Cytomegalovirus DNA load patterns developing after lung transplantation are significantly correlated with long-term patient survival

Transplantation

Volumn 87, Issue 11, 2009, Pages 1720-1726

  Kerschner, Heidrun ^a   Jaksch, Peter ^a   Karigl, Günther ^b   Popow Kraupp, Theresia ^a   Klepetko, Walter ^a   Puchhammer Stöckl, Elisabeth ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Cytomegalovirus; Lung transplantation; Survival; Viral load

Indexed keywords

CYCLOSPORIN; GANCICLOVIR; MANNOSE BINDING LECTIN; MYCOPHENOLIC ACID; PREDNISOLONE; TOLL LIKE RECEPTOR 2; VALGANCICLOVIR; VIRUS DNA;

ADULT; AGED; ARTICLE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FEMALE; GENETIC ANALYSIS; HUMAN; KAPLAN MEIER METHOD; LUNG LAVAGE; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MBL GENE; NONHUMAN; PLASMA; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECEPTOR GENE; RECIPIENT; RISK ASSESSMENT; SURGICAL MORTALITY; SURVIVAL; TLR2 GENE; VIRUS LOAD; VIRUS REPLICATION;

ADULT; AGED; BRONCHOALVEOLAR LAVAGE; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SURVIVAL RATE; SURVIVORS; VIRAL LOAD; VIRUS REPLICATION; YOUNG ADULT;

EID: 67649580468     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181a60b4e     Document Type: Article

References (49)

