Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis

Brain, Behavior, and Immunity

Volumn 29, Issue , 2013, Pages 147-155

  Weigelt, Karin ^a   Bergink, Veerle ^a   Burgerhout, Karin M ^a   Pescatori, Mario ^b   Wijkhuijs, Annemarie ^a   Drexhage, Hemmo A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Crosslinks BV   (Netherlands)

Author keywords

Immune activation; MiR 146a; MiR 212; Monocytes; Postpartum psychosis

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE DERIVATIVE; INTERLEUKIN 6; LITHIUM; MICRORNA; MICRORNA 146A; MICRORNA 212; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUERPERAL PSYCHOSIS; PUERPERIUM; TH2 CELL; VALIDATION STUDY;

ADULT; BIPOLAR DISORDER; CELL SEPARATION; COMPUTER SIMULATION; DEPRESSION, POSTPARTUM; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOWN-REGULATION; FEMALE; HUMANS; INFLAMMATION; MICRORNAS; MONOCYTES; POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; THYROIDITIS, AUTOIMMUNE;

EID: 84873446933     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.12.018     Document Type: Article

References (60)

1. Archanioti P., Gazouli M., Theodoropoulos G., Vaiopoulou A., Nikiteas N. Micro-RNAs as regulators and possible diagnostic bio-markers in inflammatory bowel disease. J. Crohn's Colitis 2011, 5:520-524.
2. Bergink V., Kushner S.A., Pop V., Kuijpens H., Lambregtse-van den Berg M.P., Drexhage R.C., Wiersinga W., Nolen W.A., Drexhage H.A. Prevalence of autoimmune thyroid dysfunction in postpartum psychosis. Br. J. Psychiatry 2011, 198:264-268.
3. Bergink V., Lambregtse-van den Berg M.P., Koorengevel K.M., Kupka R., Kushner S.A. First-onset psychosis occurring in the postpartum period: a prospective cohort study. J. Clin. Psychiatry 2011, 72:1531-1537.
4. Bergink, V., Burgerhout, K.M., Weigelt, K., Pop, V., Wit, H.d., Drexhage, R.C., Kushner, S.A., Drexhage, H.A., 2013. Immune system dysregulation in first-onset postpartum psychosis. Biol. Psychiatry 2012 [Epub ahead of print].
5. Boldin M.P., Taganov K.D., Rao D.S., Yang L., Zhao J.L., Kalwani M., Garcia-Flores Y., Luong M., Devrekanli A., Xu J., Sun G., Tay J., Linsley P.S., Baltimore D. MiR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J. Exp. Med. 2011, 208:1189-1201.
6. Bonauer, A., Carmona, G., Iwasaki, M., Mione, M., Koyanagi, M., Fischer, A., Burchfield, J., Fox, H., Doebele, C., Ohtani, K., Chavakis, E., Potente, M., Tjwa, M., Urbich, C., Zeiher, A.M., Dimmeler, S., 2009. MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice. Science (New York, N.Y. 324, 1710-1713).
7. Chang K.H., Mestdagh P., Vandesompele J., Kerin M.J., Miller N. MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer. BMC Cancer 2010, 10:173.
8. Chaudron L.H., Pies R.W. The relationship between postpartum psychosis and bipolar disorder: a review. J. Clin. Psychiatry 2003, 64:1284-1292.
9. Cheyuo C., Yang W.L., Wang P. The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection. Biol. Chem. 2012, 393:429-439.
10. Drexhage R.C., Knijff E.M., Padmos R.C., Heul-Nieuwenhuijzen L., Beumer W., Versnel M.A., Drexhage H.A. The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder. Exp. Rev. Neurother. 2010, 10:59-76.
11. Drexhage R.C., van der Heul-Nieuwenhuijsen L., Padmos R.C., van Beveren N., Cohen D., Versnel M.A., Nolen W.A., Drexhage H.A. Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients. Int. J. Neuropsychopharmacol./official scientific J. Collegium Int. Neuropsychopharmacol. (CINP) 2010, 13:1369-1381.
12. Drexhage R.C., Hoogenboezem T.H., Versnel M.A., Berghout A., Nolen W.A., Drexhage H.A. The activation of monocyte and T cell networks in patients with bipolar disorder. Brain, Behavior, Immunity 2011, 25:1206-1213.
13. Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nature Rev. 2008, 9:102-114.
14. First MB, S.R., Gibbon M, Williams JBW, ed., 1999. Structured Clinical Interview for DSM IV Axis I Disorders, Patient Edition (Nederlandse Versie). Swets & Zeitlinger, BV: Lisse, Nederland.
15. Gardiner E., Beveridge N.J., Wu J.Q., Carr V., Scott R.J., Tooney P.A., Cairns M.J. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells. Mol. Psychiatry 2011.
