Monoclonal antibody against the poly-γ-d-glutamic acid capsule of Bacillus anthracis protects mice from enhanced lethal toxin activity due to capsule and anthrax spore challenge

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 3, 2013, Pages 2804-2812

  Jang, Jeyoun ^a   Cho, Minhui ^a   Lee, Hae Ri ^a   Cha, Kiweon ^a   Chun, Jeong Hoon ^a   Hong, Kee Jong ^a   Park, Jungchan ^b   Rhie, Gi Eun ^a  

^a Korea National Institute of Health   (South Korea)

^b Hankuk University of Foreign Studies   (South Korea)

Author keywords

Bacillus anthracis; Lethal toxin; Modeling; Monoclonal antibody; Poly d glutamic acid capsule

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY POLY GAMMA DEXTRO GLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; BACILLUS ANTHRACIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG CAPSULE; DRUG CYTOTOXICITY; ENCAPSULATION; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PASSIVE IMMUNIZATION; PRIORITY JOURNAL;

ANIMALS; ANTHRAX; ANTHRAX VACCINES; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL CAPSULES; BACTERIAL TOXINS; CELLS, CULTURED; FEMALE; HUMANS; IMMUNIZATION, PASSIVE; KINETICS; MACROPHAGES; MICE; MICE, INBRED BALB C; MOLECULAR DOCKING SIMULATION; POLYGLUTAMIC ACID; SPORES, BACTERIAL; SURVIVAL ANALYSIS; VIRULENCE FACTORS;

EID: 84873601301     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.11.006     Document Type: Article

References (40)

