Molecular chaperones as a common set of proteins that regulate the invasion phenotype of head and neck cancer

Clinical Cancer Research

Volumn 17, Issue 14, 2011, Pages 4629-4641

  Chiu, Ching Chi ^a   Lin, Chien Yu ^b   Lee, Li Yu ^b   Chen, Yin Ju ^a   Lu, Ya Ching ^a   Wang, Hung Ming ^b   Liao, Chun Ta ^b   Chang, Joseph Tung Chieh ^b   Cheng, Ann Joy ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLUCOSIDASE; BETA TUBULIN; CALRETICULIN; CHAPERONE; COFILIN 2; COLLAGEN TYPE 7; ENOLASE; FILAMIN A; GENE PRODUCT; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE TRANSFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN GP 96; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90ALPHA; HEAT SHOCK PROTEIN 90BETA; HYOU1 PROTEIN; LIPOCORTIN 1; LIPOCORTIN 2; MERLIN; NUCLEOLIN; PHOSPHOGLUCOMUTASE; PLECTIN; PYRUVATE KINASE; RIBOPHORIN I; UNCLASSIFIED DRUG; VILLIN; VINCULIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CARCINOGENICITY; CELL FUNCTION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG TARGETING; FEMALE; GENE SILENCING; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; LARYNX CANCER; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; NASOPHARYNX CANCER; NUCLEOTIDE SEQUENCE; PHARYNX CANCER; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MOLECULAR CHAPERONES; NEOPLASM INVASIVENESS; PHENOTYPE; PROTEOMICS; SIGNAL TRANSDUCTION;

EID: 79960431337     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-2107     Document Type: Article

References (50)

