Clinical significance of quantitative cytomegalovirus detection in bronchoalveolar lavage fluid in lung transplant recipients

Transplant Infectious Disease

Volumn 15, Issue 1, 2013, Pages 60-69

  Schlischewsky, E ^a   Fuehner, T ^a   Warnecke, G ^a   Welte, T ^a   Haverich, A ^a   Ganzenmueller, T ^a   Heim, A ^a   Gottlieb, J ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Bronchiolitis obliterans syndrome; Bronchoalveolar lavage; Cytomegalovirus; Lung transplantation

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65;

ADULT; ANTIGEN DETECTION; ARTICLE; BRONCHIOLITIS OBLITERANS; COHORT ANALYSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; CYTOMEGALOVIRUS RETINITIS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE FREE SURVIVAL; DISEASE SURVEILLANCE; FEMALE; FOLLOW UP; GRAFT RECIPIENT; HUMAN; IMMUNOASSAY; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OUTPATIENT CARE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETRANSPLANTATION; RETROSPECTIVE STUDY; RISK FACTOR; VIRUS DETECTION; VIRUS LOAD;

ADULT; ANTIGENS, VIRAL; BRONCHIOLITIS OBLITERANS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; FEMALE; HUMANS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; VIRAL LOAD;

EID: 84873422759     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/tid.12015     Document Type: Article

References (34)

