Screening for cushing's syndrome: New immunoassays require adequate normative data

Hormone and Metabolic Research

Volumn 45, Issue 2, 2013, Pages 118-123

  Deutschbein, T ^a   Petersenn, S ^b  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b ENDOC Center for Endocrine Tumors   (Germany)

Author keywords

cortisol; Cushing's disease; glucocorticoids; hypercortisolism; measurement; reference range

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE;

CHROMATOGRAPHY; CUSHING SYNDROME; DIAGNOSTIC ACCURACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FALSE POSITIVE RESULT; GOLD STANDARD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERCORTISOLISM; IMMUNOASSAY; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; REVIEW; SALIVA; SENSITIVITY AND SPECIFICITY; TURNAROUND TIME;

CUSHING SYNDROME; HUMANS; HYDROCORTISONE; IMMUNOASSAY; MASS SCREENING; REFERENCE VALUES; SALIVA;

EID: 84873598481     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0032-1331745     Document Type: Review

References (70)

1. Boscaro M., Barzon L., Sonino N. The diagnosis of Cushing's syndrome. Atypical presentations and laboratory shortcomings. Arch Intern Med: 2000; 160 3045 3053
2. Newell-Price J., Bertagna X., Grossman A. B., Nieman L. K. Cushing's syndrome. Lancet: 2006; 367 1605 1617
3. Nieman L. K., Biller B. M., Findling J. W., Newell-Price J., Savage M. O., Stewart P. M., Montori V. M. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab: 2008; 93 1526 1540
4. Elamin M. B., Hassan Murad M., Mullan R., Erickson D., Harris K., Nadeem S., Ennis R., Erwin P. J., Montori V. M. Accuracy of diagnostic tests for Cushing's syndrome. A systematic review and meta-analyses. J Clin Endocrinol Metab: 2008; 93 1553 1562
5. Gatti R., Antonelli G., Prearo M., Spinella P., Cappellin E., de Palo E. F. Cortisol assays and diagnostic laboratory procedures in human biological fluids. Clin Biochem: 2009; 42 1205 1217
6. Raff H. Utility of salivary cortisol measurements in Cushing's syndrome and adrenal insufficiency. J Clin Endocrinol Metab: 2009; 94 3647 3655
7. Alexandraki K. I., Grossman A. B. Is urinary free cortisol of value in the diagnosis of Cushing's syndrome? Curr Opin Endocrinol Diabetes Obes: 2011; 18 259 263
8. Deutschbein T., Unger N., Hinrichs J., Walz M. K., Petersenn S. Late-night and low-dose dexamethasone-suppressed cortisol in saliva and serum for the diagnosis of cortisol-secreting adrenal adenomas. Eur J Endocrinol: 2009; 161 747 753
9. Deutschbein T., Broecker-Preuss M., Hartmann M. F., Althoff R., Wudy S. A., Mann K., Petersenn S. Measurement of urinary free cortisol by current immunoassays: Need for sex-dependent reference ranges to define hypercortisolism. Horm Metab Res: 2011; 43 714 719
10. Deutschbein T., Broecker-Preuss M., Flitsch J., Jaeger A., Althoff R., Walz M. K., Mann K., Petersenn S. Salivary cortisol as a diagnostic tool for Cushing's syndrome and adrenal insufficiency: improved screening by an automatic immunoassay. Eur J Endocrinol: 2012; 166 613 618
11. Lewis J. G. Steroid analysis in saliva: an overview. Clin Biochem Rev: 2006; 27 139 146
12. Groschl M. Current status of salivary hormone analysis. Clin Chem: 2008; 54 1759 1769
13. Wood P. Salivary steroid analysis - research or routine? Ann Clin Biochem: 2009; 46 183 196
14. Hamrahian A. H., Oseni T. S., Arafah B. M. Measurements of serum free cortisol in critically ill patients. N Engl J Med: 2004; 350 1629 1638
15. Klose M., Lange M., Rasmussen A. K., Skakkebaek N. E., Hilsted L., Haug E., Andersen M., Feldt-Rasmussen U. Factors influencing the adrenocorticotropin test: role of contemporary cortisol assays, body composition, and oral contraceptive agents. J Clin Endocrinol Metab: 2007; 92 1326 1333
16. Carroll T., Raff H., Findling J. W. Late-night salivary cortisol measurement in the diagnosis of Cushing's syndrome. Nat Clin Pract Endocrinol Metab: 2008; 4 344 350
