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Volumn 10, Issue 1, 2013, Pages 21-32

Understanding and controlling chronic immune activation in the HIV-infected patients suppressed on combination antiretroviral therapy

Author keywords

Chronic immune activation; Co infections; Combination antiretroviral therapy (cART); HIV; HIV pathogenesis and treatment; Immune activation; Microbial translocation

Indexed keywords

ACETYLSALICYLIC ACID; ACICLOVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ATORVASTATIN; CD14 ANTIGEN; CHLOROQUINE; EMTRICITABINE; GANCICLOVIR; HEPATITIS B VACCINE; HYDROXYCHLOROQUINE; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 7; LOPINAVIR PLUS RITONAVIR; MARAVIROC; MESALAZINE; METHOTREXATE; PLACEBO; PRAVASTATIN; PREBIOTIC AGENT; PROBIOTIC AGENT; RALTEGRAVIR; RIFAXIMIN; ROSUVASTATIN; SALAZOSULFAPYRIDINE; SEVELAMER; SIMVASTATIN; TENOFOVIR; VALACICLOVIR; VALGANCICLOVIR;

EID: 84873739567     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-012-0147-3     Document Type: Article
Times cited : (32)

References (100)
  • 1
    • 70349433735 scopus 로고    scopus 로고
    • Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells
    • 19728788 10.1086/605890 1:CAS:528:DC%2BD1MXhtlyqs7fE This study demonstrated the inability of cART to normalize immune activation markers in HIV-infected patients
    • • French MA, King MS, Tschampa JM, da Silva BA, Landay AL. Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells. J Infect Dis. 2009;200:1212-5. This study demonstrated the inability of cART to normalize immune activation markers in HIV-infected patients.
    • (2009) J Infect Dis , vol.200 , pp. 1212-1215
    • French, M.A.1    King, M.S.2    Tschampa, J.M.3    Da Silva, B.A.4    Landay, A.L.5
  • 2
    • 80755123417 scopus 로고    scopus 로고
    • Premature age-related comorbidities among HIV-infected persons compared with the general population
    • 21998278 10.1093/cid/cir627 By showing that non-infectious co-morbidities develop about 15 years earlier despite cART in HIV-infected patients, this study stimulated increased interest in addressing HIV infection as an independent risk factor for a variety of non-AIDS conditions
    • • Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin infect Dis. 2011;53(11):1120-6. By showing that non-infectious co-morbidities develop about 15 years earlier despite cART in HIV-infected patients, this study stimulated increased interest in addressing HIV infection as an independent risk factor for a variety of non-AIDS conditions.
    • (2011) Clin Infect Dis , vol.53 , Issue.11 , pp. 1120-1126
    • Guaraldi, G.1    Orlando, G.2    Zona, S.3
  • 3
    • 77951819361 scopus 로고    scopus 로고
    • Causes of death in HIV-1-infected individuals on combination antiretroviral therapy in high-income countries: A collaborative analysis of 14 cohort studies
    • Antiretroviral Therapy Collaboration 10.1086/652283
    • Antiretroviral Therapy Collaboration. Causes of death in HIV-1-infected individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Clin Infect Dis. 2010;50:1387-96.
    • (2010) Clin Infect Dis , vol.50 , pp. 1387-1396
  • 5
    • 53449093632 scopus 로고    scopus 로고
    • Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    • 18664624 10.1182/blood-2008-05-159301 1:CAS:528:DC%2BD1cXht1Srtb%2FJ
    • Brenchley JM, Paiardini M, Knox KS, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood. 2008;112:2826-35.
    • (2008) Blood , vol.112 , pp. 2826-2835
    • Brenchley, J.M.1    Paiardini, M.2    Knox, K.S.3
  • 7
    • 58949102533 scopus 로고    scopus 로고
    • Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients
    • 18936106 10.1136/gut.2008.150425 1:CAS:528:DC%2BD1MXisFShu7Y%3D
    • Epple HJ, Schneider T, Troeger H, et al. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut. 2009;58(2):220-7.
    • (2009) Gut , vol.58 , Issue.2 , pp. 220-227
    • Epple, H.J.1    Schneider, T.2    Troeger, H.3
  • 9
    • 0142092389 scopus 로고    scopus 로고
    • + T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy
    • DOI 10.1128/JVI.77.21.11708-11717.2003
    • Guadalupe M, Reay E, Sankaran S, et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol. 2003;77:11708-17. (Pubitemid 37271669)
    • (2003) Journal of Virology , vol.77 , Issue.21 , pp. 11708-11717
    • Guadalupe, M.1    Reay, E.2    Sankaran, S.3    Prindiville, T.4    Flamm, J.5    McNeil, A.6    Dandekar, S.7
  • 10
    • 77952916199 scopus 로고    scopus 로고
    • Microbial translocation induces persistent macrophages activation unrelated to HIV-1 levels or T-cell activation following therapy
    • 20559035 10.1097/QAD.0b013e328339e228 1:CAS:528:DC%2BC3cXmt1eht7c%3D This study showed the association between microbial translocation and immune activation despite cART
    • •• Wallet MA, Rodriguez CA, Yin L, et al. Microbial translocation induces persistent macrophages activation unrelated to HIV-1 levels or T-cell activation following therapy. AIDS. 2010;24:1281-90. This study showed the association between microbial translocation and immune activation despite cART.
    • (2010) AIDS , vol.24 , pp. 1281-1290
    • Wallet, M.A.1    Rodriguez, C.A.2    Yin, L.3
  • 11
    • 77956991705 scopus 로고    scopus 로고
    • Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: The role of interleukin 7 and interleukin 7 receptor alpha and microbial translocation
    • 20812848 10.1086/656369 1:CAS:528:DC%2BC3cXhsVSqurvF
    • Rajasuriar R, Booth D, Solomon A, et al. Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor alpha and microbial translocation. J Infect Dis. 2010;202:1254-64.