16. Haupl T., Ostensen M., Grutzkau A., Radbruch A., Burmester G.R., Villiger P.M. Reactivation of rheumatoid arthritis after pregnancy: increased phagocyte and recurring lymphocyte gene activity. Arthritis Rheum. 2008, 58:2981-2992.
17. Hellwig K., Beste C., Schimrigk S., Chan A. Immunomodulation and postpartum relapses in patients with multiple sclerosis. Ther. Adv. Neurol. Disord. 2009, 2:7-11.
18. Hergenreider E., Heydt S., Treguer K., Boettger T., Horrevoets A.J., Zeiher A.M., Scheffer M.P., Frangakis A.S., Yin X., Mayr M., Braun T., Urbich C., Boon R.A., Dimmeler S. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nature Cell Biol. 2011, 14:249-256.
19. Hollander J.A., Im H.I., Amelio A.L., Kocerha J., Bali P., Lu Q., Willoughby D., Wahlestedt C., Conkright M.D., Kenny P.J. Striatal microRNA controls cocaine intake through CREB signalling. Nature 2010, 466:197-202.
20. Hori, S., Nomura, T., Sakaguchi, S., 2003. Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science, New York, N.Y 299, 1057-1061.
21. Huang J., Perlis R.H., Lee P.H., Rush A.J., Fava M., Sachs G.S., Lieberman J., Hamilton S.P., Sullivan P., Sklar P., Purcell S., Smoller J.W. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. Am. J. Psychiatry 2010, 167:1254-1263.
22. Jones I., Craddock N. Familiality of the puerperal trigger in bipolar disorder: results of a family study. Am. J. Psychiatry 2001, 158:913-917.
23. Kim A.H., Reimers M., Maher B., Williamson V., McMichael O., McClay J.L., van den Oord E.J., Riley B.P., Kendler K.S., Vladimirov V.I. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophrenia Res. 2010, 124:183-191.
24. Knijff E.M., Breunis M.N., van Geest M.C., Kupka R.W., Ruwhof C., de Wit H.J., Nolen W.A., Drexhage H.A. A relative resistance of T cells to dexamethasone in bipolar disorder. Bipolar Disord. 2006, 8:740-750.
25. Leconte C., Leger M., Boulouard M., Tixier E., Freret T., Bernaudin M., Schumann-Bard P. Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression. Behav. Brain Res. 2012, 230:78-84.
26. Lescher J., Paap F., Schultz V., Redenbach L., Scheidt U., Rosewich H., Nessler S., Fuchs E., Gartner J., Bruck W., Junker A. MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions. J. Neuroimmunol. 2012, 246:27-33.
27. Li L., Chen X.P., Li Y.J. MicroRNA-146a and human disease. Scandinavian J. Immunol. 2010, 71:227-231.
28. Lofgren S.E., Frostegard J., Truedsson L., Pons-Estel B.A., D'Alfonso S., Witte T., Lauwerys B.R., Endreffy E., Kovacs L., Vasconcelos C., Martins da Silva B., Kozyrev S.V., Alarcon-Riquelme M.E. Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene. Genes Immun. 2012, 13:268-274.
29. Lu L.F., Boldin M.P., Chaudhry A., Lin L.L., Taganov K.D., Hanada T., Yoshimura A., Baltimore D., Rudensky A.Y. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 2010, 142:914-929.
30. Lukiw W.J., Surjyadipta B., Dua P., Alexandrov P.N. Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD). Int. J. Biochem. Mol. Biol. 2012, 3:105-116.
31. Lyons P.A., Koukoulaki M., Hatton A., Doggett K., Woffendin H.B., Chaudhry A.N., Smith K.G. Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification. BMC Genomics 2007, 8:64.
32. Murata K., Yoshitomi H., Tanida S., Ishikawa M., Nishitani K., Ito H., Nakamura T. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res. Therapy 2010, 12:R86.
33. Nahid M.A., Pauley K.M., Satoh M., Chan E.K. MiR-146a is critical for endotoxin-induced tolerance. IMPLICATION IN INNATE IMMUNITY. J. Biol. Chem. 2009, 284:34590-34599.
34. Nicholson W.K., Robinson K.A., Smallridge R.C., Ladenson P.W., Powe N.R. Prevalence of postpartum thyroid dysfunction: a quantitative review. Thyroid 2006, 16:573-582.
35. Niimoto T., Nakasa T., Ishikawa M., Okuhara A., Izumi B., Deie M., Suzuki O., Adachi N., Ochi M. MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. BMC Musculoskeletal Disord. 2010, 11:209.
36. Novina C.D., Sharp P.A. The RNAi revolution. Nature 2004, 430:161-164.
37. Oates M. Perinatal psychiatric disorders: a leading cause of maternal morbidity and mortality. British Med. Bulletin 2003, 67:219-229.
38. Padmos R.C., Bekris L., Knijff E.M., Tiemeier H., Kupka R.W., Cohen D., Nolen W.A., Lernmark A., Drexhage H.A. A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Biol. Psychiatry 2004, 56:476-482.
