BMS-189453, a novel retinoid receptor antagonist is a potent testicular toxin

Toxicological Sciences

Volumn 59, Issue 2, 2001, Pages 297-308

  Schulze, Gene E ^a   Clay, Richard J ^a   Mezza, Lawrence E ^a   Bregman, Carla L ^a   Buroker, Robert A ^a   Frantz, Jerry D ^a  

^a BRISTOL MYERS SQUIBB COMPANY   (United States)

Author keywords

In vivo; Oral; Rabbits; Rats; Retinoic acid receptor antagonist; Retinoids; Safety assessment; Testicular toxicity; Toxicity; Vitamin A

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BMS 189453; CARBOXYMETHYLCELLULOSE; COLLAGEN; DRUG VEHICLE; GLOBULAR PROTEIN; INTERLEUKIN 8; MICROCRYSTALLINE CELLULOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RECEPTOR BLOCKING AGENT; RETINOIC ACID RECEPTOR; RETINOID DERIVATIVE; RETINOID X RECEPTOR; RETINOL DERIVATIVE; SODIUM; SODIUM CHLORIDE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CONVALESCENCE; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DRUG MEGADOSE; DRUG STRUCTURE; DRUG TOLERABILITY; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; LEUKOCYTE COUNT; MALE; MORTALITY; NONHUMAN; RABBIT; RAT; RAT STRAIN; TESTIS ATROPHY; TOXICITY TESTING; WEIGHT REDUCTION;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ATROPHY; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; MALE; NEUTROPHILS; ORGAN SIZE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, RETINOIC ACID; RETINOIDS; SPECIES SPECIFICITY; SPERM COUNT; TESTIS; TIME FACTORS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0035121356     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/59.2.297     Document Type: Article

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