    • (2010) J Infect Dis , vol.202 , pp. 1254-1264
    • Rajasuriar, R.1    Booth, D.2    Solomon, A.3
  • 12
    • 84865163472 scopus 로고    scopus 로고
    • Microbial translocation in HIV infection: Causes, consequences and treatment opportunities
    • 22886237 10.1038/nrmicro2848 1:CAS:528:DC%2BC38XhtFOgsL3M This is a comprehensive overview of microbial translocation as it relates to HIV
    • • Sandler NG, Douek DC. Microbial translocation in HIV infection: causes, consequences and treatment opportunities. Nat Rev Microbiol. 2012;10:655-66. This is a comprehensive overview of microbial translocation as it relates to HIV.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 655-666
    • Sandler, N.G.1    Douek, D.C.2
  • 13
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • 19265479 10.1086/597476 1:CAS:528:DC%2BD1MXltVOms7c%3D
    • Jiang W, Lederman MM, Hunt P, et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis. 2009;199:1177-85.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 14
    • 80052882129 scopus 로고    scopus 로고
    • Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    • 21917895 10.1093/infdis/jir507 1:CAS:528:DC%2BC3MXht1SitLfN In this study, poor immune response during cART was shown to be connected to immune activation in ways that may provide opportunities for therapeutic intervention
    • •• Lederman MM, Calabrese L, Funderburg NT, et al. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis. 2011;204(8):1217-26. In this study, poor immune response during cART was shown to be connected to immune activation in ways that may provide opportunities for therapeutic intervention.
    • (2011) J Infect Dis. , vol.204 , Issue.8 , pp. 1217-1226
    • Lederman, M.M.1    Calabrese, L.2    Funderburg, N.T.3
  • 16
    • 44849089446 scopus 로고    scopus 로고
    • Effects of rifaximin on bacterial virulence mechanisms at supra- and sub-inhibitory concentrations
    • Debbia EA, Maioli E, Roveta S, et al. Effects of rifaximin on bacterial virulence mechanisms at supra- and sub-inhibitory concentrations. J Chemother. 2008;20:186-94. (Pubitemid 351797058)
    • (2008) Journal of Chemotherapy , vol.20 , Issue.2 , pp. 186-194
    • Debbia, E.A.1    Maioli, E.2    Roveta, S.3    Marchese, A.4
  • 17
    • 80052052440 scopus 로고    scopus 로고
    • Inhibition of NF-kB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells
    • 21806984 10.1016/j.ejphar.2011.06.058 1:CAS:528:DC%2BC3MXhtV2it77L
    • Mencarelli A, Renga B, Palladino G, Claudia D, et al. Inhibition of NF-kB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells. Eur J Pharmacol. 2011;668(1-2):317-24.
    • (2011) Eur J Pharmacol , vol.668 , Issue.1-2 , pp. 317-324
    • Mencarelli, A.1    Renga, B.2    Palladino, G.3    Claudia, D.4
  • 18
    • 63849083717 scopus 로고    scopus 로고
    • Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis
    • 19210289 10.1111/j.1365-2036.2009.03958.x 1:CAS:528:DC%2BD1MXlsFWltbg%3D
    • Vlachogiannakos J, Saveriadis AS, Viazis N, et al. Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis. Aliment Pharmacol Ther. 2009;29:992-9.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 992-999
    • Vlachogiannakos, J.1    Saveriadis, A.S.2    Viazis, N.3
  • 19
    • 84856407574 scopus 로고    scopus 로고
    • Rifaximin reduces endotoxemia and improves liver function and disease severity in patients with decompensated cirrhosis
    • 22030839 10.1002/hep.24751 1:CAS:528:DC%2BC38Xht1yqu74%3D
    • Kalambokis GN, Tsianos EV. Rifaximin reduces endotoxemia and improves liver function and disease severity in patients with decompensated cirrhosis. Hepatology. 2012;55(2):655-6.
    • (2012) Hepatology , vol.55 , Issue.2 , pp. 655-656
    • Kalambokis, G.N.1    Tsianos, E.V.2
  • 20
    • 84873715511 scopus 로고    scopus 로고
    • Administration of rifaximin and sulfasalazine during acute SIV infection decreases microbial translocation and coagulation marker levels and significantly impacts viral replication. Abstract 162
    • March 5-12. Seattle WA
    • Pandrea I, Haret-Richter G, Ma D, et al. Administration of rifaximin and sulfasalazine during acute SIV infection decreases microbial translocation and coagulation marker levels and significantly impacts viral replication. Abstract 162. In: Program and abstracts of the 19th Conference on Retroviruses and Opportunistic Infections. March 5-12. Seattle WA; 2012.
    • (2012) Program and Abstracts of the 19th Conference on Retroviruses and Opportunistic Infections
    • Pandrea, I.1    Haret-Richter, G.2    Ma, D.3
  • 21
    • 77449086886 scopus 로고    scopus 로고
    • Endotoxin-binding affinity of sevelamer: A potential novel anti-inflammatory mechanism
    • Sun PP, Perianayagam MC and Jaber BL. Endotoxin-binding affinity of sevelamer: a potential novel anti-inflammatory mechanism. Kidney Int Suppl. 2009;S20-5.
    • (2009) Kidney Int Suppl.
    • Sun, P.P.1    Perianayagam, M.C.2    Jaber, B.L.3
  • 22
    • 77950031877 scopus 로고    scopus 로고
    • Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia
    • 20357435 10.1159/000302723 1:STN:280:DC%2BC3crhsFGntQ%3D%3D
    • Stinghen AE, Goncalves SM, Bucharles S, et al. Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia. Blood Purif. 2010;29:352-6.
    • (2010) Blood Purif , vol.29 , pp. 352-356
    • Stinghen, A.E.1    Goncalves, S.M.2    Bucharles, S.3
  • 23
    • 80051552856 scopus 로고    scopus 로고
    • Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation
    • 21436711 10.1097/QAI.0b013e31821a603c 1:CAS:528:DC%2BC3MXovVWiur4%3D
    • Ellis CL, Ma ZM, Mann SK, et al. Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation. J Acquir Immune Defic Syndr. 2011;57(5):363-70.
    • (2011) J Acquir Immune Defic Syndr , vol.57 , Issue.5 , pp. 363-370
    • Ellis, C.L.1    Ma, Z.M.2    Mann, S.K.3
  • 25
    • 84455208831 scopus 로고    scopus 로고
    • Effect of probiotic bacteria on microbial host defense, growth and immune function in human immunodeficiency virus type-1 infection
    • 22292110 10.3390/nu3121042 1:CAS:528:DC%2BC38XjtF2ltw%3D%3D
    • Cunningham-Rundles S, Ahrne S, Johann-Liang R, et al. Effect of probiotic bacteria on microbial host defense, growth and immune function in human immunodeficiency virus type-1 infection. Nutrients. 2011;3(12):1042-70.