1. S.F. Little, and B.E. Ivins Molecular pathogenesis of Bacillus anthracis infection Microbes Infect. 1 1999 131 139
2. G. Vitale, L. Bernardi, G. Napolitani, M. Mock, and C. Montecucco Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor Biochem. J. 352 2000 739 745
3. B.E. Turk Manipulation of host signaling pathways by anthrax toxins Biochem. J. 402 2007 405 417
4. J.M. Park, F.R. Greten, Z.W. Li, and M. Karin Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition Science 297 2002 2048 2051
5. E.D. Boyden, and W.F. Dietrich Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin Nat. Genet. 38 2006 240 244
6. R. Cordoba-Rodriguez, H. Fang, C.S. Lankford, and D.M. Frucht Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of Interleukin (IL)-1β and IL-18 J. Biol. Chem. 279 2004 20563 20566
7. S.H. Leppla Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells Proc. Natl. Acad. Sci. U.S.A. 79 1982 3162 3166
8. S.H. Leppla, J.B. Robbins, R. Schneerson, and J. Shiloach Development of an improved vaccine for anthrax J. Clin. Invest. 110 2002 141 144
9. A. Scorpio, D.J. Chabot, W.A. Day, D.K. O'brien, N.J. Vietri, Y. Itoh, M. Mohamadzadeh, and A.M. Friedlander Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis Antimicrob. Agents Chemother. 51 2007 215 222
10. M. Drysdale, S. Heninger, J. Hutt, Y. Chen, C.R. Lyons, and T.M. Koehler Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax EMBO J. 24 2005 221 227
11. H. Smith, J. Keppie, and J.L. Stanley The chemical basis of the virulence of Bacillus anthracis. I. Properties of bacteria grown in vivo and preparation of extracts Br. J. Exp. Pathol. 34 1953 477 485
12. J. Keppie, P.W. Harris-Smith, and H. Smith The chemical basis of the virulence of Bacillus anthracis. Ix. Its aggressins and their mode of action. Br. J. Exp. Pathol. 44 1963 446 453
13. S. Makino, I. Uchida, N. Terakado, C. Sasakawa, and M. Yoshikawa Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis J. Bacteriol. 171 1989 722 730
14. J.W. Ezzell, T.G. Abshire, R. Panchal, D. Chabot, S. Bavari, E.K. Leffel, B. Purcell, A.M. Friedlander, and W.J. Ribot Association of Bacillus anthracis capsule with lethal toxin during experimental infection Infect. Immun. 77 2009 749 755
15. J. Jang, M. Cho, J.H. Chun, M.H. Cho, J. Park, H.B. Oh, C.K. Yoo, and G.E. Rhie The poly-γ-d-glutamic acid capsule of Bacillus anthracis enhances lethal toxin activity Infect. Immun. 79 2011 3846 3854
16. G.E. Rhie, M.H. Roehrl, M. Mourez, R.J. Collier, J.J. Mekalanos, and J.Y. Wang A dually active anthrax vaccine that confers protection against both bacilli and toxins Proc. Natl. Acad. Sci. U.S.A. 100 2003 10925 10930
17. D.J. Chabot, A. Scorpio, S.A. Tobery, S.F. Little, S.L. Norris, and A.M. Friedlander Anthrax capsule vaccine protects against experimental infection Vaccine 23 2004 43 47
18. T.R. Kozel, W.J. Murphy, S. Brandt, B.R. Blazar, J.A. Lovchik, P. Thorkildson, A. Percival, and C.R. Lyons mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia Proc. Natl. Acad. Sci. U.S.A. 101 2004 5042 5047
19. T.R. Kozel, P. Thorkildson, S. Brandt, W.H. Welch, J.A. Lovchik, D.P. AuCoin, J. Vilai, and C.R. Lyons Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule Infect. Immun. 75 2007 152 163
20. D.Y. Lee, J.H. Chun, H.J. Ha, J. Park, B.S. Kim, H.B. Oh, and G.E. Rhie Poly-γ-D-glutamic acid and protective antigen conjugate vaccines induce functional antibodies against the protective antigen and capsule of Bacillus anthracis in guinea-pigs and rabbits FEMS Immunol. Med. Microbiol. 57 2009 165 172
21. B.D. Green, L. Battisti, T.M. Koehler, C.B. Thorne, and B.E. Ivins Demonstration of a capsule plasmid in Bacillus anthracis Infect. Immun. 49 1985 291 297
22. G.E. Rhie, Y.M. Park, J.H. Chun, C.K. Yoo, W.K. Seong, and H.B. Oh Expression and secretion of the protective antigen of Bacillus anthracis in Bacillus brevis FEMS Immunol. Med. Microbiol. 45 2005 331 339
23. G. Köhler, and C. Milstein Continuous cultures of fused cells secreting antibody of predefined specificity Nature 256 1975 495 497
24. S. Romero-Steiner, D. Libutti, L.B. Pais, J. Dykes, P. Anderson, J.C. Whitin, H.L. Keyserling, and G.M. Carlone Standardization of an opsonophagocytic assay for the measurement of functional antibody activity against Streptococcus pneumonia using differentiated HL-60 cells Clin. Diagn. Lab. Immunol. 4 1997 415 422
25. E.R. Stanley Murine bone marrow-derived macrophages Methods Mol. Biol. 75 1997 301 304
26. T. Schwede, J. Kopp, N. Guex, and M.C. Peitsch Swiss Model: an automated protein homology-modeling server Nucleic Acids Res. 31 2003 3381 3385
27. Z. Chen, R. Schneerson, J. Lovchik, C.R. Lyons, H. Zhao, Z. Dai, J. Kubler-Kielb, S.H. Leppla, and R.H. Purcell Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule Proc. Natl. Acad. Sci. U.S.A. 108 2011 739 744
28. W.M. Prodinger, R. Wurzner, A. Erdei, and M.P. Dierich W.E. Paul, Fundamental Immunology I 1999 967 995 (Lippincott-Raven, PA)
29. S.G. Popov, R. Villasmil, J. Bernardi, E. Grene, J. Cardwell, A. Wu, D. Alibek, C. Bailey, and K. Alibek Lethal toxin of Bacillus anthracis causes apoptosis of macrophages Biochem. Biophys. Res. Commun. 293 2002 349 355
30. J.N. Tournier, S.R. Paccani, A. Quesnel-Hellmann, and C.T. Baldari Anthrax toxin: a weapon to systematically dismantle the host immune defenses Mol. Aspects Med. 30 2009 456 466
31. S.L. Fink, T. Bergsbaken, and B.T. Cookson Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms Proc. Natl. Acad. Sci. U.S.A. 105 2008 4312 4317
32. G. Fantuzzi, and C.A. Dinarello Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1) J. Clin. Immunol. 19 1999 1 11
33. D.P. Cerretti, C.J. Kozlosky, B. Mosley, N. Nelson, K. Van Ness, T.A. Greenstreet, C.J. March, S.R. Kronheim, T. Druck, and L.A. Cannizzaro Molecular cloning of the interleukin-1 beta converting enzyme Science 256 1992 97 100
34. S. Makino, M. Watarai, H.I. Cheun, T. Shirahata, and I. Uchida Effect of the lower molecular capsule released from the cell surface of Bacillus anthracis on the pathogenesis of anthrax J. Infect. Dis. 186 2002 227 233
35. M.H. Cho, H.J. Ahn, H.J. Ha, J. Park, J.H. Chun, B.S. Kim, H.B. Oh, and G.E. Rhie Bacillus anthracis capsule activates caspase-1 and induces interleukin-1β release from differentiated THP-1 and human monocyte-derived dendritic cell Infect. Immun. 78 2010 387 392
36. A.E. Boyer, C.P. Quinn, A.R. Hoffmaster, T.R. Kozel, E. Saile, C.K. Marston, A. Percival, B.D. Plikaytis, A.R. Woolfitt, M. Gallegos, P. Sabourin, L.G. McWilliams, J.L. Pirkle, and J.R. Barr Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaques Infect. Immun. 77 2009 3432 3441
37. M.D. Sutherland, P. Thorkildson, S.D. Parks, and T.R. Kozel In vivo fate and distribution of poly-γ-D-glutamic acid, the capsular antigen from Bacillus anthracis Infect. Immun. 76 2008 899 906
38. S. Tang, M. Moayeri, Z. Chen, H. Harma, J. Zhao, H. Hu, R.H. Purcell, S.H. Leppla, and I.K. Hewlett Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticle Clin. Vaccine Immunol. 16 2009 408 413
39. E. Won, K. Cha, J.S. Byun, D.U. Kim, S. Shin, Y.H. Kim, A.J. Rice, T. Walz, B.S. Kwon, and H.S. Cho The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily J. Biol. Chem. 285 2010 9202 9210
40. L. Bordoli, and T. Schwede Automated protein structure modeling with SWISS-MODEL workspace and the protein model portal Methods Mol. Biol. 857 2012 107 136