N 4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: Cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3396-3409

  Soares, Marcella A ^a,b   Lessa, Josane A ^a   Mendes, Isolda C ^a   Da Silva, Jeferson G ^a   Dos Santos, Raquel G ^a,b   Salum, Lívia B ^c   Daghestani, Hikmat ^d   Andricopulo, Adriano D ^c   Day, Billy W ^e   Vogt, Andreas ^e   Pesquero, Jorge L ^a   Rocha, Willian R ^a   Beraldo, Heloisa ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b CENTRO DE DESENVOLVIMENTO DA TECNOLOGIA NUCLEAR   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

2 Acetylpyridine thiosemicarbazones; Breast cancer; Cytotoxicity; Glioblastoma; Tubulin

Indexed keywords

ETOPOSIDE; N4 2 CHLOROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 2 FLUOROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 2 IODOPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 2 NITROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 3 CHLOROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 3 FLUOROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 3 IODOPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 3 NITROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 4 CHLOROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 4 FLUOROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 4 IODOPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 4 NITROPHENY 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 PHENYL 2 ACETYLPYRIDINE THIOSEMICARBAZONE; N4 PHENYL 2 ACETYLPYRIDINE THIOSEMICARBAZONE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GLIOMA; HEMOLYSIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; FEMALE; GLIOBLASTOMA; GLIOMA; HUMANS; INHIBITORY CONCENTRATION 50; MICROTUBULES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES; TUBULIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861182305     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.027     Document Type: Article

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