-
1
-
-
0029002969
-
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
-
Sanguinetti, M. C., Jiang, C., Curran, M. E., and Keating, M. T. (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81, 299-307
-
(1995)
Cell
, vol.81
, pp. 299-307
-
-
Sanguinetti, M.C.1
Jiang, C.2
Curran, M.E.3
Keating, M.T.4
-
2
-
-
0029007356
-
HERG, a human inward rectifier in the voltagegated potassium channel family
-
Trudeau, M. C., Warmke, J. W., Ganetzky, B., and Robertson, G. A. (1995) HERG, a human inward rectifier in the voltagegated potassium channel family. Science 269, 92-95
-
(1995)
Science
, vol.269
, pp. 92-95
-
-
Trudeau, M.C.1
Warmke, J.W.2
Ganetzky, B.3
Robertson, G.A.4
-
3
-
-
0028292927
-
A family of potassium channel genes related to eag in Drosophila and mammals
-
Warmke, J. W., and Ganetzky, B. (1994) A family of potassium channel genes related to eag in Drosophila and mammals. Proc. Natl. Acad. Sci. U. S. A. 91, 3438-3442
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 3438-3442
-
-
Warmke, J.W.1
Ganetzky, B.2
-
4
-
-
0035162359
-
ERG proteins and functional cardiac I(Kr) channels in rat, mouse, and human heart
-
Pond, A. L., and Nerbonne, J. M. (2001) ERG proteins and functional cardiac I(Kr) channels in rat, mouse, and human heart. Trends Cardiovasc. Med. 11, 286-294
-
(2001)
Trends Cardiovasc. Med.
, vol.11
, pp. 286-294
-
-
Pond, A.L.1
Nerbonne, J.M.2
-
5
-
-
7244226352
-
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits
-
Jones, E. M., Roti Roti, E. C., Wang, J., Delfosse, S. A., and Robertson, G. A. (2004) Cardiac IKr channels minimally comprise hERG 1a and 1b subunits. J. Biol. Chem. 279, 44690-44694
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44690-44694
-
-
Jones, E.M.1
Roti Roti, E.C.2
Wang, J.3
Delfosse, S.A.4
Robertson, G.A.5
-
6
-
-
1842847282
-
Expression of voltage-gated K? channel s in human atrium
-
Bertaso, F., Sharpe, C. C., Hendry, B. M., and James, A. F. (2002) Expression of voltage-gated K? channel s in human atrium. Basic Res. Cardiol. 97, 424-433
-
(2002)
Basic Res. Cardiol.
, vol.97
, pp. 424-433
-
-
Bertaso, F.1
Sharpe, C.C.2
Hendry, B.M.3
James, A.F.4
-
7
-
-
17044424224
-
Short QT syndrome and atrial fibrillation caused by mutation in KCNH2
-
Hong, K., Bjerregaard, P., Gussak, I., and Brugada, R. (2005) Short QT syndrome and atrial fibrillation caused by mutation in KCNH2. J. Cardiovasc. Electrophysiol. 16, 394-396
-
(2005)
J. Cardiovasc. Electrophysiol.
, vol.16
, pp. 394-396
-
-
Hong, K.1
Bjerregaard, P.2
Gussak, I.3
Brugada, R.4
-
8
-
-
0035936798
-
Molecular and cellular mechanisms of cardiac arrhythmias
-
Keating, M. T., and Sanguinetti, M. C. (2001) Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104, 569-580
-
(2001)
Cell
, vol.104
, pp. 569-580
-
-
Keating, M.T.1
Sanguinetti, M.C.2
-
9
-
-
0029925480
-
Spectrum of HERG K?-channel dysfunction in an inherited cardiac arrhythmia
-
Sanguinetti, M. C., Curran, M. E., Spector, P. S., and Keating, M. T. (1996) Spectrum of HERG K?-channel dysfunction in an inherited cardiac arrhythmia. Proc. Natl. Acad. Sci. U. S. A. 93, 2208-2212
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 2208-2212
-
-
Sanguinetti, M.C.1
Curran, M.E.2
Spector, P.S.3
Keating, M.T.4
-
10
-
-
33645317063
-
HERG potassium channels and cardiac arrhythmia
-
Sanguinetti, M. C., and Tristani-Firouzi, M. (2006) hERG potassium channels and cardiac arrhythmia. Nature 440, 463-469
-
(2006)
Nature
, vol.440
, pp. 463-469
-
-
Sanguinetti, M.C.1
Tristani-Firouzi, M.2
-
11
-
-
0032825605
-
A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiology
-
Roden, D. M., and Balser, J. R. (1999) A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiology. Cardiovasc. Res. 44, 242-246
-
(1999)
Cardiovasc. Res.
