The role of uninjured C-afferents and injured afferents in the generation of mechanical hypersensitivity after partial peripheral nerve injury in the rat

Experimental Neurology

Volumn 204, Issue 1, 2007, Pages 288-298

  Jang, Jun Ho ^a   Kim, Kyung Hwa ^a   Nam, Taick Sang ^a   Lee, Won Taek ^a   Park, Kyung Ah ^a   Kim, Dong Wook ^a   Leem, Joong Woo ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

A afferents; Capsaicin; Mechanical hypersensitivity; Neuropathic pain; Nociceptive afferents; Spinal nerve injury

Indexed keywords

CAPSAICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DORSAL RHIZOTOMY; HYPERSENSITIVITY; LUMBAR SPINE; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NOCICEPTIVE RECEPTOR; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SENSORY NERVE; SPINAL NERVE;

ANALGESICS, NON-NARCOTIC; ANIMALS; CAPSAICIN; GANGLIA, SPINAL; HYPERALGESIA; LIGATION; LUMBOSACRAL REGION; MALE; NERVE FIBERS, UNMYELINATED; NERVOUS SYSTEM DISEASES; NEURAL CONDUCTION; NEURONS, AFFERENT; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY; RHIZOTOMY; SCIATIC NERVE; SPINAL NERVES; TIME FACTORS;

EID: 33847321499     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.11.004     Document Type: Article

References (34)

1. Ali Z., Ringkamp M., Hartke T.V., Chien H.F., Flavahan N.A., Campbell J.N., and Meyer R.A. Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J. Neurophysiol. 81 (1999) 455-466
2. Bao L., Wang H.F., Cai H.-J., Tong Y.-G., Jin S.-X., Lu Y.-J., Grant G., Hökfelt T., and Zhang X. Peripheral axotomy induces only very limited sprouting of coarse myelinated afferents into inner lamina II of rat spinal cord. Eur. J. Neurosci. 16 (2002) 175-185
3. Baranowski R., Lynn B., and Pini A. The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. Br. J. Pharmacol. 89 (1986) 267-276
4. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., and Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Methods 53 (1994) 55-63
5. Devor M., and Seltzer Z. Pathophysiology of damaged nerves in relation to chronic pain. In: Wall P.D., and Melzack R. (Eds). Textbook of Pain. 4th ed. (1999), Churchill Livingston, London 129-164
6. George A., Buehl A., and Sommer C. Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha protein. Neurosci. Lett. 372 (2004) 215-219
7. V1.8 in uninjured axons enables neuropathic pain. J. Neurosci. 23 (2003) 158-166
8. Han H.C., Lee D.H., and Chung J.M. Characteristics of ectopic discharges in a rat neuropathic pain model. Pain 84 (2000) 253-261
9. Harper A.A., and Lawson S.N. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurons. J. Physiol. 359 (1985) 31-46
10. Kim S.H., and Chung J.M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50 (1992) 355-363
11. Königsmark B.W. Methods for the counting of neurons. In: Nauta W., and Ebbeson S. (Eds). Contemporary Research Methods in Neuroanatomy (1970), Springer, New York 315-340
12. Liu X., Eschenfelder S., Blenk K., Jänig W., and Habler H.J. Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in arts. Pain 84 (2000) 309-318
13. Liu C.N., Wall P.D., Ben-Dor E., Michaelis M., Amir R., and Devor M. Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain 85 (2000) 503-521
14. Lynn B. Capsaicin: actions on nociceptive C-fibers and therapeutic potential. Pain 41 (1990) 61-69
15. Ma C., Shu Y., Zheng Z., Chen Y., Yao H., Greenquist K.W., White F.A., and LaMotte R.H. Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons. J. Neurophysiol. 89 (2003) 1588-1602
16. Malcangio M., Ramer M.S., Jones M.G., and McMahon S.B. Abnormal substance P release from the spinal cord following injury to primary sensory neurons. Eur. J. Neurosci. 12 (2000) 397-399
17. Miki K., Fukuoka T., Tokunaga A., and Noguchi K. Calcitonin gene-related peptide increase in the rat spinal dorsal horn and dorsal column nucleus following peripheral nerve injury: up-regulation in a subpopulation of primary afferent sensory neurons. Neuroscience 82 (1998) 1243-1252
18. Miki K., Iwata K., Tsuboi Y., Sumino R., Fukuoka T., Tachibana T., Tokunaga A., and Noguchi K. Responses of dorsal column nuclei neurons in rats with experimental mononeuropathy. Pain 76 (1998) 407-415
19. Noguchi K., Kawai Y., Fukuoka T., Senba E., and Miki K. Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons. J. Neurosci. 15 (1995) 7633-7643
20. Obata K., Yamanaka H., Dai Y., Mizushima T., Fukuoka T., Tokunaga A., Yoshikawa H., and Noguchi K. Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion. Exp. Neurol. 188 (2004) 149-160
21. Ossipov M.H., Bian D., Malan Jr. P., Lai J., and Porreca F. Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain 79 (1999) 127-133
22. Ossipov M.H., Zhang E.-T., Carvajal C., Gardell L., Quirion R., Dumont Y., Lai J., and Porreca F. Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. J. Neurosci. 22 (2002) 9858-9867
23. Pan H.-L., Khan G.M., Alloway K.D., and Chen S.-R. Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action. J. Neurosci. 23 (2003) 2911-2919
24. Pini A., and Lynn B. C-fiber function during the 6 weeks following brief application of capsaicin to a cutaneous nerve in the rat. Eur. J. Neurosci. 3 (1990) 274-284
25. Pini A., Baranowski R., and Lynn B. Long-term reduction in the number of C-fiber nociceptors following capsaicin treatment of a cutaneous nerve in adult rats. Eur. J. Neurosci. 2 (1990) 89-97
26. Shamash S., Reichert F., and Rotshenker S. The cytokine network of Wallerian degeneration: tumor necrosis factor-α, interleukin-1α, and interleukin-1β. J. Neurosci. 22 (2002) 3052-3060
27. Sheen K., and Chung J.M. Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model. Brain Res. 610 (1993) 62-68
28. Shim B., Kim D.-W., Kim B.H., Nam T.S., Leem J.W., and Chung J.M. Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy. Neuroscience 132 (2005) 193-201
29. Sun Q., Tu H., Xing G.-G., Han J.-S., and Wan Y. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation. Exp. Neurol. 191 (2005) 128-136
30. Tsuzuki K., Kondo E., Fukuoka T., Yi D., Tsujino H., Sakagami M., and Noguchi K. Differential regulation of P2X3 mRNA expression by peripheral injury in intact and injured neurons in the rat sensory ganglia. Pain 91 (2001) 351-360
31. Woolf C.J., Shortland P., and Coggeshall R.E. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 355 (1992) 75-78
32. Woolf C.J., Shortland P., Reynolds M., Ridings J., Doubell T., and Coggeshall R.E. Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy. J. Comp. Neurol. 360 (1995) 121-134
33. Wu G., Ringkamp M., Hartke T.V., Murinson B.B., Campbell J.N., Griffin J.W., and Meyer R.A. Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers. J. Neurosci. 21 (2001) 1-5 (RC140)
34. Yoon Y., Na H., and Chung J. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain 64 (1996) 27-36