    • (2011) Nutrients , vol.3 , Issue.12 , pp. 1042-1070
    • Cunningham-Rundles, S.1    Ahrne, S.2    Johann-Liang, R.3
  • 26
    • 84860390171 scopus 로고    scopus 로고
    • Specific prebiotics modulate gut microbiota and immune activation in HAART-naïve HIV-infected adults: Results of the "cOPA" pilot randomized trial
    • 21525866 10.1038/mi.2011.15 1:CAS:528:DC%2BC3MXhtVehsrjN This pilot trial provides preliminary evidence that nutritional supplementation with prebiotics may be a clinical intervention to modulate chronic immune activation
    • • Gori A, Rizzardini G, Van'tLand B, et al. Specific prebiotics modulate gut microbiota and immune activation in HAART-naïve HIV-infected adults: results of the "COPA" pilot randomized trial. Mucosal Immunol. 2011;4(5):554-63. This pilot trial provides preliminary evidence that nutritional supplementation with prebiotics may be a clinical intervention to modulate chronic immune activation.
    • (2011) Mucosal Immunol , vol.4 , Issue.5 , pp. 554-563
    • Gori, A.1    Rizzardini, G.2    Van'Tland, B.3
  • 27
    • 84864125153 scopus 로고    scopus 로고
    • Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study
    • 22550117 10.1093/cid/cis383 1:CAS:528:DC%2BC38XpsVahs7o%3D IL-7 was shown as a potential intervention to improve T cell reconstitution in HIV-infected patient
    • •• Levy Y, Sereti I, Tambussi G, et al. Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study. Clin Infect Dis. 2012;55:291-300. IL-7 was shown as a potential intervention to improve T cell reconstitution in HIV-infected patient.
    • (2012) Clin Infect Dis , vol.55 , pp. 291-300
    • Levy, Y.1    Sereti, I.2    Tambussi, G.3
  • 29
    • 84868609542 scopus 로고    scopus 로고
    • Paucity of interleukin (IL-21) producing CD4+ T-cells is associated with Th17 cell depletion in SIV-infection of rhesus macaques
    • E pub ahead of print. Depletion of CD4 + IL21+ T cells in blood and rectal mucosa was shown in a macaque model to correlate with loss TH17 cells
    • • Micci L, Cervasi B, Ende ZS, et al. Paucity of interleukin (IL-21) producing CD4+ T-cells is associated with Th17 cell depletion in SIV-infection of rhesus macaques. Blood 2012 Sep 18. E pub ahead of print. Depletion of CD4 + IL21+ T cells in blood and rectal mucosa was shown in a macaque model to correlate with loss TH17 cells.
    • Blood
    • Micci, L.1    Cervasi, B.2    Ende, Z.S.3
  • 30
    • 79957966626 scopus 로고    scopus 로고
    • Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy
    • 21628667 10.1093/infdis/jir208 1:CAS:528:DC%2BC3MXntF2gt70%3D
    • Chun T, Murray D, Justement JS, Hallahan CW, Moir S, Kovacs C, Fauci AS. Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis. 2011;204:135-8.
    • (2011) J Infect Dis , vol.204 , pp. 135-138
    • Chun, T.1    Murray, D.2    Justement, J.S.3    Hallahan, C.W.4    Moir, S.5    Kovacs, C.6    Fauci, A.S.7
  • 31
    • 84864385246 scopus 로고    scopus 로고
    • Maraviroc and other HIV-1 entry inhibitors exhibit a class-specific redistribution effect that results in increased extracellular viral load
    • 22615275 10.1128/AAC.00409-12 1:CAS:528:DC%2BC38XhtFajs7zL
    • Kramer VG, Schader SM, Oliveira M, et al. Maraviroc and other HIV-1 entry inhibitors exhibit a class-specific redistribution effect that results in increased extracellular viral load. Antimicrob Agents Chemother. 2012;56:4154-60.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 4154-4160
    • Kramer, V.G.1    Schader, S.M.2    Oliveira, M.3
  • 32
    • 77950537810 scopus 로고    scopus 로고
    • HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
    • 20228817 10.1038/nm.2111
    • Buzon MJ, Massanella M, Llibre JM, et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nat Med. 2010;16:460-5.
    • (2010) Nat Med , vol.16 , pp. 460-465
    • Buzon, M.J.1    Massanella, M.2    Llibre, J.M.3
  • 33
    • 84860345691 scopus 로고    scopus 로고
    • Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: A randomized 48-week study
    • 10.3851/IMP1917
    • Libre JM, Buzon MJ, Massanella M, et al. Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study. Antivir Ther. 2012;17:355-64.
    • (2012) Antivir Ther , vol.17 , pp. 355-364
    • Libre, J.M.1    Buzon, M.J.2    Massanella, M.3
  • 34
    • 78549245806 scopus 로고    scopus 로고
    • Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    • 20827162 10.1097/QAD.0b013e32833ef7bb 1:CAS:528:DC%2BC3cXht1yqtr7K
    • Yukl SA, Shergill AK, McQuaid K, et al. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS. 2010;24:2451-60.
    • (2010) AIDS , vol.24 , pp. 2451-2460
    • Yukl, S.A.1    Shergill, A.K.2    McQuaid, K.3
  • 35
    • 84859752894 scopus 로고    scopus 로고
    • No effect of raltegravir intensification on viral replication markers in the blood of HIV-1 infected patients receiving antiretroviral therapy
    • 22083073 10.1097/QAI.0b013e31823fd1f2 1:CAS:528:DC%2BC38Xit1ejsL4%3D
    • Gandhi RT, Coombs RW, Chan ES, et al. No effect of raltegravir intensification on viral replication markers in the blood of HIV-1 infected patients receiving antiretroviral therapy. JAIDS. 2012;59:229-35.
    • (2012) JAIDS , vol.59 , pp. 229-235
    • Gandhi, R.T.1    Coombs, R.W.2    Chan, E.S.3
  • 36
    • 81055124940 scopus 로고    scopus 로고
    • Raltegravir treatment intensification does not alter cerebrospinal fluid HIV-1 infection or immunoactivation in subjects on suppressive therapy
    • 22021620 10.1093/infdis/jir667 1:CAS:528:DC%2BC3MXhsVyksrfE
    • Dahl V, Lee E, Peterson J, et al. Raltegravir treatment intensification does not alter cerebrospinal fluid HIV-1 infection or immunoactivation in subjects on suppressive therapy. J Infect Dis. 2011;204:1936-45.
