메뉴 건너뛰기




Volumn 58, Issue 4, 2012, Pages 275-285

Oral and parenteral anticoagulants: New kids on the block

Author keywords

Apixaban; dabigatran; novel anticoagulants; rivaroxaban

Indexed keywords

ADOMIPARIN; ANTICOAGULANT AGENT; ANTISENSE OLIGONUCLEOTIDE; APIXABAN; ARGATROBAN; ATECEGATRAN METOXIL; BETRIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; BMS 2620837; BMS 262084; BMS 593214; CLAVATADINE A; DABIGATRAN; DABIGATRAN ETEXILATE; EDOXABAN; ENOXAPARIN; EP 21709; LEPIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; PCI 274836; PEGNIVACOGIN; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; RECOMODULIN; RIVAROXABAN; RO 14; SEMULOPARIN; SOLULIN; TANOGITRAN; TB 402; TECARFARIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84873452135     PISSN: 00223859     EISSN: 09722823     Source Type: Journal    
DOI: 10.4103/0022-3859.105448     Document Type: Review
Times cited : (9)

References (81)
  • 2
    • 84856013449 scopus 로고    scopus 로고
    • Estimating the incidence of symptomatic postoperative venous thromboembolism: The importance of perspective
    • Heit JA. Estimating the incidence of symptomatic postoperative venous thromboembolism: The importance of perspective. JAMA 2012;307:306-7.
    • (2012) JAMA , vol.307 , pp. 306-7
    • Heit, J.A.1
  • 3
    • 79951473950 scopus 로고    scopus 로고
    • Atrial fibrillation, anticoagulation, fall risk and outcomes in elderly patients
    • Sellers MB, Newby LK. Atrial fibrillation, anticoagulation, fall risk and outcomes in elderly patients. Am Heart J 2011;161:241-6.
    • (2011) Am Heart J , vol.161 , pp. 241-6
    • Sellers, M.B.1    Newby, L.K.2
  • 5
    • 80051834654 scopus 로고    scopus 로고
    • Novel oral anticoagulants: Focus on stroke prevention and treatment of venous thromboembolism
    • Steffel J, Braunwald E. Novel oral anticoagulants: Focus on stroke prevention and treatment of venous thromboembolism. Eur Heart J 2011;32:1968-76.
    • (2011) Eur Heart J , vol.32 , pp. 1968-76
    • Steffel, J.1    Braunwald, E.2
  • 6
    • 80052767106 scopus 로고    scopus 로고
    • Antithrombotic medication for cardio embolic stroke prevention
    • 2011: Article ID 607852 [Last cited on 2012 May 4]
    • Font MA, Krupinski J, Arboix A. Antithrombotic medication for cardio embolic stroke prevention. Stroke Res Treat 2011;2011: Article ID 607852. Available from: http://www.downloads.hindawi.com/journals/srt/2011/607852.pdf. [Last cited on 2012 May 4].
    • (2011) Stroke Res Treat
    • Font, M.A.1    Krupinski, J.2    Arboix, A.3
  • 7
    • 80053105394 scopus 로고    scopus 로고
    • The occurrence of antibodies to heparin platelet factor 4 in cardiac and thoracic surgical patients receiving desirudin or heparin for postoperative venous thrombosis prophylaxis
    • Avidan MS, Smith JR, Skrupsky IP, Hill L, Jacobsohn E, Burnside B, et al. The occurrence of antibodies to heparin platelet factor 4 in cardiac and thoracic surgical patients receiving desirudin or heparin for postoperative venous thrombosis prophylaxis. Thromb Res 2011;128:524-9.
    • (2011) Thromb Res , vol.128 , pp. 524-9
    • Avidan, M.S.1    Smith, J.R.2    Skrupsky, I.P.3    Hill, L.4    Jacobsohn, E.5    Burnside, B.6
  • 8
    • 80052699422 scopus 로고    scopus 로고
    • Successful use of alternative anticoagulants in the management of heparin-induced thrombocytopenia with thrombotic complications
    • Alkindi S, Smith OP, Enright H. Successful use of alternative anticoagulants in the management of heparin-induced thrombocytopenia with thrombotic complications. Sultan Qaboos Univ Med J 2011;11:391-8.
    • (2011) Sultan Qaboos Univ Med J , vol.11 , pp. 391-8
    • Alkindi, S.1    Smith, O.P.2    Enright, H.3
  • 9
    • 84856776395 scopus 로고    scopus 로고
    • New anti thrombotic drugs: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-based clinical practice guidelines
    • American College of Chest Physicians
    • Weitz JI, Eikelboom JW, Samama MM: American College of Chest Physicians. New anti thrombotic drugs: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-based clinical practice guidelines. Chest 2012;141:e120S-51S.
