Inter-relationships of cardinal features and outcomes of symptomatic pediatric Plasmodium falciparum malaria in 1,933 children in Kampala, Uganda

American Journal of Tropical Medicine and Hygiene

Volumn 88, Issue 4, 2013, Pages 747-756

  Cserti Gazdewich, Christine M ^a   Dhabangi, Aggrey ^b   Musoke, Charles ^c   Ssewanyana, Isaac ^d   Ddungu, Henry ^e,f   Nakiboneka Ssenabulya, Deborah ^g   Nabukeera Barungi, Nicolette ^c   Mpimbaza, Arthur ^c   Dzik, Walter H ^h  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b Child Health and Development Centre   (Uganda)

^c MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^d Central Public Health Laboratory   (Uganda)

^e UGANDA CANCER INSTITUTE   (Uganda)

^f AFRICAN PALLIATIVE CARE ASSOCIATION   (Uganda)

^g LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^h HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

ANEMIA; ARTICLE; BLOOD CELL COUNT; BRAIN MALARIA; CHILD; CLINICAL FEATURE; DISEASE SEVERITY; FEMALE; HUMAN; HYPOGLYCEMIA; HYPOXIA; INFANT; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LEUKOCYTOSIS; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MORTALITY; OUTCOME ASSESSMENT; OXIMETRY; PARASITEMIA; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; RESPIRATORY DISTRESS; SCHOOL CHILD; SPLENOMEGALY; THROMBOCYTOPENIA; UGANDA;

ACIDOSIS, LACTIC; ANEMIA; ANOXIA; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; HUMANS; HYPOGLYCEMIA; INFANT; LEUKOCYTOSIS; LOGISTIC MODELS; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; MALE; PARASITEMIA; PLASMODIUM FALCIPARUM; PROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SPLENOMEGALY; THROMBOCYTOPENIA; UGANDA;

EID: 84873706901     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.12-0668     Document Type: Article

References (37)

