Analysis of the Enzymatic Properties of a Broad Family of Alanine Aminotransferases

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  McAllister, Chandra H ^a   Facette, Michelle ^a   Holt, Andrew ^a   Good, Allen G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALANINE GLYOXYLATE AMINOTRANSFERASE; ESCHERICHIA COLI ENDOTOXIN; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN;

ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; ESCHERICHIA COLI; GROWTH INHIBITION; HUMAN; IN VIVO STUDY; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION;

ALANINE TRANSAMINASE; AMINO ACID SEQUENCE; ANIMALS; GRAM-NEGATIVE BACTERIA; HUMANS; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84873595916     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055032     Document Type: Article

References (41)

1. Mehta PK, Hale TI, Christen P, (1993) Aminotransferases: demonstration of homology and division into evolutionary subgroups. FEBS J 214: 549-61.
2. Miyashita Y, Dolferus R, Ismond KP, Good AG, (2007) Alanine aminotransferase catalyses the breakdown of alanine after hypoxia in Arabidopsis thaliana. Plant J 49: 1108-21.
3. Kameya M, Arai H, Ishii M, Igarashi Y, (2010) Purification of three aminotransferases from Hydrogenobacter thermophilus TK-6-novel types of alanine or glycine aminotransferase: enzymes and catalysis. FEBS J 277: 1876-85.
4. Jadaho SB, Yang RZ, Lin Q, Hu H, Anania FA, et al. (2004) Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver. Hepatology 39: 1297-302.
5. Liepman AH, Olsen LJ, (2003) Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis. Plant Physiol 131: 215-227.
6. Good AG, DePauw M, Kridl JC, Theodoris G, Shrawat AK (2007a) Nitrogen-efficient monocot plants. US Patent #20070162995.
7. Good AG, Johnson SJ, DePauw M, Carroll RT, Savidov N, et al. (2007b) Engineering nitrogen use efficiency with alanine aminotransferase. Can J Bot 85: 252-62.
8. Shrawat AK, Carroll RT, DePauw M, Taylor GJ, Good AG, (2008) Genetic engineering of improved nitrogen use efficiency in rice by the tissue-specific expression of alanine aminotransferase. Plant Biotech J 6: 722-32.
9. Masclaux-Daubresse C, Daniel-Vedel F, Dechorgnat J, Chardon F, Gaufichon FL, (2010) Nitrogen uptake, assimilation and remobilization in plants: challenges for sustainable and productive agriculture. Ann Bot 105: 1141-57.
10. Kant S, Bi Y-M, Rothstein SJ, (2011) Understanding plant response to nitrogen limitation for the improvement of crop nitrogen use efficiency. Access 62: 1499-1509.
11. McAllister CH, Beatty PH, Good AG, (2012) Engineering nitrogen use efficient crop plants; the current status. Plant Biotech J 10: 1011-25.
12. Sohocki MM, Sullivan LS, Harrison WR, Sodergren EJ, Elder FF, et al. (1997) Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites. Genomics 40: 247-52.
13. Yang R, Park S, Reagan WJ, Goldstein R, Zhong S, et al. (2009) Alanine aminotransferase isoenzyme: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Hepatology 49: 598-607.
14. Beatty PH, Shrawat AK, Carroll RT, Zhu T, Good AG, (2009) Transcriptome analysis of nitrogen-efficient rice over-expressing alanine aminotransferase. Plant Biotech J 7: 562-76.
15. Vigeolas H, Waldeck P, Zank T, Geigenberger P, (2007) Increasing seed oil content in oil-seed rape (Brassica napus L.) by over-expression of a yeast glycerol-3-phosphate dehydrogenase under the control of a seed-specific promoter. Plant Biotech J 5: 431-41.
16. Paine JA, (2005) Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nature Biotech 23: 482-87.
17. Duff SMG, Rydel TJ, McClerren AL, Zhang W, Li JY, et al. (2012) The enzymology of alanine aminotransferase (AlaAT) isoforms from Hordeum vulgare and other organisms, and the HvAlaAT crystal structure. Arch Biochem Biophys, doi: 10.1016/j.abb.2012.06.006.
18. Brückner H, Westhauser T, (2003) Chromatographic determination of L- and D-amino acids in plants. Amino Acids 24: 43-55.
19. Brückner H, Westhauser T, (1994) Chromatographic determination of D-amino acids as native constituents of vegetables and fruitsa). Chromatographia 39: 419-26.