    • (2012) Chest , vol.141
    • Weitz, J.I.1    Eikelboom, J.W.2    Samama, M.M.3
  • 10
    • 74249100188 scopus 로고    scopus 로고
    • New oral anticoagulants in development
    • Weitz JI. New oral anticoagulants in development. Thromb Haemost 2010;103:62-70.
    • (2010) Thromb Haemost , vol.103 , pp. 62-70
    • Weitz, J.I.1
  • 11
    • 79952066638 scopus 로고    scopus 로고
    • Future directions of stroke prevention in atrial fibrillation: The potential impact of novel anticoagulants and stroke risk stratification
    • Cabral KP, Ansell J, Hylek EM. Future directions of stroke prevention in atrial fibrillation: The potential impact of novel anticoagulants and stroke risk stratification. J Thromb Haemost 2011;9:441-9.
    • (2011) J Thromb Haemost , vol.9 , pp. 441-9
    • Cabral, K.P.1    Ansell, J.2    Hylek, E.M.3
  • 12
    • 84856619789 scopus 로고    scopus 로고
    • Direct thrombin inhibitors and factor Xa inhibitor in patients with cerebrovascular disease
    • Morales-Vidal S, Schneck MJ, Flaster M, Biller J. Direct thrombin inhibitors and factor Xa inhibitor in patients with cerebrovascular disease. Expert Rev Neurother 2012;12:179-90.
    • (2012) Expert Rev Neurother , vol.12 , pp. 179-90
    • Morales-Vidal, S.1    Schneck, M.J.2    Flaster, M.3    Biller, J.4
  • 13
    • 84993811207 scopus 로고    scopus 로고
    • Efficacy and safety of novel anticoagulants compared with established agents
    • Rybak I, Ehle M, Buckley L, Fanikos J. Efficacy and safety of novel anticoagulants compared with established agents. Ther Adv Hematol 2011;2:175-95.
    • (2011) Ther Adv Hematol , vol.2 , pp. 175-95
    • Rybak, I.1    Ehle, M.2    Buckley, L.3    Fanikos, J.4
  • 14
    • 84859603846 scopus 로고    scopus 로고
    • New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper
    • Coordinating Committee
    • De Caterina R, Husted S, Wallentin L, Andreotti F, Arnesen H, Bachmann F, et al.: Coordinating Committee. New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper. J Am Coll Cardiol 2012;59:1413-25.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1413-25
    • De Caterina, R.1    Husted, S.2    Wallentin, L.3    Andreotti, F.4    Arnesen, H.5    Bachmann, F.6
  • 16
    • 85058721877 scopus 로고    scopus 로고
    • Rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation: Rationale and design of the ROCKET-AF Study
    • The Executive Steering Committee on behalf of the ROCKET-AF Study Investigators
    • The Executive Steering Committee on behalf of the ROCKET-AF Study Investigators. Rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation: Rationale and design of the ROCKET-AF Study. Am Heart J 2010;159:340-7.
    • (2010) Am Heart J , vol.159 , pp. 340-7
  • 18
    • 35449007749 scopus 로고    scopus 로고
    • Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thrombo-embolism after total knee replacement: The REMODEL randomized trial
    • Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thrombo-embolism after total knee replacement: The REMODEL randomized trial. J Thromb Haemost 2007;5:2178-85.
    • (2007) J Thromb Haemost , vol.5 , pp. 2178-85
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3    Kurth, A.A.4    Van Dijk, C.N.5    Frostick, S.P.6
  • 20
    • 77953791161 scopus 로고    scopus 로고
    • Dabigatran versus enoxaparin for prevention of venous thromboembolism after hip or knee arthroplasty: A pooled analysis of three trials
    • Friedman RJ, Dahl OE, Rosencher N, Caprini JA, Kurth AA, Francis CW, et al. Dabigatran versus enoxaparin for prevention of venous thromboembolism after hip or knee arthroplasty: A pooled analysis of three trials. Thromb Res 2010;126:175-82.
    • (2010) Thromb Res , vol.126 , pp. 175-82
    • Friedman, R.J.1    Dahl, O.E.2    Rosencher, N.3    Caprini, J.A.4    Kurth, A.A.5    Francis, C.W.6
  • 21
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomized, double blind, non-inferiority trial
    • Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomized, double blind, non-inferiority trial. Lancet 2007;370:949-56.
    • (2007) Lancet , vol.370 , pp. 949-56
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3    Kurth, A.A.4    Van Dijk, C.N.5    Frostick, S.P.6
  • 23
    • 78650619315 scopus 로고    scopus 로고
    • Oral Rivaroxaban for symptomatic venous thromboembolism
    • The EINSTEIN Investigators
    • The EINSTEIN Investigators. Oral Rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010;363:2499-510.
    • (2010) N Engl J Med , vol.363 , pp. 2499-510
  • 25
    • 84859385808 scopus 로고    scopus 로고
    • Oral Rivaroxaban for the treatment of symptomatic pulmonary embolism
    • The Einstein PE investigators
    • The Einstein PE investigators. Oral Rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012;366:1287-97.
