Serum spleen tyrosine kinase and vascular endothelial growth factor-C levels predict lymph node metastasis of oesophageal squamous cell carcinoma

European Journal of Cardio-thoracic Surgery

Volumn 43, Issue 3, 2013, Pages

  Duan, Lincan ^a   Ye, Lianhua ^a   Zhao, Guangqiang ^a   Wu, Zhengwei ^a   Jin, Congguo ^a   Cai, Xinyi ^a   Li, Gaofeng ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Enzyme linked immunosorbent assays; Lymph node metastasis; Oesophageal squamous cell carcinoma; Serum spleen tyrosine kinase; Serum VEGF C

Indexed keywords

PROTEIN KINASE SYK; VASCULOTROPIN C;

ADULT; AGED; ARTICLE; CANCER SURGERY; CONTROLLED STUDY; CORRELATION COEFFICIENT; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

AGED; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROTEIN-TYROSINE KINASES; ROC CURVE; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84873657160     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezs637     Document Type: Article

References (25)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
2. Liu J, Xie X, Zhou C, Peng S, Rao D, Fu J. Which factors are associated with actual 5-year survival of oesophageal squamous cell carcinoma? Eur J Cardiothorac Surg 2012;41:e7-11.
3. Alitalo K. The lymphatic vasculature in disease. Nat Med 2011;17: 1371-80.
4. Sleeman J, Schmid A, Thiele W. Tumor lymphatics. Semin Cancer Biol 2009;19:285-97.
5. Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 2004;5:74-80.
6. Kozlowski M, Kowalczuk O, Milewski R, Chyczewski L, Niklinski J, Laudanski J. Serum vascular endothelial growth factors C and D in patients with oesophageal cancer. Eur J Cardiothorac Surg 2010;38:260-7.
7. Kimura H, Kato H, Tanaka N, Inose T, Faried A, Sohda M et al. Preoperative serum vascular endothelial growth factor-C (VEGF-C) levels predict recurrence in patients with esophageal cancer. Anticancer Res 2008;28:165-9.
8. Hirakawa S, Brown LF, Kodama S, Paavonen K, Alitalo K, Detmar M. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 2007;109:1010-7.
9. Buchner M, Baer C, Prinz G, Dierks C, Burger M, Zenz T et al. Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood 2010; 115:4497-506.
10. Bohmer R, Neuhaus B, Buhren S, Zhang D, Stehling M, Bock B et al. Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell 2010;18:437-49.
11. Uckun FM, Qazi S. Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas. Expert Rev Anticancer Ther 2010;10:1407-18.
12. Coopman PJ, Mueller SC. The Syk tyrosine kinase: a new negative regulator in tumor growth and progression. Cancer Lett 2006;241:159-73.
13. Chen XL, Li L, Zhang YJ. [Regulatory role of Syk gene on vascular endothelial growth factor C expression in breast cancer]. Zhonghua Bing Li Xue Za Zhi 2011;40:805-9.
14. Duff SE, Li C, Jeziorska M, Kumar S, Saunders MP, Sherlock D et al. Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. Br J Cancer 2003;89:426-30.
15. Duan L, Huang Y, Li G, Liu X, Zhang Y. [The role and significance of serum SYK and VEGF-C in metastasis of the lymph nodes of pulmonary adenocarcinoma]. Zhongguo Fei Ai Za Zhi 2008;11:802-4.
16. Katsuta M, Miyashita M, Makino H, Nomura T, Shinji S, Yamashita K et al. Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp Mol Pathol 2005;78:123-30.
17. Mobius C, Freire J, Becker I, Feith M, Brucher BL, Hennig M et al. VEGF-C expression in squamous cell carcinoma and adenocarcinoma of the esophagus. World J Surg 2007;31:1768-72; discussion 1773-4.
18. Chen M, Cai E, Huang J, Yu P, Li K. Prognostic value of vascular endothelial growth factor expression in patients with esophageal cancer: a systematic review and meta-analysis. Cancer Epidemiol Biomark Prev 2012; 21:1126-34.
19. Makinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J 2001;20: 4762-73.
20. Repana K, Papazisis K, Foukas P, Valeri R, Kortsaris A, Deligiorgi E et al. Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness. Anticancer Res 2006;26:4949-54.
21. Coopman PJ, Do MT, Barth M, Bowden ET, Hayes AJ, Basyuk E et al. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 2000;406:742-7.
22. Zyss D, Montcourrier P, Vidal B, Anguille C, Merezegue F, Sahuquet A et al. The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression. Cancer Res 2005;65:10872-80.
23. Yuan Y, Wang J, Li J, Wang L, Li M, Yang Z et al. Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. Clin Cancer Res 2006;12:6687-95.
24. Bailet O, Fenouille N, Abbe P, Robert G, Rocchi S, Gonthier N et al. Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest. Cancer Res 2009;69: 2748-56.
25. Wang S, Ding YB, Chen GY, Xia JG, Wu ZY. Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma. World J Gastroenterol 2004;10:1815-8.