Influence of IL-1RN Intron 2 variable number of tandem repeats (VNTR) polymorphism on bipolar disorder

Neuropsychobiology

Volumn 67, Issue 2, 2013, Pages 116-121

  Rafiei, A ^a   Hosseini, S H ^b   Taheri, M ^b   Hosseni Khah, Z ^a   Hajilooi, M ^c   Mazaheri, Z ^d  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d Sina Hospital Hamedan   (Iran)

Author keywords

Bipolar disorder; Interleukin 1 receptor antagonist gene; Polymorphism; Variable number of tandem repeats

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ADULT; AGE; ALLELE; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DISEASE COURSE; DNA POLYMORPHISM; FEMALE; GENE AMPLIFICATION; GENOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MANIA; ONSET AGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VARIABLE NUMBER OF TANDEM REPEAT; BASE PAIRING; CASE CONTROL STUDY; DISEASE DURATION; DNA DETERMINATION; DSM-IV-TR; ETHNIC GROUP; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY;

ADULT; BIPOLAR DISORDER; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTRONS; IRAN; MALE; MIDDLE AGED; MINISATELLITE REPEATS; PSYCHIATRIC STATUS RATING SCALES; YOUNG ADULT;

EID: 84873573748     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000346112     Document Type: Article

References (42)

