메뉴 건너뛰기




Volumn 12, Issue 2, 2012, Pages 179-190

Direct thrombin inhibitors and factor Xa inhibitors in patients with cerebrovascular disease

Author keywords

apixaban; dabigatran; direct factor Xa inhibitors; direct thrombin inhibitors; rivaroxaban; stroke

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; APIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; DABIGATRAN; RIVAROXABAN; THROMBIN INHIBITOR; WARFARIN;

EID: 84856619789     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.11.185     Document Type: Review
Times cited : (12)

References (42)
  • 2
    • 79955933219 scopus 로고    scopus 로고
    • ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation a report of the American College of Cardiology Foundation
    • American Heart Association Task Force on practice guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
    • Fuster V, Rydén LE, Cannom DS, et al. ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. J. Am. Coll. Cardiol. 57(11), e101-e98 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.57 , Issue.11
    • Fuster, V.1    Rydén, L.E.2    Cannom, D.S.3
  • 3
    • 71649105333 scopus 로고    scopus 로고
    • Increasing prevalence of atrialfibrillation and flutter in the United States
    • Naccarelli GV, Varker H, Lin J, Schulman KL. Increasing prevalence of atrialfibrillation and flutter in the United States. Am. J. Cardiol. 104(11), 1534-1539 (2009).
    • (2009) Am. J. Cardiol. , vol.104 , Issue.11 , pp. 1534-1539
    • Naccarelli, G.V.1    Varker, H.2    Lin, J.3    Schulman, K.L.4
  • 4
    • 0035832261 scopus 로고    scopus 로고
    • Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The anticoagulation and risk factors in atrial fibrillation (ATRIA) study
    • Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 285(18), 2370-2375 (2001). (Pubitemid 32424106)
    • (2001) Journal of the American Medical Association , vol.285 , Issue.18 , pp. 2370-2375
    • Go, A.S.1    Hylek, E.M.2    Phillips, K.A.3    Chang, Y.C.4    Henault, L.E.5    Selby, J.V.6    Singer, D.E.7
  • 6
    • 79955444271 scopus 로고    scopus 로고
    • Ischaemic cardiovascular mortality in patients with non-valvular atrial fibrillation according to CHADS2 score
    • Kim YD, Cha MJ, Kim J, et al. Ischaemic cardiovascular mortality in patients with non-valvular atrial fibrillation according to CHADS2 score. Thromb. Haemost. 105(4), 712-720 (2011).
    • (2011) Thromb. Haemost. , vol.105 , Issue.4 , pp. 712-720
    • Kim, Y.D.1    Cha, M.J.2    Kim, J.3
  • 7
    • 20444395760 scopus 로고    scopus 로고
    • Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: Results from a population-based study
    • DOI 10.1161/01.STR.0000166053.83476.4a
    • Marini C, De Santis F, Sacco S, et al. Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study. Stroke 36, 1115-1119 (2005). (Pubitemid 40803473)
    • (2005) Stroke , vol.36 , Issue.6 , pp. 1115-1119
    • Marini, C.1    De Santis, F.2    Sacco, S.3    Russo, T.4    Olivieri, L.5    Totaro, R.6    Carolei, A.7
  • 8
    • 77955872745 scopus 로고    scopus 로고
    • A novel, user-friendly score (HAS-BLED) to assess one-year risk of major bleeding in atrial fibrillation patients: The Euro Heart Survey
    • Pisters R, Lane DA, Nieuwelaat R, et al. A novel, user-friendly score (HAS-BLED) to assess one-year risk of major bleeding in atrial fibrillation patients: The Euro Heart Survey. Chest 138, 1093-1100 (2010).
    • (2010) Chest , vol.138 , pp. 1093-1100
    • Pisters, R.1    Lane, D.A.2    Nieuwelaat, R.3
  • 9
    • 57149140461 scopus 로고    scopus 로고
    • Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    • ACTIVE W Investigators
    • Connolly SJ, Pogue J, Eikelboom J, et al. ACTIVE W Investigators. Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range. Circulation 118(17), 2029-2037(2008).
    • (2008) Circulation , vol.118 , Issue.17 , pp. 2029-2037
    • Connolly, S.J.1    Pogue, J.2    Eikelboom, J.3
  • 10
    • 0036066718 scopus 로고    scopus 로고
    • Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: Results of the managing anticoagulation services trial
    • DOI 10.1016/S0002-9343(02)01131-2, PII S0002934302011312
    • Matchar DB, Samsa GP, Cohen SJ, et al. Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial. Am. J. Med. 113(1), 42-51 (2002). (Pubitemid 34775159)
    • (2002) American Journal of Medicine , vol.113 , Issue.1 , pp. 42-51
    • Matchar, D.B.1    Samsa, G.P.2    Cohen, S.J.3    Oddone, E.Z.4    Jurgelski, A.E.5
  • 11
    • 33744945247 scopus 로고    scopus 로고
    • Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W), a randomized controlled trial
    • Connolly S, Pogue J, Hart R, et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W), a randomized controlled trial. Lancet 367, 1903-1912 (2006).
    • (2006) Lancet , vol.367 , pp. 1903-1912
    • Connolly, S.1    Pogue, J.2    Hart, R.3
  • 13
    • 0345414673 scopus 로고    scopus 로고
    • Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomised controlled trial
    • DOI 10.1016/S0140-6736(03)14841-6
    • Olsson SB. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III), randomized controlled trial. Lancet 362, 1691-1698 (2003). (Pubitemid 37468318)
    • (2003) Lancet , vol.362 , Issue.9397 , pp. 1691-1698
    • Olsson, S.B.1
  • 15
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • RE-LY Steering Committee and Investigators erratum in: N. Engl. J. Med. 363(19), 1877 (2010)
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al.; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. 361(12), 1139-1151 (2009); erratum in: N. Engl. J. Med. 363(19), 1877 (2010).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.12 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 17
    • 77956977472 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran compared with warfarin at different levels of international normalized ratio control for stroke prevention in atrial fibrillation: An analysis of the RE-LY trial
    • RE-LY investigators
    • Wallentin L, Yusuf S, Ezekowitz MD, et al. RE-LY investigators. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalized ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet 376(9745), 975-983 (2010).
    • (2010) Lancet , vol.376 , Issue.9745 , pp. 975-983
    • Wallentin, L.1    Yusuf, S.2    Ezekowitz, M.D.3
  • 18
    • 79957715797 scopus 로고    scopus 로고
    • Anticoagulant options -why the FDA approved a higher but not a lower dose of dabigatran
    • Beasley BN, Unger EF, Temple R. Anticoagulant options -why the FDA approved a higher but not a lower dose of dabigatran. N. Engl. J. Med. 364(19), 1788-1790 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , Issue.19 , pp. 1788-1790
    • Beasley, B.N.1    Unger, E.F.2    Temple, R.3
  • 20
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • ROCKET AF Investigators
    • Patel MR, Mahaffey KW, Garg J, et al. ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N. Engl. J. Med. 365(10), 883-891 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , Issue.10 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 21
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • AVERROES Steering Committee and Investigators
    • Connolly SJ, Eikelboom J, Joyner C, et al. AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N. Engl. J. Med. 364(9), 806-817 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , Issue.9 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 22
    • 77649249878 scopus 로고    scopus 로고
    • Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial: Design and rationale
    • ARISTOTLE Investigators
    • Lopes RD, Alexander JH, Al-Khatib SM, et al. ARISTOTLE Investigators. Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial: design and rationale. Am. Heart J. 159(3), 331-339 (2010).
    • (2010) Am. Heart J. , vol.159 , Issue.3 , pp. 331-339
    • Lopes, R.D.1    Alexander, J.H.2    Al-Khatib, S.M.3
  • 23
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • ARISTOTLE Committees and Investigators
