New roles for PPARs in cholesterol homeostasis

Trends in Pharmacological Sciences

Volumn 22, Issue 9, 2001, Pages 441-443

  Ricote, Mercedes ^a   Glass, Christopher K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN E; CD36 ANTIGEN; CHOLESTEROL; CORIOLIC ACID; DIMORPHECOLIC ACID; FIBRIC ACID DERIVATIVE; GELATINASE B; HIGH DENSITY LIPOPROTEIN; HORMONE RECEPTOR; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYUNSATURATED FATTY ACID; RECEPTOR SUBTYPE; SCAVENGER RECEPTOR; THIAZOLIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ATHEROGENESIS; ATHEROSCLEROSIS; CARBOHYDRATE METABOLISM; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; FOAM CELL; HOMEOSTASIS; HUMAN; HYPERTRIGLYCERIDEMIA; INFLAMMATION; LIPID METABOLISM; MACROPHAGE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RISK FACTOR; SHORT SURVEY; TISSUE DISTRIBUTION;

EID: 0035450498     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01802-2     Document Type: Review

References (21)

1. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
2. The PPARs: From orphan receptors to drug discovery
3. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
4. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
5. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
6. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
7. Macrophages in human atheroma contain PPARγ: Differentiation-dependent peroxisomal proliferator-activated receptor γ expression and reduction of MMP-9 activity through PPARγ activation in mononuclear phagocytes in vitro
8. Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages
9. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
10. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-γ
11. Peroxisome proliferator-activated receptor γligands inhibit development of atherosclerosis in LDL receptor-deficient mice
12. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
13. Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: Pleiotropic effects on CD36 expression and HDL
14. Reduction of atherosclerosis in apolipoprotein E-knockout mice by activation of the retinoid X receptor
15. PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
16. PPAR-γ-dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
17. The role of PPAR-γ in macrophage differentiation and cholesterol uptake
18. A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
19. A selective peroxisome proliferator-activated receptorδ agonist promotes reverse cholesterol transport
20. Anti-inflammatory cyclopentenone prostaglandins are direct
21. 2 inhibits multiple steps in the NF-κB signaling pathway