17. Nunes M. L., Vattaut S., Corcuff J. B., Rault A., Loiseau H., Gatta B., Valli N., Letenneur L., Tabarin A. Late-night salivary cortisol for diagnosis of overt and subclinical Cushing's syndrome in hospitalized and ambulatory patients. J Clin Endocrinol Metab: 2009; 79 1532 1539
18. Carroll T., Raff H., Findling J. W. Late-night salivary cortisol for the diagnosis of Cushing syndrome: a meta-analysis. Endocr Pract: 2009; 15 335 342
19. Raff H., Raff J. L., Findling J. W. Late-night salivary cortisol as a screening test for Cushing's syndrome. J Clin Endocrinol Metab: 1998; 83 2681 2686
20. Castro M., Elias P. C., Quidute A. R., Halah F. P., Moreira A. C. Outpatient screening for Cushing's syndrome: the sensitivity of the combination of circadian rhythm and overnight dexamethasone suppression salivary cortisol tests. J Clin Endocrinol Metab: 1999; 84 878 882
21. Papanicolaou D. A., Mullen N., Kyrou I., Nieman L. K. Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab: 2002; 87 4515 4521
22. Putignano P., Toja P., Dubini A., Pecori Giraldi F., Corsello S. M., Cavagnini F. Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing's syndrome. J Clin Endocrinol Metab: 2003; 88 4153 4157
23. Yaneva M., Mosnier-Pudar H., Dugue M. A., Grabar S., Fulla Y., Bertagna X. Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes. J Clin Endocrinol Metab: 2004; 89 3345 3351
24. Trilck M., Flitsch J., Ludecke D. K., Jung R., Petersenn S. Salivary cortisol measurement - a reliable method for the diagnosis of Cushing's syndrome. Exp Clin Endocrinol Diabetes: 2005; 113 225 230
25. Viardot A., Huber P., Puder J. J., Zulewski H., Keller U., Muller B. Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test. J Clin Endocrinol Metab: 2005; 90 5730 5736
26. Doi M., Sekizawa N., Tani Y., Tsuchiya K., Kouyama R., Tateno T., Izumiyama H., Yoshimoto T., Hirata Y. Late-night salivary cortisol as a screening test for the diagnosis of Cushing's syndrome in Japan. Endocr J: 2008; 55 121 126
27. Cardoso E. M., Arregger A. L., Tumilasci O. R., Contreras L. N. Diagnostic value of salivary cortisol in Cushing's syndrome (CS). Clin Endocrinol (Oxf): 2009; 70 516 521
28. Baid S. K., Sinaii N., Wade M., Rubino D., Nieman L. K. Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism. J Clin Endocrinol Metab: 2007; 92 3102 3107
29. Zerikly R. K., Amiri L., Faiman C., Gupta M., Singh R. J., Nutter B., Kennedy L., Hatipoglu B., Weil R. J., Hamrahian A. H. Diagnostic characteristics of late-night salivary cortisol using liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab: 2010; 95 4555 4559
30. van Aken M. O., Romijn J. A., Miltenburg J. A., Lentjes E. G. Automated measurement of salivary cortisol. Clin Chem: 2003; 49 1408 1409
31. Vogeser M., Durner J., Seliger E., Auernhammer C. Measurement of late-night salivary cortisol with an automated immunoassay system. Clin Chem Lab Med: 2006; 44 1441 1445
32. Sereg M., Toke J., Patócs A., Varga I., Igaz P., Szücs N., Horányi J., Pusztai P., Czirják S., Gláz E., Rácz K., Tóth M. Diagnostic performance of salivary cortisol and serum osteocalcin measurements in patients with overt and subclinical Cushing's syndrome. Steroids: 2011; 76 38 42
33. Yaneva M., Kirilov G., Zacharieva S. Midnight salivary cortisol, measured by highly sensitive electrochemiluminescence immunoassay, for the diagnosis of Cushing's syndrome. Central Eur J Med: 2009; 4 59 64
34. Beko G., Varga I., Glaz E., Sereg M., Feldman K., Toth M., Racz K., Patocs A. Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods. Clin Chim Acta: 2010; 411 364 367
35. Carrozza C., Corsello S. M., Paragliola R. M., Ingraudo F., Palumbo S., Locantore P., Sferrazza A., Pontecorvi A., Zuppi C. Clinical accuracy of midnight salivary cortisol measured by automated electrochemiluminescence immunoassay method in Cushing's syndrome. Ann Clin Biochem: 2010; 47 228 232
