyclooxygenase inhibition differentially depresses long-lasting versus brief synaptically-elicited responses of rat spinal dorsal horn neurons in vivo. Pain. 1999;82:173-186.
10. Radhakrishnan V, Henry JL. Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344. Neuroscience. 1995;64:943-958.
11. Drew GM, Siddall PJ, Duggan AW. Responses of spinal neurones to cutaneous and dorsal root stimuli in rats with mechanical allodynia after contusive spinal cord injury. Brain Res. 2001; 893:59-69.
12. You HJ, Mørch CD, Arendt-Nielsen L. Electrophysiological characterization of facilitated spinal withdrawal reflex to repetitive electrical stimuli and its modulation by central glutamate receptor in spinal anesthetized rats. Brain Res. 2004;1009: 110-119.
13. Morisset V, Nagy F. Nociceptive integration in the rat spinal cord: role of non-linear membrane properties of deep dorsal horn neurons. Eur J Neurosci. 1998;10:3642-3652.
14. Reali C, Fossat P, Landry M, Russo RE, Nagy F. Intrinsic membrane properties of spinal dorsal horn neurones modulate nociceptive information processing in vivo. J Physiol. 2011;589: 2733-2743.
15. Voisin DL, Nagy F. Sustained L-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation. Neuroscience. 2001;102:461-472.
16. Morisset V, Nagy F. Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons. Eur J Neurosci. 2000;12:3087-3095.
17. Szallasi A, Blumberg PM. Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience. 1989;30:515-520.
18. Szallasi A, Blumberg PM. Vanilloid receptor loss in rat sensory ganglia associated with long term desensitization to resiniferatoxin. Neurosci Lett. 1992;140:51-54.
19. Ma QP. Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats. Neurosci Lett. 2002;319: 87-90.
20. Mitchell K, Bates BD, Keller JM, Lopez M, Scholl L, Navarro J, et al. Ablation of rat TRPV1-expressing Adelta/C-fibers with resiniferatoxin: analysis of withdrawal behaviors, recovery of function and molecular correlates. Mol Pain. 2010;6:94.
21. Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol. 1980;20:441-462.
22. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55-63.
23. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 1988;32:77-88.
24. Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res. 1980;47:1-9.
25. Zhang X, Chen G, Xue Q, Yu B. Early changes of β-Catenins and Menins in spinal cord dorsal horn after peripheral nerve injury. Cell Mol Neurobiol. 2010;30:885-890.
26. Schoffnegger D, Ruscheweyh R, Sandkühler J. Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats. Pain. 2008;135:300-310.
27. Vega-Avelaira D, Géranton SM, Fitzgerald M. Differential regulation of immune responses and macrophage/neuron interactions in the dorsal root ganglion in young and adult rats following nerve injury. Mol Pain. 2009;5:70.
28. Grant ER, Dubin AE, Zhang SP, Zivin RA, Zhong Z. Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: a method to resolve ionic dependence of VR1-mediated cell death. J Pharmacol Exp Ther. 2002;300:9-17.
29. Suter MR, Berta T, Gao YJ, Decosterd I, Ji RR. Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury. Mol Pain. 2009;5:53.
30. Ossipov MH, Bian D, Malan TPJ, Lai J, Porreca F. Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain. 1999;79: 127-133.
31. Corder G, Siegel A, Intondi AB, Zhang X, Zadina JE, Taylor BK. A novel method to quantify histochemical changes throughout the mediolateral axis of the substantia gelatinosa after spared nerve injury: characterization with TRPV1 and substance P. J Pain. 2010;11:388-398.
32. Casals-Díaz L, Vivó M, Navarro X. Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat. Exp Neurol. 2009;217:84-95.
33. Jang JH, Kim KH, Nam TS, Lee WT, Park KA, Kim DW, et al. The role of uninjured C-afferents and injured afferents in the generation of mechanical hypersensitivity after partial peripheral nerve injury in the rat. Exp Neurol. 2007;204:288-298.
34. Fossat P, Dobremez E, Bouali-Benazzouz R, Favereaux A, Bertrand SS, Kilk K, et al. Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J Neurosci. 2010;30:1073-1085.
35. Ohnami S, Tanabe M, Shinohara S, Takasu K, Kato A, Ono H. Role of voltage-dependent calcium channel subtypes in spinal long-term potentiation of C-fiber-evoked field potentials. Pain. 2011;152:623-631.
36. Vanegas H, Schaible H. Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain. 2000;85:9-18.