1. Alexander BD, Tapson VF. Infectious complications of lung transplantation. Transpl Infect Dis 2001; 3 (3): 128-137.
2. Snydman DR, Limaye AP, Potena L, Zamora MR. Update and review: state-of-the-art management of cytomegalovirus infection and disease following thoracic organ transplantation. Transplant Proc 2011; 43 (Suppl 3): 1-17.
3. Hodson EM, Craig JC, Strippoli GF, Webster AC. Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients. Cochrane Database Syst Rev 2008; April 16 (2): CD003774.
4. Drew WL. Laboratory diagnosis of cytomegalovirus infection and disease in immunocompromised patients. Curr Opin Infect Dis 2007; 20 (4): 408-411.
5. Engelmann I, Petzold DR, Kosinska A, Hepkema BG, Schulz TF, Heim A. Rapid quantitative PCR assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens. J Med Virol 2008; 80 (3): 467-477.
6. Henke-Gendo C, Ganzenmueller T, Kluba J, Harste G, Raggub L, Heim A. Improved quantitative PCR protocols for adenovirus and CMV with an internal inhibition control system and automated nucleic acid isolation. J Med Virol 2012; 84 (6): 890-896.
7. Engelmann I, Welte T, Fuehner T, et al. Detection of Epstein-Barr virus DNA in peripheral blood is associated with the development of bronchiolitis obliterans syndrome after lung transplantation. J Clin Virol 2009; 45 (1): 47-53.
8. Kotton CN. Management of cytomegalovirus infection in solid organ transplantation. Nat Rev Nephrol 2010; 6 (12): 711-721.
9. Humar A, Michaels M. American Society of Transplantation recommendations for screening, monitoring and reporting of infectious complications in immunosuppression trials in recipients of organ transplantation. Am J Transplant 2006; 6 (2): 262-274.
10. Stewart S, Fishbein MC, Snell GI, et al. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant 2007; 26(12): 1229-1242.
11. Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 2002; 21 (3): 297-310.
12. Balthesen M, Messerle M, Reddehase MJ. Lungs are a major organ site of cytomegalovirus latency and recurrence. J Virol 1993; 67 (9): 5360-5366.
13. Zamora MR. Cytomegalovirus and lung transplantation. Am J Transplant 2004; 4 (8): 1219-1226.
14. Gerna G, Lilleri D, Rognoni V, et al. Preemptive therapy for systemic and pulmonary human cytomegalovirus infection in lung transplant recipients. Am J Transplant 2009; 9 (5): 1142-1150.
15. Riise GC, Andersson R, Bergström T, Lundmark A, Nilsson FN, Olofsson S. Quantification of cytomegalovirus DNA in BAL fluid: a longitudinal study in lung transplant recipients. Chest 2000; 118(6): 1653-1660.
16. Westall GP, Michaelides A, Williams TJ, Snell GI, Kotsimbos TC. Human cytomegalovirus load in plasma and bronchoalveolar lavage fluid: a longitudinal study of lung transplant recipients. J Infect Dis 2004; 190 (6): 1076-1083.
17. Avery RK. Management of late, recurrent, and resistant cytomegalovirus in transplant patients. Transplant Rev 2007; 21: 65-76.
18. Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med 2007; 357 (25): 2601-2614.
19. Ettinger NA, Bailey TC, Trulock EP, et al. Cytomegalovirus infection and pneumonitis. Impact after isolated lung transplantation: Washington University Lung Transplant Group. Am Rev Respir Dis 1993; 147 (4): 1017-1023.
20. Duncan AJ, Dummer JS, Paradis IL, et al. Cytomegalovirus infection and survival in lung transplant recipients. J Heart Lung Transplant 1991; 10 (5 Pt 1): 638-644.
21. Kerschner H, Jaksch P, Karigl G, Popow-Kraupp T, Klepetko W, Puchhammer-Stöckl E. Cytomegalovirus DNA load patterns developing after lung transplantation are significantly correlated with long-term patient survival. Transplantation 2009; 87 (11): 1720-1726.
22. Mitsani D, Nguyen MH, Kwak EJ, et al. Cytomegalovirus disease among donor-positive/recipient-negative lung transplant recipients in the era of valganciclovir prophylaxis. J Heart Lung Transplant 2010; 29 (9): 1014-1020.
23. Paraskeva M, Bailey M, Levvey BJ, et al. Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome. Am J Transplant 2011; 11 (10): 2190-2196.
24. Manuel O, Kumar D, Moussa G, et al. Lack of association between beta-herpesvirus infection and bronchiolitis obliterans syndrome in lung transplant recipients in the era of antiviral prophylaxis. Transplantation 2009; 87 (5): 719-725.
25. Tamm M, Aboyoun CL, Chhajed PN, Rainer S, Malouf MA, Glanville AR. Treated cytomegalovirus pneumonia is not associated with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2004; 170 (10): 1120-1123.
26. Costa C, Delsedime L, Solidoro P, et al. Herpesviruses detection by quantitative real-time polymerase chain reaction in bronchoalveolar lavage and transbronchial biopsy in lung transplant: viral infections and histopathological correlation. Transplant Proc 2010; 42 (4): 1270-1274.
27. Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002; 34 (8): 1094-1097.
28. Hohenthal U, Itälä M, Salonen J, et al. Bronchoalveolar lavage in immunocompromised patients with haematological malignancy-value of new microbiological methods. Eur J Haematol 2005; 74(3): 203-211.
29. Zedtwitz-Liebenstein K, Jaksch P, Bauer C, et al. Association of cytomegalovirus DNA concentration in epithelial lining fluid and symptomatic cytomegalovirus infection in lung transplant recipients. Transplantation 2004; 77 (12): 1897-1899.
30. Chemaly RF, Yen-Lieberman B, Chapman J, et al. Clinical utility of cytomegalovirus viral load in bronchoalveolar lavage in lung transplant recipients. Am J Transplant 2005; 5 (3): 544-548.
31. Rayes N, Seehofer D, Lullius SG, et al. Monitoring of human cytomegalovirus, HHV-6 and HHV-7 infection in kidney transplant recipients by molecular methods to predict HCMV disease after transplantation: a prospective study. Ann Transplant 2005; 10 (2): 23-28.
32. Villa M, Lage E, Ballesteros S, et al. Preemptive therapy for the prevention of cytomegalovirus disease following heart transplantation directed by PP65 antigenemia. Transplant Proc 2003; 35 (2): 732-734.
33. Boehler A, Estenne M. Post-transplant bronchiolitis obliterans. Eur Respir J 2003; 22 (6): 1007-1018.
34. Piiparinen H, Höckerstedt K, Grönhagen-Riska C, Lautenschlager I. Comparison of two quantitative CMV PCR tests, Cobas Amplicor CMV Monitor and TaqMan assay, and pp65-antigenemia assay in the determination of viral loads from peripheral blood of organ transplant patients. J Clin Virol 2004; 30(3): 258-266.