    • (2012) N Engl J Med , vol.366 , pp. 1287-97
  • 26
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double blind randomized controlled trial
    • Kakkar AK, Brenner B, Dahl OE, Erikson BI, Mouret P, Muntz J, et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double blind randomized controlled trial. Lancet 2008;372:31-9.
    • (2008) Lancet , vol.372 , pp. 31-9
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3    Erikson, B.I.4    Mouret, P.5    Muntz, J.6
  • 27
    • 65549169515 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomized trial
    • Turpie AG, Lassen MR, Davidson BL, Bauer KA, Gent M, Kwong LM, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomized trial. Lancet 2009;373:1673-80.
    • (2009) Lancet , vol.373 , pp. 1673-80
    • Turpie, A.G.1    Lassen, M.R.2    Davidson, B.L.3    Bauer, K.A.4    Gent, M.5    Kwong, L.M.6
  • 29
    • 77649113258 scopus 로고    scopus 로고
    • The ADVANCE-2 investigators Apixaban versus enoxaparin for thromboprophylaxis after knee replacement(ADVANCE-2): A randomized double-blind trial
    • Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Hornick P. The ADVANCE-2 investigators. Apixaban versus enoxaparin for thromboprophylaxis after knee replacement(ADVANCE-2): A randomized double-blind trial. Lancet 2010;375:807-15.
    • (2010) Lancet , vol.375 , pp. 807-15
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3    Pineo, G.4    Chen, D.5    Hornick, P.6
  • 30
    • 78650587760 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after hip replacement: The ADVANCE 3 trial
    • Lassen MR, Gallus A, Raskob G, Pineo G, Chen D, Ramirez LM, et al. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement: The ADVANCE 3 trial. N Engl J Med 2010;363:2487-98.
    • (2010) N Engl J Med , vol.363 , pp. 2487-98
    • Lassen, M.R.1    Gallus, A.2    Raskob, G.3    Pineo, G.4    Chen, D.5    Ramirez, L.M.6
  • 31
    • 79953836474 scopus 로고    scopus 로고
    • Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATEII A randomized, double-blind non inferiority trial
    • Eriksson BI, Dahl OE, Huo MH, Kurth AA, Hantel S, Hermansson K, et al. Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATEII). A randomized, double-blind non inferiority trial. Thromb Haemost 2011;105:721-9.
    • (2011) Thromb Haemost , vol.105 , pp. 721-9
    • Eriksson, B.I.1    Dahl, O.E.2    Huo, M.H.3    Kurth, A.A.4    Hantel, S.5    Hermansson, K.6
  • 32
    • 80052232522 scopus 로고    scopus 로고
    • Dabigatran vs Placebo in patients with acute coronary syndromes on dual antiplatelet therapy: A randomized, double-blind, phase II trial
    • Oldgren J, Budaj A, Granger CB, Khder Y, Roberts J, Sieqbahn A, et al. Dabigatran vs. Placebo in patients with acute coronary syndromes on dual antiplatelet therapy: A randomized, double-blind, phase II trial. Eur Heart J 2011;32:2781-9.
    • (2011) Eur Heart J , vol.32 , pp. 2781-9
    • Oldgren, J.1    Budaj, A.2    Granger, C.B.3    Khder, Y.4    Roberts, J.5    Sieqbahn, A.6
  • 33
    • 67649562905 scopus 로고    scopus 로고
    • Rivaroxaban versus placebo in patients with acute coronary syndrome (ATLAS ACS-TIMI 46): A randomized, doubleblind, phase II trial
    • Mega JL, Braunwald E, Mohanavelu S, Burton P, Poulter R, Misselwitz F, et al. Rivaroxaban versus placebo in patients with acute coronary syndrome (ATLAS ACS-TIMI 46): A randomized, doubleblind, phase II trial. Lancet 2009;374:29-38.
    • (2009) Lancet , vol.374 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3    Burton, P.4    Poulter, R.5    Misselwitz, F.6
  • 35
    • 68249092118 scopus 로고    scopus 로고
    • Aptamers as inhibitors of target proteins Expert
    • Mussailidis S, Hardy A. Aptamers as inhibitors of target proteins. Expert. Expert Opin Ther Pat 2009;19:1073-82.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1073-82
    • Mussailidis, S.1    Hardy, A.2
  • 36
    • 79958101790 scopus 로고    scopus 로고
    • Future anticoagulants in interventional cardiology: Anti-IXa and anti Xa agents in percutaneous coronary intervention
    • Lombo B, Diez JG. Future anticoagulants in interventional cardiology: Anti-IXa and anti Xa agents in percutaneous coronary intervention. Future Cardiol 2011;7:281-5.
    • (2011) Future Cardiol , vol.7 , pp. 281-5
    • Lombo, B.1    Diez, J.G.2
  • 37
    • 56749092148 scopus 로고    scopus 로고
    • Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase
    • Muller J, Freitag D, Mayer G, Potzsch B. Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase. J Thromb Haemost 2008;6:2105-12.
