Gallium(III) complexes with 2-acetylpyridine-derived thiosemicarbazones: Antimicrobial and cytotoxic effects and investigation on the interactions with tubulin

BioMetals

Volumn 26, Issue 1, 2013, Pages 151-165

  Lessa, Josane A ^a   Soares, Marcella A ^b,c   Dos Santos, Raquel G ^b   Mendes, Isolda C ^c   Salum, Livia B ^d   Daghestani, Hikmat N ^e   Andricopulo, Adriano D ^d   Day, Billy W ^f   Vogt, Andreas ^f   Beraldo, Heloisa ^c  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b CENTRO DE DESENVOLVIMENTO DA TECNOLOGIA NUCLEAR   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Antimicrobial activity; Cytotoxicity; Gallium(III) complexes; Thiosemicarbazones; Tubulin

Indexed keywords

2 ACETYLPYRIDINE THIOSEMICARBAZONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BIS[N 4 CHLOROPHENYL 2 ACETYLPYRIDINETHIOSEMICARBAZONATO]GALLIUM (III)NITRATE; BIS[N 4 FLUOROPHENYL 2 ACETYLPYRIDINETHIOSEMICARBAZONATO]GALLIUM (III)NITRATE; BIS[N 4 IODOPHENYL 2 ACETYLPYRIDINETHIOSEMICARBAZONATO]GALLIUM (III)NITRATE; BIS[N 4 NITROPHENYL 2 ACETYLPYRIDINETHIOSEMICARBAZONATO]GALLIUM (III)NITRATE TRIHYDRATE; BIS[N PARA TOLYL 2 ACETYLPYRIDINETHIOSEMICARBAZONATO]GALLIUM (III)NITRATE; ETOPOSIDE; FLUCONAZOLE; GALLIUM; TETRACYCLINE; TUBULIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANDIDA ALBICANS; CELL ASSAY; CELL CYCLE ARREST; CELL DENSITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MICROTUBULE ORGANIZING CENTER; MITOSIS; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN ASSEMBLY; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ANALYSIS; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CANDIDA ALBICANS; CELL CYCLE CHECKPOINTS; CELL SHAPE; COORDINATION COMPLEXES; CRYSTALLOGRAPHY, X-RAY; ERYTHROCYTES; GALLIUM; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MCF-7 CELLS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN MULTIMERIZATION; PSEUDOMONAS AERUGINOSA; PYRIDINES; STAPHYLOCOCCUS AUREUS; THIOSEMICARBAZONES; TUBULIN; TUBULIN MODULATORS;

CANDIDA ALBICANS; PSEUDOMONAS AERUGINOSA;

EID: 84873410373     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9603-1     Document Type: Article

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