36. Jeyaraman K., Ammini A. C., Nandita G., Dwivedi S. N. Late-night salivary cortisol in normal subjects and in patients with Cushing's syndrome. Postgrad Med J: 2010; 86 399 404
37. Sakihara S., Kageyhama K., Oki Y., Doi M., Iwasaki Y., Takayasu S., Moriyama T., Terui K., Nibawara T., Hirata Y., Hashimoto K., Suda T. Evaluation of plasma, salivary, and urinary cortisol levels for diagnosis of Cushing's syndrome. Endocr J: 2010; 57 331 337
38. Belaya Z. E., Iljin A. V., Melnichenko G. A., Rozhinskaya L. Y., Dragunova N. V., Dzeranova L. K., Butrova S. A., Troshina E. A., Dedov I. I. Diagnostic performance of late-night salivary cortisol measured by automated electrochemiluminescence immunoassay in obese and overweight patients referred to exclude Cushing's syndrome. Endocrine: 2012; 41 494 500
39. Carrasco C. A., Garcia M., Goycoolea M., Cerda J., Bertherat J., Padilla O., Meza D., Wohllk N., Quiroga T. Reproducibility and performance of one or two samples of salivary cortisol in the diagnosis of Cushing's syndrome using an automated immunoassay system. Endocrine: 2012; 41 487 493
40. Barrou Z., Guiban D., Maroufi A., Fournier C., Dugue M. A., Luton J. P., Thomopoulos P. Overnight dexamethasone suppression test: comparison of plasma and salivary cortisol measurement for the screening of Cushing's syndrome. Eur J Endocrinol: 1996; 134 93 96
41. Raff H., Homar P. J., Burns E. A. Comparison of two methods for measuring salivary cortisol. Clin Chem: 2002; 48 207 208
42. Roberts R. F., Roberts W. L. Performance characteristics of five automated serum cortisol immunoassays. Clin Biochem: 2004; 37 489 493
43. Holder G. External quality assessment of urinary-free cortisol measurement in the UK against a gas chromatography mass spectroscopy reference method. Ann Clin Biochem: 1995; 32 84 90
44. Turpeinen U., Markkanen H., Valimaki M., Stenman U. H. Determination of urinary free cortisol by HPLC. Clin Chem: 1997; 43 1386 1391
45. Wood L., Ducroq D. H., Fraser H. L., Gillingwater S., Evans C., Pickett A. J., Rees D. W., John R., Turkes A. Measurement of urinary free cortisol by tandem mass spectrometry and comparison with results obtained by gas chromatography-mass spectrometry and two commercial immunoassays. Ann Clin Biochem: 2008; 45 380 388
46. Fong B. M., Tam S., Leung K. S. Improved liquid chromatography-tandem mass spectrometry method in clinical utility for the diagnosis of Cushing's syndrome. Anal Bioanal Chem: 2010; 396 783 790
47. Papanicolaou D. A., Yanovski J. A., Cutler G. B. Jr, Chrousos G. P., Nieman L. K. A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states. J Clin Endocrinol Metab: 1998; 83 1163 1167
48. Reimondo G., Allasino B., Bovio S., Paccotti P., Angeli A., Terzolo M. Evaluation of the effectiveness of midnight serum cortisol in the diagnostic procedures for Cushing's syndrome. Eur J Endocrinol: 2005; 153 803 809
49. Newell-Price J., Trainer P., Perry L., Wass J., Grossman A., Besser M. A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf): 1995; 43 545 550
50. Pecori Giraldi F., Ambrogio A. G., De Martin M., Fatti L. M., Scacchi M., Cavagnini F. Specificity of first-line tests for the diagnosis of Cushing's syndrome: assessment in a large series. J Clin Endocrinol Metab: 2007; 92 4123 4129
51. Gorges R., Knappe G., Gerl H., Ventz M., Stahl F. Diagnosis of Cushing's syndrome: re-evaluation of midnight plasma cortisol vs urinary free cortisol and low-dose dexamethasone suppression test in a large patient group. J Endocrinol Invest: 1999; 22 241 249
52. Vilar L., Freitas M. C., Naves L. A., Canadas V., Albuquerque J. L., Botelho C. A., Egito C. S., Arruda M. J., Silva L. M., Arahata C. M., Agra R., Lima L. H., Azevedo M., Casulari L. A. The role of non-invasive dynamic tests in the diagnosis of Cushing's syndrome. J Endocrinol Invest: 2008; 31 1008 1013