, vol.44
, pp. 242-246
-
-
Roden, D.M.1
Balser, J.R.2
-
12
-
-
22144499678
-
Modulation of I(Kr) inactivation by mutation N588K in KCNH2: A link to arrhythmogenesis in short QT syndrome
-
Cordeiro, J. M., Brugada, R., Wu, Y. S., Hong, K., and Dumaine, R. (2005) Modulation of I(Kr) inactivation by mutation N588K in KCNH2: A link to arrhythmogenesis in short QT syndrome. Cardiovasc. Res. 67, 498-509
-
(2005)
Cardiovasc. Res.
, vol.67
, pp. 498-509
-
-
Cordeiro, J.M.1
Brugada, R.2
Wu, Y.S.3
Hong, K.4
Dumaine, R.5
-
13
-
-
0028914969
-
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
-
Curran, M. E., Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D., and Keating, M. T. (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80, 795-803
-
(1995)
Cell
, vol.80
, pp. 795-803
-
-
Curran, M.E.1
Splawski, I.2
Timothy, K.W.3
Vincent, G.M.4
Green, E.D.5
Keating, M.T.6
-
14
-
-
0029926887
-
Fast inactivation causes rectification of the IKr channel
-
Spector, P. S., Curran, M. E., Zou, A., Keating, M. T., and Sanguinetti, M. C. (1996) Fast inactivation causes rectification of the IKr channel. J. Gen. Physiol. 107, 611-619
-
(1996)
J. Gen. Physiol.
, vol.107
, pp. 611-619
-
-
Spector, P.S.1
Curran, M.E.2
Zou, A.3
Keating, M.T.4
Sanguinetti, M.C.5
-
15
-
-
0030933457
-
Contribution of sialic acid to the voltage dependence of sodium channel gating. A possible electrostatic mechanism
-
Bennett, E., Urcan, M. S., Tinkle, S. S., Koszowski, A. G., and Levinson, S. R. (1997) Contribution of sialic acid to the voltage dependence of sodium channel gating. A possible electrostatic mechanism. J. Gen. Physiol. 109, 327-343
-
(1997)
J. Gen. Physiol.
, vol.109
, pp. 327-343
-
-
Bennett, E.1
Urcan, M.S.2
Tinkle, S.S.3
Koszowski, A.G.4
Levinson, S.R.5
-
16
-
-
0036487068
-
Isoform-specific effects of sialic acid on voltage-dependent Na-channel gating: Functional sialic acids are localized to the S5-S6 loop of domain I
-
Bennett, E. S. (2002) Isoform-specific effects of sialic acid on voltage-dependent Na-channel gating: Functional sialic acids are localized to the S5-S6 loop of domain I. J. Physiol. 538, 675-690
-
(2002)
J. Physiol.
, vol.538
, pp. 675-690
-
-
Bennett, E.S.1
-
17
-
-
84862214081
-
Modulation of voltagegated ion channels by sialylation
-
2012
-
Ednie, A. R., and Bennett, E. S. (2011) Modulation of voltagegated ion channels by sialylation. Compr. Physiol. 2, 1269-1301, 2012.
-
(2011)
Compr. Physiol.
, vol.2
, pp. 1269-1301
-
-
Ednie, A.R.1
Bennett, E.S.2
-
18
-
-
33748741303
-
Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating
-
Johnson, D., and Bennett, E. S. (2006) Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating. J. Biol. Chem. 281, 25875-25881
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25875-25881
-
-
Johnson, D.1
Bennett, E.S.2
-
19
-
-
42049115729
-
Gating of the shaker potassium channel is modulated differentially by N-glycosylation and sialic acids
-
Johnson, D., and Bennett, E. S. (2008) Gating of the shaker potassium channel is modulated differentially by N-glycosylation and sialic acids. Pflügers Arch. 456, 393-405
-
(2008)
Pflügers Arch.