    • (2008) J Thromb Haemost , vol.6 , pp. 2105-12
    • Muller, J.1    Freitag, D.2    Mayer, G.3    Potzsch, B.4
  • 38
    • 84873430252 scopus 로고    scopus 로고
    • Edoxaban versus enoxaparin for the prevention of venous thromboembolism: Pooled analysis of venous thromboembolism and bleeding from STARS E-3 and STARS J-V
    • December 12 [Last cited on 2012 Aug 23], American Society of Hematology 2011 Annual Meeting
    • Fuji T, Fujita S, Tachibana S, Kawai Y. Edoxaban versus enoxaparin for the prevention of venous thromboembolism: Pooled analysis of venous thromboembolism and bleeding from STARS E-3 and STARS J-V. American Society of Hematology 2011 Annual Meeting; December 12, 2011: SanDiego, CA. Abstract 208. Available from: http://www.the heart.org/article/1329499/print.do. [Last cited on 2012 Aug 23].
    • (2011) SanDiego, CA. Abstract 208
    • Fuji, T.1    Fujita, S.2    Tachibana, S.3    Kawai, Y.4
  • 39
    • 77957932391 scopus 로고    scopus 로고
    • Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: Design and rationale for the Effective aNti coaGulation with factor xA next GEneration in atrial fibrillation-thrombolysis in Myocardial Infarction study 48 (ENGAGE AF-TIMI 48
    • Ruff CT, Giugliano RP, Antman EM, Crugnale SE, Bocanegra R, Mercuri M, et al. Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: Design and rationale for the Effective aNti coaGulation with factor xA next GEneration in atrial fibrillation- thrombolysis in Myocardial Infarction study 48 (ENGAGE AF-TIMI 48). Am Heart J 2010;160:635-41.
    • (2010) Am Heart J , vol.160 , pp. 635-41
    • Ruff, C.T.1    Giugliano, R.P.2    Antman, E.M.3    Crugnale, S.E.4    Bocanegra, R.5    Mercuri, M.6
  • 40
    • 79961079039 scopus 로고    scopus 로고
    • A phase 2 randomized parallel group dose finding multicenter multinational study of the safety tolerability and pilot efficacy of three blinded doses of the oral factor Xa inhibitor betrixaban compared with open label dose adjusted warfarin in patients with non valvular atrial fibrillation (Explore-Xa) Late breaking clinical trial session II
    • Presented at the March Atlanta, GA [Last cited on 2012 May 05]
    • Ezekowitz MD. A phase 2, randomized parallel group, dose finding, multicenter, multinational study of the safety, tolerability and pilot efficacy of three blinded doses of the oral factor Xa inhibitor betrixaban compared with open label dose adjusted warfarin in patients with non valvular atrial fibrillation (Explore-Xa) Late breaking clinical trial session II. Presented at the American College of Cardiology 59th Annual Scientific sessions, March 2010 Atlanta, GA. Available from: http://www.portola.com/pdfs/Betrixaban-EXPLORE-ACC- 032010.pdf. [Last cited on 2012 May 05].
    • (2010) American College of Cardiology 59th Annual Scientific Sessions
    • Ezekowitz, M.D.1
  • 41
    • 60849097858 scopus 로고    scopus 로고
    • A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT
    • Turpie AG, Bauer KA, Davidson BL, Fisher WD, Gent M, Huo MH, et al. A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT). Thromb Haemost 2009;101:68-76.
    • (2009) Thromb Haemost , vol.101 , pp. 68-76
    • Turpie, A.G.1    Bauer, K.A.2    Davidson, B.L.3    Fisher, W.D.4    Gent, M.5    Huo, M.H.6
  • 42
    • 69949096467 scopus 로고    scopus 로고
    • Otamixaban for the treatment of patients with non-ST elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42), a randomized, double-blind, active controlled, Phase 2 trial
    • Sabatine MS, Antman EM, Widimsky P, Ebrahim IO, Kiss RG, Saaiman A, et al. Otamixaban for the treatment of patients with non-ST elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42), a randomized, double-blind, active controlled, Phase 2 trial. Lancet 2009;374:787-95.
    • (2009) Lancet , vol.374 , pp. 787-95
    • Sabatine, M.S.1    Antman, E.M.2    Widimsky, P.3    Ebrahim, I.O.4    Kiss, R.G.5    Saaiman, A.6
  • 43
    • 34548712332 scopus 로고    scopus 로고
    • Extended prophylaxis of venous thromboembolism with Idraparinux
    • The van Gogh Investigators
    • The van Gogh Investigators. Extended prophylaxis of venous thromboembolism with Idraparinux. N Engl J Med 2007;357:1105-12.