1. World Health Organization, 2010. Guidelines for the Treatment of Malaria. Geneva: World Health Organization.
2. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, Newton C, Winstanley P, Warn P, Peshu N, 1995. Indicators of life-threatening malaria in African children. N Engl J Med 332: 1399-1404.
3. Marsh K, Snow RW, 1997. Host-parasite interaction and morbidity in malaria endemic areas. Philos Trans R Soc Lond B Biol Sci 352: 1385-1394. (Pubitemid 27434104)
4. Waller D, Krishna S, Crawley J, Miller K, Nosten F, Chapman D, ter Kuile FO, Craddock C, Berry C, Holloway PA, 1995. Clinical features and outcome of severe malaria in Gambian children. Clin Infect Dis 21: 577-587.
5. White NJ, Miller KD, Marsh K, Berry CD, Turner RC, Williamson DH, Brown J, 1987. Hypoglycaemia in African children with severe malaria. Lancet 1: 708-711. (Pubitemid 17036985)
6. Lackritz EM, Campbell CC, Ruebush TK II, Hightower AW, Wakube W, Steketee RW, Were JB, 1992. Effect of blood transfusion on survival among children in a Kenyan hospital. Lancet 340: 524-528.
7. Slutsker L, Taylor TE, Wirima JJ, Steketee RW, 1994. In-hospital morbidity and mortality due to malaria-associated severe anaemia in two areas of Malawi with different patterns of malaria infection. Trans R Soc Trop Med Hyg 88: 548-551. (Pubitemid 24325205)
8. Krishna S, Waller DW, ter Kuile F, Kwiatkowski D, Crawley J, Craddock CF, Nosten F, Chapman D, Brewster D, Holloway PA, 1994. Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance. Trans R Soc Trop Med Hyg 88: 67-73. (Pubitemid 24068852)
9. Taylor TE, Borgstein A, Molyneux ME, 1993. Acid-base status in paediatric Plasmodium falciparum malaria. Q J Med 86: 99-109. (Pubitemid 23125002)
10. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71: 441-459. (Pubitemid 19161768)
11. English M, Waruiru C, Amukoye E, Murphy S, Crawley J, Mwangi I, Peshu N, Marsh K, 1996. Deep breathing in children with severe malaria: indicator of metabolic acidosis and poor outcome. Am J Trop Med Hyg 55: 521-524. (Pubitemid 26392716)
12. English M, Waruiru C, Marsh K, 1996. Transfusion for respiratory distress in life-threatening childhood malaria. Am J Trop Med Hyg 55: 525-530. (Pubitemid 26392717)
13. English M, Sauerwein R, Waruiru C, Mosobo M, Obiero J, Lowe B, Marsh K, 1997. Acidosis in severe childhood malaria. QJM 90: 263-270. (Pubitemid 27180001)
14. Schellenberg D, Menendez C, Kahigwa E, Font F, Galindo C, Acosta C, Schellenberg JA, Aponte JJ, Kimario J, Urassa H, Mshinda H, Tanner M, Alonso P, 1999. African children with malaria in an area of intense Plasmodium falciparum transmission: features on admission to the hospital and risk factors for death. Am J Trop Med Hyg 61: 431-438. (Pubitemid 29428716)
15. Dzeing-Ella A, Nze Obiang PC, Tchoua R, Planche T, Mboza B, Mbounja M, Muller-Roemer U, Jarvis J, Kendjo E, Ngou-Milama E, Kremsner PG, Krishna S, Kombila M, 2005. Severe falciparum malaria in Gabonese children: clinical and laboratory features. Malar J 4: 1.
16. Issifou S, Kendjo E, Missinou MA, Matsiegui PB, Dzeing-Ella A, Dissanami FA, Kombila M, Krishna S, Kremsner PG, 2007. Differences in presentation of severe malaria in urban and rural Gabon. Am J Trop Med Hyg 77: 1015-1019. (Pubitemid 351837785)
17. Ranque S, Poudiougou B, Traore A, Keita M, Oumar AA, Safeukui I, Marquet S, Cabantous S, Diakite M, Mintha D, Cisse MB, Keita MM, Dessein AJ, Doumbo OK, 2008. Life-threatening malaria in African children: a prospective study in a mesoendemic urban setting. Pediatr Infect Dis J 27: 130-135.
18. Idro R, Karamagi C, Tumwine J, 2004. Immediate outcome and prognostic factors for cerebral malaria among children admitted to Mulago Hospital, Uganda. Ann Trop Paediatr 24: 17-24. (Pubitemid 38379731)
19. Idro R, Ndiritu M, Ogutu B, Mithwani S, Maitland K, Berkley J, Crawley J, Fegan G, Bauni E, Peshu N, Marsh K, Neville B, Newton C, 2007. Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children. JAMA 297: 2232-2240. (Pubitemid 47010881)
20. Mockenhaupt FP, Ehrhardt S, Burkhardt J, Bosomtwe SY, Laryea S, Anemana SD, Otchwemah RN, Cramer JP, Dietz E, Gellert S, Bienzle U, 2004. Manifestation and outcome of severe malaria in children in northern Ghana. Am J Trop Med Hyg 71: 167-172. (Pubitemid 39108825)
21. Jarvis JN, Planche T, Bicanic T, Dzeing-Ella A, Kombila M, Issifou S, Borrmann S, Kremsner PG, Krishna S, 2006. Lactic acidosis in Gabonese children with severe malaria is unrelated to dehydration. Clin Infect Dis 42: 1719-1725. (Pubitemid 43839437)
22. Newton CR, Valim C, Krishna S, Wypij D, Olola C, Agbenyega T, Taylor TE, 2005. The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters. Clin Infect Dis 41: 948-957. (Pubitemid 41368215)
23. Roca-Feltrer A, Carneiro I, Smith L, Schellenberg JR, Greenwood B, Schellenberg D, 2010. The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings. Malar J 9: 282.
24. Vekemans J, Marsh K, Greenwood B, Leach A, Kabore W, Soulanoudjingar S, Asante KP, Ansong D, Evans J, Sacarlal J, Bejon P, Kamthunzi P, Salim N, Njuguna P, Hamel MJ, Otieno W, Gesase S, Schellenberg D, 2011. Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. Malar J 10: 221.
25. Anstey NM, Price RN, 2007. Improving case definitions for severe malaria. PLoS Med 4: e267.
26. Cserti-Gazdewich CM, Dhabangi A, Musoke C, Ssewanyana I, Ddungu H, Nakiboneka-Ssenabulya D, Nabukeera-Barungi N, Mpimbaza A, Dzik WH, 2012. Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection. Br J Haematol 159: 223-236.
27. Opoka RO, Xia Z, Bangirana P, John CC, 2008. Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria. Pediatr Infect Dis J 27: 319-324. (Pubitemid 351483066)
28. Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, Maitland K, Williams T, Scott JA, English M, Lowe BS, Peshu N, Newton CR, Marsh K, 2007. Defining childhood severe falciparum malaria for intervention studies. PLoS Med 4: e251.
29. McMorran BJ, Marshall VM, de Graaf C, Drysdale KE, Shabbar M, Smyth GK, Corbin JE, Alexander WS, Foote SJ, 2009. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 323: 797-800.
30. Gerardin P, Rogier C, Ka AS, Jouvencel P, Brousse V, Imbert P, 2002. Prognostic value of thrombocytopenia in African children with falciparum malaria. Am J Trop Med Hyg 66: 686-691. (Pubitemid 35001039)
31. Pain A, Ferguson DJ, Kai O, Urban BC, Lowe B, Marsh K, Roberts DJ, 2001. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proc Natl Acad Sci USA 98: 1805-1810. (Pubitemid 32165579)
32. Wassmer SC, Lepolard C, Traore B, Pouvelle B, Gysin J, Grau GE, 2004. Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells. J Infect Dis 189: 180-189. (Pubitemid 38147240)
33. Wassmer SC, Taylor T, Maclennan CA, Kanjala M, Mukaka M, Molyneux ME, Grau GE, 2008. Platelet-induced clumping of Plasmodium falciparum-infected erythrocytes from Malawian patients with cerebral malaria-possible modulation in vivo by thrombocytopenia. J Infect Dis 197: 72-78. (Pubitemid 351263469)
34. Bridges DJ, Bunn J, van Mourik JA, Grau G, Preston RJ, Molyneux M, Combes V, O'Donnell JS, de Laat B, Craig A, 2010. Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. Blood 115: 1472-1474.
35. Mayor A, Hafiz A, Bassat Q, Rovira-Vallbona E, Sanz S, Machevo S, Aguilar R, Cistero P, Sigauque B, Menendez C, Alonso PL, Chitnis CE, 2011. Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor. PLoS ONE 6: e19422.
36. Phiri HT, Bridges DJ, Glover SJ, van Mourik JA, de Laat B, M'Baya B, Taylor TE, Seydel KB, Molyneux ME, Faragher EB, Craig AG, Bunn JE, 2011. Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. PLoS ONE 6: e25626.
37. Cox D, McConkey S, 2010. The role of platelets in the pathogenesis of cerebral malaria. Cell Mol Life Sci 67: 557-568.