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Volumn 35, Issue 3, 2013, Pages 253-260

The roots of cancer: Stem cells and the basis for tumor heterogeneity

Author keywords

Cancer stem cell; Cell of mutation; Cell of origin; Clonal evolution; Tumor initiating cell

Indexed keywords

ANDROGEN DEPRIVATION THERAPY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER STEM CELL; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL RENEWAL; CELL TRANSFORMATION; CLONAL EVOLUTION; EPITHELIUM BASAL CELL; GENETIC MANIPULATION; HUMAN; MALIGNANT TRANSFORMATION; NEURAL STEM CELL; NONHUMAN; ONCOGENE; PROSTATE CANCER; SIGNAL TRANSDUCTION; STEM CELL RESEARCH; TUMOR SUPPRESSOR GENE;

EID: 84873566048     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201200101     Document Type: Article
Times cited : (58)

References (45)
  • 1
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader JE. 2011. Cells of origin in cancer. Nature 469: 314-22.
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 2
    • 79960809488 scopus 로고    scopus 로고
    • Mosaic analysis with double markers reveals tumor cell of origin in glioma
    • Liu C, Sage JC, Miller MR, Verhaak RG, et al. 2011. Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell 146: 209-21.
    • (2011) Cell , vol.146 , pp. 209-221
    • Liu, C.1    Sage, J.C.2    Miller, M.R.3    Verhaak, R.G.4
  • 3
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • Alcantara Llaguno S, Chen J, Kwon CH, Jackson EL, et al. 2009. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15: 45-56.
    • (2009) Cancer Cell , vol.15 , pp. 45-56
    • Alcantara Llaguno, S.1    Chen, J.2    Kwon, C.H.3    Jackson, E.L.4
  • 4
    • 65649142176 scopus 로고    scopus 로고
    • Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
    • Wang Y, Yang J, Zheng H, Tomasek GJ, et al. 2009. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15: 514-26.
    • (2009) Cancer Cell , vol.15 , pp. 514-526
    • Wang, Y.1    Yang, J.2    Zheng, H.3    Tomasek, G.J.4
  • 5
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu Y, Guignard F, Zhao D, Liu L, et al. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8: 119-30.
    • (2005) Cancer Cell , vol.8 , pp. 119-130
    • Zhu, Y.1    Guignard, F.2    Zhao, D.3    Liu, L.4
  • 6
    • 70349438989 scopus 로고    scopus 로고
    • A luminal epithelial stem cell that is a cell of origin for prostate cancer
    • Wang X, Kruithof-de Julio M, Economides KD, Walker D, et al. 2009. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461: 495-500.
    • (2009) Nature , vol.461 , pp. 495-500
    • Wang, X.1    Kruithof-de Julio, M.2    Economides, K.D.3    Walker, D.4
  • 7
    • 79955530295 scopus 로고    scopus 로고
    • Purification and direct transformation of epithelial progenitor cells from primary human prostate
    • Goldstein AS, Drake JM, Burnes DL, Finley DS, et al. 2011. Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nat Protoc 6: 656-67.
    • (2011) Nat Protoc , vol.6 , pp. 656-667
    • Goldstein, A.S.1    Drake, J.M.2    Burnes, D.L.3    Finley, D.S.4
  • 8
    • 77955121375 scopus 로고    scopus 로고
    • Identification of a cell of origin for human prostate cancer
    • Goldstein AS, Huang J, Guo C, Garraway IP, et al. 2010. Identification of a cell of origin for human prostate cancer. Science 329: 568-71.
    • (2010) Science , vol.329 , pp. 568-571
    • Goldstein, A.S.1    Huang, J.2    Guo, C.3    Garraway, I.P.4
  • 9
    • 77249178726 scopus 로고    scopus 로고
    • Basal epithelial stem cells are efficient targets for prostate cancer initiation
    • Lawson DA, Zong Y, Memarzadeh S, Xin L, et al. 2010. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci USA 107: 2610-5.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2610-2615
    • Lawson, D.A.1    Zong, Y.2    Memarzadeh, S.3    Xin, L.4
  • 10
    • 84861881705 scopus 로고    scopus 로고
    • Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status
    • Taylor RA, Toivanen R, Frydenberg M, Pedersen J, et al. 2012. Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status. Stem Cells 30: 1087-96.
    • (2012) Stem Cells , vol.30 , pp. 1087-1096
    • Taylor, R.A.1    Toivanen, R.2    Frydenberg, M.3    Pedersen, J.4
  • 11
    • 84863078902 scopus 로고    scopus 로고
    • Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation
    • Choi N, Zhang B, Zhang L, Ittmann M, et al. 2012. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell 21: 253-65.