, vol.456
, pp. 393-405
-
-
Johnson, D.1
Bennett, E.S.2
-
20
-
-
7244225020
-
The sialic acid component of the beta1 subunit modulates voltage-gated sodium channel function
-
Johnson, D., Montpetit, M. L., Stocker, P. J., and Bennett, E. S. (2004) The sialic acid component of the beta1 subunit modulates voltage-gated sodium channel function. J. Biol. Chem. 279, 44303-44310
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44303-44310
-
-
Johnson, D.1
Montpetit, M.L.2
Stocker, P.J.3
Bennett, E.S.4
-
21
-
-
70349515573
-
Regulated and aberrant glycosylation modulate cardiac electrical signaling
-
Montpetit, M. L., Stocker, P. J., Schwetz, T. A., Harper, J. M., Norring, S. A., Schaffer, L., North, S. J., Jang-Lee, J., Gilmartin, T., Head, S. R., Haslam, S. M., Dell, A., Marth, J. D., and Bennett, E. S. (2009) Regulated and aberrant glycosylation modulate cardiac electrical signaling. Proc. Natl. Acad. Sci. U. S. A. 106, 16517-16522
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 16517-16522
-
-
Montpetit, M.L.1
Stocker, P.J.2
Schwetz, T.A.3
Harper, J.M.4
Norring, S.A.5
Schaffer, L.6
North, S.J.7
Jang-Lee, J.8
Gilmartin, T.9
Head, S.R.10
Haslam, S.M.11
Dell, A.12
Marth, J.D.13
Bennett, E.S.14
-
22
-
-
76749154148
-
N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating
-
Schwetz, T. A., Norring, S. A., and Bennett, E. S. (2010) N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating. Biochim. Biophys. Acta 1798, 367-375
-
(2010)
Biochim Biophys. Acta
, vol.1798
, pp. 367-375
-
-
Schwetz, T.A.1
Norring, S.A.2
Bennett, E.S.3
-
23
-
-
79953001206
-
Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating
-
Schwetz, T. A., Norring, S. A., Ednie, A. R., and Bennett, E. S. (2011) Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating. J. Biol. Chem. 286, 4123-4132
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 4123-4132
-
-
Schwetz, T.A.1
Norring, S.A.2
Ednie, A.R.3
Bennett, E.S.4
-
24
-
-
33644598193
-
Differential sialylation modulates voltage-gated Na-channel gating throughout the developing myocardium
-
Stocker, P. J., and Bennett, E. S. (2006) Differential sialylation modulates voltage-gated Na-channel gating throughout the developing myocardium. J. Gen. Physiol. 127, 253-265
-
(2006)
J. Gen. Physiol.
, vol.127
, pp. 253-265
-
-
Stocker, P.J.1
Bennett, E.S.2
-
25
-
-
0029742881
-
Expression of Kv1.1 delayed rectifier potassium channels in Lec mutant Chinese hamster ovary cell lines reveals a role for sialidation in channel function
-
Thornhill, W. B., Wu, M. B., Jiang, X., Wu, X., Morgan, P. T., and Margiotta, J. F. (1996) Expression of Kv1.1 delayed rectifier potassium channels in Lec mutant Chinese hamster ovary cell lines reveals a role for sialidation in channel function. J. Biol. Chem. 271, 19093-19098
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19093-19098
-
-
Thornhill, W.B.1
Wu, M.B.2
Jiang, X.3
Wu, X.4
Morgan, P.T.5
Margiotta, J.F.6
-
26
-
-
0037592321
-
Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism
-
Watanabe, I., Wang, H. G., Sutachan, J. J., Zhu, J., Recio-Pinto, E., and Thornhill, W. B. (2003) Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism. J. Physiol. 550, 51-66
-
(2003)
J. Physiol.
, vol.550
, pp. 51-66
-
-
Watanabe, I.1
Wang, H.G.2
Sutachan, J.J.3
Zhu, J.4
Recio-Pinto, E.5
Thornhill, W.B.6
-
27
-
-
33947302602
-
The glycosylation state of Kv1.2 potassium channels affects trafficking, gating, and simulated action potentials
-
Watanabe, I., Zhu, J., Sutachan, J. J., Gottschalk, A., Recio-Pinto, E., and Thornhill, W. B. (2007) The glycosylation state of Kv1.2 potassium channels affects trafficking, gating, and simulated action potentials. Brain Res. 1144, 1-18
-
(2007)
Brain Res.
