Multi-scale modeling of glycosylation modulation dynamics in cardiac electrical signaling

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2011, Pages 104-107

  Du, Dongping ^a   Yang, Hui ^a   Norring, Sarah A ^b   Bennett, Eric S ^b  

^a University of South Florida   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

cardiac myocyte action potential; glycosylation modulation; long QT syndrome; Multi Scale simulation model

Indexed keywords

ACTION POTENTIALS; CARDIAC ACTION POTENTIAL; CARDIAC ARRHYTHMIA; CARDIAC CELL; CARDIAC CELL MODEL; CARDIAC MYOCYTES; CARDIAC TISSUES; CHANNEL GATING; CHANNEL MODULATION; COMPUTER MODELS; DRUG DESIGN; ELECTRICAL BEHAVIORS; ION CHANNEL; LONG-QT SYNDROME; MULTI-SCALE MODELING; MULTI-SCALE SIMULATION; MULTISCALES; PHYSICAL EXPERIMENTS; REPOLARIZATION; SIALYLATION; TISSUE FUNCTION; UNDERLYING MECHANISM;

COMPUTER SIMULATION; DYNAMICS; ESTERIFICATION; HEART; HISTOLOGY; MODELS; MODULATION; TISSUE;

GLYCOSYLATION;

ERG1 POTASSIUM CHANNEL; GLUCAN SYNTHASE; GLYCOSIDASE; POTASSIUM CHANNEL HERG;

ACTION POTENTIAL; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CARBOHYDRATE METABOLISM; CHANNEL GATING; COMPUTER SIMULATION; GLYCOSYLATION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HUMAN; METABOLISM; PHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; CARBOHYDRATE METABOLISM; COMPUTER SIMULATION; ETHER-A-GO-GO POTASSIUM CHANNELS; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HEART CONDUCTION SYSTEM; HUMANS; ION CHANNEL GATING; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC;

EID: 84861952064     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2011.6089907     Document Type: Conference Paper

References (9)

1. H. Morita, J. Wu and D. P. Zipes, "The QT syndromes: long and short," The Lancet, vol. 372, pp. 750-763, 2008.
2. D. Dubin, Ion Adventure in the Heartland-Exploring the Heart's Ionic-Molecular Microcosm. Tampa,FL: Cover Publishing Company, 2003.
3. S. A. Norring, T. A. Schwetz, A. R. Ednie, H. Yang and E. S. Bennett, "N-Glycans Limit hERG1A Channel Function," Submitted for Publication, 2011.
4. J. R. Silva and Y. Rudy, "Multi-scale electrophysiology modeling: from atom to organ," The Journal of General Physiology, vol. 135, pp. 575-581, June 01, 2010.
5. E. V. Bondarenko and L. R. Rasmusson, "Simulations of propagated mouse ventricular action potentials: effects of molecular heterogeneity," Am J Physiol Heart Circ Physiol, vol. 293, pp. H1816-H1832, 2007.
6. T. A. Schwetz, S. A. Norring and E. S. Bennett, "N-glycans modulate K(v) 1.5 gating but have no effect on K(v)1.4 gating," Biochim Biophys Acta, vol. 1798, pp. 367-375, 2009.
7. M. L. Montpetit, P. J. Stocker, T. A. Schwetz, J. M. Harper, S. A. Norring, L. Schaffer, S. J. North, J. Jang-Lee, T. Gilmartin, S. R. Head, S. M. Haslam, A. Dell, J. D. Marth and E. S. Bennett, "Regulated and aberrant glycosylation modulate cardiac electrical signaling," Proc Natl Acad Sci USA, vol. 106, pp. 16517-16522, 2009.
8. K. H. W. J. ten Tusscher, D. Noble, P. J. Noble and A. V. Panfilov, "A model for human ventricular tissue," Am J Physiol Heart Circ Physiol, vol. 286, pp. 1573-1589, 2004.
9. K. H. W. J. ten Tusscher and A. V. Panfilov, "Alternans and spiral breakup in a human ventricular tissue model," Am J Physiol Heart Circ Physiol, vol. 291, pp. H1088-H1100, September 01, 2006.