53. Grumbach M. M., Biller B. M., Braunstein G. D., Campbell K. K., Carney J. A., Godley P. A., Harris E. L., Lee J. K., Oertel Y. C., Posner M. C., Schlechte J. A., Wieand H. S. Management of the clinically inapparent adrenal mass ("incidentalomao"). Ann Int Med: 2003; 138 424 429
54. Cronin C., Igoe D., Duffy M. J., Cunningham S. K., McKenna T. J. The overnight dexamethasone test is a worthwhile screening procedure. Clin Endocrinol (Oxf): 1990; 33 27 33
55. Montwill J., Igoe D., McKenna T. J. The overnight dexamethasone test is the procedure of choice in screening for Cushing's syndrome. Steroids: 1994; 59 296 298
56. Wood P. J., Barth J. H., Freedman D. B., Perry L., Sheridan B. Evidence for the low dose dexamethasone suppression test to screen for Cushing's syndrome - recommendations for a protocol for biochemistry laboratories. Ann Clin Biochem: 1997; 34 222 229
57. Isidori A. M., Kaltsas G. A., Mohammed S., Morris D. G., Jenkins P., Chew S. L., Monson J. P., Besser G. M., Grossman A. B. Discriminatory value of the low-dose dexamethasone suppression test in establishing the diagnosis and differential diagnosis of Cushing's syndrome. J Clin Endocrinol Metab: 2003; 88 5299 5306
58. Barth J. H., Seth J., Howlett T. A., Freedman D. B. A survey of endocrine function tests by clinical biochemistry laboratories in the UK. Ann Clin Biochem: 1995; 32 442 449
59. Lin C. L., Wu T. J., Machacek D. A., Jiang N. S., Kao P. C. Urinary free cortisol and cortisone determined by high performance liquid chromatography in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab: 1997; 82 151 155
60. Morineau G., Gosling J., Patricot M. C., Soliman H., Boudou P., al halnak A., Le Brun G., Brérault J. L., Julien R., Villette J. M., Fiet J. Convenient chromatographic prepurification step before measurement of urinary cortisol by radioimmunoassay. Clin Chem: 1997; 43 786 793
61. Murphy B. E. How much "UFCo" is really cortisol? Clin Chem: 2000; 46 793 794
62. McCann S. J., Gillingwater S., Keevil B. G. Measurement of urinary free cortisol using liquid chromatography-tandem mass spectrometry: comparison with the urine adapted ACS:180 serum cortisol chemiluminescent immunoassaay and development of a new reference range. Ann Clin Biochem: 2005; 42 112 118
63. Taylor R. L., Machacek D., Singh R. J. Validation of a high-throughput liquid chromatography-tandem mass spectrometry method for urinary cortisol and cortisone. Clin Chem: 2002; 48 1511 1519
64. Kushnir M. M., Rockwood A. L., Nelson G. J., Terry A. H., Meikle A. W. Liquid chromatography-tandem mass spectrometry analysis of urinary free cortisol. Clin Chem: 2003; 49 965 967
65. Ching S. Y., Lim E. M., Beilby J., Bhagat C., Rossi E., Walsh J. P., Pullan P. Urine free cortisol analysis by automated immunoassay and high-performance liquid chromatography for the investigation of Cushing's syndrome. Ann Clin Biochem: 2006; 43 402 407
66. Kennedy D. M., Selby C., Lawson N. Measurement of urinary free cortisol using the ACS:180 serum cortisol chemiluminescent immunoassay. Ann Clin Biochem: 2000; 37 520 528
67. Lamb E. J., Noonan K. A., Burrin J. M. Urine-free cortisol excretion: evidence of sex-dependence. Ann Clin Biochem: 1994; 31 455 458
68. Palermo M., Shackleton C. H., Mantero F., Stewart P. M. Urinary free cortisone and the assessment of 11-beta-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol (Oxf): 1996; 45 605 611
69. Laudat M. H., Cerdas S., Fournier C., Guiban D., Guilhaume B., Luton J. P. Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function. J Clin Endocrinol Metab: 1988; 66 343 348
70. Restituto P., Galofré J. C., Gil M. J., Mugueta C., Santos S., Monreal J. I., Varo N. Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders. Clin Biochem: 2008; 41 688 692