    • (2011) J Infect Dis , vol.204 , pp. 1936-1945
    • Dahl, V.1    Lee, E.2    Peterson, J.3
  • 37
    • 80054739868 scopus 로고    scopus 로고
    • Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: A randomized controlled trial
    • 21930607 10.1093/infdis/jir559 1:CAS:528:DC%2BC3MXhtlCntr3O
    • Byakwaga H, Kelly M, Purcell DF, et al. Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trial. J Infect Dis. 2011;204:1532-40.
    • (2011) J Infect Dis , vol.204 , pp. 1532-1540
    • Byakwaga, H.1    Kelly, M.2    Purcell, D.F.3
  • 38
    • 77749277080 scopus 로고    scopus 로고
    • Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy
    • 20156060 10.1086/650749 1:CAS:528:DC%2BC3cXksVGlurw%3D
    • McMahon D, Jones J, Markovitz DM, et al. Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy. Clin Infect Dis. 2010;50(6):912-9.
    • (2010) Clin Infect Dis , vol.50 , Issue.6 , pp. 912-919
    • McMahon, D.1    Jones, J.2    Markovitz, D.M.3
  • 39
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • 19470482 10.1073/pnas.0903107106 1:CAS:528:DC%2BD1MXot1Cgurk%3D
    • Dinoso JB, Kim SY, Wiegand AM, et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci U S A. 2009;106(23):9403-8.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.23 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3
  • 40
    • 77949592502 scopus 로고    scopus 로고
    • Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection
    • 20186346 10.1371/journal.pone.0009390
    • Archin NM, Cheema M, Parker D, et al. Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. PLoS One. 2010;5:e9390.
    • (2010) PLoS One , vol.5 , pp. 9390
    • Archin, N.M.1    Cheema, M.2    Parker, D.3
  • 41
    • 84155165636 scopus 로고    scopus 로고
    • Effect of raltegravir intensification on HIV proviral DNA in the blood and gut mucosa of men on long-term therapy: A randomized controlled trial
    • 22089379 10.1097/QAD.0b013e32834e8955 1:CAS:528:DC%2BC3MXhs1Cqur7L
    • Chege D, Kovacs C, la Porte C, et al. Effect of raltegravir intensification on HIV proviral DNA in the blood and gut mucosa of men on long-term therapy: a randomized controlled trial. AIDS. 2012;26:167-74.
    • (2012) AIDS , vol.26 , pp. 167-174
    • Chege, D.1    Kovacs, C.2    La Porte, C.3
  • 42
    • 0030668834 scopus 로고    scopus 로고
    • Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers or combinations of HLA DR and CD38 expression
    • 9358102 10.1097/00042560-199710010-00003 1:STN:280:DyaK1c%2FhvFWgtg%3D%3D
    • Liu Z, Cumberland WG, Hultin LE, et al. Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers or combinations of HLA DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16:83-92.
    • (1997) J Acquir Immune Defic Syndr Hum Retrovirol. , vol.16 , pp. 83-92
    • Liu, Z.1    Cumberland, W.G.2    Hultin, L.E.3
  • 43
    • 77953631013 scopus 로고    scopus 로고
    • Effect of treating co-infections on HIV-1 viral load: A systematic review
    • 20610327 10.1016/S1473-3099(10)70093-1 This review demonstrated that co-infections contribute significantly to immune activation in HIV infection and makes a case for treatment/suppression of culprit pathogens
    • • Modjarrad K, Vermund SH. Effect of treating co-infections on HIV-1 viral load: a systematic review. Lancet Infect Dis. 2010;10:455-63. This review demonstrated that co-infections contribute significantly to immune activation in HIV infection and makes a case for treatment/suppression of culprit pathogens.
    • (2010) Lancet Infect Dis , vol.10 , pp. 455-463
    • Modjarrad, K.1    Vermund, S.H.2
  • 44
    • 85085229320 scopus 로고    scopus 로고
    • T Cell activation in HIV-1/Herpes Simplex Virus-2-coinfected Kenyan women receiving valacyclovir
    • Roxby AC, Liu AY, Drake AL, et al. T Cell activation in HIV-1/Herpes Simplex Virus-2-coinfected Kenyan women receiving valacyclovir. AIDS Res Human Retroviruses 2012 Sep 4. E pub ahead of print.
    • (2012) AIDS Res Human Retroviruses
    • Roxby, A.C.1    Liu, A.Y.2    Drake, A.L.3
  • 45
    • 84855829142 scopus 로고    scopus 로고
    • Prevalence and risk factors associated with herpes simplex virus-2 infection in a contemporary cohort of HIV-infected persons in the United States
    • Patel P, Bush T, Desai S, et al. Prevalence and risk factors associated with herpes simplex virus-2 infection in a contemporary cohort of HIV-infected persons in the United States. Sex Trams Dis. 2012;39(2):254-60.
    • (2012) Sex Trams Dis , vol.39 , Issue.2 , pp. 254-260
    • Patel, P.1    Bush, T.2    Desai, S.3
  • 46
    • 84864767476 scopus 로고    scopus 로고
    • Herpes simplx virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS cohort study
    • 22472456 10.1016/j.atherosclerosis.2012.03.002 1:CAS:528: DC%2BC38XltVKmu78%3D
    • Hechter RC, Budoff M, Hodis HN, et al. Herpes simplx virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: multicenter AIDS cohort study. Atherosclerosis. 2012;223(2):433-6.
    • (2012) Atherosclerosis , vol.223 , Issue.2 , pp. 433-436
    • Hechter, R.C.1    Budoff, M.2    Hodis, H.N.3
  • 48
    • 84864141560 scopus 로고    scopus 로고
    • Inflammation, immune activation, and CVD risk in individuals with HIV infection
    • 22820794 10.1001/jama.2012.8488 1:CAS:528:DC%2BC38Xht1CksLfK
    • Stein JH, Hsue PY. Inflammation, immune activation, and CVD risk in individuals with HIV infection. JAMA. 2012;308(4):405-6.
    • (2012) JAMA , vol.308 , Issue.4 , pp. 405-406
    • Stein, J.H.1    Hsue, P.Y.2
  • 49
    • 77954170594 scopus 로고    scopus 로고
    • Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
    • Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med. 2010;20(4):202-13.
    • (2010) Rev Med , vol.20 , Issue.4 , pp. 202-213
    • Cannon, M.J.1    Schmid, D.S.2    Hyde, T.B.3
  • 50
    • 77955686431 scopus 로고    scopus 로고
    • Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature
    • 20632887 10.1086/655472
    • Van de Berg PJ, Heutinck KM, Raabe R, et al. Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature. J Infect Dis. 2010;202(5):690-9.
