Hip fracture type: Important role of parathyroid hormone (PTH) response to hypovitaminosis D

Bone

Volumn 47, Issue 2, 2010, Pages 400-407

  Fisher, Alexander ^a,b   Srikusalanukul, Wichat ^a,b   Davis, Michael ^a,b   Smith, Paul ^a,b  

^a CANBERRA HOSPITAL   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

25(OH) vitamin D; Bone and mineral metabolism; Hip fracture type; PTH

Indexed keywords

ALKALINE PHOSPHATASE; C REACTIVE PROTEIN; CALCIUM; MAGNESIUM; PARATHYROID HORMONE; PHOSPHATE; TROPONIN I; VITAMIN D;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BONE METABOLISM; BONE TURNOVER; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HIP FRACTURE; HORMONE ACTION; HUMAN; KIDNEY FUNCTION TEST; LIVER FUNCTION TEST; MAGNESIUM BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MINERAL METABOLISM; OSTEOLYSIS; PHOSPHATE BLOOD LEVEL; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; THYROID FUNCTION TEST; THYROID HORMONE METABOLISM; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; BONE; BONE REMODELING; CLASSIFICATION; DRUG EFFECT; METABOLISM; PATHOPHYSIOLOGY; REGRESSION ANALYSIS; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; BONE AND BONES; BONE REMODELING; HIP FRACTURES; HUMANS; PARATHYROID HORMONE; REGRESSION ANALYSIS; TREATMENT OUTCOME; VITAMIN D DEFICIENCY;

EID: 77955984469     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.04.610     Document Type: Article

References (59)

