Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Simonelli, Luca ^a   Pedotti, Mattia ^a   Beltramello, Martina ^a   Livoti, Elsa ^a   Calzolai, Luigi ^b   Sallusto, Federica ^a   Lanzavecchia, Antonio ^a,c   Varani, Luca ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b JOINT RESEARCH CENTRE   (Italy)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DENGUE VIRUS ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ANTIBODY COMBINING SITE; ANTIBODY ENGINEERING; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SEROTYPE; VALIDATION PROCESS; VIRUS CELL INTERACTION; VIRUS NEUTRALIZATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGEN-ANTIBODY COMPLEX; BINDING SITES, ANTIBODY; COMPUTER-AIDED DESIGN; DENGUE; DENGUE VIRUS; EPITOPE MAPPING; EPITOPES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PLASMON RESONANCE;

EID: 84873549727     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055561     Document Type: Article

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