    • (2007) N Engl J Med , vol.357 , pp. 1105-12
  • 44
    • 79960387858 scopus 로고    scopus 로고
    • Bleeding risk in patients with atrial fibrillation: The AMADEUS study
    • Lane DA, Kamphuisen PW, Minini P, Buller HR, Lip GY. Bleeding risk in patients with atrial fibrillation: The AMADEUS study. Chest 2011;140:146-55.
    • (2011) Chest , vol.140 , pp. 146-55
    • Lane, D.A.1    Kamphuisen, P.W.2    Minini, P.3    Buller, H.R.4    Lip, G.Y.5
  • 45
    • 84855836270 scopus 로고    scopus 로고
    • Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: A randomized, double blind, double dummy, non-inferiority trial
    • Buller HR, Gallus AS, Pillion G, Prins MH, Raskob GE, Decousus H, et al. Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: A randomized, double blind, double dummy, non-inferiority trial. Lancet 2012;379:123-9.
    • (2012) Lancet , vol.379 , pp. 123-9
    • Buller, H.R.1    Gallus, A.S.2    Pillion, G.3    Prins, M.H.4    Raskob, G.E.5    Decousus, H.6
  • 46
    • 78650941964 scopus 로고    scopus 로고
    • Efficacy and safety of once weekly subcutaneous idrabiotaparinux in the treatment of patients with symptomatic deep venous thrombosis
    • The EQUINOX investigators
    • The EQUINOX investigators. Efficacy and safety of once weekly subcutaneous idrabiotaparinux in the treatment of patients with symptomatic deep venous thrombosis. J Thromb Haemost 2011;9:92-9.
    • (2011) J Thromb Haemost , vol.9 , pp. 92-9
  • 47
    • 84860440559 scopus 로고    scopus 로고
    • Semuloparin for prevention of venous thromboembolism after major orthopedic surgery: Results from three randomized clinical trials, SAVE-HIP1, SAVE-HIP2 and SAVE-KNEE
    • Lassen MR, Fisher W, Mouret P, Agnelli G, George D, Kakkar A, et al. Semuloparin for prevention of venous thromboembolism after major orthopedic surgery: Results from three randomized clinical trials, SAVE-HIP1, SAVE-HIP2 AND SAVE-KNEE. J Thromb Haemost 2012;10:822-32.
    • (2012) J Thromb Haemost , vol.10 , pp. 822-32
    • Lassen, M.R.1    Fisher, W.2    Mouret, P.3    Agnelli, G.4    George, D.5    Kakkar, A.6
  • 48
    • 84873467108 scopus 로고    scopus 로고
    • Semuloparin for thromboprophylaxis during chemotherapy
    • [Last cited on 2012 May 08]
    • Dehnel T. Semuloparin for thromboprophylaxis during chemotherapy. Lancet Oncol 2012;13:e143. Available from: http://www.thelancet. com/journals/lanonc/ article/PIIS1470-2045(12)70079-7/full text. [Last cited on 2012 May 08].
    • (2012) Lancet Oncol , vol.13
    • Dehnel, T.1
  • 49
    • 84857129296 scopus 로고    scopus 로고
    • For SAVE-ONCO investigators. Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer
    • Agnelli G, George DJ, Kakkar AK, Fisher W, Lassen MR, Mismetti P, et al.: For SAVE-ONCO investigators. Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer. N Engl J Med 2012;366:601-9.
    • (2012) N Engl J Med , vol.366 , pp. 601-9
    • Agnelli, G.1    George, D.J.2    Kakkar, A.K.3    Fisher, W.4    Lassen, M.R.5    Mismetti, P.6
  • 51
    • 70449592260 scopus 로고    scopus 로고
    • M 118-A rationally engineered low molecular weight heparin designed specifically for the treatment of acute coronary syndromes
    • Kishimoto TK, Qi YW, Long A, Capila I, Sasisekhran R, Guerrero L, et al. M 118-a rationally engineered low molecular weight heparin designed specifically for the treatment of acute coronary syndromes. Thromb Haemost 2009;102:900-6.
    • (2009) Thromb Haemost , vol.102 , pp. 900-6
    • Kishimoto, T.K.1    Qi, Y.W.2    Long, A.3    Capila, I.4    Sasisekhran, R.5    Guerrero, L.6
  • 52
    • 84855781095 scopus 로고    scopus 로고
    • Sulfated Low molecular weight lignins inhibit a select group of heparin-binding serine proteases
    • Henry BL, Thakkar JN, Liang A, Desai UR. Sulfated Low molecular weight lignins inhibit a select group of heparin-binding serine proteases. Biochem Biophys Res Commun 2012;417:382-6.
    • (2012) Biochem Biophys Res Commun , vol.417 , pp. 382-6
    • Henry, B.L.1    Thakkar, J.N.2    Liang, A.3    Desai, U.R.4
  • 54
    • 80052467986 scopus 로고    scopus 로고
    • A small molecule factor Xia inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits
    • Wong PC, Crain EJ, Watson CA, Schumacher WA. A small molecule factor Xia inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits. J Thromb Thrombolysis 2011;32:129-37.