    • (2010) J Infect Dis , vol.202 , Issue.5 , pp. 690-699
    • Van De Berg, P.J.1    Heutinck, K.M.2    Raabe, R.3
  • 51
    • 79955011716 scopus 로고    scopus 로고
    • Role of CMV in immune senescence
    • 20869407 10.1016/j.virusres.2010.09.010 1:CAS:528:DC%2BC3MXltFaisrw%3D
    • Pawelec G, Derhovanessian E. Role of CMV in immune senescence. Virus Res. 2011;157(2):175-9.
    • (2011) Virus Res. , vol.157 , Issue.2 , pp. 175-179
    • Pawelec, G.1    Derhovanessian, E.2
  • 52
    • 84861553601 scopus 로고    scopus 로고
    • Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women
    • 22492856 10.1093/infdis/jis276 1:CAS:528:DC%2BC38XnvVyitbw%3D
    • Parrinello CM, Sinclair E, Landay AL, et al. Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women. J Infect Dis. 2012;205:1788-96.
    • (2012) J Infect Dis , vol.205 , pp. 1788-1796
    • Parrinello, C.M.1    Sinclair, E.2    Landay, A.L.3
  • 53
    • 77952507646 scopus 로고    scopus 로고
    • Cytomegolavirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease
    • 20126452 10.1371/journal.pone.0008886
    • Naeger DM, Martin JN, Sinclair E, et al. Cytomegolavirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease. PLoS One. 2010;5(1):e8886.
    • (2010) PLoS One , vol.5 , Issue.1 , pp. 8886
    • Naeger, D.M.1    Martin, J.N.2    Sinclair, E.3
  • 55
    • 79955028940 scopus 로고    scopus 로고
    • Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy
    • 21502083 10.1093/infdis/jir060 1:CAS:528:DC%2BC3MXkvFajsLg%3D This study provides randomized clinical trial evidence that suppression of CMV replication can reduce immune activation in HIV-infected patients who have relatively poor CD4 count response to cART
    • •• Hunt PW, Martin JN, Sinclair E, et al. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis. 2011;203:1474-83. This study provides randomized clinical trial evidence that suppression of CMV replication can reduce immune activation in HIV-infected patients who have relatively poor CD4 count response to cART.
    • (2011) J Infect Dis. , vol.203 , pp. 1474-1483
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3
  • 56
    • 84856975410 scopus 로고    scopus 로고
    • Epstein-Barr virus load and immune activation in human immunodeficiency virus type 1-infected patients
    • 22209290 10.1016/j.jcv.2011.12.013 1:CAS:528:DC%2BC38Xit1SksLg%3D Highlights the potential contribution of EBV, a common herpesvirus, to immune activation. This is important because EBV infection is rarely considered or adjusted for in clinical trials
    • • Petrara MR, Cattelan AM, Zanchetta M, et al. Epstein-Barr virus load and immune activation in human immunodeficiency virus type 1-infected patients. J Clin Virol. 2012;53:195-200. Highlights the potential contribution of EBV, a common herpesvirus, to immune activation. This is important because EBV infection is rarely considered or adjusted for in clinical trials.
    • (2012) J Clin Virol , vol.53 , pp. 195-200
    • Petrara, M.R.1    Cattelan, A.M.2    Zanchetta, M.3
  • 58
    • 84866728218 scopus 로고    scopus 로고
    • Chronic immune activation and decreased CD4 cell counts associated with hepatitis C infection in HIV-1 natural viral supressors
    • 22824629 10.1097/QAD.0b013e328357f5d1 1:CAS:528:DC%2BC38Xhtl2lsbbM
    • Sajadi MM, Pulijuala R, Redfield RR, Talwani R. Chronic immune activation and decreased CD4 cell counts associated with hepatitis C infection in HIV-1 natural viral supressors. AIDS. 2012;26:1879-84.
    • (2012) AIDS , vol.26 , pp. 1879-1884
    • Sajadi, M.M.1    Pulijuala, R.2    Redfield, R.R.3    Talwani, R.4
  • 59
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; And International Association for the Study of Obesity
    • 19805654 10.1161/CIRCULATIONAHA.109.192644 1:CAS:528:DC%2BD1MXht1OrtrrK
    • Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640-5.
    • (2009) Circulation , vol.120 , Issue.16 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 60
    • 85027917510 scopus 로고    scopus 로고
    • Metabolic syndrome before and after initiation of antiretroviral therapy in treatment-naïve HIV-infected individuals
    • E pub July 23, 2012
    • Krishnan S, Schouten JT, Atkinson B, et al. Metabolic syndrome before and after initiation of antiretroviral therapy in treatment-naïve HIV-infected individuals. J Acquir Immune Defic Syndr. 2012 E pub July 23, 2012.
    • (2012) J Acquir Immune Defic Syndr.
    • Krishnan, S.1    Schouten, J.T.2    Atkinson, B.3
  • 61
    • 84870058819 scopus 로고    scopus 로고
    • Adaptive immunity in obesity and insulin resistance
    • doi: 10.1038/nrendo.2012.114
    • Sell H, Habich C, Eckel J. Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol. 201;doi: 10.1038/nrendo.2012.114.
    • Nat Rev Endocrinol. , vol.201
    • Sell, H.1    Habich, C.2    Eckel, J.3
  • 62
    • 31844451010 scopus 로고    scopus 로고
    • Anti-inflammatory effects of statins: Clinical evidence and basic mechanisms
    • 16341063 10.1038/nrd1901 1:CAS:528:DC%2BD2MXht1yktbjP
    • Jain MK, Ridker PM. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov. 2005;4:977-87.