1. Czerski PM, Rybakowski F, Kapelski P, Rybakowski JK, Dmitrzak-Weglarz M, Leszczyńska-Rodziewicz A, Słopień A, Skibińska M, Kaczmarkiewicz-Fass M, Hauser J: Association of tumor necrosis factor -308G/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish population. Neuropsychobiology 2008; 57: 88-94.
2. Goldstein BI, Kemp DE, Soczynska JK, Mc- Intyre RS: Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry Clinical Neurosci 2009; 70: 1078-1090.
3. Rothwell NJ, Luheshi GN: Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci 2000; 23: 618-625.
4. Stroemer RP, Rothwell NJ: Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1 beta in the rat. J Cereb Blood Flow Metab 1998; 18: 833-839.
5. Luheshi NM, Kovacs KJ, Lopez-Castejon G, Brough D, Denes A: Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues. J Neuroinflammation 2011; 8: 186.
6. Soderlund J, Olsson SK, Samuelsson M, Walther- Jallow L, Johansson C, Erhardt S, Landen M, Engberg G: Elevation of cerebrospinal fluid interleukin-1β in bipolar disorder. J Psychiatry Neurosci 2011; 36: 114-118.
7. Cox A, Camp NJ, Nicklin MJ, di Giovine FS, Duff GW: An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers. Am J Hum Genet 1998; 62: 1180- 1188.
8. Nicklin MJ, Weith A, Duff GW: A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics 1994; 19: 382-384.
9. Arend WP, Malyak M, Guthridge CJ, Gabay C: Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 1998; 16: 27-55.
10. McIntyre KW, Stepan GJ, Kolinsky KD, Benjamin WR, Plocinski JM, Kaffka KL, Campen CA, Chizzonite RA, Kilian PL: Inhibition of interleukin-1 binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody. J Exp Med 1991; 173: 931-939.
11. Arend WR: The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev 2002; 13: 323-340.
12. Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E: Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 2008; 63: 801-808.
13. Tarlow JK, Blakemore AI, Lennard A, Solari R, Hughes HN, Steinkasserer A, Duff GW: Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 1993; 91: 403-404.
14. Witkin SS, Gerber S, Ledger WJ: Influence of interleukin-1 receptor antagonist gene polymorphism on disease. Clin Infect Dis 2002; 34: 204-209.
15. Hacker UT, Erhardt S, Tschop K, Jelinek T, Endres S: Influence of the IL-1ra gene polymorphism on in vivo synthesis of IL-1ra and IL-1beta after live yellow fever vaccination. Clin Exp Immunol 2001; 125: 465-469.
16. Santtila S, Savinainen K, Hurme M: Presence of the IL-1RN allele 2 (IL1RN 2) is associated with enhanced IL-1beta production in vitro. Scand J Immunol 1998; 47: 195-198.
17. Wilkinson RJ, Patel P, Llewelyn M, Hirsch CS, Pasvol G, Snounou G, Davidson RN, Toossi Z: Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis. J Exp Med 1999; 189: 1863-1874.
18. Kim SJ, Lee HJ, Koo HG, Kim JW, Song JY, Kim MK, Shin DH, Jin SY, Hong MS, Park HJ, Yoon SH, Park HK, Chung JH: Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder. Psychiatr Genet 2004; 14: 165-167.
19. Zanardini R, Bocchio-Chiavetto L, Scassellati C, Bonvicini C, Tura GB, Rossi G, Perez J, Gennarelli M: Association between IL- 1beta -511C/T and IL-1RA (86bp)n repeats polymorphisms and schizophrenia. J Psychiatr Res 2003; 37: 457-462.
20. Laurent C, Thibaut F, Ravassard P, Campion D, Samolyk D, Lafargue C, Petit M, Martinez M, Mallet J: Detection of two new polymorphic sites in the human interleukin-1beta gene: lack of association with schizophrenia in a French population. Psychiatr Genet 1997; 7: 103-105.
21. Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Koizumi M, Someya T: Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population. Psychiatry Clin Neurosci 2007; 61: 364-369.
22. Toyooka K, Watanabe Y, Iritani S, Shimizu E, Iyo M, Nakamura R, Asama K, Makifuchi T, Kakita A, Takahashi H, Someya T, Nawa H: A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients. Neurosci Res 2003; 46: 299-307.
23. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, American Psychiatric Press, 1994.
24. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215-1218.
25. Zhao B, Schwartz JP: Involvement of cytokines in normal CNS development and neurological disease: recent progress and perspectives. J Neurosci Res 1998; 52: 7-16.
26. Papiol S, Molina V, Desco M, Rosa A, Reig S, Sanz J, Palomo T, Fananas L: Gray matter deficits in bipolar disorder are associated with genetic variability at interleukin-1 beta gene (2q13). Genes Brain Behav 2008; 7: 796- 801.
27. Papiol S, Rosa A, Gutierrez B, Martin B, Salgado P, Catalan R, Arias B, Fananas L: Interleukin- 1 cluster is associated with genetic risk for schizophrenia and bipolar disorder. J Med Genet 2004; 41: 219-223.
28. Meisenzahl EM, Rujescu D, Kirner A, Giegling I, Kathmann N, Leinsinger G, Maag K, Hegerl U, Hahn K, Moller HJ: Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia. Am J Psychiatry 2001; 158: 1316-1319.
29. Papiol S, Molina V, Desco M, Rosa A, Reig S, Gispert JD, Sanz J, Palomo T, Fananas L: Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene. Neuroimage 2005; 27: 1002-1006.
30. Allan SM, Rothwell NJ: Cytokines and acute neurodegeneration. Nat Rev Neurosci Res 2001; 2: 734-744.
31. Nawa H, Takahashi M, Patterson PH: Cytokine and growth factor involvement in schizophrenia - support for the developmental model. Mol Psychiatry 2000; 5: 594- 603.
32. Dewberry RM, Crossman DC, Francis SE: Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis. Arterioscler Thromb Vasc Biol 2000; 20: 2394-2400.
33. Chourasia D, Achyut BR, Tripathi S, Mittal B, Mittal RD, Ghoshal UC: Genotypic and functional roles of IL-1B and IL-1RN on the risk of gastroesophageal reflux disease: the presence of IL-1B-511 T/IL-1RN 1 (T1) haplotype may protect against the disease. Am J Gastroenterol 2009; 104: 2704-2713.
34. Danis VA, Millington M, Hyland VJ, Grennan D: Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin Exp Immunol 1995; 99: 303-310.
35. Chistyakov DA, Savost'anov KV, Turakulov RI, Petunina NA, Trukhina LV, Kudinova AV, Balabolkin MI, Nosikov VV: Complex association analysis of graves disease using a set of polymorphic markers. Mol Genet Metab 2000; 70: 214-218.
36. Dinarello CA: The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 2002; 20:S1-S13.
37. Song C, Horrobin DF, Leonard BE: The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1beta in rats. Pharmacopsychiatry 2006; 39: 88-99.
38. Alvarez-Rodriguez L, Carrasco-Marin E, Lopez-Hoyos M, Mata C, Fernandez-Prieto L, Ruiz-Soto M, Calvo J, Rodriguez-Valverde V, Ruiz T, Blanco R, Corrales A, Martinez- Taboada VM: Interleukin-1RN gene polymorphisms in elderly patients with rheumatic inflammatory chronic conditions: Association of IL-1RN 2/2 genotype with polymyalgia rheumatica. Hum Immunol 2009; 70: 49-54.
39. Rezaii AA, Hoseinipanah SM, Hajilooi M, Rafiei AR, Shikh N, Haidari M: Interleukin- 1 receptor antagonist gene polymorphism and susceptibility to ischemic stroke. Immunol Invest 2009; 38: 220-230.
40. Marx CE, Jarskog LF, Lauder JM, Lieberman JA, Gilmore JH: Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophrenia. Biol Psychiatry 2001; 50: 743- 749.
41. Hadjigeorgiou GM, Paterakis K, Dardiotis E, Dardioti M, Aggelakis K, Tasiou A, Xiromerisiou G, Komnos A, Zintzaras E, Scarmeas N, Papadimitriou A, Karantanas A: IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury. Neurology 2005; 65: 1077-1082.
42. Touzani O, Boutin H, Chuquet J, Rothwell N: Potential mechanisms of interleukin-1 involvement in cerebral ischaemia. J Neuroimmunol 1999; 100: 203-215.