Ulinastatin inhibits unilateral ureteral obstruction-induced renal interstitial fibrosis in rats via transforming growth factor β (TGF-β)/Smad signalling pathways

International Immunopharmacology

Volumn 15, Issue 2, 2013, Pages 406-413

  Ning, Xiao Hua ^a   Ge, Xiao Feng ^a   Cui, Yan ^a   An, Hui Xia ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

p Smad2 3; Renal interstitial fibrosis; TGF 1; Ulinastatin; Unilateral ureteral obstruction (UUO)

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CREATININE; NITROGEN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ULINASTATIN; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; STAINING; UNILATERAL URETERAL OBSTRUCTION; UREA NITROGEN BLOOD LEVEL; URETER OBSTRUCTION; WESTERN BLOTTING;

ACTINS; ANIMALS; BLOOD UREA NITROGEN; COLLAGEN TYPE I; CREATININE; FIBROSIS; GLYCOPROTEINS; KIDNEY; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRYPSIN INHIBITORS; URETERAL OBSTRUCTION;

EID: 84873718382     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.12.019     Document Type: Article

References (25)

1. A.A. Eddy Molecular basis of renal fibrosis Pediatr Nephrol 15 2000 290 301
2. B. Rodríguez-Iturbe, and García G. García The role of tubulointerstitial inflammation in the progression of chronic renal failure Nephron Clin Pract 116 2010 c81 c88
3. Y. Liu Renal fibrosis: new insights into the pathogenesis and therapeutics Kidney Int 69 2006 213 217
4. D. Zhang, L. Sun, W. Xian, F. Liu, G. Ling, and L. Xiao Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-b/Smad activity Lab Invest 90 2010 436 447
5. M. Iwano EMT and TGF-beta in renal fibrosis Front Biosci (Schol Ed) 2 2010 229 238
6. H.W. Schnaper, T. Hayashida, and A.C. Poncelet It's a Smad world: regulation of TGF-beta signaling in the kidney J Am Soc Nephrol 13 2002 887 893
7. E. Fries, and A.M. Blom Bikunin - not just a plasma proteinase inhibitor Int J Biochem Cell Biol 32 2000 125 137
8. J. Bingyang, L. Jinping, L. Mingzheng, W. Guyan, and F. Zhengyi Effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. Effect of ulinastatin on inflammatory response J Cardiovasc Surg (Torino) 48 2007 497 503
9. C.J. Gao, J.N. Huan, W. Li, and J.J. Tang Protective effects of ulinastatin on pancreatic and renal damage in rats following early scald injury Burns 35 2009 547 552
10. Q. Yang, X. Liu, M. Liu, L. Zhang, and Y. Guan Ulinastatin-mediated protection against zymosan-induced multiple organ dysfunction in rats Biologicals 38 2010 552 556
11. H. Katoh, H. Ishikawa, M. Hasegawa, Y. Yoshida, Y. Suzuki, and T. Ohno Protective effect of urinary trypsin inhibitor on the development of radiation-induced lung fibrosis in mice J Radiat Res (Tokyo) 51 2010 325 332
12. M. Satoh, N. Kashihara, Y. Yamasaki, K. Maruyama, K. Okamoto, and Y. Maeshima Renal interstitial fibrosis is reduced in angiotensin II type 1a receptor-deficient mice J Am Soc Nephrol 12 2001 317 325
13. G.H. Feng, L. Dong, and Z.L. Lei Effect of ulinastatin on coagulation function in patients undergoing orthotopic liver transplantation Chin J Anesthesiol 29 2009 296 298
14. C. Gao, R. Li, and S. Wang Ulinastatin protects pulmonary tissues from lipopolysaccharide-induced injury as an immunomodulator J Trauma Acute Care Surg 72 2012 169 176
15. Y.J. Wu, Q. Ling, X.H. Zhou, Y. Wang, H.Y. Xie, and J.R. Yu Urinary trypsin inhibitor attenuates hepatic ischemia-reperfusion injury by reducing nuclear factor-kappa B activation Hepatobiliary Pancreat Dis Int 8 2009 53 58
16. I.W. Shin, I.S. Jang, S.M. Lee, K.E. Park, S.H. Ok, and J.T. Sohn Myocardial protective effect by ulinastatin via an anti-inflammatory response after regional ischemia/reperfusion injury in an in vivo rat heart model Korean J Anesthesiol 61 2011 499 505
17. Y.Y. Ge, Y. Xu, J.Q. Cheng, J.M. Chen, R.M. Xu, and Y.D. Jiang Case-control study on the effect of ulinastatin on postoperative complications in elderly patients undergoing hip joint replacement Zhongguo Gu Shang 24 2011 459 462
18. R.A. Risdon, J.C. Sloper, and H.E. De Wardener Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis Lancet 2 1968 363 366
19. R.L. Chevalier, M.S. Forbes, and B.A. Thornhill Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy Kidney Int 75 2009 1145 1152
20. Y.C. Yeh, W.C. Wei, Y.K. Wang, S.C. Lin, J.M. Sung, and M.J. Tang Transforming growth factor-β1 induces Smad3-dependent β1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis Am J Pathol 177 2010 1743 1754
21. T. Shirakihara, K. Horiguchi, K. Miyazawa, S. Ehata, T. Shibata, and I. Morita TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition EMBO J 30 2011 783 795
22. M.K. Phanish, N.A. Wahab, P. Colville-Nash, B.M. Hendry, and M.E. Dockrell The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells Biochem J 393 2006 601 607
23. Y.H. Liu New insights into epithelial-mesenchymal transition in kidney fibrosis J Am Soc Nephrol 21 2010 212 222
24. D.C. Clarke, M.L. Brown, R.A. Erickson, Y. Shi, and X. Liu Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics Mol Cell Biol 29 2009 2443 2455
25. H.Y. Lan Diverse roles of TGF-β/Smads in renal fibrosis and inflammation Int J Biol Sci 7 2011 1056 1067