N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 5, 2013, Pages 1150-1158

  Novikov, Mikhail S ^a   Valuev Elliston, Vladimir T ^b   Babkov, Denis A ^a   Paramonova, Maria P ^a   Ivanov, Alexander V ^b   Gavryushov, Sergey A ^b   Khandazhinskaya, Anastasia L ^b   Kochetkov, Sergey N ^b   Pannecouque, Christophe ^c   Andrei, Graciela ^c   Snoeck, Robert ^c   Balzarini, Jan ^c   Seley Radtke, Katherine L ^d  

^a VOLGOGRAD STATE MEDICAL UNIVERSITY   (Russian Federation)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

Benzophenone; Cinnamyl; HIV; NNRTIs; Nonnucleoside reverse transcriptase inhibitors; Uracil

Indexed keywords

1 [2 (4 METHYLPHENOXY)ETHYL] 3 (1 PHENYLETHYL)URACIL; 1 [2 (4 METHYLPHENOXY)ETHYL] 3 (2 PHENYLETHYL)URACIL; 1 [2 (4 METHYLPHENOXY)ETHYL] 3 (2,4,6 TRIMETHYLBENZYL)URACIL; 1 [2 (4 METHYLPHENOXY)ETHYL] 3 (2,5 DIMETHYLBENZYL)URACIL; 1 [2 (4 METHYLPHENOXY)ETHYL] 3 (3,5 DIMETHYLBENZYL)URACIL; 1 CINNAMYLURACIL; 1 CINNAMYLURACIL 3 (3,5 DIBROMOBENZYL)URACIL; 1 CINNAMYLURACIL 3 (3,5 DICHLOROBENZYL)URACIL; 1 CINNAMYLURACIL 3 (3,5 DIFLUOROBENZYL)URACIL; 3 (2 METHYLBENZYL) 1 [2 (4 METHYLPHENOXY)ETHYL]URACIL; 3 (3 BROMO 5 METHYLBENZYL) 1 CINNAMYLURACIL; 3 (3 METHYLBENZYL) 1 [2 (4 METHYLPHENOXY)ETHYL]URACIL; 3 (4 METHYLBENZYL) 1 [2 (4 METHYLPHENOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (2 NAPHTHYLOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (3 METHYLPHENOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (3,5 DIMETHYLPHENOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (4 CHLOROPHENOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (4 CYANOPHENOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (4 FLUOROPHENOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (4 METHYLPHENOXY)ETHYL]QUINAZOLINE 2,4(1H,3H) DIONE; 3 BENZYL 1 [2 (4 METHYLPHENOXY)ETHYL]THYMINE; 3 BENZYL 1 [2 (4 PHENYLPHENOXY)ETHYL]URACIL; 3 BENZYL 1 [2 (4 TERT BUTYLPHENOXY)ETHYL]URACIL; 3 BENZYL 1 CINNAMYLURACIL; CIDOFOVIR; GANCICLOVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL DERIVATIVE; CINNAMIC ACID DERIVATIVE; DRUG DERIVATIVE; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; URACIL;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; VIRUS REPLICATION; BINDING SITE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MOLECULAR DOCKING; MUTATION; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BINDING SITES; CELL LINE; CINNAMATES; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; MUTATION; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL;

EID: 84873714736     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.027     Document Type: Article

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