Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes

Journal of General Physiology

Volumn 117, Issue 2, 2001, Pages 119-131

  Weber, Christopher R ^a   Ginsburg, Kenneth S ^a   Philipson, Kenneth D ^b   Shannon, Thomas R ^a   Bers, Donald M ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiac electrophysiology; Dog; Ferret; Mouse; Na Ca exchanger

Indexed keywords

CALCIUM;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOL; FERRET; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; MOUSE; NONHUMAN; SARCOLEMMA; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT; TRANSGENE; TRANSGENIC MOUSE;

ALLOSTERIC REGULATION; ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM-TRANSPORTING ATPASES; COMPUTER SIMULATION; CYTOSOL; DOGS; FERRETS; MICE; MODELS, BIOLOGICAL; MUSCLE FIBERS; MUTAGENESIS; MYOCARDIUM; NICKEL; SARCOPLASMIC RETICULUM; SODIUM-CALCIUM EXCHANGER;

EID: 0035005037     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.117.2.119     Document Type: Article

References (50)

1. 2+ exchanger
2. 2+ exchange in the isolated cardiac sarcolemma vesicles by using a rapid-response fluorescent probe
3. i in intact rabbit cardiac myocytes
4. Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle
5. i waves in cardiac myocytes
6. Inward current channels activated by intracellular Ca in cultured cardiac cells
7. Barium- and calcium-permeable channels open at negative membrane potentials in rat ventricular myocytes
8. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum
9. 2+ exchange activity by cytosolic Ca in transfected Chinese hamster ovary cells
10. tr and related contraction in isolated guinea-pig ventricular myocytes
11. 2+ exchange in inside-out patches excised from guinea-pig ventricular myocytes
12. Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects of thapsigargin and isoproterenol
13. A new generation of Ca indicators with greatly improved fluorescence properties
14. Abnormal intracellular calcium handling in myocardium from patients with endstage heart failure
15. Control of the Na-Ca exchanger in isolated heart cells. II. Beat-dependent activation in normal cells by intracellular calcium
16. 2+ exchange in giant excised sarcolemmal membrane patches
17. 2+ exchange system in giant membrane patches
18. Steady state and dynamic properties of cardiac sodium-calcium exchange: Secondary modulation by cytoplasmic calcium and ATP
19. Passive Ca buffering and SR Ca uptake in permeabilized rabbit ventricular myocytes
20. 2+
21. 2+ exchanger after a Ca concentration jump
22. Identification of sodium-calcium exchange current in single ventricular cells of guinea-pig
23. 2+ exchanger
24. Transient inward current in guinea-pig atrial myocytes reflects a change of sodium-calcium exchange current
25. Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: Studies in adult rabbit ventricular myocytes
26. A dynamic model of the cardiac ventricular action potential: I. Simulations of ionic currents and concentration changes
27. 2+ exchanger
28. 2+ exchanger by Ca: Mutational analysis of the Ca binding domain
29. 2+ exchange assessed in transgenic mouse hearts
30. Sodium-calcium exchange current: Dependence on internal Ca and Na and competitive binding of external Na and Ca
31. The generation of electric currents in cardiac fibers by Na/Ca exchange
32. Molecular studies of the cardiac sarcolemmal sodium-calcium exchanger
33. 2+ exchanger
34. Strontium-induced creep currents associated with tonic contractions in cardiac myocytes isolated from guinea-pigs
35. The role of sodium-calcium exchange during the cardiac action potential
36. Upregulation of Na/Ca exchanger expression and function in an arrhythmogenic rabbit model of heart failure
37. The stoichiometry of the cardiac sodium-calcium exchange system
38. 2+ sparks and local control theories for cardiac excitation-contraction coupling
39. 2+ channel isoform in murine atrial myocytes (AT-1 cells)
40. Surface: Volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: Species-dependence and developmental effects
41. 2+ release causes myocyte depolarization: Underlying mechanism and threshold for triggered action potentials
42. Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes
43. Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes
44. 2+ exchange in cardiac sarcolemmal vesicles
45. Calcium activation of the sodium calcium exchanger in intact cardiac myocytes
46. Calcium activation of Na/Ca exchanger in mouse myocytes overexpressing canine NCX1
47. i transients in murine ventricular myocytes
48. Protein kinase inhibitor H-89 reverses forskolin stimulation of cardiac L-type calcium current