Paeoniflorin acts as a liver X receptor agonist

Journal of Asian Natural Products Research

Volumn 15, Issue 1, 2013, Pages 35-45

  Lin, Hsiang Ru ^a  

^a NATIONAL KAOHSIUNG NORMAL UNIVERSITY   (Taiwan)

Author keywords

liver X receptor (LXR); Paeonia lactiflora (Paeoniaceae); paeoniflorin

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ABC TRANSPORTER A1; CHOLESTEROL 7ALPHA MONOOXYGENASE; GSK 3987; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PAEONIFLORIN; PHOSPHOLIPID TRANSFER PROTEIN; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HYBRID CELL; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; PROMOTER REGION; REPORTER GENE; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION; TRANSIENT TRANSFECTION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; ATP-BINDING CASSETTE TRANSPORTERS; BENZOATES; BRIDGED COMPOUNDS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; GLUCOSIDES; HEP G2 CELLS; HUMANS; LIVER; LUCIFERASES; MOLECULAR STRUCTURE; ORPHAN NUCLEAR RECEPTORS; PAEONIA; RATS; STEROID HYDROXYLASES; TRANSCRIPTION FACTORS;

EID: 84873587436     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2012.742510     Document Type: Article

References (23)

1. J.M. Olefsky, J. Biol. Chem. 276, 36863 (2001).
2. P. Tontonoz and D.J. Mangelsdorf, Mol. Endocrinol. 17, 985 (2003).
3. T.M. Stulnig, K.R. Steffensen, H. Gao, M. Reimers, K. Dahlman-Wright, G.U. Schuster, and J.A. Gustafsson, Mol. Pharmacol. 62, 1299 (2002).
4. S. Gupta, W.M. Pandak, and P.B. Hylemon, Biochem. Biophys. Res. Commun. 26, 338 (2002).
5. P. Costet, Y. Luo, N. Wang, and A.R. Tall, J. Biol. Chem. 275, 28240 (2000).
6. R.A. DeBose-Boyd, J. Ou, J.L. Goldstein, and M.S. Brown, Proc. Natl. Acad. Sci. U.S.A. 98, 1477 (2001).
7. B.A. Laffitte, J.J. Repa, S.B. Joseph, D.C. Wilpitz, H.R. Kast, D.J. Mangelsdorf, and P. Tontonoz, Proc. Natl. Acad. Sci. U.S.A. 98, 507 (2001).
8. B.A. Laffitte, L.C. Chao, J. Li, R. Walczak, S. Hummasti, S.B. Joseph, A. Castrillo, D.C. Wilpitz, D.J. Mangelsdorf, J.L. Collins, E. Saez, and P. Tontonoz, Proc. Natl. Acad. Sci. U.S.A. 100, 5419 (2003).
9. R. Grempler, S. Gu?nther, K.R. Steffensen, M. Nilsson, A. Barthel, D. Schmoll, and R. Walther, Biochem. Biophys. Res. Commun. 338, 981 (2005).
10. K.T. Dalen, S.M. Ulven, K. Bamberg, J.A. Gustafsson, and H.I. Nebb, J. Biol. Chem. 278, 48283 (2003).
11. P.H. Yen, P.V. Kiem, N.X. Nhiem, N.H. Tung, T.H. Quang, C.V. Minh, J.W. Kim, E.M. Choi, and Y.H. Kim, Arch. Pharmacol. Res. 30, 1179 (2007).
12. Q.Q. Mao, X.M. Zhong, Z.Y. Li, and Z. Huang, Phytother. Res. 25, 681 (2010).
13. Y.K. Koo, J.M. Kim, J.Y. Koo, S.S. Kang, K. Bae, Y.S. Kim, J.H. Chung, and H.S. Yun-Choi, Pharmazie 65, 624 (2010).
14. X. Li, J. Shen, Z. Zhong, J. Peng, H. Wen, J. Li, Q. Luo, and W. Wei, Parasitology 137, 1213 (2010).
15. H.O. Yang, W.K. Ko, J.Y. Kim, and H.S. Ro, Fitoterapia 75, 45 (2004).
16. R. Ohashi, H. Mu, X. Wang, Q. Yao, and C. Chen, QJM 98, 845 (2005).
17. P.A. Mak, H.R. Kast-Woelbern, A.M. Anisfeld, and P.A. Edwards, J. Lipid Res. 43, 2037 (2002).
18. J.Y. Chiang, R. Kimmel, and D. Stroup, Gene 262, 257 (2001).
19. S. Svensson, T. Ostberg, M. Jacobsson, C. Norstro?m, K. Stefansson, D. Hallen, I.C. Johansson, K. Zachrisson, D. Ogg, and L. Jendeberg, EMBO J. 22, 4625 (2003).
20. N. Mitro, P.A. Mak, L. Vargas, C. Godio, E. Hampton, V. Molteni, A. Kreusch, and E. Saez, Nature 445, 219 (2007).
21. X. Fradera, D. Vu, O. Nimz, R. Skene, D. Hosfield, R. Wynands, A.J. Cooke, A. Haunsø, A. King, D.J. Bennett, R. McGuire, and J.C. Uitdehaag, J. Mol. Biol. 399, 120 (2010).
22. M.C. Jaye, J.A. Krawiec, N. Campobasso, A. Smallwood, C. Qiu, Q. Lu, J.J. Kerrigan, M. De Los Frailes Alvaro, B. Laffitte, W.S. Liu, J.P. Marino Jr, C.R. Meyer, J.A. Nichols, D.J. Parks, P. Perez, L. Sarov-Blat, S.D. Seepersaud, K.M. Steplewski, S.K. Thompson, P. Wang, M.A. Watson, C.L. Webb, D. Haigh, J.A. Caravella, C.H. Macphee, T.M. Willson, and J.L. Collins, J. Med. Chem. 48, 5419 (2005).
23. N.Y. Kalaany, K.C. Gauthier, A.M. Zavacki, P.P. Mammen, T. Kitazume, J.A. Peterson, J.D. Horton, D.J. Garry, A.C. Bianco, and D.J. Mangelsdorf, Cell Metab. 1, 231 (2005).