    • (2011) J Thromb Thrombolysis , vol.32 , pp. 129-37
    • Wong, P.C.1    Crain, E.J.2    Watson, C.A.3    Schumacher, W.A.4
  • 55
    • 78649471947 scopus 로고    scopus 로고
    • Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: A novel antithrombotic strategy with lowered bleeding risk
    • Zhang H, Lowenberg EC, Crosby JR, MacLeod AR, Zhao C, Gao D. Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: A novel antithrombotic strategy with lowered bleeding risk. Blood 2010;116:4684-92.
    • (2010) Blood , vol.116 , pp. 4684-92
    • Zhang, H.1    Lowenberg, E.C.2    Crosby, J.R.3    MacLeod, A.R.4    Zhao, C.5    Gao, D.6
  • 56
    • 45749139231 scopus 로고    scopus 로고
    • Clavatadine A, A natural product with selective recognition and irreversible inhibition of factor XIa
    • Buchanan MS, Carroll AR, Wessling D, Jobling M, Avery VM, Davis RA, et al. Clavatadine A, A natural product with selective recognition and irreversible inhibition of factor XIa. J Med Chem 2008;51:3583-7.
    • (2008) J Med Chem , vol.51 , pp. 3583-7
    • Buchanan, M.S.1    Carroll, A.R.2    Wessling, D.3    Jobling, M.4    Avery, V.M.5    Davis, R.A.6
  • 57
    • 77955468444 scopus 로고    scopus 로고
    • First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy undergoing percutaneous coronary intervention
    • Cohen MG, Purdy DA, Rossi JS, Grinfeld LR, Myles SK, Aberle LH, et al. First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy undergoing percutaneous coronary intervention. Circulation 2010;122:614-22.
    • (2010) Circulation , vol.122 , pp. 614-22
    • Cohen, M.G.1    Purdy, D.A.2    Rossi, J.S.3    Grinfeld, L.R.4    Myles, S.K.5    Aberle, L.H.6
  • 58
    • 84861736559 scopus 로고    scopus 로고
    • The REG 1 anticoagulation system: A novel actively controlled factor IX inhibitor using RNA aptamer technology for treatment of acute coronary syndrome
    • [Last cited on 2012 May 4]
    • Vavalle JP, Cohen MG. The REG 1 anticoagulation system: A novel actively controlled factor IX inhibitor using RNA aptamer technology for treatment of acute coronary syndrome. Future Cardiol 2012. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22420328. [Last cited on 2012 May 4].
    • (2012) Future Cardiol
    • Vavalle, J.P.1    Cohen, M.G.2
  • 59
    • 84859760328 scopus 로고    scopus 로고
    • Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction
    • Sullenger B, Woodruff RD, Monroe DM. Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction. J Biol Chem 2012;28:12779-86.
    • (2012) J Biol Chem , vol.28 , pp. 12779-86
    • Sullenger, B.1    Woodruff, R.D.2    Monroe, D.M.3
  • 60
    • 79953330537 scopus 로고    scopus 로고
    • Single intravenous administration of TB 402 for the prophylaxis of venous thromboembolism after total knee replacement: A dose-escalating, randomized, controlled trial
    • Verhamme P, Tangelder M, Verhaeghe R, Ageno W, Glazer S, Prins M, et al. Single intravenous administration of TB 402 for the prophylaxis of venous thromboembolism after total knee replacement: A dose-escalating, randomized, controlled trial. J Thromb Haemost 2011;9:664-71.
    • (2011) J Thromb Haemost , vol.9 , pp. 664-71
    • Verhamme, P.1    Tangelder, M.2    Verhaeghe, R.3    Ageno, W.4    Glazer, S.5    Prins, M.6
  • 61
    • 79957963193 scopus 로고    scopus 로고
    • How tifacogin could not captivate severe community acquired pneumonia
    • Sanchez JF, Le L, Arroliga AC. How tifacogin could not captivate severe community acquired pneumonia. Am J Respir Crit Care Med 2011;183:1449-50.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1449-50
    • Sanchez, J.F.1    Le Arroliga L, A.C.2
  • 62
    • 58849160498 scopus 로고    scopus 로고
    • RNAPc2 inhibits colorectal cancer in mice through tissue factor
    • Zhao J, Aguilar G, Palencia S, Newton E, Abo A. rNAPc2 inhibits colorectal cancer in mice through tissue factor. Clin Cancer Res 2009;15:208-16.
    • (2009) Clin Cancer Res , vol.15 , pp. 208-16
    • Zhao, J.1    Aguilar, G.2    Palencia, S.3    Newton, E.4    Abo, A.5
  • 64
    • 77955458657 scopus 로고    scopus 로고
    • BMS-593214, an active site-directed factor VIIa inhibitor: Enzyme kinetics, antithrombotic and antihaemostatic studies
    • Wong PC, Luettgen JM, Rendina AR, Kettner CA, Xin B, Knabb RM, et al. BMS-593214, an active site-directed factor VIIa inhibitor: Enzyme kinetics, antithrombotic and antihaemostatic studies. Thromb Haemost 2010;104:261-9.
