Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex

BioMetals

Volumn 26, Issue 1, 2013, Pages 1-12

  Hsu, Chun Wei ^a   Kuo, Chia Feng ^b   Chuang, Show Mei ^a   Hou, Ming Hon ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b SHIH CHIEN UNIVERSITY   (Taiwan)

Author keywords

C Myc expression; Cell viability; Dimer; Divalent metal; DNA cleavage; DNA binding; Mithramycin; Nickel(II)

Indexed keywords

ANTINEOPLASTIC METAL COMPLEX; DOUBLE STRANDED DNA; HYDROGEN PEROXIDE; MITHRAMYCIN NICKEL COMPLEX; MYC PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CHELATION; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA CLEAVAGE; DNA STRAND BREAKAGE; DRUG DNA INTERACTION; DRUG STRUCTURE; HUMAN; HUMAN CELL; KINETICS; PROTEIN EXPRESSION; STOICHIOMETRY; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

ANTIBIOTICS, ANTINEOPLASTIC; CHELATING AGENTS; COORDINATION COMPLEXES; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION; HELA CELLS; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; INVERTED REPEAT SEQUENCES; IRON; NICKEL; PLASMIDS; PLICAMYCIN; PROTO-ONCOGENE PROTEINS C-MYC; SURFACE PLASMON RESONANCE; THIAZOLIDINEDIONES; TRANSITION TEMPERATURE;

EID: 84873409485     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9589-8     Document Type: Article

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