Impaired bone mineralization accompanied by low vitamin D and secondary hyperparathyroidism in patients with femoral neck fracture

Osteoporosis International

Volumn 24, Issue 2, 2013, Pages 641-649

  Seitz, S ^a   Koehne, T ^a   Ries, C ^a   De Novo Oliveira, A ^a   Barvencik, F ^a   Busse, B ^a   Eulenburg, C ^a   Schinke, T ^a   Puschel K ^a   Rueger, J M ^a   Amling, M ^a   Pogoda, P ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

BMDD; Femoral neck fracture; Histomorphometry; Osteoporosis; Vitamin D deficiency

Indexed keywords

PARATHYROID HORMONE; VITAMIN D;

AGED; ARTICLE; BONE MASS; BONE MINERAL; BONE MINERALIZATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; SECONDARY HYPERPARATHYROIDISM; VITAMIN BLOOD LEVEL;

ABSORPTIOMETRY, PHOTON; AGED; AGED, 80 AND OVER; ALKALINE PHOSPHATASE; BONE DENSITY; CALCIFICATION, PHYSIOLOGIC; CASE-CONTROL STUDIES; FEMALE; FEMORAL NECK FRACTURES; HUMANS; HYPERPARATHYROIDISM, SECONDARY; MALE; OSTEOPOROTIC FRACTURES; PARATHYROID HORMONE; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84873743475     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-2011-0     Document Type: Article

References (30)

1. Seeman E, Delmas PD (2006) Bone quality - the material and structural basis of bone strength and fragility. N Engl J Med 354:2250-2261
2. Lane NE (2006) Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol 194:S3-11
3. Mazess R, Collick B, Trempe J, Barden H, Hanson J (1989) Performance evaluation of a dual-energy x-ray bone densitometer. Calcif Tissue Int 44:228-232
4. Boehm HF, Eckstein F, Wunderer C, Kuhn V, Lochmueller EM, Schreiber K, Mueller D, Rummeny EJ, Link TM (2005) Improved performance of hip DXA using a novel region of interest in the upper part of the femoral neck: in vitro study using bone strength as a standard of reference. J Clin Densitom 8:488-494
5. Bousson V, Le Bras A, Roqueplan F et al (2006) Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int 17:855-864
6. Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Mineral Res 18:1947-1954
7. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES (2008) Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Mineral Res 23:1326-1333
8. Buitrago-Tellez CH, Bonnaire F, Schulze C, Gufler H, Honninger A, Kuner E, Langer M (1997) Quantitative CT assessment of the proximal femur. Experimental studies on its correlation with breaking load in femoral neck fractures. RöFö 167:627-632
9. Huber MB, Carballido-Gamio J, Bauer JS, Baum T, Eckstein F, Lochmuller EM, Majumdar S, Link TM (2008) Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT - correlation with biomechanical strength measurement. Radiology 247:472-481
10. Fazzalari N, Moore RJ, Manthey BA, Vernon-Roberts B (1989) Comparative study of iliac crest and proximal femur histomorphometry in normal patients. J Clin Pathol 42:745-748
11. Amling M, Herden S, Posl M, Hahn M, Ritzel H, Delling G (1996) Heterogeneity of the skeleton: comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus. J Bone Mineral Res 11:36-45
12. Loveridge N, Power J, Reeve J, Boyde A (2004) Bone mineralization density and femoral neck fragility. Bone 35:929-941
13. Zebaze RM, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, Mackie EJ, Seeman E (2010) Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet 375:1729-1736
14. Khosla S, Kleerekoper M (1999) Biochemical markers of bone turnover. In: Favus MG (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 4th edn. Lippincott Williams & Wilkins, Philadelphia
15. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Mineral Res 2:595-610
16. Aaron JE, Makins NB, Francis RM, Peacock M (1984) Staining of the calcification front in human bone using contrasting fluorochromes in vitro. J Histochem Cytochem 32:1251-1261
17. Compston JE, Vedi S, Webb A (1985) Relationship between toluidine blue-stained calcification fronts and tetracycline-labeled surfaces in normal human iliac crest biopsies. Calcif Tissue Int 37:32-35
18. Roschger P, Paschalis EP, Fratzl P, Klaushofer K (2008) Bone mineralization density distribution in health and disease. Bone 42:456-466
19. Roschger P, Plenk H Jr, Klaushofer K, Eschberger J (1995) A new scanning electron microscopy approach to the quantification of bone mineral distribution: backscattered electron image grey-levels correlated to calcium K alpha-line intensities. Scanning Microsc 9:75-86
20. Boyde A, Maconnachie E, Reid SA, Delling G, Mundy GR (1986) Scanning electron microscopy in bone pathology: review of methods, potential and applications. Scan Electron Microsc 4:1537-1554
21. Jones SJ, Glorieux FH, Travers R, Boyde A (1999) The microscopic structure of bone in normal children and patients with osteogenesis imperfecta: a survey using backscattered electron imaging. Calcif Tissue Int 64:8-17
22. Lai JK, Lucas RM, Clements MS, Roddam AW, Banks E (2010) Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies. BMC Publ Health 10:331
23. Tsangari H, Findlay DM, Zannettino AC, Pan B, Kuliwaba JS, Fazzalari NL (2006) Evidence for reduced bone formation surface relative to bone resorption surface in female femoral fragility fracture patients. Bone 39:1226-1235
24. Priemel M, von Domarus C, Klatte TO et al (2009) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 25:305-312
25. Lips P (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477-501
26. Fisher A, Srikusalanukul W, Davis M, Smith P (2010) Hip fracture type: important role of parathyroid hormone (PTH) response to hypovitaminosis D. Bone 47:400-407
27. Glendenning P, Chew GT, Seymour HM, Gillett MJ, Goldswain PR, Inderjeeth CA, Vasikaran SD, Taranto M, Musk AA, Fraser WD (2009) Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. Bone 45:870-875
28. Madsen CM, Jorgensen HL, Lind B, Ogarrio HW, Riis T, Schwarz P, Duus BR, Lauritzen JB (2012) Secondary hyperparathyroidism and mortality in hip fracture patients compared to a control group from general practice. Injury (in press)
29. Ruffoni D, Fratzl P, Roschger P, Phipps R, Klaushofer K, Weinkamer R (2008) Effect of temporal changes in bone turnover on the bone mineralization density distribution: a computer simulation study. J Bone Miner Res 23:1905-1914
30. Busse B, Hahn M, Soltau M, Zustin J, Puschel K, Duda GN, Amling M (2009) Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae. Bone 45:1034-1043