    • (2005) Nat Rev Drug Discov. , vol.4 , pp. 977-987
    • Jain, M.K.1    Ridker, P.M.2
  • 63
    • 34547804662 scopus 로고    scopus 로고
    • Immunomodulation by statins: Inhibition of cholesterol vs. isoprenoid biosynthesis
    • DOI 10.1016/j.biopha.2007.06.005, PII S0753332207001205
    • Kuipers HF, van den Elsen PJ. Immunomodulation by statins: inhibition of cholesterol vs. isoprenoid biosynthesis. Biomed Pharmacother. 2007;61:400-7. (Pubitemid 47239347)
    • (2007) Biomedicine and Pharmacotherapy , vol.61 , Issue.7 , pp. 400-407
    • Kuipers, H.F.1    Van Den Elsen, P.J.2
  • 64
    • 0034533147 scopus 로고    scopus 로고
    • Statins as a newly recognized type of immunomodulator
    • DOI 10.1038/82219
    • Kwak B, Mulhaupt F, Myit S, Mach F. Statins as a newly recognized type of immunomodulator. Nat Med. 2000;6:1399-402. (Pubitemid 32001026)
    • (2000) Nature Medicine , vol.6 , Issue.12 , pp. 1399-1402
    • Kwak, B.1    Mulhaupt, F.2    Myit, S.3    Mach, F.4
  • 65
    • 79955609315 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein levels fall during statin therapy in HIV-infected patients receiving ritonavir-boosted protease inhibitors
    • 21422984 10.1097/QAD.0b013e328346be29 1:CAS:528:DC%2BC3MXlsV2ntLk%3D
    • Aslangul E, Fellahi S, Assoumou LK, Bastard JP, Capeau J, Costagliola D. High-sensitivity C-reactive protein levels fall during statin therapy in HIV-infected patients receiving ritonavir-boosted protease inhibitors. AIDS. 2011;25:1128-31.
    • (2011) AIDS , vol.25 , pp. 1128-1131
    • Aslangul, E.1    Fellahi, S.2    Assoumou, L.K.3    Bastard, J.P.4    Capeau, J.5    Costagliola, D.6
  • 66
    • 84864311097 scopus 로고    scopus 로고
    • Statin therapy decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-alpha in HIV-infected patients treated with ritonavir-boosted protease inhibitors
    • Calza L, Trapani F, Bartoletti M, et al. Statin therapy decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-alpha in HIV-infected patients treated with ritonavir-boosted protease inhibitors. HIV Clin Trials. 13(3):153-61.
    • HIV Clin Trials. , vol.13 , Issue.3 , pp. 153-161
    • Calza, L.1    Trapani, F.2    Bartoletti, M.3
  • 67
    • 79952341800 scopus 로고    scopus 로고
    • High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: Results of a double-bind randomized placebo controlled clinical trial
    • 21325137 10.1093/infdis/jiq115 1:CAS:528:DC%2BC3MXis1aqsLs%3D
    • Ganesan A, Crum-Cianflone N, Higgins J, et al. High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-bind randomized placebo controlled clinical trial. J Infect Dis. 2011;203:756-64.
    • (2011) J Infect Dis , vol.203 , pp. 756-764
    • Ganesan, A.1    Crum-Cianflone, N.2    Higgins, J.3
  • 68
    • 43649093166 scopus 로고    scopus 로고
    • Statin-induced inhibition of HIV-1 release from latently infected UI cells reveals a critical role for protein prenylation in HIV-1 replication
    • 18406652 10.1016/j.micinf.2008.01.009 1:CAS:528:DC%2BD1cXmsVGit78%3D
    • Amet T, Nonaka M, Dewan MZ, et al. Statin-induced inhibition of HIV-1 release from latently infected UI cells reveals a critical role for protein prenylation in HIV-1 replication. Microbes Infect. 2008;10:471-80.
    • (2008) Microbes Infect , vol.10 , pp. 471-480
    • Amet, T.1    Nonaka, M.2    Dewan, M.Z.3
  • 70
    • 79958821408 scopus 로고    scopus 로고
    • Improvement in atherogenic lipid profiles in HIV-infected persons participating in ACTG 5087 who were treated with pravastatin, fenofibrate or the combination
    • 20824151 10.1016/j.jacl.2010.04.003
    • Fichtenbaum CJ, Yeh TM, Evans SE, Aberg SA. Improvement in atherogenic lipid profiles in HIV-infected persons participating in ACTG 5087 who were treated with pravastatin, fenofibrate or the combination. J Clin Lipidol. 2010;4:279-87.
    • (2010) J Clin Lipidol , vol.4 , pp. 279-287
    • Fichtenbaum, C.J.1    Yeh, T.M.2    Evans, S.E.3    Aberg, S.A.4
  • 71
    • 79958779542 scopus 로고    scopus 로고
    • Downregulation of CD38 activation markers by atorvastatin in HIV patients with undetectable viral load
    • 21508802 10.1097/QAD.0b013e328347c083
    • De Wit S, Delforge M, Necsol CV, Clumeck N. Downregulation of CD38 activation markers by atorvastatin in HIV patients with undetectable viral load. AIDS. 2011;25(10):1332-3.
    • (2011) AIDS , vol.25 , Issue.10 , pp. 1332-1333
    • De Wit, S.1    Delforge, M.2    Necsol, C.V.3    Clumeck, N.4
  • 73
    • 29644444564 scopus 로고    scopus 로고
    • Effects of statins on endothelial function and lipid profile in HIV infected persons receiving protease inhibitor-containing anti-retroviral combination therapy: A randomised double blind crossover trial
    • DOI 10.1136/hrt.2004.056523
    • Hürlimann D, Chenevard R, Ruschitzka F, et al. Effects of statins on endothelial function and lipid profile in HIV infected persons receiving protease inhibitor-containing antiretroviral combination therapy: a randomized double blind crossover trial. Heart. 2006;92(1):110-2. (Pubitemid 43021872)
    • (2006) Heart , vol.92 , Issue.1 , pp. 110-112
    • Hurlimann, D.1    Chenevard, R.2    Ruschitzka, F.3    Flepp, M.4    Enseleit, F.5    Bechir, M.6    Kobza, R.7    Muntwyler, J.8    Ledergerber, B.9    Luscher, T.F.10    Noll, G.11    Weber, R.12
  • 74
    • 79960202601 scopus 로고    scopus 로고
    • Association between use of HMG CoA reductase inhibitors and mortality in HIV-infected patients
    • 21765919 10.1371/journal.pone.0021843 1:CAS:528:DC%2BC3MXpvVGis7s%3D
    • Moore RD, Bartlett JG, Gallant JE. Association between use of HMG CoA reductase inhibitors and mortality in HIV-infected patients. PLoS One. 2011;6(7):e21843.