1. Mautalen C.A., Vega E.M., Einhorn T.A. Are the etiologies of cervical and trochanteric hip fractures different?. Bone 1996, 18:133S-137S.
2. Duboeuf F., Hans D., Schott A.M., Kotzki P.O., Favier F., Marcelli C., et al. Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: the EPIDOS Study. J Bone Miner Res 1997, 12:1895-1902.
3. Stewart A., Porter R.W., Primrose W.R., Walker L.G., Reid D.M. Cervical and trochanteric hip fractures: bone mass and other parameters. Clin Rheumatol 1999, 18:201-206.
4. Bell K.L., Loveridge N., Power J., Garrahan N., Meggitt B.F., Reeve J. Regional differences in cortical porosity in the fractured femoral neck. Bone 1999, 24:57-64.
5. Partanen J., Jamsa T., Jalovaara P. Influence of the upper femur and pelvic geometry on the risk and type of hip fractures. J Bone Miner Res 2001, 16:1540-1546.
6. Gnudi S., Ripamonti C., Lisi L., Fini M., Giardino R., Giavaresi G. Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women. Osteoporos Int 2002, 13:69-73.
7. Pulkkinen P., Partanen J., Jalovaara P., Jamsa T. Combination of bone mineral density and upper femur geometry improves the prediction of hip fracture. Osteoporos Int 2004, 15:274-280.
8. Di Monaco M., Vallero F., Di Monaco R., Mautino F., Cavanna A. Body composition and hip fracture type in elderly women. Clin Rheumatol 2004, 23:6-10.
9. Mayhew P.M., Thomas C.D., Clement J.G., Loveridge N., Beck T.J., Bonfield W., et al. Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 2005, 366:129-135.
10. Pulkkinen P., Eckstein F., Lochmuller E.M., Kuhn V., Jamsa T. Association of geometric factors and failure load level with the distribution of cervical vs. trochanteric hip fractures. J Bone Miner Res 2006, 21:895-901.
11. Haentjens P., Autier P., Barette M., Venken K., Vanderschueren D., Boonen S. Survival and functional outcome according to hip fracture type: a one-year prospective cohort study in elderly women with an intertrochanteric or femoral neck fracture. Bone 2007, 41:958-964.
12. Fratzl-Zelman N., Roschger P., Gourrier A., Weber M., Misof B.M., Loveridge N., et al. Combination of nanoindentation and quantitative backscattered electron imaging revealed altered bone material properties associated with femoral neck fragility. Calcif Tissue Int 2009, 85:335-343.
13. Bonjour J.P., Schurch M.A., Rizzoli R. Nutritional aspects of hip fractures. Bone 1996, 18:139S-144S.
14. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001, 22:477-501.
15. Sahota O., Gaynor K., Harwood R.H., Hosking D.J. Hypovitaminosis D and 'functional hypoparathyroidism'-the NoNoF (Nottingham Neck of Femur) study. Age Ageing 2001, 30:467-472.
16. Ensrud K.E., Lui L.Y., Taylor B.C., Ishani A., Shlipak M.G., Stone K.L., et al. Renal function and risk of hip and vertebral fractures in older women. Arch Intern Med 2007, 167:133-139.
17. LaCroix A.Z., Lee J.S., Wu L., Cauley J.A., Shlipak M.G., Ott S.M., et al. Cystatin-C, renal function, and incidence of hip fracture in postmenopausal women. J Am Geriatr Soc 2008, 56:1434-1441.
18. Singh Mangat K., Mehra A., Yunas I., Nightingale P., Porter K. Is estimated peri-operative glomerular filtration rate associated with post-operative mortality in fractured neck of femur patients?. Injury 2008, 39:1141-1146.
19. Sahota O., Mundey M.K., San P., Godber I.M., Lawson N., Hosking D.J. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone 2004, 35:312-319.
20. Compston J.E. Skeletal actions of intermittent parathyroid hormone: effects on bone remodelling and structure. Bone 2007, 40:1447-1452.
21. Rejnmark L., Vestergaard P., Brot C., Mosekilde L. Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics. Clin Endocrinol (Oxf) 2008, 69:29-35.
22. Kuchuk N.O., Pluijm S.M., van Schoor N.M., Looman C.W., Smit J.H., Lips P. Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab 2009, 94:1244-1250.
23. Sakuma M., Endo N., Oinuma T., Hayami T., Endo E., Yazawa T., et al. Vitamin D and intact PTH status in patients with hip fracture. Osteoporos Int 2006, 17:1608-1614.
24. Epstein S. Is cortical bone hip? What determines cortical bone properties?. Bone 2007, 41:S3-S8.
25. Sakuma M., Endo N., Oinuma T. Serum 25-OHD insufficiency as a risk factor for hip fracture. J Bone Miner Metab 2007, 25:147-150.
26. Glendenning P., Chew G.T., Seymour H.M., Gillett M.J., Goldswain P.R., Inderjeeth C.A., et al. Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. Bone 2009, 45:870-875.
27. Partanen J., Heikkinen J., Jamsa T., Jalovaara P. Characteristics of lifetime factors, bone metabolism, and bone mineral density in patients with hip fracture. J Bone Miner Metab 2002, 20:367-375.
28. Robbins J.A., Schott A.M., Garnero P., Delmas P.D., Hans D., Meunier P.J. Risk factors for hip fracture in women with high BMD: EPIDOS study. Osteoporos Int 2005, 16:149-154.
29. Fox K.M., Magaziner J., Hebel J.R., Kenzora J.E., Kashner T.M. Intertrochanteric versus femoral neck hip fractures: differential characteristics, treatment, and sequelae. J Gerontol A Biol Sci Med Sci 1999, 54:M635-M640.
30. Levey A.S., Bosch J.P., Lewis J.B., Greene T., Rogers N., Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999, 130:461-470.
31. Kushida K., Takahashi M., Kawana K., Inoue T. Comparison of markers for bone formation and resorption in premenopausal and postmenopausal subjects, and osteoporosis patients. J Clin Endocrinol Metab 1995, 80:2447-2450.
