The role of individual gastric emptying of pellets in the prediction of diclofenac in vivo dissolution

Journal of Controlled Release

Volumn 166, Issue 3, 2013, Pages 286-293

  Klein, Sandra ^a   Garbacz, Grzegorz ^a,b   Pišlar, Mitja ^c   Locatelli, Igor ^c   Liu, Chong ^a   Weitschies, Werner ^a   Siegmund, Werner ^a   Mrhar, Aleš ^c   Bogataj, Marija ^c  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b Physiolution GmbH   (Germany)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Absorption profiles; Diclofenac; Gastric emptying; In vitro dissolution; Pellets; Predicted individual in vivo dissolution

Indexed keywords

CRITICAL FACTORS; DEGREE OF SIMILARITY; DICLOFENAC; DISSOLUTION PROFILES; DRUG RELEASE; EXTENDED RELEASE; GASTRIC EMPTYING; GASTROINTESTINAL TRACT; IN-VITRO; IN-VITRO DISSOLUTION; IN-VIVO; RESIDENCE TIME;

DISSOLUTION; MATHEMATICAL MODELS; ORE PELLETS;

PELLETIZING;

DICLOFENAC;

ARTICLE; COMPARATIVE STUDY; DRUG ABSORPTION; DRUG PELLET; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PH; PREDICTION; PRIORITY JOURNAL; SMALL INTESTINE; STOMACH EMPTYING;

ABSORPTION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DICLOFENAC; GASTRIC EMPTYING; HUMANS; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; SOLUBILITY; TIME FACTORS;

EID: 84873740254     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.032     Document Type: Article

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