New approaches to male non-hormonal contraception

Contraception

Volumn 87, Issue 3, 2013, Pages 296-299

  Nya Ngatchou, Jean Jacques ^a   Amory, John K ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Adjudin; Contraception; Gamendazole; Lonidamine; Retinoic acid; Spermatogenesis

Indexed keywords

ADJUDIN; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BMS 189453; FERTILYSIN; GAMENDAZOLE; LONIDAMINE; MALE CONTRACEPTIVE AGENT; RETINOIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; CONFERENCE PAPER; CONTRACEPTION; DRUG APPROVAL; DRUG SAFETY; GENE EXPRESSION; HEART PALPITATION; HUMAN; MALE NON HORMONAL CONTRACEPTION; NAUSEA; NONHUMAN; SEMINIFEROUS TUBULE; SIDE EFFECT; SIGNAL TRANSDUCTION; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOZOON DENSITY; SWEATING; TESTOSTERONE BLOOD LEVEL; VOMITING;

ANIMALS; CONTRACEPTION; CONTRACEPTIVE AGENTS, MALE; DIAMINES; HUMANS; HYDRAZINES; INDAZOLES; MALE; RETINOIDS; TRETINOIN;

EID: 84873407995     PISSN: 00107824     EISSN: 18790518     Source Type: Journal    
DOI: 10.1016/j.contraception.2012.08.016     Document Type: Conference Paper

References (34)

1. Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat. World Population prospects: the 2008 revision Available at http://www.un.org/esa/population/ Retrieved 09/30/11
2. J.J. Speidel, and R.A. Grossman Addressing global health, economic, and environmental problems through family planning Obstet Gynecol 117 2011 1394 1398
3. S. Singh, G. Sedgh, and R. Hussain Unintended pregnancy: worldwide levels, trends and outcomes Stud Fam Plann 41 2010 241 250
4. I. Shah, and E. Ahman Unsafe abortion in 2008: global and regional level and trends Reprod Health Matters 18 2010 90 101
5. S. Singh, M.E. Darroch, L.S. Ashford, and M. Vlassoff Adding it up: the costs and benefits of investing in family planning and maternal and newborn health 2009 Alan Guttmacher Institute New York (NY)
6. L.J. Piccinino, and W.D. Mosher Trends in contraceptive use in the United States: 1982:1995 Fam Plan Persp 30 1998 4 10
7. J. Trussell, and B. Vaughan Contraceptive failure, method-related discontinuation and resumption of use: results from the 1995 National Survey of Family Growth Fam Plann Perspect 31 1999 64 72
8. S.-Q. Li, M. Goldstein, J. Shu, and D.H. Huber The no-scalpel vasectomy J Urol 145 1991 341 344
9. C.W. Martin, R.A. Anderson, and L. Cheng Potential impact of hormonal male contraception: cross-cultural implications for development of novel male preparations Hum Reprod 15 2000 637 645
10. K. Heinemann, F. Saad, M. Wiesemes, S. White, and L. Heinemann Attitudes towards male fertility control: results of a multinational survey on four continents Hum Reprod 20 2005 549 556
11. A.F. Glasier, R. Anakwe, and D. Everington Would women trust their partners to use a male pill? Hum Reprod 15 2000 646 649
12. C.Y. Cheng, B. Silvestrini, and J. Grima Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis Biol Reprod 65 2001 449 461
13. G.Y. Cheng, and D. Mruk Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testes Spermatogenesis 1 2011 137 146
14. K.-W. Mok, D.D. Mruk, P.P.Y. Lie, W.-Y. Lui, and C.Y. Cheng Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes Reproduction 141 2011 571 580
15. D.D. Mruk, C.H. Wong, B. Silvestrini, and C.Y. Cheng A male contraceptive targeting germ cell adhesion Nat Med 12 2006 1323 1328
16. J.S. Tash, B. Attardi, S.A. Hild, R. Chakrasali, S.R. Jakkaraj, and G.I. Georg A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose Biol Reprod 78 2008 1127 1138
17. J.S. Tash, R. Chakrasali, and S.R. Jakkaraj Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 and EEF1A1, and stimulates II1a transcription in rat Sertoli cells Biol Reprod 78 2008 1139 1152
18. S.B. Wolbach, and P.R. Howe Tissue changes following deprivation of fat soluble A vitamin J Exp Med 42 1925 753 777
19. N. Vernet, C. Dennefeld, and C. Rochett-Egly Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis Endocrinology 147 2006 96 110
20. J. Koubova, D. Menke, Q. Zhou, B. Capel, M.D. Griswold, and D.C. Page Retinoic acid regulates sex-specific timing of meiotic initiation in mice Proc Natl Acad Sci USA 103 2006 2472 2479
21. J.M. Dufour, and K.H. Kim Cellular and subcellular localization of six retinoid receptors in rat testis during postnatal devlopment: identification of potential heterimeric receptors Biol Reprod 61 1999 1300 1308
22. T. Lufkin, D. Lohnes, and M. Mark High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice Proc Natl Acad Sci USA 90 1993 7225 7229
23. D. Lohnes, P. Kastner, A. Dierich, M. Mark, M. LeMeur, and P. Chambon Function of retinoic acid receptor gamma in the mouse Cell 73 1993 643 658
24. P. Kastner, M. Mark, and M. Leid Abnormal spermatogenesis in RXR beta mutant mice Genes Dev 10 1996 80 92
25. G.E. Schulze, R.J. Clay, L.E. Mezza, C.L. Bregman, R.A. Buroker, and J.D. Frantz BMS-189453, a novel retinoid receptor antagonist, is a potent testicular toxin Toxicol Sci 59 2001 297 308
26. S.S. Chung, X. Wang, S.S. Roberts, S.M. Griffey, P.R. Reczek, and D.J. Wolgemuth Oral administration of a retinoic acid receptor antagonist reversibly inhibits spermatogenesis in mice Endocrinology 152 2011 2492 2502
27. S.S. Chung, W. Sung, X. Wang, and D.J. Wolgemuth Retinoic acid receptor alpha is required for synchronization of spermatogenic cycles and its absence results in progressive breakdown of the spermatogenic process Dev Dyn 230 2004 754 766
28. S.S. Chung, X. Wang, and D.J. Wolgemuth Male sterility in mice lacking retinoic acid receptor alpha involves specific abnormalties in spermiogenesis Differentiation 73 2005 188 198
29. C.G. Heller, D.J. Moore, and C.A. Paulsen Suppression of spermatogenesis and chronic toxicity in men by a new series of bis (dichloroacetyl) diamines Toxicol Appl Pharmacol 3 1961 1 11
30. F. Coulston, A.L. Beyler, and H.P. Drobeck The biologic actions of a new series of bis(dichloroacetyl) diamines Toxicol Appl Pharmacol 2 1960 715 721
31. A.L. Beyler, G.O. Potts, F. Coulston, and A.R. Surrey The selective testicular effects of certain bis-(dichloroacetyl) diamines Endocrinology 69 1961 819 833
32. C.G. Heller, B.Y. Flageolle, and L.J. Matson Histopathology of the human testes as affected by bis (dichloroacetyl) diamines Exp Mol Path 2 1963 107 114
33. World Health Organization Task Force on Methods for the Regulation of Male Fertility. Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men Fertil Steril 65 1996 821 829
34. J.K. Amory, C.H. Muller, and A.J. Shimshoni Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis J Androl 32 2011 111 119