39. Padmos R.C., Hillegers M.H., Knijff E.M., Vonk R., Bouvy A., Staal F.J., de Ridder D., Kupka R.W., Nolen W.A., Drexhage H.A. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch. General Psychiatry 2008, 65:395-407.
40. Paraboschi E.M., Solda G., Gemmati D., Orioli E., Zeri G., Benedetti M.D., Salviati A., Barizzone N., Leone M., Duga S., Asselta R. Genetic association and altered gene expression of mir-155 in multiple sclerosis patients. Int. J. Mol. Sci. 2011, 12:8695-8712.
41. Paraboschi E.M., Solda G., Gemmati D., Orioli E., Zeri G., Benedetti M.D., Salviati A., Barizzone N., Leone M., Duga S., Asselta R. Genetic association and altered gene expression of mir-155 in multiple sclerosis patients. Int. J. Mol. Sci. 2012, 12:8695-8712.
42. Pauley K.M., Cha S. MiRNA-146a in rheumatoid arthritis: a new therapeutic strategy. Immunotherapy 2011, 3:829-831.
43. Pauley K.M., Stewart C.M., Gauna A.E., Dupre L.C., Kuklani R., Chan A.L., Pauley B.A., Reeves W.H., Chan E.K., Cha S. Altered miR-146a expression in Sjogren's syndrome and its functional role in innate immunity. Eur. J. Immunol. 2011, 41:2029-2039.
44. Perkins D.O., Jeffries C.D., Jarskog L.F., Thomson J.M., Woods K., Newman M.A., Parker J.S., Jin J., Hammond S.M. MicroRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol. 2007, 8:R27.
45. Perry M.M., Moschos S.A., Williams A.E., Shepherd N.J., Larner-Svensson H.M., Lindsay M.A. Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J. Immunol. 2008, 180:5689-5698.
46. Rong H., Liu T.B., Yang K.J., Yang H.C., Wu D.H., Liao C.P., Hong F., Yang H.Z., Wan F., Ye X.Y., Xu D., Zhang X., Chao C.A., Shen Q.J. MicroRNA-134 plasma levels before and after treatment for bipolar mania. J. Psychiatric Res. 2011, 45:92-95.
47. Saba R., Gushue S., Huzarewich R.L., Manguiat K., Medina S., Robertson C., Booth S.A. MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State. PloS one 2012, 7:e30832.
48. Smalheiser N.R., Lugli G., Rizavi H.S., Torvik V.I., Turecki G., Dwivedi Y. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PloS one 2012, 7:e33201.
49. Spinelli M.G. Postpartum psychosis: detection of risk and management. Am. J. Psychiatry 2009, 166:405-408.
50. Tsitsiou E., Lindsay M.A. MicroRNAs and the immune response. Curr. opin. Pharmacol. 2009, 9:514-520.
51. van der Heul-Nieuwenhuijsen L., Padmos R.C., Drexhage R.C., de Wit H., Berghout A., Drexhage H.A. An inflammatory gene-expression fingerprint in monocytes of autoimmune thyroid disease patients. J. Clin. Endocrinol. Metabol. 2010, 95:1962-1971.
52. Wada R., Akiyama Y., Hashimoto Y., Fukamachi H., Yuasa Y. MiR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int. J. Cancer 2009, 127:1106-1114.
53. Wallenius M., Skomsvoll J.F., Irgens L.M., Salvesen K.A., Koldingsnes W., Mikkelsen K., Kaufmann C., Kvien T.K. Postpartum onset of rheumatoid arthritis and other chronic arthritides: results from a patient register linked to a medical birth registry. Annals Rheum. Dis. 2010, 69:332-336.
54. Wanet A., Tacheny A., Arnould T., Renard P. miR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic Acids Res 2012.
55. Weigelt K., Carvalho L.A., Drexhage R.C., Wijkhuijs A., de Wit H., van Beveren N.J., Birkenhager T.K., Bergink V., Drexhage H.A. TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. Brain, Behavior, Immunity 2011, 25:1162-1169.
56. Wildin R.S., Smyk-Pearson S., Filipovich A.H. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J. Med. Gen. 2002, 39:537-545.
57. Wing K., Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nature Immunol. 2010, 11:7-13.
58. Witwer K.W., Sarbanes S.L., Liu J., Clements J.E. A plasma microRNA signature of acute lentiviral infection biomarkers of central nervous system disease. AIDS (London, England) 2011, 25:2057-2067.
59. Zhou R., Yuan P., Wang Y., Hunsberger J.G., Elkahloun A., Wei Y., Damschroder-Williams P., Du J., Chen G., Manji H.K. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology 2009, 34:1395-1405.
60. Zilahi E., Tarr T., Papp G., Griger Z., Sipka S., Zeher M. Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjogren's syndrome. Immunol. Lett. 2012, 141:165-168.