    • (2012) Cancer Cell , vol.21 , pp. 253-265
    • Choi, N.1    Zhang, B.2    Zhang, L.3    Ittmann, M.4
  • 12
    • 80054987127 scopus 로고    scopus 로고
    • Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate
    • Liu J, Pascal LE, Isharwal S, Metzger D, et al. 2011. Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate. Mol Endocrinol 25: 1849-57.
    • (2011) Mol Endocrinol , vol.25 , pp. 1849-1857
    • Liu, J.1    Pascal, L.E.2    Isharwal, S.3    Metzger, D.4
  • 13
    • 84865988399 scopus 로고    scopus 로고
    • Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis
    • Zhang L, Zhang B, Han SJ, Shore AN, et al. 2012. Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res 21: 1117-23.
    • (2012) Transgenic Res , vol.21 , pp. 1117-1123
    • Zhang, L.1    Zhang, B.2    Han, S.J.3    Shore, A.N.4
  • 14
    • 0035017872 scopus 로고    scopus 로고
    • The metaplastic effects of estrogen on mouse prostate epithelium: proliferation of cells with basal cell phenotype
    • Risbridger GP, Wang H, Frydenberg M, Cunha G. 2001. The metaplastic effects of estrogen on mouse prostate epithelium: proliferation of cells with basal cell phenotype. Endocrinology 142: 2443-50.
    • (2001) Endocrinology , vol.142 , pp. 2443-2450
    • Risbridger, G.P.1    Wang, H.2    Frydenberg, M.3    Cunha, G.4
  • 16
    • 77951723424 scopus 로고    scopus 로고
    • Molecular sampling of prostate cancer: a dilemma for predicting disease progression
    • Sboner A, Demichelis F, Calza S, Pawitan Y, et al. 2010. Molecular sampling of prostate cancer: a dilemma for predicting disease progression. BMC Med Genomics 3: 8.
    • (2010) BMC Med Genomics , vol.3 , pp. 8
    • Sboner, A.1    Demichelis, F.2    Calza, S.3    Pawitan, Y.4
  • 17
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • Visvader JE. 2009. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 23: 2563-77.
    • (2009) Genes Dev , vol.23 , pp. 2563-2577
    • Visvader, J.E.1
  • 18
    • 77956218241 scopus 로고    scopus 로고
    • BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    • Molyneux G, Geyer FC, Magnay FA, McCarthy A, et al. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7: 403-17.
    • (2010) Cell Stem Cell , vol.7 , pp. 403-417
    • Molyneux, G.1    Geyer, F.C.2    Magnay, F.A.3    McCarthy, A.4
  • 19
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim E, Vaillant F, Wu D, Forrest NC, et al. 2009. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 15: 907-13.
    • (2009) Nat Med , vol.15 , pp. 907-913
    • Lim, E.1    Vaillant, F.2    Wu, D.3    Forrest, N.C.4
  • 20
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen A, Rocha AS, Ousset M, Beck B, et al. 2011. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479: 189-93.
    • (2011) Nature , vol.479 , pp. 189-193
    • Van Keymeulen, A.1    Rocha, A.S.2    Ousset, M.3    Beck, B.4
  • 21
    • 33646045010 scopus 로고    scopus 로고
    • Stem cells and cancer: two faces of Eve
    • Clarke MF, Fuller M. 2006. Stem cells and cancer: two faces of Eve. Cell 124: 1111-5.
    • (2006) Cell , vol.124 , pp. 1111-1115
    • Clarke, M.F.1    Fuller, M.2
  • 23
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: impact, heterogeneity, and uncertainty
    • Magee JA, Piskounova E, Morrison SJ. 2012. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 21: 283-96.
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 24
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB, Eaves CJ, et al. 2006. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66: 9339-44.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3    Eaves, C.J.4
  • 25
    • 67649939163 scopus 로고    scopus 로고
    • The increasing complexity of the cancer stem cell paradigm
    • Rosen JM, Jordan CT. 2009. The increasing complexity of the cancer stem cell paradigm. Science 324: 1670-3.
    • (2009) Science , vol.324 , pp. 1670-1673
    • Rosen, J.M.1    Jordan, C.T.2
  • 26
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. 2009. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138: 822-9.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 28
    • 84865222310 scopus 로고    scopus 로고
    • Defining the mode of tumour growth by clonal analysis
    • Driessens G, Beck B, Caauwe A, Simons BD, et al. 2012. Defining the mode of tumour growth by clonal analysis. Nature 488: 527-30.
    • (2012) Nature , vol.488 , pp. 527-530