32. Takahashi M., Naitou K., Ohishi T., Nagano A. Comparison of biochemical markers of bone turnover and bone mineral density between hip fracture and vertebral fracture. J Clin Densitom 2003, 6:211-218.
33. Bell K.L., Loveridge N., Power J., Rushton N., Reeve J. Intracapsular hip fracture: increased cortical remodeling in the thinned and porous anterior region of the femoral neck. Osteoporos Int 1999, 10:248-257.
34. Lochmuller E.M., Muller R., Kuhn V., Lill C.A., Eckstein F. Can novel clinical densitometric techniques replace or improve DXA in predicting bone strength in osteoporosis at the hip and other skeletal sites?. J Bone Miner Res 2003, 18:906-912.
35. Riggs B.L., Melton Iii L.J., Robb R.A., Camp J.J., Atkinson E.J., Peterson J.M., et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res 2004, 19:1945-1954.
36. Szulc P., Duboeuf F., Schott A.M., Dargent-Molina P., Meunier P.J., Delmas P.D. Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study. Osteoporos Int 2006, 17:231-236.
37. Pulkkinen P., Partanen J., Jalovaara P., Jamsa T. BMD T-score discriminates trochanteric fractures from unfractured controls, whereas geometry discriminates cervical fracture cases from unfractured controls of similar BMD. Osteoporos Int Sept 26 2009, [Electronic publication ahead of print].
38. Penrod J.D., Litke A., Hawkes W.G., Magaziner J., Koval K.J., Doucette J.T., et al. Heterogeneity in hip fracture patients: age, functional status, and comorbidity. J Am Geriatr Soc 2007, 55:407-413.
39. Mehta P., Kifley A., Wang J.J., Rochtchina E., Mitchell P., Sue C.M. Population prevalence and incidence of Parkinson's disease in an Australian community. Intern Med J 2007, 37:812-814.
40. Eastwood E.A., Magaziner J., Wang J., Silberzweig S.B., Hannan E.L., Strauss E., et al. Patients with hip fracture: subgroups and their outcomes. J Am Geriatr Soc 2002, 50:1240-1249.
41. Di Monaco M., Vallero F., Di Monaco R., Tappero R., Cavanna A. Hip-fracture type does not affect the functional outcome after acute in-patient rehabilitation: a study of 684 elderly women. Eura Medicophys 2007, 43:439-444.
42. Aharonoff G.B., Koval K.J., Skovron M.L., Zuckerman J.D. Hip fractures in the elderly: predictors of one year mortality. J Orthop Trauma 1997, 11:162-165.
43. Shah M.R., Aharonoff G.B., Wolinsky P., Zuckerman J.D., Koval K.J. Outcome after hip fracture in individuals ninety years of age and older. J Orthop Trauma 2001, 15:34-39.
44. Karagiannis A., Papakitsou E., Dretakis K., Galanos A., Megas P., Lambiris E., et al. Mortality rates of patients with a hip fracture in a southwestern district of Greece: ten-year follow-up with reference to the type of fracture. Calcif Tissue Int 2006, 78:72-77.
45. Chen J.S., Sambrook P.N., March L., Cameron I.D., Cumming R.G., Simpson J.M., et al. Hypovitaminosis D and parathyroid hormone response in the elderly: effects on bone turnover and mortality. Clin Endocrinol (Oxf) 2008, 68:290-298.
46. Lau E.M., Woo J., Swaminathan R., MacDonald D., Donnan S.P. Plasma 25-hydroxyvitamin D concentration in patients with hip fracture in Hong Kong. Gerontology 1989, 35:198-204.
47. Kurosu H., Kuro O.M. The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol 2009, 299:72-78.
48. Torres P.U., Prie D., Beck L., De Brauwere D., Leroy C., Friedlander G. Klotho gene, phosphocalcic metabolism, and survival in dialysis. J Ren Nutr 2009, 19:50-56.
49. Yokota H., Raposo J.F., Chen A., Jiang C., Ferreira H.G. Evaluation of the role of FGF23 in mineral metabolism. Gene Regul Syst Bio 2009, 3:131-142.
50. Komaba H., Fukagawa M. FGF23: a key player in mineral and bone disorder in CKD. Nefrologia 2009, 29:392-396.
51. Stubbs J.R., Quarles L.D. Fibroblast growth factor 23: uremic toxin or innocent bystander in chronic kidney disease?. Nephrol News Issues 2009, 23(33-4):36-37.
52. Bjorkman M.P., Sorva A.J., Risteli J., Tilvis R.S. Low parathyroid hormone levels in bedridden geriatric patients with vitamin D deficiency. J Am Geriatr Soc 2009, 57:1045-1050.
53. Brot C., Jorgensen N.R., Sorensen O.H. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr 1999, 53:920-926.
54. Jorde R., Saleh F., Figenschau Y., Kamycheva E., Haug E., Sundsfjord J. Serum parathyroid hormone (PTH) levels in smokers and non-smokers. The fifth Tromso study. Eur J Endocrinol 2005, 152:39-45.
55. Sneve M., Jorde R. Cross-sectional study on the relationship between body mass index and smoking, and longitudinal changes in body mass index in relation to change in smoking status: the Tromso Study. Scand J Public Health 2008, 36:397-407.
56. Silver J., Kilav R., Naveh-Many T. Mechanisms of secondary hyperparathyroidism. Am J Physiol Renal Physiol 2002, 283:F367-F376.
57. Sahota O., Mundey M.K., San P., Godber I.M., Hosking D.J. Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Osteoporos Int 2006, 17:1013-1021.
58. Souberbielle J.C., Lawson-Body E., Hammadi B., Sarfati E., Kahan A., Cormier C. The use in clinical practice of parathyroid hormone normative values established in vitamin D-sufficient subjects. J Clin Endocrinol Metab 2003, 88:3501-3504.
59. Fisher A., Goh S., Srikusalanukul W., Davis M. Elevated serum PTH is independently associated with poor outcomes in older patients with hip fracture and vitamin D inadequacy. Calcif Tissue Int 2009, 84:301-309.