2′,4′-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2′-O,4′-C-methylene-bridged/linked bicyclic ribonucleotides

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1288-1292

  Kasahara, Yuuya ^a   Irisawa, Yuuta ^a   Ozaki, Hiroaki ^a   Obika, Satoshi ^b   Kuwahara, Masayasu ^a  

^a GUNMA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Bridged (locked) nucleic acid aptamer; Capillary electrophoresis systematic evolution of ligands by exponential enrichment (CE SELEX); KOD DNA polymerase; Xeno nucleic acid (XNA)

Indexed keywords

2' O 4' C METHYLENE; ALKENE DERIVATIVE; APTAMER; BICYCLIC RIBONUCLEOTIDE; BRIDGED LOCKED NUCLEIC ACID APTAMER; DNA; DNA POLYMERASE; NUCLEOTIDE DERIVATIVE; THROMBIN; UNCLASSIFIED DRUG; 2',4' BNA(NC); 2',4'-BNA(NC); BRIDGED COMPOUND; DNA DIRECTED DNA POLYMERASE; LOCKED NUCLEIC ACID; NUCLEOTIDE; OLIGONUCLEOTIDE; RIBONUCLEOTIDE;

ARTICLE; CAPILLARY ELECTROPHORESIS; CAPILLARY ELECTROPHORESIS SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; CROSS LINKING; DNA LIBRARY; DRUG SYNTHESIS; HUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; CHEMISTRY; GENE LIBRARY; GENETICS; METABOLISM; METHODOLOGY; PROCEDURES; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT APTAMER TECHNIQUE;

APTAMERS, NUCLEOTIDE; BRIDGED COMPOUNDS; DNA-DIRECTED DNA POLYMERASE; GENE LIBRARY; HUMANS; NUCLEOTIDES; OLIGONUCLEOTIDES; RIBONUCLEOTIDES; SELEX APTAMER TECHNIQUE;

EID: 84873727247     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.093     Document Type: Article

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