Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1197-1200

  Griebenow, Nils ^a   Schirok, Hartmut ^a   Mittendorf, Joachim ^a   Straub, Alexander ^a   Follmann, Markus ^a   Stasch, Johannes Peter ^a   Knorr, Andreas ^a   Schlemmer, Karl Heinz ^a   Redlich, Gorden ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Acidic heterocycles; Carboxylic acid isosteres; Guanylate cyclase; SAR; Stimulator

Indexed keywords

1,2,4 OXADIAZOL 5 (2H) ONE; 1,2,4 OXADIAZOL 5 (2H) THIONE; 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL] 5 MORPHOLINO 4,6 PYRIMIDINEDIAMINE; GUANYLATE CYCLASE ACTIVATOR; LIFICIGUAT; RIOCIGUAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SOLUBILITY; DRUG SYNTHESIS; IC 50; NONHUMAN; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; GUANYLATE CYCLASE; PYRAZOLES; PYRIDINES; RATS; STIMULATION, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873740604     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.028     Document Type: Article

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