    • (2011) PLoS One , vol.6 , Issue.7 , pp. 21843
    • Moore, R.D.1    Bartlett, J.G.2    Gallant, J.E.3
  • 75
    • 80052426010 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) use and risk of non-Hodgkin lymphoma in HIV-positive persons
    • 21681055 10.1097/QAD.0b013e328349c67a 1:CAS:528:DC%2BC3MXhtFWksb%2FO
    • Chao C, Xu L, Abrams DI, et al. HMG-CoA reductase inhibitors (statins) use and risk of non-Hodgkin lymphoma in HIV-positive persons. AIDS. 2011;25(14):1771-7.
    • (2011) AIDS , vol.25 , Issue.14 , pp. 1771-1777
    • Chao, C.1    Xu, L.2    Abrams, D.I.3
  • 76
    • 0030483522 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by hydroxychloroquine: Mechanism of action and comparision with zidovudine
    • DOI 10.1016/S0149-2918(96)80063-4
    • Chiang G, Sassaroli M, Louise M, Chen H, Stecher VJ, Sperber K. Inhibition of HIV replication by hydroxychloroquine. Clin Ther. 1996;18(6):1080-92. (Pubitemid 27077112)
    • (1996) Clinical Therapeutics , vol.18 , Issue.6 , pp. 1080-1092
    • Chiang, G.1    Sassaroli, M.2    Louie, M.3    Chen, H.4    Stecher, V.J.5    Sperber, K.6
  • 77
    • 6344294872 scopus 로고    scopus 로고
    • The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity
    • DOI 10.1128/JVI.78.21.12054-12057.2004
    • Rayne F, Vendeville A, Bonhoure A, Beaumelle B. The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity. J Virol. 2004;78(21):12054-7. (Pubitemid 39390790)
    • (2004) Journal of Virology , vol.78 , Issue.21 , pp. 12054-12057
    • Rayne, F.1    Vendeville, A.2    Bonhoure, A.3    Beaumelle, B.4
  • 78
    • 33847189903 scopus 로고    scopus 로고
    • Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4 positive T-lymphocytes
    • 10.1186/1742-4690-4-6
    • Narding MA, Baan E, Pollakis G, Paxton WA. Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4 positive T-lymphocytes. Retrovirology. 2007;30(4):6.
    • (2007) Retrovirology , vol.30 , Issue.4 , pp. 6
    • Narding, M.A.1    Baan, E.2    Pollakis, G.3    Paxton, W.A.4
  • 79
    • 54049138748 scopus 로고    scopus 로고
    • Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection
    • 18789806 10.1016/j.virol.2008.07.039 1:CAS:528:DC%2BD1cXht12ltrzM
    • Vijaykumar TS, Nath A, Chauhan A. Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection. Virology. 2008;381:1-5.
    • (2008) Virology , vol.381 , pp. 1-5
    • Vijaykumar, T.S.1    Nath, A.2    Chauhan, A.3
  • 81
    • 75749126515 scopus 로고    scopus 로고
    • Chloroquine modulates HIV-1 induced plasmacytoid dendritic cell alpha interferon: Implication for T-cell activation
    • 10.1128/AAC.01246-09
    • Martison JA, Montoya CJ, Usuga X, et al. Chloroquine modulates HIV-1 induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation. Antimicrob Agents Chemother. 2010;54(2):871-81.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.2 , pp. 871-881
    • Martison, J.A.1    Montoya, C.J.2    Usuga, X.3
  • 83
    • 0000391671 scopus 로고
    • Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells
    • Ziegler HK, Unanue ER. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc Natl Acad Sci U S A. 1982;79(1):175-8. (Pubitemid 12181509)
    • (1982) Proceedings of the National Academy of Sciences of the United States of America , vol.79 , Issue.1 , pp. 175-178
    • Ziegler, H.K.1    Unanue, E.R.2
  • 84
    • 78049505077 scopus 로고    scopus 로고
    • Reduction in immune activation with chloroquine therapy during chronic HIV infection
    • 20844049 10.1128/JVI.01466-10 1:CAS:528:DC%2BC3cXhsVKksLnF
    • Murray SM, Down CM, Boulware DR, et al. Reduction in immune activation with chloroquine therapy during chronic HIV infection. J Virol. 2010;84(22):12082-6.
    • (2010) J Virol , vol.84 , Issue.22 , pp. 12082-12086
    • Murray, S.M.1    Down, C.M.2    Boulware, D.R.3
  • 86
    • 0029121276 scopus 로고
    • Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1
    • 8565026 10.1016/0149-2918(95)80039-5 1:STN:280:DyaK28%2FpvVehuw%3D%3D
    • Sperber K, Louie M, Kraus T, et al. Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1. Clin Ther. 1995;17(4):622-36.
    • (1995) Clin Ther , vol.17 , Issue.4 , pp. 622-636
    • Sperber, K.1    Louie, M.2    Kraus, T.3
  • 87
    • 84864149976 scopus 로고    scopus 로고
    • Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy. A randomized trial
    • 22820788 10.1001/jama.2012.6936 1:CAS:528:DC%2BC38Xht1Ghtb7P In the absence of cART, hydroxychloroquine was found to have no beneficial impact and potential safety concerns emerged from this study
    • •• Paton IN, Goodall RL, Dunn DT, et al. Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy. A randomized trial. JAMA. 2012;308(4):353-61. In the absence of cART, hydroxychloroquine was found to have no beneficial impact and potential safety concerns emerged from this study.
    • (2012) JAMA , vol.308 , Issue.4 , pp. 353-361
    • Paton, I.N.1    Goodall, R.L.2    Dunn, D.T.3
  • 88
    • 80053203528 scopus 로고    scopus 로고
    • Hydroxychlroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders
    • 21576701 10.1182/blood-2011-01-329060 1:CAS:528:DC%2BC3MXht1Ogu73M
    • Piconi S, Parisotto S, Rizzardini G, et al. Hydroxychlroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders. Blood. 2011;118(12):3263-72.
    • (2011) Blood , vol.118 , Issue.12 , pp. 3263-3272
    • Piconi, S.1    Parisotto, S.2    Rizzardini, G.3
  • 89
    • 59849088257 scopus 로고    scopus 로고
    • CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation
    • 19109148 1:CAS:528:DC%2BD1cXhsFCis7nK
    • Camargo JF, Quinones MP, Mummidi S, et al. CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation. J Immunol. 2009;182:171-82.
    • (2009) J Immunol , vol.182 , pp. 171-182
    • Camargo, J.F.1    Quinones, M.P.2    Mummidi, S.3
  • 90
    • 80053644416 scopus 로고    scopus 로고
    • In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells
    • 21985364 10.1111/j.1365-2249.2011.04409.x 1:CAS:528:DC%2BC3MXhsFamsrjK
    • Rossi R, Lichtner M, De Rosa A, et al. In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells. Clin Exp Immunol. 2011;166:184-90.
