Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury

Journal of Urology

Volumn 189, Issue 3, 2013, Pages 1155-1161

  Hannan, Johanna L ^a   Albersen, Maarten ^b,c   Kutlu, Omer ^a   Gratzke, Christian ^d   Stief, Christian G ^d   Burnett, Arthur L ^a   Lysiak, Jeffrey J ^e   Hedlund, Petter ^b,f   Bivalacqua, Trinity J ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY OF VIRGINIA   (United States)

^f LINKÖPING UNIVERSITY   (Sweden)

Author keywords

apoptosis; erectile dysfunction; penis; prostatectomy; rho associated kinases

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN ROCK2; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ERECTILE DYSFUNCTION; MALE; NERVE STIMULATION; NONHUMAN; PENIS ERECTION; PENIS INJURY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

AMIDES; ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERECTILE DYSFUNCTION; MALE; NITRIC OXIDE; PENILE ERECTION; PENIS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; UP-REGULATION;

EID: 84873717012     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2012.09.104     Document Type: Article

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