Phosphorylation of Mps1 by BRAF V600E prevents Mps1 degradation and contributes to chromosome instability in melanoma

Oncogene

Volumn 32, Issue 6, 2013, Pages 713-723

  Liu, J ^a   Cheng, X ^a   Zhang, Y ^a   Li, S ^a   Cui, H ^a   Zhang, L ^a   Shi, R ^a   Zhao, Z ^a   He, C ^a   Wang, C ^b   Zhao, H ^a   Zhang, C ^a   Fisk, H A ^c   Guadagno, T M ^d   Cui, Y ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c OHIO STATE UNIVERSITY   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

BRAFV600E; centrosome amplification; chromosome instability; melanoma; Mps1

Indexed keywords

APC PROTEIN; B RAF KINASE; CELL CYCLE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CDC27; PROTEIN KINASE; PROTEIN MPS1; UNCLASSIFIED DRUG; BRAF PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; TTK PROTEIN, HUMAN;

ANEUPLOIDY; ARTICLE; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MELANOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SPINDLE CELL; UBIQUITINATION; GENETICS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ANEUPLOIDY; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CENTROSOME; CHROMOSOMAL INSTABILITY; HUMANS; MELANOMA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION; UBIQUITINATION;

MLCS; MLOWN;

EID: 84873727642     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.94     Document Type: Article

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