    • (2010) Thromb Haemost , vol.104 , pp. 261-9
    • Wong, P.C.1    Luettgen, J.M.2    Rendina, A.R.3    Kettner, C.A.4    Xin, B.5    Knabb, R.M.6
  • 65
    • 79961081848 scopus 로고    scopus 로고
    • Thrombomodulin alpha in the treatment of infectious patients complicated by disseminated intravascular coagulation: Sub analysis from phase III trial
    • Aikawa N, Shimazaki S, Yamamoto Y, Saito H, Maruyama I, Ohno R, et al. Thrombomodulin alpha in the treatment of infectious patients complicated by disseminated intravascular coagulation: Sub analysis from phase III trial. Shock 2011;35:349-54.
    • (2011) Shock , vol.35 , pp. 349-54
    • Aikawa, N.1    Shimazaki, S.2    Yamamoto, Y.3    Saito, H.4    Maruyama, I.5    Ohno, R.6
  • 66
    • 84866253982 scopus 로고    scopus 로고
    • Thrombomodulin: A bifunctional modulator of inflammation and coagulation in sepsis
    • [10 pages] [Last cited on 2012 May 04]
    • Okamoto T, Tanigami H, Suzuki K, Shimaoka M. Thrombomodulin: A bifunctional modulator of inflammation and coagulation in sepsis. Crit Care Res Pract 2012;2012:614545. [10 pages]. Available from: http://www.hindawi.com/ journals/ccrp/2012/614545. [Last cited on 2012 May 04].
    • (2012) Crit Care Res Pract , vol.2012 , pp. 614545
    • Okamoto, T.1    Tanigami, H.2    Suzuki, K.3    Shimaoka, M.4
  • 67
    • 70449598272 scopus 로고    scopus 로고
    • From heparin to EP217609: The long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile
    • Petitou M, Nancy-Portebois V, Dubreucq G, Motte V, Meuleman D, de Kort M, et al. From heparin to EP217609: The long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile. Thromb Haemost 2009;102:804-10.
    • (2009) Thromb Haemost , vol.102 , pp. 804-10
    • Petitou, M.1    Nancy-Portebois, V.2    Dubreucq, G.3    Motte, V.4    Meuleman, D.5    De Kort, M.6
  • 68
    • 84858016010 scopus 로고    scopus 로고
    • Specificity and selectivity profile of EP217609: A new neutralizable dual action anticoagulant that targets thrombin and factor Xa
    • Olson ST, Swanson R, Petitou M. Specificity and selectivity profile of EP217609: A new neutralizable dual action anticoagulant that targets thrombin and factor Xa. Blood 2012;119:2187-95.
    • (2012) Blood , vol.119 , pp. 2187-95
    • Olson, S.T.1    Swanson, R.2    Petitou, M.3
  • 69
    • 70349705645 scopus 로고    scopus 로고
    • The first evaluation of a novel vitamin K antagonist, tecarfarin (ATI-5923) in patients with atrial fibrillation
    • Ellis DJ, Usman MH, Milner PG, Canafax DM, Ezekowitz MD. The first evaluation of a novel vitamin K antagonist, tecarfarin (ATI-5923) in patients with atrial fibrillation. Circulation 2009;120: 1029-35.
    • (2009) Circulation , vol.120 , pp. 1029-35
    • Ellis, D.J.1    Usman, M.H.2    Milner, P.G.3    Canafax, D.M.4    Ezekowitz, M.D.5
  • 70
    • 79955023407 scopus 로고    scopus 로고
    • Warfarin versus new agents: Interpreting the data
    • Ansell J. Warfarin versus new agents: Interpreting the data. Hematol Am Soc Hematol Educ Program 2010;2010:212-8.
    • (2010) Hematol Am Soc Hematol Educ Program , vol.2010 , pp. 212-8
    • Ansell, J.1
  • 71
    • 80051794851 scopus 로고    scopus 로고
    • Factor XI and XII as antithrombotic targets
    • Muller F, Gailani D, Renne T. Factor XI and XII as antithrombotic targets. Curr Opin Hematol 2011;18:349-55.
    • (2011) Curr Opin Hematol , vol.18 , pp. 349-55
    • Muller, F.1    Gailani, D.2    Renne, T.3
  • 72
    • 77950899732 scopus 로고    scopus 로고
    • Factor XIIa inhibitor recombinant human albumin infestin 4 abolishes occlusive arterial thrombus formation without affecting bleeding
    • Hagedorn I, Schmidbauer S, Pleines I, Kleinschnitz C, Kronthaler U, Stoll G, et al. Factor XIIa inhibitor recombinant human albumin infestin 4 abolishes occlusive arterial thrombus formation without affecting bleeding. Circulation 2010;121:1510-7.