20. Ward DE, Kengen SW, van Der Oost J, de Vos WM, (2000) Purification and characterization of the alanine aminotransferase from the hyperthermophilic archaeon Pyrococcus furiosus and its role in alanine production. J Bacteriol 182: 2559-66.
21. Wiśniewski P, Szklarczyk J, Macia{ogonek}ga M, Paszkowski A, (2006) L-alanine?: 2-oxoglutarate aminotransferase isoenzymes from Arabidopsis thaliana leaves. Acta Physiol Plant 28: 577-88.
22. Good AG, Muench DG, (1992) Purification and characterization of an anaerobically induced alanine aminotransferase from barley roots. Plant Physiol 99: 1520-5.
23. Marangoni B (2003) Enzyme Kinetics: A Modern Approach. New Jersey: John Wiley and Sons Inc.
24. Singh B (1999) Plant Amino Acids: Biochemistry and Biotechnology. New York Marcel Dekker, Inc.
25. Jiao Z, Si X, Li G, Zhang Z, Xu X, (2010) Unintended compositional changes in transgenic rice seeds (Oryza sativa L.) studied by spectral and chromatographic analysis coupled with chemometrics methods. J Agric Food Chem 58: 1746-54.
26. Narsai R, Howell KA, Carroll A, Ivanova A, Millar AH, et al. (2009) Defining core metabolic and transcriptomic responses to oxygen availability in rice embryos and young seedlings. Plant Phys 151: 306-22.
27. Branco-Price C, Kaiser KA, Jang CJH, Larive CK, Bailey-Serres J, (2008) Selective mRNA translation coordinates energetic and metabolic adjustments to cellular oxygen deprivation and reoxygenation in Arabidopsis thaliana. The Plant J 56: 743-55.
28. Kim SH, Schneider BL, Reitzer L, (2010) Genetics and regulation of the major enzymes of alanine synthesis in Escherichia coli. J Bacteriol 192: 5304-11.
29. Hatch MD, Mau SL, (1977) Association of NADP- and NAD-linked malic enzyme activities in Zea mays: relation to C4 pathway photosynthesis. Arch Biochem Biophys 179: 361-69.
30. Duff SMG, Qi Q, Reich T, Wu X, Brown T, et al. (2011) A kinetic comparison of asparagine synthetase isozymes from higher plants. Plant Physiol Biochem 49: 251-6.
31. Ninfa AJ, Jiang P, (2005) PII signal transduction proteins: sensors of alpha-ketoglutarate that regulate nitrogen metabolism. Curr Opin Microbiol 8: 168-73.
32. Bunik VI, Fernie AR, (2009) Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation. Biochem J 422: 405-21.
33. Jiang P, Ninfa AJ, (2009) Alpha-ketoglutarate controls the ability of the Escherichia coli PII signal transduction protein to regulate the activities of NRII (NrB) but does not control the binding of PII to NRII. Biochem 48: 11514-21.
34. Uhrig RG, Ng KKS, Moorhead GBG, (2009) PII in higher plants: a modern role for an ancient protein. Trends Plant Sci 14: 505-11.
35. Jing X, Zhang S, (2011) An ancient molecule with novel function: Alanine aminotransferase as a lipopolysaccharide binding protein with bacteriocidal activity. Dev Comp Immunol 35: 94-104.
36. Wong KF, Luk JM, Cheng RH, Klickstein LB, Fan ST, (2007) Characterization of two novel LPS-binding sites in leukocyte integrin betaA domain. FASEB J 21: 3231-9.
37. Kikuchi H, Hirose S, Toki S, Akama K, Takaiwa F, (1999) Molecular characterization of a gene for alanine aminotransferase from rice (Oryza sativa). Plant Mol Biol 39: 149-59.
38. Lock Y-Y (2011) Engineering nitrogen use efficiency in Oryza sativa by the developmental over-expression of barley alanine aminotransferase using a novel rice promoter. M.Sc. thesis, University of Alberta.
39. Wolansky MA (2005) Genetic manipulation of aspartate aminotransferase levels in Brassica napus: effects on nitrogen use efficiency. M.Sc. thesis, University of Alberta.
40. Muench DG, Good AG, (1994) Hypoxically inducible barley alanine aminotransferase: cDNA cloning and expression analysis. Plant Mol Biol 24: 417-27.
41. Ricoult C, Echeverria LO, Cliquet JB, Limami AM, (2006) Characterization of alanine aminotransferase (AlaAT) multigene family and hypoxic response in young seedlings of the model legume Medicago truncatula. J Exp Bot 57: 3079-89.