    • Granger CB, Alexander JH, McMurray JJ, et al. ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. 365(11), 981-992 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , Issue.11 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 24
    • 77957932391 scopus 로고    scopus 로고
    • Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: Design and rationale for the Effective Anticoagulation with Factor Xa Next Generation in Atrialfibrillation- Thrombolysis in Myocardial Infarction Study 48 (ENGAGE AF-TIMI 48)
    • Ruff CT, Giugliano RP, Antman EM, et al. Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective Anticoagulation with Factor Xa Next Generation in Atrialfibrillation-Thrombolysis in Myocardial Infarction Study 48 (ENGAGE AF-TIMI 48). Am. Heart J. 160(4), 635-641 (2010).
    • (2010) Am. Heart J. , vol.160 , Issue.4 , pp. 635-641
    • Ruff, C.T.1    Giugliano, R.P.2    Antman, E.M.3
  • 25
    • 84856617791 scopus 로고    scopus 로고
    • Randomized clinical trial of three doses of a long-acting oral factor Xa inhibitor betrixaban, in patients with atrial fibrillation
    • Atlanta, Georgia, USA, 14-16 March
    • Ezekowitz M, Diaz R, Dorian P, et al. Randomized clinical trial of three doses of a long-acting oral factor Xa inhibitor betrixaban, in patients with atrial fibrillation. Presented at: The American College of Cardiology's 59th Annual Scientific Session. Atlanta, Georgia, USA, 14-16 March 2010.
    • (2010) The American College of Cardiology's 59th Annual Scientific Session
    • Ezekowitz, M.1    Diaz, R.2    Dorian, P.3
  • 26
    • 84856624420 scopus 로고    scopus 로고
    • Phase II randomized, parallel group, dose-finding, multicenter, multinational study of the safety, tolerability and pilot efficacy of three blinded doses of the oral factor Xa inhibitor betrixaban compared with warfarin in AF. EXPLORE-Xa
    • Georgia, USA, 14-16 March
    • Gorina E, Connolly S, Diaz R, et al. Phase II randomized, parallel group, dose-finding, multicenter, multinational study of the safety, tolerability and pilot efficacy of three blinded doses of the oral factor Xa inhibitor betrixaban compared with warfarin in AF. EXPLORE-Xa. Presented at: Presented at: The American College of Cardiology's 59th Annual Scientific Session. Atlanta, Georgia, USA, 14-16 March 2010.
    • (2010) The American College of Cardiology's 59th Annual Scientific Session. Atlanta
    • Gorina, E.1    Connolly, S.2    Diaz, R.3
  • 27
    • 20144366696 scopus 로고    scopus 로고
    • Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    • Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators
    • Chimowitz MI, Lynn MJ, Howlett-Smith H, et al. Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N. Engl. J. Med. 352(13), 1305-1316 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , Issue.13 , pp. 1305-1316
    • Chimowitz, M.I.1    Lynn, M.J.2    Howlett-Smith, H.3
  • 29
    • 0036278194 scopus 로고    scopus 로고
    • Warfarin-Aspirin Recurrent Stroke Study (WARSS) trial: Is warfarin really a reasonable therapeutic alternative to aspirin for preventing recurrent noncardioembolic ischemic stroke?
    • DOI 10.1161/01.STR.0000016922.22707.27
    • Hankey GJ. Warfarin-Aspirin Recurrent Stroke Study (WARSS) Trial: is warfarin really a reasonable therapeutic alternative to aspirin for preventing recurrent noncardioembolic ischemic stroke? Stroke 33(6), 1723-1726 (2002). (Pubitemid 34619986)
    • (2002) Stroke , vol.33 , Issue.6 , pp. 1723-1726
    • Hankey, G.J.1    Fisher, M.2
  • 30
    • 33745052164 scopus 로고    scopus 로고
    • Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: Subgroup analyses from the warfarin-aspirin recurrent stroke study
    • DOI 10.1159/000092331
    • Sacco RL, Prabhakaran S, Thompson JL, et al. WARSS Investigators. Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: subgroup analyses from the Warfarin-Aspirin Recurrent Stroke Study. Cerebrovasc. Dis. 22(1), 4-12 (2006). (Pubitemid 43875154)
    • (2006) Cerebrovascular Diseases , vol.22 , Issue.1 , pp. 4-12