1. Chen YJ, Chang JT, Liao CT, Wang HM, Yen TC, Chiu CC, et al. Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci 2008;99:1507-14.
2. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45:309-16.
3. Han J, Kioi M, Chu WS, Kasperbauer JL, Strome SE, Puri RK. Identification of potential therapeutic targets in human head & neck squamous cell carcinoma. Head Neck Oncol 2009;1:27.
4. Chen C, Méndez E, Houck J, Fan W, Lohavanichbutr P, Doody D, et al. Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2008;17: 2152-62.
5. Hensen EF, De Herdt MJ, Goeman JJ, Oosting J, Smit VT, Cornelisse CJ, et al. Gene-expression of metastasized versus non-metastasized primary head and neck squamous cell carcinomas: a pathway-based analysis. BMC Cancer 2008;8:168.
6. Erdem NF, Carlson ER, Gerard DA. Characterization of gene expression profiles of 3 different human oral squamous cell carcinoma cell lines with different invasion and metastatic capacities. J Oral Maxillofac Surg 2008;66:918-27. (Pubitemid 351514833)
7. Zuehlke A, Johnson JL. Hsp90 and co-chaperones twist the functions of diverse client proteins. Biopolymers 2010;93:211-7.
8. Henderson B. Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators. Cell Biochem Funct 2010;28:1-14.
9. Chang JT, Chan SH, Lin CY, Lin TY, Wang HM, Liao CT, et al. Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15. Mol Cancer Ther 2007;6:2271-9. (Pubitemid 47294755)
10. Chen YJ, Chang JT, Lee L, Wang HM, Liao CT, Chiu CC, et al. DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. Oncogene 2007;26:467-76. (Pubitemid 46122837)
11. Chiu CC, Lin CY, Lee LY, Chen YJ, Kuo TF, Chang JT, et al. Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention. Mol Cancer Ther 2008;7:2788-97.
12. Kang CJ, Chen YJ, Liao CT, Wang HM, Chang JT, Lin CY, et al. Transcriptome profiling and network pathway analysis of genes associated with invasive phenotype in oral cancer. Cancer Lett 2009;284:131-40.
13. Lin TY, Chang JT, Wang HM, Chan SH, Chiu CC, Lin CY, et al. Proteomics of the radioresistant phenotype in head-and-neck cancer: GP96 as a novel prediction marker and sensitizing target for radiotherapy. Int J Radiat Oncol Biol Phys 2010;78:246-56.
14. Chang JT, Chen LC, Wei SY, Chen YJ, Wang HM, Liao CT, et al. Increase diagnostic efficacy by combined use of fingerprint markers in mass spectrometry-plasma peptidomes from nasopharyngeal cancer patients for example. Clin Biochem 2006;39: 1144-51. (Pubitemid 44838573)
15. Cheng AJ, Chen LC, Chien KY, Chen YJ, Chang JT, Wang HM, et al. Oral cancer plasma tumor marker identified with bead-based affinity fractionated proteomic technology. Clin Chem 2005;51:2236-44. (Pubitemid 41692565)
16. Chen YJ, Liao CT, Chen PJ, Lee LY, Li YC, Chen IH, et al. Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract. Head Neck 2011;33:257-66.
17. Chang JT, Yang HT, Wang TCV, Cheng AJ. Upstream stimulatory factor (USF) as a transcriptional suppressor of human telomerase reverse transcriptase (hTERT) in oral cancer cells. Mol Carcinog 2005;44:183-92. (Pubitemid 41552751)
18. Cappello F, deMacario EC, Marasa L, Zummo G, Macario AJ. Hsp60 expression, new localtions, functions and perspectives for cancer diagnosis and therapy. Cancer Biol Ther 2008;7:801-9.
19. Calderwood SK, Mambula SS, Gray PJ Jr. Extracellular heat shock proteins in cell signaling and immunity. Ann NY Acad Sci 2007;1113:28-39.
20. Ghosh JC, Dohi T, Kang BH, Altieri DC. Hsp60 regulation of tumor cell apoptosis. J Biol Chem 2008;283:5188-94.
21. Campanella C, Bucchieri F, Ardizzone NM, Marino Gammazza A, Montalbano A, Ribbene A, et al. Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. Eur J Histochem 2008;52:221-8.
22. Hwang YJ, Lee SP, Kim SY, Choi YH, Kim MJ, Lee CH, et al. Expression of heat shock protein 60 kDa is upregulated in cervical cancer. Yonsei Med J 2009;53:399-406.
23. Glaessgen A, Jonmarker S, Lindberg A, Nilsson B, Lewensohn R, Ekman P, et al. Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer. APMIS 2008;116:888-95.
24. Desmetz C, Bibeau F, Boissière F, Bellet V, Rouanet P, Maudelonde T, et al. Proteomics-based identification of HSP60 as a tumor associated antigen in early stage breast cancer and ductal carcinoma in situ. J Proteome Res 2008;7:3830-7.
25. Cappello F, Di Stefano A, David S, Rappa F, Anzalone R, La Rocca G, et al. Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease. Cancer 2006;107:2417-24. (Pubitemid 44748525)
26. Lebret T, Watson RW, Molinié V, O'Neill A, Gabriel C, Fitzpatrick JM, et al. Heat shock proteins HSP27. SHP60, SHP70 and SHP90: expression in bladder carcinoma. Cancer 2003;98:970-7.
27. Trombetta ES, Simons JF, Helenius A. Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a highly bound noncatalytic HDEL-containing subunit. J Bio Chem 1996;271:27509-16. (Pubitemid 26367313)
28. D'Alessio C, Fermandez F, Trombetta ES, Parodi AJ. Genetic evidence for the heterodimeric structure of glucosidase. II. The effect of disrupting the subunit-encoding genes on glycoprotein folding. J Bio Chem 1999;274:25899-905.
29. Jones DC, Mehlert A, Guther ML, Ferguson MA. Deletion of the glucosidase II gene in Trypanosoma brucel reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein. J Biol Chem 2005;280:35929-42. (Pubitemid 41633861)
30. Drenth JP, Martina JA, van de Kerkhof R, Bonifacino JS, Jansen JB. Polycystic liver disease is a disorder of cotranslational protein processing. Trends Mol Med 2005;11:37-42. (Pubitemid 40092673)
31. Drenth JP, Martina JA, Te Morsche RH, Jansen JB, Bonifacino JS. Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease. Gastroenterology 2004;126:1819-27. (Pubitemid 38736347)
32. Dennis JW, Lau KS. N-glycans in cancer progression. Glycobiology 2008;18:750-60.
33. Laidler P, Litynska A. Tumor cell N-glycans in metastasis. Acta Biochim Pol 1997;44:343-57.
34. Chen B, Piel WH, Gui L, Bruford E, Monteiro A. The Hsp90 family of genes in the human genome: insights into their divergence and evolution. Genomics 2005;86:627-37. (Pubitemid 41752943)
35. Koga F, Kihara K, Neckers L. Inhibition of cancer invasion and metastasis by targeting the molecular chaperons heat-shock protein 90. Anticancer Res 2009;29:797-807.
36. Li Y, Zhang T, Schwartz SJ, Sun D. New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Update 2009;12:17-27.
37. Maki RG, Old LJ, Srvastava PK. Human homologue of murine tumor rejection antigen gp96: 5-prime-regulatory and coding regions and relationship to stress-induced proteins. Proc Nat Acad Sci 1990;87:5658-62.
38. Murshid A, Gong J, Calderwood SK. Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation. Expert Rev Vaccines 2008;7:1019-10.
39. Langer R, Feith M, Siewert JR, Wester HJ, Hoefler H. Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC cancer 2008;8:70.
40. Wang Q, He Z, Zhang J, Wang Y, Wang T, Tong S, et al. Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance. Cancer Detect Prev 2005;29:544-51. (Pubitemid 41758494)
41. Wang XP, Qiu FR, Liu GZ, Chen RF. Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma. World J Gastroenterol 2005;11:1056-9.
42. Zheng HC, Takahashi H, Li XH, Hara T, Masuda S, Guan YF, et al. Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas. Hum Pathol 2008;39:1042-9.
43. Hendershot LM, Valentine VA, Lee AS, Morris SW, Shapiro DN. Localization of the gene conding human Bip/Grp78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34. Genomics 1994;20:281-4. (Pubitemid 24108409)
44. Li J, Lee AS. Stress induction of Grp78/Bip and its role in cancer. Curr Mol Med 2006;6:45-54.
45. Quinones QJ, de Ridder GG, Pizzo SV. Grp78: a chaperon with diverse roles beyond the endoplasmic reticulum. Histol Histopathol 2008;23:1409-16.
46. Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P, et al. Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci USA 2008;105:19444-9.
47. Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol 2008;28:666-77.
48. Kelber JA, Panopoulos AD, Shani G, Booker EC, Belmonte JC, Vale WW, et al. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene 2009;28:2324-36.
49. Lin CY, Chen WH, Liao CT, Chen IH, Chiu CC, Wang HM, et al. Positive association of Grp78 during oral cancer progression and the prognostic value in oral precancer lesions. Head Neck 2010;32:1028-39.
50. Pappin DJ, Hojrup P, Bleasby AJ. Rapid identification of proteins by peptide-mass fingerprint. Curr Biol 1993;3:327-32.