Clinical utility of cytomegalovirus viral load in bronchoalveolar lavage in lung transplant recipients

American Journal of Transplantation

Volumn 5, Issue 3, 2005, Pages 544-548

  Chemaly, Roy F ^a   Yen Lieberman, Belinda ^a   Chapman, Jeffrey ^a   Reilly, Amy ^a   Bekele, B Nebiyou ^b   Gordon, Steven M ^a   Procop, Gary W ^a   Shrestha, Nabin ^a   Isada, Carlos M ^a   DeCamp, Malcolm ^a   Avery, Robin K ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

BAL; CMV; Lung transplant; Viral load

Indexed keywords

ACICLOVIR; AZATHIOPRINE; CYCLOSPORIN; GANCICLOVIR; HYPERIMMUNE GLOBULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; BLOOD LEVEL; BRONCHIOLITIS OBLITERANS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; MALE; PNEUMONIA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE HYBRID CAPTURE ASSAY; RECIPIENT; SEROPREVALENCE; VIRUS CULTURE; VIRUS LOAD;

ADULT; AGED; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; VIRAL LOAD;

EID: 20044373430     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2005.00747.x     Document Type: Article

References (23)

1. Rubin RH. Impact of cytomegalovirus infection on organ transplant recipients. Rev Infect Dis 1990; 12(Suppl. 7): S754.
2. Ettinger NA, Bailey TC, Trulock EP et al. Cytomegalovirus infection and pneumonitis: impact after isolated lung transplantation. Am Rev Respir Dis 1993; 147: 1017-1023.
3. Paradis IL, Williams P. Infection after lung transplantation. Semin Respir Infect 1993; 8: 207-215.
4. Dauber JH, Paradis IL, Dummer JS. Infectious complications in pulmonary allograft recipients. Clin Chest Med 1990; 11: 291-308.
5. Avery RK. Special considerations regarding CMV in lung transplantation. Transpl Infect Dis 1999; 1(Suppl. 1): 13-18.
6. Mazzulli T, Drew WL, Yen-Lieberman B et al. Multicenter comparison of the Digene hybrid capture assay (version 2.0), the pp65 antigenemia assay, and cell culture for detection of cytomegalovirus viremia. J Clin Microbiol 1999; 37: 958-963.
7. Humar A, Gregson D, Caliendo AM et al. Clinical utility of quantitative cytomegalovirus viral load determination for predicting cytomegalovirus disease in liver transplant recipients. Transplantation 1999; 68: 1305-1311.
8. Mendez J, Espy M, Smith TF, Wilson J, Wiesner R, Paya CV. Clinical significance of viral load in the diagnosis of cytomegalovirus disease after liver transplantation. Transplantation 1998; 65: 1477-1481.
9. Sia IG, Wilson JA, Groettum CM, Espy MJ, Smith TF, Paya CV. Cytomegalovirus (CMV) DNA load predicts relapsing CMV infection after solid organ transplantation. J Infect Dis 2000; 181: 717-720.
10. Drew WL. Ganciclovir resistance: a matter of time and titre. Lancet 2000; 356: 609-610.
11. Solans EP, Garrity ER, McCabe M, Martinez R, Husain AN, Garrity ER Jr. Early diagnosis of cytomegalovirus pneumonitis in lung transplant patients. Arch Pathol Lab Med 1995; 119: 33-35.
12. Erice A, Hertz MI, Snyder LS, Englund J, Edelman CK, Balfour HH. Evaluation of centrifugation cultures of bronchoalveolar lavage fluid for the diagnosis of cytomegalovirus pneumonitis. Diagn Microbiol Infect Dis 1988; 10: 205-212.
13. Liesnard C, De Wit L, Motte S, Brancart F, Content J. Rapid diagnosis of cytomegalovirus lung infection by DNA amplification in bronchoalveolar lavages. Mol Cell Probes 1994; 8: 273-283.
14. Chemaly RF, Yen-Lieberman B, Castilla EA et al. Correlation between viral loads of cytomegalovirus in blood and bronchoalveolar lavage specimens from lung transplant recipients determined by histology and immunohistochemistry. J Clin Microbiol 2004; 42: 2168-2172.
15. Hertz MI, Jordan C, Savik SK et al. Randomized trial of daily versus three-times-weekly prophylactic ganciclovir after lung and heart-lung transplantation. J Heart Lung Transplant 1998; 17: 913-920.
16. Kathawalla SA, Stilwell PC, Gordon S et al. Cytomegalovirus infection in seromismatched lung transplant recipients with and without prophylaxis with CMV immunoglobulin. Transplant Proc 1996; 28(6 Suppl. 2): 16.
17. Lurain NS, Bhorade SM, Pursell KJ et al. Analysis and characterization of antiviral drug-resistant cytomegalovirus isolates from solid organ transplant recipients. J Infect Dis 2002; 186: 760-768.
18. Bhorade SM, Sandesara C, Garrity ER et al. Quantification of cytomegalovirus (CMV) viral load by the hybrid capture assay allows for early detection of CMV disease in lung transplant recipients. J Heart Lung Transplant 2001; 20: 928-934.
19. Michaelides A, Liolios L, Glare EM et al. Increased human cytomegalovirus (HCMV) DNA load in peripheral blood leukocytes after lung transplantation correlates with HCMV pneumonitis. Transplantation 2001; 72: 141-147.
20. Sanchez JL, Kruger RM, Paranjothi S et al. Relationship of cytomegalovirus viral load in blood to pneumonitis in lung transplant recipients. Transplantation 2001; 72: 733-735.
21. Ruse GC, Andersson R, Bergstrom T, Lundmark A, Nilsson FN, Olofsson S. Quantification of cytomegalovirus DNA in BAL fluid: a longitudinal study in lung transplant recipients. Chest 2000; 118: 1653-1660.
22. Boivin G, Olson CA, Quirk MR, Kringstad B, Hertz MI, Jordan MC. Quantitation of cytomegalovirus DNA and characterization of viral gene expression in bronchoalveolar cells of infected patients with and without pneumonitis. J Infect Dis 1996; 173: 1304-1312.
23. Bewig B, Haacke TC, Tiroke A et al. Detection of CMV pneumonitis after lung transplantation using PCR of DNA from bronchoalveolar lavage cells. Respiration 2000; 67: 166-172.