Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 3, 2013, Pages 711-723

  Kim, Mi Ju ^a   Hong, Kyung Soo ^a   Kim, Hak Bong ^a   Lee, Su Hoon ^a   Bae, Jae Ho ^a   Kim, Dong Wan ^b   Dao, Trong Tuan ^c   Oh, Won Keun ^c   Kang, Chi Dug ^a   Kim, Sun Hee ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Changwon National University   (South Korea)

^c Chosun University   (South Korea)

Author keywords

c Myc; CHOP; Ku70; SIRT1; TRAIL

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; DEATH RECEPTOR 5; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MYC PROTEIN; SIRTUIN 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ACETYLATION; APOPTOSIS; ARTICLE; CELL GROWTH; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ACETYLATION; ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANTIGENS, NUCLEAR; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL PROLIFERATION; DNA-BINDING PROTEINS; DOWN-REGULATION; HEP G2 CELLS; HUMANS; MICE; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; SIRTUIN 1; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP;

EID: 84873498486     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.12.005     Document Type: Article

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