Molecular determinants of allosteric regulation in NCX proteins

Advances in Experimental Medicine and Biology

Volumn 961, Issue , 2013, Pages 35-48

  Giladi, Moshe ^a   Khananshvili, Daniel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Allosteric regulation; Disorder to order transition; NCX

Indexed keywords

AMINO ACID; ARGININE; ASPARAGINE; CALCIUM ION; ISOPROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN;

BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CALCIUM BINDING; CELL MEMBRANE TRANSPORT; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; CYTOSOL; HUMAN; INTRACELLULAR SIGNALING; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM;

EID: 84873592383     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4756-6_4     Document Type: Conference Paper

References (59)

1. M.J. Berridge, M.D. Bootman, H.L. Roderick, Calcium signalling: dynamics, homeostasis and remodelling. Nature Rev. Mol. Cell. Biol. 4, 517-529 (2003)
2. 2+ exchanger is essential for regulation: Crystal structures and mutational analysis. Proc. Natl. Acad. Sci. U.S.A. 104, 18467-18472 (2007)
3. M.P. Blaustein, W.J. Lederer, Sodium/calcium exchange: its physiological implications. Physiol. Rev. 79, 763-854 (1999)
4. L. Boyman, R. Hiller, W.J. Lederer, D. Khananshvili, Direct loading of the puri fi ed endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 protein. Biochemistry 47, 6602-6611 (2008)
5. L. Boyman, H. Mikhasenko, R. Hiller, D. Khananshvili, Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein. J. Biol. Chem. 284, 6185-6193 (2009)
6. 2+ exchanger. J. Biol. Chem. 286, 28811-28820 (2011)
7. V. Breukels, G.W. Vuister, Binding of calcium is sensed structurally and dynamically throughout the second calcium-binding domain of the sodium/calcium exchanger. Proteins 78, 1813-1824 (2010)
8. 2+ -binding domain of NCX1 binds Mg 2+ with high af fi nity. Biochemistry 50, 8804-8812 (2011)
9. M.B. Cannell, C. Soeller, Analysing cardiac excitationcontraction coupling with mathematical models of local control. Prog. Biophys. Mol. Biol. 85, 141-162 (2004)
10. E. Carafoli, Intracellular calcium homeostasis. Ann. Rev. Biochem. 56, 395-433 (1987)
11. 2+ exchanger? Channels 1, 397-399 (2007)
12. 2+ exchanger. J. Biol. Chem. 284, 14688-14692 (2009)
13. 2+ and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes. J. Physiol. (Lond.) 529, 661-668 (2000)
14. 2+ extrusion mechanisms in dialyzed squid axons. Biochim. Biophys. Acta 688, 237-245 (1982)
15. R. DiPolo, L. Beauge, Sodium/calcium exchanger: influence of metabolic regulation on ion carrier interactions. Physiol. Rev. 86, 155-203 (2006)
16. 2+ exchanger in the guinea-pig. J. Physiol. (Lond.) 480, 9-20 (1994)
17. A.E. Doering, D.A. Eisner, W.J. Lederer, Cardiac Na-Ca exchange and pH. Ann. N. Y. Acad. Sci. 779, 182-198 (1996)
18. 2+ exchanger (NCX1) isoforms. J. Biol. Chem. 277, 33957-33962 (2002)
19. 2+ exchanger. J. Gen. Physiol. 114, 701-711 (1999)
20. 2+ from the regulatory two-domain tandem of NCX1. J. Biol. Chem. 285, 28117-28125 (2010)
21. 2+ -driven interdomain module governs eukariotic NCX regulation. PloS One 7(6): E39985 (2012)
22. K.S. Ginsburg et al., Simultaneous measurement of [Na] i, [Ca] i, and I NCX in intact cardiac myocytes. Ann. N. Y. Acad. Sci. 976, 157-158 (2002)
23. +, and H + during acidosis in rat ventricular myocytes. Am. J. Physiol. 262, C348-C357 (1992)
24. D. Häussinger, T. Ahrens, H.J. Sass, O. Pertz, J. Engel, S. Grzesiek, Calcium-dependent homoassociation of E-cadherin by NMR spectroscopy: Changes in mobility, conformation and mapping of contact regions. J. Mol. Biol. 324, 823-839 (2002)
25. 2+ sensors. Mol. Cell 22, 15-25 (2006)
26. 2+ exchanger features a dual electrostatic switch mechanism. Proc. Natl. Acad. Sci. U.S.A. 106, 14333-14338 (2009)
27. D.W. Hilgemann, S. Matsuoka, G.A. Nagel, A. Collins, Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation. J. Gen. Physiol. 100, 905-932 (1992a)
28. D.W. Hilgemann, A. Collins, S. Matsuoka, Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP. J. Gen. Physiol. 100, 933-961 (1992b)
29. 2+ exchanger? Focus on "sodium-dependent inactivation of sodium-calcium exchange in transfected Chinese hamster ovary cells". Am. J. Physiol. Cell Physiol. 295, C869-C871 (2008)
30. 2+ . J. Gen. Physiol. 108, 67-74 (1996)
31. 2+ exchanger dimers. Proc. Natl. Acad. Sci. U.S.A. 108, 1699-1704 (2011)
32. 2+ . J. Mol. Biol. 377, 945-955 (2008)
33. 2+ exchanger. Mol. Cell. Biol. 23B, 309-356 (1998)
34. D. Khananshvili, The SLC8 gene family of sodiumcalcium exchangers (NCX)-structure, function, and regulation in health and disease. Mol. Asp. Med. (2012) in press
35. 2+ exchanger. J. Biol. Chem. 269, 22847-22852 (1994)
36. 2+ exchanger. Mol. Cell. Biochem. 160-161, 27-32 (1996)
37. 2+ transport. Biochem. J. 406, 365-382 (2007)
38. 2+ ions with positive cooperativity. Biochemistry 43, 16320-16328 (2004)
39. 2+ exchanger. Proc. Natl. Acad. Sci. U.S.A. 90, 3870-3874 (1993)
40. 2+ binding domain. J. Gen. Physiol. 105, 403-420 (1995)
41. 2+ binding mode of rabphilin-3A. J. Biol. Chem. 282, 5015-5025 (2007)
42. 2+ binding motif. J. Biol. Chem. 281, 21577-21581 (2006)
43. D.A. Nicoll, X. Ren, M. Ottolia, M. Phillips, A.R. Parades, J. Abramson, K.D. Philipson, What we know about the structure of NCX1 and how it relates to its function. Ann. NY Acad. Sci. 1099, 1-6 (2007)
44. 2+ exchanger detected by FRET. Biophys. J. 87, 899-906 (2004)
45. 2+ exchanger. J. Biol. Chem. 284, 32735-32741 (2009)
46. 2+ exchanger and secondary regulation. Channels 4, 1-4 (2010)
47. K.D. Philipson, D.A. Nicoll, Sodium-calcium exchange: A molecular perspective. Annu. Rev. Physiol. 62, 111-133 (2000)
48. 2+ exchange in canine cardiac sarcolemmal vesicles. Circ. Res. 50, 287-293 (1982)
49. S.M. Pogwizd, K. Schlotthauer, L. Li, W. Yuan, D.M. Bers, Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward recti fi er potassium current, and residual beta-adrenergic responsiveness. Circ. Res. 88, 1159-1167 (2001)
50. J. Reeves, M. Condrescu, Ionic regulation of the cardiac sodium-calcium exchanger. Channels 2, 322-328 (2008)
51. 2+ -binding domain. J. Biol. Chem. 273, 15879-15882 (1998)
52. 2+ exchanger. J. Biol. Chem. 286, 32123-32131 (2011)
53. 2+ sparks: An investigative mathematical model of calcium-induced calcium release. Biophys. J. 83, 59-78 (2002)
54. R.V. Stahelin, J. Wang, N.R. Blatner, J.D. Rafter, D. Murray, W. Cho, The origin of C1A-C2 interdomain interactions in protein kinase C. J. Biol. Chem. 280, 36452-36463 (2005)
55. C.R. Weber, K.S. Ginsburg, K.D. Philipson et al., Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiomyocytes. J. Gen. Physiol. 117, 119-131 (2001)
56. S. Wei et al., Cytosolic free magnesium modulates Na/Ca exchange currents in pig myocytes. Cardiovasc. Res. 53, 334-340 (2002)
57. 2+ regulation and its alternative splicing modi fi cation. J. Mol. Biol. 387, 104-112 (2009)
58. 2+ exchanger reveal incremental conformational transitions. J. Biol. Chem. 285, 2554-2561 (2010)
59. 2+ inhibitory mechanism of Drosophila Na/Ca exchanger CALX and its modi fication by alternative splicing. Structure 19, 1509-1517 (2011)