    • Sacco, R.L.1    Prabhakaran, S.2    Thompson, J.L.P.3    Murphy, A.4    Sciacca, R.R.5    Levin, B.6    Mohr, J.P.7
  • 31
    • 36249031088 scopus 로고    scopus 로고
    • Antiplatelet therapy vs. anticoagulation in cervical artery dissection: Rationale and design of the Cervical Artery Dissection in Stroke Study (CADISS)
    • Cervical Artery Dissection in Stroke Study Trial Investigators
    • Cervical Artery Dissection in Stroke Study Trial Investigators. Antiplatelet therapy vs. anticoagulation in cervical artery dissection: rationale and design of the Cervical Artery Dissection in Stroke Study (CADISS). Int. J. Stroke 2(4), 292-296 (2007).
    • (2007) Int. J. Stroke , vol.2 , Issue.4 , pp. 292-296
  • 32
    • 1442274806 scopus 로고    scopus 로고
    • Prognosis of Cerebral Vein and Dural Sinus Thrombosis: Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT)
    • DOI 10.1161/01.STR.0000117571.76197.26
    • Ferro JM, Canhão P, Stam J, et al. ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 35(3), 664-670 (2004). (Pubitemid 38280838)
    • (2004) Stroke , vol.35 , Issue.3 , pp. 664-670
    • Ferro, J.M.1    Canhao, P.2    Stam, J.3    Bousser, M.-G.4    Barinagarrementeria, F.5
  • 33
    • 78149359985 scopus 로고    scopus 로고
    • Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis
    • ISCVT Investigators
    • Coutinho JM, Ferro JM, Canhão P, et al. ISCVT Investigators. Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis. Stroke 41(11), 2575-2580 (2010).
    • (2010) Stroke , vol.41 , Issue.11 , pp. 2575-2580
    • Coutinho, J.M.1    Ferro, J.M.2    Canhão, P.3
  • 34
    • 76149086177 scopus 로고    scopus 로고
    • Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome
    • Okuma H, Kitagawa Y, Yasuda T, et al. Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome. Int. J. Med. Sci. 7(1), 15-18 (2009).
    • (2009) Int. J. Med. Sci. , vol.7 , Issue.1 , pp. 15-18
    • Okuma, H.1    Kitagawa, Y.2    Yasuda, T.3
  • 35
    • 33144465561 scopus 로고    scopus 로고
    • Warfarin Versus Aspirin in Patients with Reduced Cardiac Ejection Fraction (WARCEF): Rationale, objectives, and design
    • DOI 10.1016/j.cardfail.2005.07.007, PII S1071916405007153
    • Pullicino P, Thompson JL, Barton B, et al. WARCEF Investigators. Warfarin versus aspirin in patients with reduced cardiac ejection fraction (WARCEF), rationale, objectives, and design. J. Card. Fail. 12(1), 39-46 (2006). (Pubitemid 43267750)
    • (2006) Journal of Cardiac Failure , vol.12 , Issue.1 , pp. 39-46
    • Pullicino, P.1    Thompson, J.L.P.2    Barton, B.3    Levin, B.4    Graham, S.5    Freudenberger, R.S.6
  • 36
    • 79551589662 scopus 로고    scopus 로고
    • Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation
    • Freeman JV, Zhu RP, Owens DK, et al. Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation. Ann. Intern. Med. 154(1), 1-11 (2011).
    • (2011) Ann. Intern. Med. , vol.154 , Issue.1 , pp. 1-11
    • Freeman, J.V.1    Zhu, R.P.2    Owens, D.K.3
  • 37
    • 80055092067 scopus 로고    scopus 로고
    • Direct thrombin inhibitors: Clinical uses, mechanism of action, and laboratory measurement
    • Rhea JM, Molinaro RJ. Direct thrombin inhibitors: clinical uses, mechanism of action, and laboratory measurement. MLO Med. Lab. Obs. 43(8), 20-24 (2011).
    • (2011) MLO Med. Lab. Obs. , vol.43 , Issue.8 , pp. 20-24
    • Rhea, J.M.1    Molinaro, R.J.2
  • 38
    • 83055178394 scopus 로고    scopus 로고
    • Novel oral anticoagulants and their role in clinical practice
    • Wittkowsky AK. Novel oral anticoagulants and their role in clinical practice. Pharmacotherapy 31(12), 1175-1191 (2011).
    • (2011) Pharmacotherapy , vol.31 , Issue.12 , pp. 1175-1191
    • Wittkowsky, A.K.1
  • 41
    • 84856624422 scopus 로고    scopus 로고
    • AstraZeneca clinical trials
    • AstraZeneca clinical trials. www.astrazenecaclinicaltrials.com/other- drug-products/discontinued-products/exanta/


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.