    • (2010) Circulation , vol.121 , pp. 1510-7
    • Hagedorn, I.1    Schmidbauer, S.2    Pleines, I.3    Kleinschnitz, C.4    Kronthaler, U.5    Stoll, G.6
  • 73
    • 84855748942 scopus 로고    scopus 로고
    • Apixaban versus warfarin in atrial fibrillation
    • Vassiliou VS. Apixaban versus warfarin in atrial fibrillation. N Engl J Med 2012;366:88-90.
    • (2012) N Engl J Med , vol.366 , pp. 88-90
    • Vassiliou, V.S.1
  • 74
    • 84857438475 scopus 로고    scopus 로고
    • New oral anticoagulants should not be used as first line agents to prevent thromboembolism in patients with atrial fibrillation
    • Ansell J. New oral anticoagulants should not be used as first line agents to prevent thromboembolism in patients with atrial fibrillation. Circulation 2012;125:165-70.
    • (2012) Circulation , vol.125 , pp. 165-70
    • Ansell, J.1
  • 75
    • 84858234693 scopus 로고    scopus 로고
    • Challenges and controversies in the medical management of primary and anti thrombotic related intracerebral hemorrhage
    • Moussouttas M. Challenges and controversies in the medical management of primary and anti thrombotic related intracerebral hemorrhage. Ther Adv Neurol Disord 2012;5:43-56.
    • (2012) Ther Adv Neurol Disord , vol.5 , pp. 43-56
    • Moussouttas, M.1
  • 76
    • 84856631805 scopus 로고    scopus 로고
    • Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor with haemostatic agents
    • Fukuda T, Honda Y, Kamisato C, Morishima Y, Shibano T. Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor with haemostatic agents. Thromb Haemost 2012;107: 253-9.
    • (2012) Thromb Haemost , vol.107 , pp. 253-9
    • Fukuda, T.1    Honda, Y.2    Kamisato, C.3    Morishima, Y.4    Shibano, T.5
  • 77
    • 84856303923 scopus 로고    scopus 로고
    • Determination of the anticoagulant effects of new oral anticoagulants: An unmet need
    • Harenberg J, Marx S, Erdle S, Kramer R. Determination of the anticoagulant effects of new oral anticoagulants: An unmet need. Expert Rev Hematol 2012;5:107-13.
    • (2012) Expert Rev Hematol , vol.5 , pp. 107-13
    • Harenberg, J.1    Marx, S.2    Erdle, S.3    Kramer, R.4
  • 78
    • 83255188726 scopus 로고    scopus 로고
    • Is it safe to stop anticoagulants after successful surgery for atrial fibrillation?
    • Gray RM, Nagendran M, Maruthappu M. Is it safe to stop anticoagulants after successful surgery for atrial fibrillation? Interact CardioVasc Thorac Surg 2011;13:642-9.
    • (2011) Interact CardioVasc Thorac Surg , vol.13 , pp. 642-9
    • Gray, R.M.1    Nagendran, M.2    Maruthappu, M.3
  • 79
    • 79960667366 scopus 로고    scopus 로고
    • Battle of oral anticoagulants in the field of atrial fibrillation scrutinized from a clinical practice (the real world) perspective
    • [Last cited on 2012 May 05]
    • Altman R, Vidal HO. Battle of oral anticoagulants in the field of atrial fibrillation scrutinized from a clinical practice (the real world) perspective. Thromb J 2011;9:12. Available from: http://www. thrombosisjournal.com/content/ pdf/1477-9560-912.pdf. [Last cited on 2012 May 05].
    • (2011) Thromb J , vol.9 , pp. 12
    • Altman, R.1    Vidal, H.O.2
  • 80
    • 78650034786 scopus 로고    scopus 로고
    • Novel anticoagulants for stroke prevention in atrial fibrillation: Current clinical evidence and future developments
    • Schirmer SH, Baumhakel M, Neuberger HR, Hohnloser SH, van Gelder IC, Lip GY, et al. Novel anticoagulants for stroke prevention in atrial fibrillation: Current clinical evidence and future developments. J Am Coll Cardiol 2010;56:2067-76.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 2067-76
    • Schirmer, S.H.1    Baumhakel, M.2    Neuberger, H.R.3    Hohnloser, S.H.4    Van Gelder, I.C.5    Lip, G.Y.6
  • 81
    • 84859605332 scopus 로고    scopus 로고
    • New oral anticoagulants for atrial fibrillation: A review of clinical trials
    • O'Dell KM, Igawa D, Hsin J. New oral anticoagulants for atrial fibrillation: A review of clinical trials. Clin Ther 2012;34:894-901.
    • (2012) Clin Ther , vol.34 , pp. 894-901
    • O'Dell, K.M.1    Igawa, D.2    Hsin, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.