JTS-653 blocks afferent nerve firing and attenuates bladder overactivity without affecting normal voiding function

Journal of Urology

Volumn 189, Issue 3, 2013, Pages 1137-1146

  Kitagawa, Yoshihiro ^a   Wada, Masashi ^a   Kanehisa, Tomokazu ^a   Miyai, Atsuko ^a   Usui, Kenji ^a   Maekawa, Mariko ^a   Sakata, Masahiro ^a   Matsuo, Akira ^a   Hayashi, Mikio ^a   Matsushita, Mutsuyoshi ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

capsaicin; resiniferatoxin; Trpv1 protein, rat; urinary bladder, overactive; visceral afferents

Indexed keywords

ACETIC ACID; CAPSAICIN; CARBACHOL; JTS 653; PROPIVERINE; RESINIFERATOXIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER MUSCLE; BLADDER PRESSURE; CONTROLLED STUDY; CYSTOMETRY; FEMALE; MICTURITION; MUSCLE CONTRACTION; NONHUMAN; OVERACTIVE BLADDER; PELVIC NERVE; PRIORITY JOURNAL; RAT; SENSORY NERVE; URINE VOLUME; URODYNAMICS;

ADMINISTRATION, INTRAVESICAL; ANIMALS; BENZOXAZINES; DISEASE MODELS, ANIMAL; FEMALE; NEURONS, AFFERENT; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URINATION;

EID: 84873734542     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2012.09.055     Document Type: Article

References (29)

1. M.J. Caterina, M.A. Schumacher, M. Tominaga The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 1997 816
2. M. Tominaga, M.J. Caterina, A.B. Malmberg The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 1998 531
3. Y. Yiangou, P. Facer, A. Ford Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder BJU Int 87 2001 774
4. A. Charrua, C. Reguenga, J.M. Cordeiro Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells J Urol 182 2009 2944
5. D. Daly, W. Rong, R. Chess-Williams Bladder afferent sensitivity in wild-type and TRPV1 knockout mice J Physiol 583 2007 663
6. L.A. Birder, A.J. Kanai, W.C. de Groat Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells Proc Natl Acad Sci U S A 98 2001 13396
7. A. Apostolidis, C.M. Brady, Y. Yiangou Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin Urology 65 2005 400
8. M. Li, Y. Sun, J.M. Simard Increased transient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathic overactive bladder urothelial cells Neurourol Urodyn 30 2011 606
9. P. Dinis, A. Charrua, A. Avelino Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis J Neurosci 24 2004 11253
10. A. Charrua, C.D. Cruz, F. Cruz Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis J Urol 177 2007 1537
11. X. Zhang, Y. Igawa, O. Ishizuka Effects of resiniferatoxin desensitization of capsaicin-sensitive afferents on detrusor over-activity induced by intravesical capsaicin, acetic acid or ATP in conscious rats Naunyn Schmiedebergs Arch Pharmacol 367 2003 473
12. A. Avelino, F. Cruz TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications Naunyn Schmiedebergs Arch Pharmacol 373 2006 287
13. J.S. Cefalu, M.A. Guillon, L.R. Burbach Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder J Urol 182 2009 776
14. A. Charrua, C.D. Cruz, S. Narayanan GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models J Urol 181 2009 379
15. A. Santos-Silva, A. Charrua, C.D. Cruz Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist Auton Neurosci 166 2012 35
16. Y. Kitagawa, A. Miyai, K. Usui Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy) pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel transient receptor potential vanilloid 1 antagonist J Pharmacol Exp Ther 342 2012 520
17. T.L. Yaksh, P.A. Durant, C.R. Brent Micturition in rats: a chronic model for study of bladder function and effect of anesthetics Am J Physiol 251 1986 R1177
18. T. Mitsui, H. Kakizaki, S. Matsuura Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats J Neurophysiol 86 2001 2276
19. A. Ohtake, C. Saitoh, H. Yuyama Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents Biol Pharmacol Bull 30 2007 54
20. C. Saitoh, C. Kitada, W. Uchida The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder Eur J Pharmacol 570 2007 182
21. W. Yu, W.G. Hill, G. Apodaca Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium Am J Physiol Renal Physiol 300 2011 F49
22. T. Yamada, S. Ugawa, T. Ueda Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder J Histochem Cytochem 57 2009 277
23. N. Aizawa, Y. Igawa, K.E. Andersson Effects of intravesical instillation of ATP on rat bladder primary afferent activity and its relationship with capsaicin-sensitivity Neurourol Urodyn 30 2011 163
24. H. Kobayashi, M. Yoshiyama, H. Zakoji Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms BJU Int 104 2009 1746
25. L.A. Birder, Y. Nakamura, S. Kiss Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1 Nat Neurosci 5 2002 856
26. H.J. Habler, W. Janig, M. Koltzenburg Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat J Physiol 425 1990 545
27. A. Avelino, C. Cruz, I. Nagy Vanilloid receptor 1 expression in the rat urinary tract Neuroscience 109 2002 787
28. P. Angelico, C. Velasco, L. Guarneri Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions BMC Pharmacol 5 2005 14
29. N.R. Gavva, A.W. Bannon, S. Surapaneni The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation J Neurosci 27 2007 3366