    • (2011) Clin Exp Immunol , vol.166 , pp. 184-190
    • Rossi, R.1    Lichtner, M.2    De Rosa, A.3
  • 91
    • 84866951694 scopus 로고    scopus 로고
    • A pilot trial of adding maraviroc to suppressive antiretroviral therapy for suboptimal CD4+ T-cell recovery despite sustained virologic suppression: ACTG A5256
    • 22740718 10.1093/infdis/jis376 1:CAS:528:DC%2BC38XhtFansLrM This study found that maraviroc lowered markers of immune activation but the results contrasted those of a similar study (reference 90). This underscores the importance of standardizing procedures for sample collection and processing in clinical trials, particularly those that involve cell-based biomarkers
    • • Wilkin TJ, Lalama CM, McKinnon J, et al. A pilot trial of adding maraviroc to suppressive antiretroviral therapy for suboptimal CD4+ T-cell recovery despite sustained virologic suppression: ACTG A5256. J Infect Dis. 2012;206(4):534-42. This study found that maraviroc lowered markers of immune activation but the results contrasted those of a similar study (reference 90). This underscores the importance of standardizing procedures for sample collection and processing in clinical trials, particularly those that involve cell-based biomarkers.
    • (2012) J Infect Dis , vol.206 , Issue.4 , pp. 534-542
    • Wilkin, T.J.1    Lalama, C.M.2    McKinnon, J.3
  • 92
    • 82955187838 scopus 로고    scopus 로고
    • Intensification of antiretroviral therapy with a CCR5 antagonist in patients with chronic HIV-1 infection: Effect on T cells latently infected
    • 22174752 10.1371/journal.pone.0027864 1:CAS:528:DC%2BC3MXhs1Oqur%2FP
    • Gutierrez C, Diaz L, Vallejo A, et al. Intensification of antiretroviral therapy with a CCR5 antagonist in patients with chronic HIV-1 infection: effect on T cells latently infected. PLoS One. 2011;6:e27864.
    • (2011) PLoS One , vol.6 , pp. 27864
    • Gutierrez, C.1    Diaz, L.2    Vallejo, A.3
  • 93
    • 84863082813 scopus 로고    scopus 로고
    • Maraviroc as intensification for HIV-1-positive immunological non-responders (INRs) despite virological suppression during HAART
    • 10.1186/1758-2652-13-S4-P44
    • Rusconi S, Vitiello P, Adorni F, et al. Maraviroc as intensification for HIV-1-positive immunological non-responders (INRs) despite virological suppression during HAART. J Int AIDS Soc. 2010;13 Suppl 4:044.
    • (2010) J Int AIDS Soc , vol.13 , Issue.SUPPL. 4 , pp. 044
    • Rusconi, S.1    Vitiello, P.2    Adorni, F.3
  • 95
    • 78650223820 scopus 로고    scopus 로고
    • Treatment intensification has no effect on the HIV-1 central nervous system infection in patients on suppressive antiretroviral therapy
    • 20847699 10.1097/QAI.0b013e3181f5b3d1 1:CAS:528:DC%2BC3cXhsVWht7jM
    • Yilmaz A, Verhofstede C, D'Avolio A, et al. Treatment intensification has no effect on the HIV-1 central nervous system infection in patients on suppressive antiretroviral therapy. J Acquir Immune Defic Syndr. 2010;55:590-6.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , pp. 590-596
    • Yilmaz, A.1    Verhofstede, C.2    D'Avolio, A.3
  • 96
    • 0034933712 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
    • DOI 10.1136/ard.60.8.729
    • Cutolo M, Sulli A, Pizzorni C, Seriolo B, et al. Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Ann Rheum Dis. 2001;60:729-35. (Pubitemid 32685871)
    • (2001) Annals of the Rheumatic Diseases , vol.60 , Issue.8 , pp. 729-735
    • Cutolo, M.1    Sulli, A.2    Pizzorni, C.3    Seriolo, B.4
  • 97
    • 0035985787 scopus 로고    scopus 로고
    • Molecular action of methotrexate in inflammatory diseases
    • DOI 10.1186/ar419
    • Chan ESL, Cronstein BN. Molecular action of methotrexate in inflammatory diseases. Arthritis Res. 2002;4:266-473. (Pubitemid 34716307)
    • (2002) Arthritis Research , vol.4 , Issue.4 , pp. 266-273
    • Chan, E.S.L.1    Cronstein, B.N.2
  • 98
    • 0037029418 scopus 로고    scopus 로고
    • Methotrexate and mortality in patients with rheumatoid arthritis: A prospective study
    • DOI 10.1016/S0140-6736(02)08213-2
    • Choi HK, Hernan MA, Seeger JD, Robins JM, Wolfe F. Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet. 2002;359:1173-7. (Pubitemid 34304256)
    • (2002) Lancet , vol.359 , Issue.9313 , pp. 1173-1177
    • Choi, H.K.1    Hernan, M.A.2    Seeger, J.D.3    Robins, J.M.4    Wolfe, F.5
  • 99
    • 39749147710 scopus 로고    scopus 로고
    • The incidence and prevalence of extra-articular and systemic manifestations in a cohort of newly-diagnosed patients with rheumatoid arthritis between 1999 and 2006
    • DOI 10.1185/030079908X261177
    • Hochberg MC, Johnston SS, John AK. The incidence and prevalence of extra-articular and systemic manifestations in a cohort of newly-diagnosed patients with rheumatoid arthritis between 1999 and 2006. Curr Med Res Opin. 2008;24:469-80. (Pubitemid 351294396)
    • (2008) Current Medical Research and Opinion , vol.24 , Issue.2 , pp. 469-480
    • Hochberg, M.C.1    Johnston, S.S.2    John, A.K.3
  • 100
    • 80054698399 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease
    • 21855836 10.1016/j.amjcard.2011.06.054 1:CAS:528:DC%2BC3MXhtlejtLnN
    • Micha R, Imamura F, Wyler von Ballmoos M, et al. Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease. Am J Cardiol. 2011;108(9):1362-70.
    • (2011) Am J Cardiol , vol.108 , Issue.9 , pp. 1362-1370
    • Micha, R.1    Imamura, F.2    Wyler Von Ballmoos, M.3


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