    • Driessens, G.1    Beck, B.2    Caauwe, A.3    Simons, B.D.4
  • 29
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J, Li Y, Yu TS, McKay RM, et al. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488: 522-6.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4
  • 31
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana E, Shackleton M, Foster HR, Fullen DR, et al. 2010. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 18: 510-23.
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3    Fullen, D.R.4
  • 32
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumour formation by single human melanoma cells
    • Quintana E, Shackleton M, Sabel MS, Fullen DR, et al. 2008. Efficient tumour formation by single human melanoma cells. Nature 456: 593-8.
    • (2008) Nature , vol.456 , pp. 593-598
    • Quintana, E.1    Shackleton, M.2    Sabel, M.S.3    Fullen, D.R.4
  • 33
  • 35
    • 78751623400 scopus 로고    scopus 로고
    • Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-kappaB signalling
    • Rajasekhar VK, Studer L, Gerald W, Socci ND, et al. 2011. Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-kappaB signalling. Nat Commun 2: 162.
    • (2011) Nat Commun , vol.2 , pp. 162
    • Rajasekhar, V.K.1    Studer, L.2    Gerald, W.3    Socci, N.D.4
  • 36
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, et al. 1999. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 59: 5002-11.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4
  • 37
    • 79960876771 scopus 로고    scopus 로고
    • Brief report: a bioassay to identify primary human prostate cancer repopulating cells
    • Toivanen R, Berman DM, Wang H, Pedersen J, et al. 2011. Brief report: a bioassay to identify primary human prostate cancer repopulating cells. Stem Cells 29: 1310-4.
    • (2011) Stem Cells , vol.29 , pp. 1310-1314
    • Toivanen, R.1    Berman, D.M.2    Wang, H.3    Pedersen, J.4
  • 38
    • 0035177262 scopus 로고    scopus 로고
    • Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression
    • Collins AT, Habib FK, Maitland NJ, Neal DE. 2001. Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression. J Cell Sci 114: 3865-72.
    • (2001) J Cell Sci , vol.114 , pp. 3865-3872
    • Collins, A.T.1    Habib, F.K.2    Maitland, N.J.3    Neal, D.E.4
  • 39
    • 72249113369 scopus 로고    scopus 로고
    • high stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model
    • high stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res 69: 8555-62.
    • (2009) Cancer Res , vol.69 , pp. 8555-8562
    • Mulholland, D.J.1    Xin, L.2    Morim, A.3    Lawson, D.4
  • 40
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC. 2012. Clonal evolution in cancer. Nature 481: 306-13.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 41
    • 78751661556 scopus 로고    scopus 로고
    • Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
    • Notta F, Mullighan CG, Wang JC, Poeppl A, et al. 2011. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 469: 362-7.
    • (2011) Nature , vol.469 , pp. 362-367
    • Notta, F.1    Mullighan, C.G.2    Wang, J.C.3    Poeppl, A.4
  • 42
    • 78751644099 scopus 로고    scopus 로고
    • Genetic variegation of clonal architecture and propagating cells in leukaemia
    • Anderson K, Lutz C, van Delft FW, Bateman CM, et al. 2011. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469: 356-61.
    • (2011) Nature , vol.469 , pp. 356-361
    • Anderson, K.1    Lutz, C.2    van Delft, F.W.3    Bateman, C.M.4
  • 43
    • 84860642507 scopus 로고    scopus 로고
    • The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration
    • Qin J, Liu X, Laffin B, Chen X, et al. 2012. The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration. Cell Stem Cell 10: 556-69.
    • (2012) Cell Stem Cell , vol.10 , pp. 556-569
    • Qin, J.1    Liu, X.2    Laffin, B.3    Chen, X.4
  • 44
    • 80053904142 scopus 로고    scopus 로고
    • Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
    • Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, et al. 2011. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 9: 357-65.
    • (2011) Cell Stem Cell , vol.9 , pp. 357-365
    • Dieter, S.M.1    Ball, C.R.2    Hoffmann, C.M.3    Nowrouzi, A.4
  • 45
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, et al. 2011. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146: 633-44.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.