, vol.1144
, pp. 1-18
-
-
Watanabe, I.1
Zhu, J.2
Sutachan, J.J.3
Gottschalk, A.4
Recio-Pinto, E.5
Thornhill, W.B.6
-
28
-
-
0035958924
-
Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure
-
Ufret-Vincenty, C. A., Baro, D. J., Lederer, W. J., Rockman, H. A., Quinones, L. E., and Santana, L. F. (2001) Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. J. Biol. Chem. 276, 28197-28203
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 28197-28203
-
-
Ufret-Vincenty, C.A.1
Baro, D.J.2
Lederer, W.J.3
Rockman, H.A.4
Quinones, L.E.5
Santana, L.F.6
-
29
-
-
0034886921
-
Differential contribution of sialic acid to the function of repolarizing K-currents in ventricular myocytes
-
Ufret-Vincenty, C. A., Baro, D. J., and Santana, L. F. (2001) Differential contribution of sialic acid to the function of repolarizing K-currents in ventricular myocytes. Am. J. Physiol. Cell Physiol. 281, C464-C474
-
(2001)
Am. J. Physiol. Cell Physiol.
, vol.281
-
-
Ufret-Vincenty, C.A.1
Baro, D.J.2
Santana, L.F.3
-
30
-
-
77950838871
-
A novel mutation and first report of dilated cardiomyopathy in ALG6-CDG (CDG-Ic): A case report
-
Al-Owain, M., Mohamed, S., Kaya, N., Zagal, A., Matthijs, G., and Jaeken, J. (2010) A novel mutation and first report of dilated cardiomyopathy in ALG6-CDG (CDG-Ic): A case report. Orphanet J. Rare Dis. 5, 7
-
(2010)
Orphanet J. Rare Dis.
, vol.5
, pp. 7
-
-
Al-Owain, M.1
Mohamed, S.2
Kaya, N.3
Zagal, A.4
Matthijs, G.5
Jaeken, J.6
-
31
-
-
84873449274
-
Cardiomyopathy in the congenital disorders of glycosylation (CDG): A case of late presentation and literature review. Short report 186. [Online]
-
doi: 10.1007/s10545-009-1262-1
-
Footitt, E. J., Karimova, A., Burch, M., Yayeh, T., Dupre, T., Vuillaumier-Barrot, S., Chantret, I., Moore, S. E., Seta, N., and Grunewald, S. (2009) Cardiomyopathy in the congenital disorders of glycosylation (CDG): A case of late presentation and literature review. Short report 186. [Online]. J. Inherit. Metab Dis. doi: 10.1007/s10545-009-1262-1
-
(2009)
J. Inherit. Metab Dis.
-
-
Footitt, E.J.1
Karimova, A.2
Burch, M.3
Yayeh, T.4
Dupre, T.5
Vuillaumier-Barrot, S.6
Chantret, I.7
Moore, S.E.8
Seta, N.9
Grunewald, S.10
-
32
-
-
33745381312
-
Genetic defects in the human glycome
-
Freeze, H. H. (2006) Genetic defects in the human glycome. Nat. Rev. Genet. 7, 537-551
-
(2006)
Nat. Rev. Genet.
, vol.7
, pp. 537-551
-
-
Freeze, H.H.1
-
33
-
-
2142657353
-
Cardiomyopathy in congenital disorders of glycosylation
-
Gehrmann, J., Sohlbach, K., Linnebank, M., Bohles, H. J., Buderus, S., Kehl, H. G., Vogt, J., Harms, E., and Marquardt, T. (2003) Cardiomyopathy in congenital disorders of glycosylation. Cardiol. Young 13, 345-351
-
(2003)
Cardiol. Young
, vol.13
, pp. 345-351
-
-
Gehrmann, J.1
Sohlbach, K.2
Linnebank, M.3
Bohles, H.J.4
Buderus, S.5
Kehl, H.G.6
Vogt, J.7
Harms, E.8
Marquardt, T.9
-
34
-
-
0038042511
-
Komrower lecture. Congenital disorders of glycosylation (CDG): It's all in it!