1. Gerna G, Lilleri D. Monitoring transplant patients for human cytomegalovirus: Diagnostic update. Herpes 2006; 13: 4.
2. Zamora MR, Davis RD, Leonard C. Management of cytomegalovirus infection in lung transplant recipients: Evidence-based recommendations. Transplantation 2005; 80: 157.
3. Streblow DN, Orloff SL, Nelson JA. Acceleration of allograft failure by cytomegalovirus. Curr Opin Immunol 2007; 19: 577.
4. Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med 2007; 357: 2601.
5. Weinberg A, Hodges TN, Li S, et al. Comparison of PCR, antigenemia assay, and rapid blood culture for detection and prevention of cytomegalovirus disease after lung transplantation. J Clin Microbiol 2000; 38: 768.
6. Michaelides A, Facey D, Spelman D, et al. HCMV DNA detection and quantitation in the plasma and PBL of lung transplant recipients: COBAS Amplicor HCMV monitor test versus in-house quantitative HCMV PCR. J Clin Virol 2003; 28: 111.
7. Boeckh M, Huang M, Ferrenberg J, et al. Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR. J Clin Microbiol 2004; 42: 1142.
8. Razonable RR, Brown RA, Wilson J, et al. The clinical use of various blood compartments for cytomegalovirus (CMV)DNAquantitation in transplant recipients with CMV disease. Transplantation 2002; 73: 968.
9. Emery VC, Sabin CA, Cope AV, et al. Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet 2000; 355: 2032.
10. Humar A, Kumar D, Boivin G, et al. Cytomegalovirus (CMV) virus load kinetics to predict recurrent disease in solid-organ transplant patients with CMV disease. J Infect Dis 2002; 186: 829.
11. Sia IG, Wilson JA, Groettum CM, et al. Cytomegalovirus (CMV) DNA load predicts relapsing CMV infection after solid organ transplantation. J Infect Dis 2000; 181: 717.
12. Trulock EP, Christie JD, Edwards LB, et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth official adult lung and heart-lung transplantation report-2007. J Heart Lung Transplant 2007; 26: 782.
13. Westall G, Kotsimbos T, Brooks A. CMV-specific CD8 T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation. Am J Transplant 2006; 6: 577.
14. Westall GP, Brooks AG, Kotsimbos T. CD8- T-cell maturation following lung transplantation: The differential impact of CMV and acute rejection. Transpl Immunol 2007; 18: 186.
15. Ettinger NA, Bailey TC, Trulock EP, et al. Cytomegalovirus infection and pneumonitis. Impact after isolated lung transplantation. Washington University Lung Transplant Group. Am Rev Respir Dis 1993; 147: 1017.
16. Kijpittayarit S, Eid AJ, Brown RA, et al. Relationship between Toll-like receptor 2 polymorphism and cytomegalovirus disease after liver transplantation. Clin Infect Dis 2007; 44: 1315.
17. Manuel O, Pascual M, Trendelenburg M, et al. Association between mannose-binding lectin deficiency and cytomegalovirus infection after kidney transplantation. Transplantation 2007; 83: 359.
18. Ljungman P, Griffiths P, Paya C. Definitions of Cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002; 34: 1094.
19. Popow-Kraupp T, Kunz C. Detection of cytomegalovirus in clinical specimens by virus isolation and by a monoclonal antibody against the early nuclear antigen. J Med Virol 1988; 24: 275.
20. Jack D, Bidwell J, Turner M, et al. Simultaneous genotyping for all three known structural mutations in the human mannose-binding lectin gene. Hum Mutat 1997; 9: 41.
21. Hamann L, Hamprecht A, Gomma A, et al. Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Tolllike receptor-2, -4, and -9 genes. J Immunol Methods 2004; 285: 281.
22. Tikkanen JM, Kallio EA, Bruggeman CA, et al. Prevention of cytomegalovirus infection-enhanced experimental obliterative bronchiolitis by antiviral prophylaxis or immunosuppression in rat tracheal allografts. Am J Respir Crit Care Med 2001; 164: 672.
23. Wiebe K, Fraund S, Steinmuller C, et al. Rat cytomegalovirus and Listeria monocytogenes infection enhance chronic rejection after allogenic rat lung transplantation. Transpl Int 2005; 18: 1166.
24. Soule JL, Streblow DN, Andoh TF, et al. Cytomegalovirus accelerates chronic allograft nephropathy in a rat renal transplant model with associated provocative chemokine profiles. Transplant Proc 2006; 38: 3214.
25. Simon CO, Seckert CK, Dreis D, et al. Role for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs. J Virol 2005; 79: 326.
26. Fietze E, Prosch S, Reinke P, et al. Cytomegalovirus infection in transplant recipients. The role of tumor necrosis factor. Transplantation1994; 58: 675.
27. McCormick AL, Meiering CD, Smith GB, et al. Mitochondrial cell death suppressors carried by human and murine cytomegalovirus confer resistance to proteasome inhibitor-induced apoptosis. J Virol 2005; 79: 12205.
28. Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med 1998; 338: 1741.
29. Hodson EM, Craig JC, Strippoli GF, et al. Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients. Cochrane Database Syst Rev 2008: CD003774.
30. Ruttmann E, Geltner C, Bucher B, et al. Combined CMV prophylaxis improves outcome and reduces the risk for bronchiolitis obliterans syndrome (BOS) after lung transplantation. Transplantation 2006; 81: 1415.
31. Chmiel C, Speich R, Hofer M, et al. Ganciclovir/valganciclovir prophylaxis decreases cytomegalovirus-related events and bronchiolitis obliterans syndrome after lung transplantation. Clin Infect Dis 2008; 46: 831.
32. Sagedal S, Hartmann A, Nordal KP, et al. Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival. Kidney Int 2004; 66: 329.
33. Danziger-Isakov LA, DelaMorena M, Hayashi RJ, et al. Cytomegalovirus viremia associated with death or retransplantation in pediatric lung-transplant recipients. Transplantation 2003; 75: 1538.
34. Regoes RR, Bowen EF, Cope AV, et al. Modelling cytomegalovirus replication patterns in the human host: Factors important for pathogenesis. Proc Biol Sci 2006; 273: 1961.
35. Schafer P, Tenschert W, Cremaschi L, et al. Area under the viraemia curve versus absolute viral load: Utility for predicting symptomatic cytomegalovirus infections in kidney transplant patients. J Med Virol2001; 65: 85.
36. Bauer CC, Jaksch P, Aberle SW, et al. Relationship between cytomegalovirus DNA load in epithelial lining fluid and plasma of lung transplant recipients and analysis of coinfection with Epstein-Barr virus and human herpesvirus 6 in the lung compartment. J Clin Microbiol 2007; 45: 324.
37. Westall GP, Michaelides A, Williams TJ, et al. Human cytomegalovirus load in plasma and bronchoalveolar lavage fluid: A longitudinal study of lung transplant recipients. J Infect Dis 2004; 190: 1076.
38. Chemaly RF, Yen-Lieberman B, Chapman J, et al. Clinical utility of cytomegalovirus viral load in bronchoalveolar lavage in lung transplant recipients. Am J Transplant 2005; 5: 544.
39. Michaelides A, Liolios L, Glare EM, et al. Increased human cytomegalovirus (HCMV) DNA load in peripheral blood leukocytes after lung transplantation correlates with HCMV pneumonitis. Transplantation2001; 72: 141.
40. Weigt SS, Elashoff RM, Keane MP, et al. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am J Transplant 2008; 8: 1512.
41. Pipeling MR, West EE, Osborne CM, et al. Differential CMV-specific CD8- effector T cell responses in the lung allograft predominate over the blood during human primary infection. J Immunol2008; 181: 546.
42. Levitsky J, Freifeld AG, Puumala S, et al. Cytomegalovirus viremia in solid organ transplantation: Does the initial viral load correlate with risk factors and outcomes? Clin Transplant 2008; 22: 222.
43. Freeman RB, Paya C, Pescovitz MD, et al. Risk factors for cytomegalovirus viremia and disease developing after prophylaxis in high-risk solid-organ transplant recipients. Transplantation 2004; 78: 1765.
44. Gorzer I, Kerschner H, Jaksch P, et al. Virus load dynamics of individual CMV-genotypes in lung transplant recipients with mixed-genotype infections. J Med Virol 2008; 80: 1405.
45. Puchhammer-Stockl E, Gorzer I, Zoufaly A, et al. Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients. Transplantation 2006; 81: 187.
46. Humar A, Kumar D, Gilbert C, et al. Cytomegalovirus (CMV) glycoprotein B genotypes and response to antiviral therapy, in solid-organtransplant recipients with CMV disease. J Infect Dis 2003; 188: 581.
47. Cervera C, Lozano F, Saval N, et al. The influence of innate immunity gene receptors polymorphisms in renal transplant infections. Transplantation 2007; 83: 1493.
48. Sagedal S, Thiel S, Hansen TK, et al. Impact of the complement lectin pathway on cytomegalovirus disease early after kidney transplantation. Nephrol Dial Transplant 2008; 23: 4054.
49. Verschuren JJ, Roos A, Schaapherder AF, et al. Infectious complications after simultaneous pancreas-kidney transplantation: A role for the lectin pathway of complement activation. Transplantation 2008; 85: 75.