Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes

Biochemical and Biophysical Research Communications

Volumn 431, Issue 2, 2013, Pages 192-196

  Liu, Jian Jun ^a   Toy, Wan Ching ^a   Liu, Sylvia ^a   Cheng, Anton ^a   Lim, Boon Khim ^a   Subramaniam, Tavin ^a   Sum, Chee Fang ^a   Lim, Su Chi ^a  

^a KHOO TECK PUAT HOSPITAL   (Singapore)

Author keywords

Acetyl keto boswellic acid; Adipocyte; Lypolysis; PPAR

Indexed keywords

ACETYL KETO BETA BOSWELLIC ACID; ANTIOBESITY AGENT; BOSWELLIC ACID; FAT DROPLET; HORMONE SENSITIVE LIPASE; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; URSOLIC ACID;

ADIPOCYTE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSOL; DOSE RESPONSE; DOWN REGULATION; FATTY ACID ANALYSIS; HUMAN; HUMAN CELL; LIPOLYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; UPREGULATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTI-OBESITY AGENTS; BIOLOGICAL MARKERS; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; HUMANS; LIPOLYSIS; MICE; PHOSPHOPROTEINS; PPAR GAMMA; TRITERPENES;

MURINAE;

EID: 84873427669     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.136     Document Type: Article

References (16)

1. Khanna D., Sethi G., Ahn K.S., Pandey M.K., Kunnumakkara A.B., Sung B., Aggarwal A., Aggarwal B.B. Natural products as a gold mine for arthritis treatment. Curr. Opin. Pharmacol. 2007, 7:344-351.
2. Liu J.J., Nilsson A., Oredsson S., Badmaev V., Duan R.D. Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int. J. Mol. Med. 2002, 10:501-505.
3. Liu J.J., Nilsson A., Oredsson S., Badmaev V., Zhao W.Z., Duan R.D. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002, 23:2087-2093.
4. Sengupta K., Alluri K.V., Satish A.R., Mishra S., Golakoti T., Sarma K.V., Dey D., Raychaudhuri S.P. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis. Res. Ther. 2008, 10:R85.
5. de Melo C.L., Queiroz M.G., Arruda Filho A.C., Rodrigues A.M., de Sousa D.F., Almeida J.G., Pessoa O.D., Silveira E.R., Menezes D.B., Melo T.S., Santos F.A., Rao V.S. Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet. J. Agric. Food Chem. 2009, 57:8776-8781.
6. Kunkel S.D., Suneja M., Ebert S.M., Bongers K.S., Fox D.K., Malmberg S.E., Alipour F., Shields R.K., Adams C.M. MRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab. 2011, 13:627-638.
7. Rao V.S., de Melo C.L., Queiroz M.G., Lemos T.L., Menezes D.B., Melo T.S., Santos F.A. Ursolic acid, a pentacyclic triterpene from sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. J. Med. Food 2011, 14:1375-1382.
8. Kim Y.J., Hwang S.J., Bae Y.C., Jung J.S. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 2009, 27:3093-3102.
9. Brasaemle D.L. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J. Lipid Res. 2007, 48:2547-2559.
10. Camp H.S., Ren D., Leff T. Adipogenesis and fat-cell function in obesity and diabetes. Trends Mol. Med. 2002, 8:442-447.
11. Schweiger M., Schreiber R., Haemmerle G., Lass A., Fledelius C., Jacobsen P., Tornqvist H., Zechner R., Zimmermann R. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J. Biol. Chem. 2006, 281:40236-40241.
12. Zechner R., Zimmermann R., Eichmann T.O., Kohlwein S.D., Haemmerle G., Lass A., Madeo F. Fat Signals-lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012, 15:279-291.
13. Guilherme A., Virbasius J.V., Puri V., Czech M.P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 2008, 9:367-377.
14. Auwerx J., Martin G., Guerre-Millo M., Staels B. Transcription, adipocyte differentiation, and obesity. J. Mol. Med. 1996, 74:347-352.
15. Christodoulides C., Vidal-Puig A. PPARs and adipocyte function. Mol. Cell. Endocrinol. 2010, 318:61-68.
16. Ren D., Collingwood T.N., Rebar E.J., Wolffe A.P., Camp H.S. PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis. Genes Dev. 2002, 16:27-32.