-
Jaeken, J. (2003) Komrower lecture. Congenital disorders of glycosylation (CDG): It's all in it! J. Inherit. Metab. Dis. 26, 99-118
-
(2003)
J. Inherit. Metab. Dis.
, vol.26
, pp. 99-118
-
-
Jaeken, J.1
-
35
-
-
2942557120
-
Congenital disorders of glycosylation (CDG): Update and new developments
-
Jaeken, J. (2004) Congenital disorders of glycosylation (CDG): Update and new developments. J. Inherit. Metab. Dis. 27, 423-426
-
(2004)
J. Inherit. Metab. Dis.
, vol.27
, pp. 423-426
-
-
Jaeken, J.1
-
36
-
-
3442881366
-
Congenital disorders of glycosylation: A booming chapter of pediatrics
-
Jaeken, J., and Carchon, H. (2004) Congenital disorders of glycosylation: A booming chapter of pediatrics. Curr. Opin. Pediatr. 16, 434-439
-
(2004)
Curr. Opin. Pediatr.
, vol.16
, pp. 434-439
-
-
Jaeken, J.1
Carchon, H.2
-
37
-
-
34249884225
-
Expanding spectrum of congenital disorder of glycosylation Ig (CDG-Ig): Sibs with a unique skeletal dysplasia, hypogammaglobulinemia, cardiomyopathy, genital malformations, and early lethality
-
Kranz, C., Basinger, A. A., Gucsavas-Calikoglu, M., Sun, L., Powell, C. M., Henderson, F. W., Aylsworth, A. S., and Freeze, H. H. (2007) Expanding spectrum of congenital disorder of glycosylation Ig (CDG-Ig): Sibs with a unique skeletal dysplasia, hypogammaglobulinemia, cardiomyopathy, genital malformations, and early lethality. Am. J. Med. Genet. A 143A, 1371-1378
-
(2007)
Am. J. Med. Genet. A
, vol.143 A
, pp. 1371-1378
-
-
Kranz, C.1
Basinger, A.A.2
Gucsavas-Calikoglu, M.3
Sun, L.4
Powell, C.M.5
Henderson, F.W.6
Aylsworth, A.S.7
Freeze, H.H.8
-
38
-
-
0036299606
-
Role of glycosylation in cell surface expression and stability of HERG potassium channels
-
Gong, Q., Anderson, C. L., January, C. T., and Zhou, Z. (2002) Role of glycosylation in cell surface expression and stability of HERG potassium channels. Am. J. Physiol. Heart Circ. Physiol. 283, H77-H84
-
(2002)
Am. J. Physiol. Heart Circ. Physiol.
, vol.283
-
-
Gong, Q.1
Anderson, C.L.2
January, C.T.3
Zhou, Z.4
-
39
-
-
0016711695
-
Selection and characterization of eight phenotypically distinct lines of lectin-resistant Chinese hamster ovary cell
-
Stanley, P., Caillibot, V., and Siminovitch, L. (1975) Selection and characterization of eight phenotypically distinct lines of lectin-resistant Chinese hamster ovary cell. Cell 6, 121-128
-
(1975)
Cell
, vol.6
, pp. 121-128
-
-
Stanley, P.1
Caillibot, V.2
Siminovitch, L.3
-
40
-
-
33751227495
-
Congenital disorders of N-glycosylation including diseases associated with O-as well as N-glycosylation defects
-
Leroy, J. G. (2006) Congenital disorders of N-glycosylation including diseases associated with O-as well as N-glycosylation defects. Pediatr. Res. 60, 643-656
-
(2006)
Pediatr. Res.
, vol.60
, pp. 643-656
-
-
Leroy, J.G.1
-
41
-
-
0037605951
-
Congenital disorders of glycosylation: Review of their molecular bases, clinical presentations and specific therapies
-
Marquardt, T., and Denecke, J. (2003) Congenital disorders of glycosylation: Review of their molecular bases, clinical presentations and specific therapies. Eur. J. Pediatr. 162, 359-379
-
(2003)
Eur. J. Pediatr.
, vol.162
, pp. 359-379
-
-
Marquardt, T.1
Denecke, J.2
-
42
-
-
33748195979
-
Glycosylation in cellular mechanisms of health and disease
-
Ohtsubo, K., and Marth, J. D. (2006) Glycosylation in cellular mechanisms of health and disease. Cell 126, 855-867
-
(2006)
Cell
, vol.126
, pp. 855-867
-
-
Ohtsubo, K.1
Marth, J.D.2
-
43
-
-
1642336146
-
A model for human ventricular tissue
-
Ten Tusscher, K. H., Noble, D., Noble, P. J., and Panfilov, A. V. (2004) A model for human ventricular tissue. Am. J. Physiol. Heart Circ. Physiol. 286, H1573-H1589
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.286
-
-
Ten Tusscher, K.H.1
Noble, D.2
Noble, P.J.3
Panfilov, A.V.4
-
46
-
-
84861952064
-
Multi-scale modeling of glycosylation modulation dynamics in cardiac electrical signaling
-
Du, D., Yang, H., Norring, S. A., and Bennett, E. S. (2011) Multi-scale modeling of glycosylation modulation dynamics in cardiac electrical signaling. IEEE Proc. Eng. Med. Biol. Soc. 2011, 104-107
-
(2011)
IEEE Proc. Eng. Med. Biol. Soc.
