CCAAT/enhancer binding proteins in normal mammary development and breast cancer

Breast Cancer Research

Volumn 4, Issue 3, 2002, Pages 113-121

  Zahnow, Cynthia A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Breast cancer; CCAAT enhancer binding proteins; Dominant negative transcription factor; Mammary development; Translational regulation

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; DNA; ISOPROTEIN; LEUCINE ZIPPER PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; APOPTOSIS; BREAST CANCER; BREAST CARCINOGENESIS; BREAST DEVELOPMENT; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; EPITHELIUM CELL; GENE DELETION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MAMMARY GLAND; MOUSE; NONHUMAN; PROTEIN DEGRADATION; RAT; REGULATORY MECHANISM; REVIEW; RNA TRANSLATION; TRANSGENE;

ANIMALS; BREAST; BREAST NEOPLASMS; CCAAT-ENHANCER-BINDING PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC;

EID: 0036091518     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr428     Document Type: Review

References (62)

1. Biological role of the CCAAT/enhancer-binding protein family of transcription factors
2. The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite
3. Energy transfer analysis of Fos-Jun dimerization and DNA binding
4. Scissors-grip model for DNA recognition by a family of leucine zipper proteins
5. Characterization of C/EBPbeta isoforms in normal versus neoplastic mammary epithelial cells
6. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
7. Lactation status influences expression of CCAAT/enhancer binding protein isoform mRNA in the mouse mammary gland
8. Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression
9. C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
10. Composite response elements mediate hormonal and developmental regulation of milk protein gene expression
11. Cooperative effects of STAT5 (signal transducer and activator of transcription 5) and C/EBPbeta (CCAAT/enhancer-binding protein-beta) on beta-casein gene transcription are mediated by the glucocorticoid receptor
12. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials
13. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: Transcriptional activator lacking antimitotic activity
14. The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland
15. Expression of the genes encoding CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution
16. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
17. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
18. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice
19. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
20. Impaired energy homeostasis in C/EBP alpha knockout mice
21. Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene
22. CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
23. LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation
24. CCAAT enhancer-binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy
25. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and upregulation of the eukaryotic translation initiation factor 2alpha are correlated with epithelial cells
26. Expression and function of CCAAT/enhancer binding proteinbeta (C/EBPbeta) LAP and LIP isoforms in mouse mammary gland, tumors and cultured mammary epithelial cells
27. Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer
28. Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome receptor gamma: Mechanism of desmoplastic reaction
29. Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: An epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta
30. Expression of the gadd153 gene in normal and tumor breast tissues by a sensitive RT-PCR method
31. Glutamine deprivation induces the expression of GADD45 and GADD153 primarily by mRNA stabilization
32. A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation
33. Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice
34. Translational control of C/EBPalpha and C/EBPbeta isoform expression
35. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
36. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis
37. CCAAT/enhancer-binding protein delta regulates mammary epithelial cell G0 growth arrest and apoptosis
38. The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: Specific increase in C/EBPbeta during epithelial tumour progression
39. Increased expression of the transcription factors CCAAT-enhancer binding protein-beta (C/EBBeta) and C/EBzeta (CHOP) correlate with invasiveness of human colorectal cancer
40. Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development
41. Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins
42. Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase response
43. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
44. C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage
45. Generation of truncated C/EBPbeta isoforms by in vitro proteolysis
46. Upstream open reading frames as regulators of mRNA translation
47. Inhibition of CCAAT/enhancer-binding protein alpha and beta translation by upstream open reading frames
48. elF4E expression in tumors: Its possible role in progression of malignancies
49. CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms
50. Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein alpha mRNA
51. Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta
52. Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding
53. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
54. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain
55. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha
56. Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha
57. Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta
58. Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription
59. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
60. C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
61. The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor
62. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction