Ultra-deep mutant spectrum profiling: Improving sequencing accuracy using overlapping read pairs

BMC Genomics

Volumn 14, Issue 1, 2013, Pages

  Chen Harris, Haiyin ^a   Borucki, Monica K ^a   Torres, Clinton ^a   Slezak, Tom R ^a   Allen, Jonathan E ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Biomarker; Diagnostics; DNA mutational analysis; High throughput sequencing; Overlapping read pairs; Quasispecies; Rare mutations; Sequencing error correction; Viral evolution

Indexed keywords

ACCURACY; ANALYTIC METHOD; ANALYTICAL ERROR; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; GENE MUTATION; NONHUMAN; OVERLAPPING READ PAIRS; PROCESS OPTIMIZATION; STATISTICAL MODEL; ULTRA DEEP MUTANT SPECTRUM PROFILING;

BENCHMARKING; DNA MUTATIONAL ANALYSIS; GENOME, VIRAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MUTATION; POLYMERASE CHAIN REACTION; VIRUSES;

EID: 84873699702     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-14-96     Document Type: Article

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