, vol.2011
, pp. 104-107
-
-
Du, D.1
Yang, H.2
Norring, S.A.3
Bennett, E.S.4
-
47
-
-
0033557696
-
N-linked glycosylation sites determine HERG channel surface membrane expression
-
Petrecca, K., Atanasiu, R., Akhavan, A., and Shrier, A. (1999) N-linked glycosylation sites determine HERG channel surface membrane expression. J. Physiol. 515, 41-48
-
(1999)
J. Physiol.
, vol.515
, pp. 41-48
-
-
Petrecca, K.1
Atanasiu, R.2
Akhavan, A.3
Shrier, A.4
-
48
-
-
58149382415
-
The Kv1.2 potassium channel: The position of an N-glycan on the extracellular linkers affects its protein expression and function
-
Zhu, J., Recio-Pinto, E., Hartwig, T., Sellers, W., Yan, J., and Thornhill, W. B. (2009) The Kv1.2 potassium channel: The position of an N-glycan on the extracellular linkers affects its protein expression and function. Brain Res. 1251, 16-29
-
(2009)
Brain Res.
, vol.1251
, pp. 16-29
-
-
Zhu, J.1
Recio-Pinto, E.2
Hartwig, T.3
Sellers, W.4
Yan, J.5
Thornhill, W.B.6
-
49
-
-
77954656282
-
The corrected QT interval in 24 h ECGs in neonates
-
Krasemann, T., Bente, K., and Burkhardtsmaier, G. (2010) The corrected QT interval in 24 h ECGs in neonates. Clin. Res. Cardiol. 99, 309-314
-
(2010)
Clin. Res. Cardiol.
, vol.99
, pp. 309-314
-
-
Krasemann, T.1
Bente, K.2
Burkhardtsmaier, G.3
-
50
-
-
77949402826
-
Levofloxacin can be used effectively as a positive control in thorough QT/QTc studies in healthy volunteers
-
Taubel, J., Naseem, A., Harada, T., Wang, D., Arezina, R., Lorch, U., and Camm, A. J. (2010) Levofloxacin can be used effectively as a positive control in thorough QT/QTc studies in healthy volunteers. Br. J. Clin. Pharmacol. 69, 391-400
-
(2010)
Br. J. Clin. Pharmacol.
, vol.69
, pp. 391-400
-
-
Taubel, J.1
Naseem, A.2
Harada, T.3
Wang, D.4
Arezina, R.5
Lorch, U.6
Camm, A.J.7
-
51
-
-
79151474418
-
An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
-
Gintant, G. (2011) An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation. Pharmacol. Ther. 129, 109-119
-
(2011)
Pharmacol. Ther.
, vol.129
, pp. 109-119
-
-
Gintant, G.1
-
52
-
-
48149092512
-
Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics
-
Vargas, H. M., Bass, A. S., Breidenbach, A., Feldman, H. S., Gintant, G. A., Harmer, A. R., Heath, B., Hoffmann, P., Lagrutta, A., Leishman, D., McMahon, N., Mittelstadt, S., Polonchuk, L., Pugsley, M. K., Salata, J. J., and Valentin, J. P. (2008) Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics. J. Pharmacol. Toxicol. Methods 58, 72-76
-
(2008)
J. Pharmacol. Toxicol. Methods
, vol.58
, pp. 72-76
-
-
Vargas, H.M.1
Bass, A.S.2
Breidenbach, A.3
Feldman, H.S.4
Gintant, G.A.5
Harmer, A.R.6
Heath, B.7
Hoffmann, P.8
Lagrutta, A.9
Leishman, D.10
McMahon, N.11
Mittelstadt, S.12
Polonchuk, L.13
Pugsley, M.K.14
Salata, J.J.15
Valentin, J.P.16
-
53
-
-
70049093343
-
Role of hERG potassium channel assays in drug development
-
Priest, B. T., Bell, I. M., and Garcia, M. L. (2008) Role of hERG potassium channel assays in drug development. Channels (Austin) 2, 87-93
-
(2008)
Channels (Austin
, vol.2
, pp. 87-93
-
-
Priest, B.T.1
Bell, I.M.2
Garcia, M.L.3
-
54
-
-
0032886622
-
Inactivation gating determines nicotine blockade of human HERG channels
-
Wang, H. Z., Shi, H., Liao, S. J., and Wang, Z. (1999) Inactivation gating determines nicotine blockade of human HERG channels. Am. J. Physiol. 277, H1081-H1088
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Wang, H.Z.1
Shi, H.2
Liao, S.J.3
Wang, Z.4
-
55
-
-
69549130724
-
H(1) antihistamine drug promethazine directly blocks hERG K? channel
-
Jo, S. H., Hong, H. K., Chong, S. H., Lee, H. S., and Choe, H. (2009) H(1) antihistamine drug promethazine directly blocks hERG K? channel . Pharmacol. Res. 60, 429-437
-
(2009)
Pharmacol. Res.
