CCAAT/Enhancer Binding Protein β (C/EBPβ) Isoforms as Transcriptional Regulators of the Pro-Invasive CDH3/P-Cadherin Gene in Human Breast Cancer Cells

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Albergaria, André ^a,b   Resende, Carlos ^a   Nobre, Ana Rita ^a   Ribeiro, Ana Sofia ^a   Sousa, Bárbara ^a   Machado, José Carlos ^a,b   Seruca, Raquel ^a,b   Paredes, Joana ^a,b   Schmitt, Fernando ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; LUCIFERASE; P CADHERIN; CADHERIN; CDH3 PROTEIN, HUMAN; ISOPROTEIN;

ARTICLE; BINDING SITE; BREAST CANCER; CADHERIN 3 GENE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ASSAY; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; BREAST TUMOR; ENZYME IMMUNOASSAY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; REGULATORY SEQUENCE; SITE DIRECTED MUTAGENESIS; TUMOR CELL CULTURE; TUMOR INVASION; WESTERN BLOTTING;

BINDING SITES; BLOTTING, WESTERN; BREAST NEOPLASMS; CADHERINS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; LUCIFERASES; MUTAGENESIS, SITE-DIRECTED; NEOPLASM INVASIVENESS; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTIONAL ACTIVATION; TUMOR CELLS, CULTURED;

EID: 84873547668     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055749     Document Type: Article

References (36)

1. Poli V, (1998) The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem 273: 29279-29282.
2. Sebastian T, Johnson PF, (2006) Stop and go: anti-proliferative and mitogenic functions of the transcription factor C/EBPbeta. Cell Cycle 5: 953-957.
3. Zahnow CA, (2002) CCAAT/enhancer binding proteins in normal mammary development and breast cancer. Breast Cancer Res 4: 113-121.
4. Zahnow CA, Cardiff RD, Laucirica R, Medina D, Rosen JM, (2001) A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation. Cancer Res 61: 261-269.
5. Zahnow CA, (2009) CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases. Expert Rev Mol Med 11: e12.
6. Lekstrom-Himes J, Xanthopoulos KG, (1998) Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem 273: 28545-28548.
7. Xiong W, Hsieh CC, Kurtz AJ, Rabek JP, Papaconstantinou J, (2001) Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites. Nucleic Acids Res 29: 3087-3098.
8. Milde-Langosch K, Loning T, Bamberger AM, (2003) Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins. Breast Cancer Res Treat 79: 175-185.
9. Calkhoven CF, Muller C, Leutz A, (2000) Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes Dev 14: 1920-1932.
10. Takeichi M, (1988) The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 102: 639-655.
11. Paredes J, Albergaria A, Oliveira JT, Jeronimo C, Milanezi F, et al. (2005) P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clin Cancer Res 11: 5869-5877.
12. Paredes J, Correia AL, Ribeiro AS, Albergaria A, Milanezi F, et al. (2007) P-cadherin expression in breast cancer: a review. Breast Cancer Res 9: 214.
13. Paredes J, Lopes N, Milanezi F, Schmitt FC, (2007) P-cadherin and cytokeratin 5: useful adjunct markers to distinguish basal-like ductal carcinomas in situ. Virchows Arch 450: 73-80.
14. Paredes J, Stove C, Stove V, Milanezi F, Van Marck V, et al. (2004) P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. Cancer Res 64: 8309-8317.
15. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, et al. (2000) Molecular portraits of human breast tumours. Nature 406: 747-752.
16. Sousa B, Paredes J, Milanezi F, Lopes N, Martins D, et al. (2010) P-cadherin, vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study. Histol Histopathol 25: 963-974.
17. Ribeiro AS, Albergaria A, Sousa B, Correia AL, Bracke M, et al. (2010) Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. Oncogene 29: 392-402.
18. Albergaria A, Ribeiro AS, Pinho S, Milanezi F, Carneiro V, et al. (2010) ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBP{beta} in CDH3 gene activation. Hum Mol Genet 19: 2554-2566.
19. Shimomura Y, Wajid M, Shapiro L, Christiano AM, (2008) P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle. Development 135: 743-753.
20. Faraldo MM, Teuliere J, Deugnier MA, Birchmeier W, Huelsken J, et al. (2007) beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells. FEBS Lett 581: 831-836.
21. Gorski JJ, James CR, Quinn JE, Stewart GE, Staunton KC, et al. (2010) BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer. Breast Cancer Res Treat 122: 721-731.
22. Bracke ME, Van Larebeke NA, Vyncke BM, Mareel MM, (1991) Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro. Br J Cancer 63: 867-872.
23. Gamallo C, Moreno-Bueno G, Sarrio D, Calero F, Hardisson D, et al. (2001) The prognostic significance of P-cadherin in infiltrating ductal breast carcinoma. Mod Pathol 14: 650-654.
24. Peralta Soler A, Knudsen KA, Salazar H, Han AC, Keshgegian AA, (1999) P-cadherin expression in breast carcinoma indicates poor survival. Cancer 86: 1263-1272.
25. Turashvili G, McKinney SE, Goktepe O, Leung SC, Huntsman DG, et al. (2011) P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer. Mod Pathol 24: 64-81.
26. Albergaria A, Ribeiro AS, Vieira AF, Sousa B, Nobre AR, et al. (2011) P-cadherin role in normal breast development and cancer. Int J Dev Biol 55: 811-822.
27. Van Marck V, Stove C, Jacobs K, Van den Eynden G, Bracke M, (2011) P-cadherin in adhesion and invasion: opposite roles in colon and bladder carcinoma. Int J Cancer 128: 1031-1044.
28. Van Marck V, Stove C, Van Den Bossche K, Stove V, Paredes J, et al. (2005) P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma. Cancer Res 65: 8774-8783.
29. Cheung LW, Leung PC, Wong AS, (2010) Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. Oncogene 29: 2427-2440.
30. Mandeville JA, Silva Neto B, Vanni AJ, Smith GL, Rieger-Christ KM, et al. (2008) P-cadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells. BJU Int 102: 1707-1714.
31. Taniuchi K, Nakagawa H, Hosokawa M, Nakamura T, Eguchi H, et al. (2005) Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Cancer Res 65: 3092-3099.
32. Radice GL, Ferreira-Cornwell MC, Robinson SD, Rayburn H, Chodosh LA, et al. (1997) Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol 139: 1025-1032.
33. Vieira AF, Ricardo S, Ablett MP, Dionísio MR, Mendes N, et al. (2012) P-cadherin is co-expressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer. Stem Cells.
34. LaMarca HL, Visbal AP, Creighton CJ, Liu H, Zhang Y, et al. (2010) CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland. Stem Cells 28: 535-544.
35. Zahnow CA, Younes P, Laucirica R, Rosen JM, (1997) Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. J Natl Cancer Inst 89: 1887-1891.
36. Gomis RR, Alarcon C, Nadal C, Van Poznak C, Massague J, (2006) C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell 10: 203-214.