, vol.60
, pp. 429-437
-
-
Jo, S.H.1
Hong, H.K.2
Chong, S.H.3
Lee, H.S.4
Choe, H.5
-
56
-
-
0034028029
-
Cardiac K? channel s and drug-acquired long QT syndrome
-
Drici, M. D., and Barhanin, J. (2000) Cardiac K? channel s and drug-acquired long QT syndrome. Therapie 55, 185-193
-
(2000)
Therapie
, vol.55
, pp. 185-193
-
-
Drici, M.D.1
Barhanin, J.2
-
57
-
-
79251602239
-
Drug-induced hERG block and long QT syndrome
-
Witchel, H. J. (2011) Drug-induced hERG block and long QT syndrome. Cardiovasc. Ther. 29, 251-259
-
(2011)
Cardiovasc. Ther.
, vol.29
, pp. 251-259
-
-
Witchel, H.J.1
-
58
-
-
0642303107
-
N-Glycosylation-dependent block is a novel mechanism for drug-induced cardiac arrhythmia
-
Park, K. H., Kwok, S. M., Sharon, C., Berga, R., and Sesti, F. (2003) N-Glycosylation-dependent block is a novel mechanism for drug-induced cardiac arrhythmia. FASEB J. 17, 2308-2309
-
(2003)
FASEB J.
, vol.17
, pp. 2308-2309
-
-
Park, K.H.1
Kwok, S.M.2
Sharon, C.3
Berga, R.4
Sesti, F.5
-
59
-
-
78650825624
-
A KCR1 variant implicated in susceptibility to the long QT syndrome
-
Hayashi, K., Fujino, N., Ino, H., Uchiyama, K., Sakata, K., Konno, T., Masuta, E., Funada, A., Sakamoto, Y., Tsubokawa, T., Hodatsu, A., Yasuda, T., Kanaya, H., Kim, M. Y., Kupershmidt, S., Higashida, H., and Yamagishi, M. (2011) A KCR1 variant implicated in susceptibility to the long QT syndrome. J. Mol. Cell. Cardiol. 50, 50-57
-
(2011)
J. Mol. Cell. Cardiol.
, vol.50
, pp. 50-57
-
-
Hayashi, K.1
Fujino, N.2
Ino, H.3
Uchiyama, K.4
Sakata, K.5
Konno, T.6
Masuta, E.7
Funada, A.8
Sakamoto, Y.9
Tsubokawa, T.10
Hodatsu, A.11
Yasuda, T.12
Kanaya, H.13
Kim, M.Y.14
Kupershmidt, S.15
Higashida, H.16
Yamagishi, M.17
-
60
-
-
34247111885
-
HERG is protected from pharmacological block by alpha-1,2- glucosyltransferase function
-
Nakajima, T., Hayashi, K., Viswanathan, P. C., Kim, M. Y., Anghelescu, M., Barksdale, K. A., Shuai, W., Balser, J. R., and Kupershmidt, S. (2007) HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function. J. Biol. Chem. 282, 5506-5513
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 5506-5513
-
-
Nakajima, T.1
Hayashi, K.2
Viswanathan, P.C.3
Kim, M.Y.4
Anghelescu, M.5
Barksdale, K.A.6
Shuai, W.7
Balser, J.R.8
Kupershmidt, S.9
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