CART peptide induces neuroregeneration in stroke rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 2, 2013, Pages 300-310

  Luo, Yu ^a   Shen, Hui ^a   Liu, Hua Shan ^a   Yu, Seong Jin ^a   Reiner, David J ^a   Harvey, Brandon K ^a   Hoffer, Barry J ^a   Yang, Yihong ^a   Wang, Yun ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

BDNF; CART; MRI; neuroregeneration; stroke

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BROXURIDINE; CELL MARKER; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; CYCLINE; FLUORESCENT DYE; FLUORO RUBY; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MUSASHI 1 PROTEIN; N ACETYLASPARTIC ACID; NEUROMODULIN; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ARTICLE; BRAIN; BRAIN CORTEX LESION; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL MIGRATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CONVALESCENCE; DEGENERATIVE DISEASE; DRUG DELIVERY SYSTEM; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NERVE CELL CULTURE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR UPREGULATION; SCORING SYSTEM; SUBVENTRICULAR ZONE;

ADMINISTRATION, INTRANASAL; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL MOVEMENT; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; GAP-43 PROTEIN; MALE; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; NEURODEGENERATIVE DISEASES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA-BINDING PROTEINS; STROKE; TIME FACTORS; UP-REGULATION;

EID: 84873404626     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.172     Document Type: Article

References (35)

1. Goldstein LB. Acute ischemic stroke treatment in 2007. Circulation 2007; 116: 1504-1514.
2. Douglass J, McKinzie AA, Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 1995; 15: 2471-2481.
3. Vrang N, Larsen PJ, Kristensen P. Cocaine-amphetamine regulated transcript (CART) expression is not regulated by amphetamine. Neuroreport 2002; 13: 1215-1218.
4. Liu HS, Shen H, Harvey BK, Castillo P, Lu H, Yang Y et al. Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats. Neuroimage 2011; 56: 280-289.
5. Vrang N, Larsen PJ, Tang-Christensen M, Larsen LK, Kristensen P. Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids. Brain Res 2003; 965: 45-50.
6. Roh MS, Cui FJ, Ahn YM, Kang UG. Up-regulation of cocaine-and amphetamine-regulated transcript (CART) in the rat nucleus accumbens after repeated elec-troconvulsive shock. Neurosci Res 2009; 65: 210-213.
7. Xu Y, Zhang W, Klaus J, Young J, Koerner I, Sheldahl LC et al. Role of cocaine-and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Proc Natl Acad Sci USA 2006; 103: 14489-14494.
8. Jia J, Chen X, Zhu W, Luo Y, Hua Z, Xu Y. CART protects brain from damage through ERK activation in ischemic stroke. Neuropeptides 2008; 42: 653-661.
9. Mao P, Ardeshiri A, Jacks R, Yang S, Hurn PD, Alkayed NJ. Mitochondrial mechanism of neuroprotection by CART. Eur J Neurosci 2007; 26: 624-632.
10. Wu B, Hu S, Yang M, Pan H, Zhu S. CART peptide promotes the survival of hippocampal neurons by upregulating brain-derived neurotrophic factor. Biochem Biophys Res Commun 2006; 347: 656-661.
11. Abrahams JM, Gokhan S, Flamm ES, Mehler MF. De novo neurogenesis and acute stroke: are exogenous stem cells really necessary? Neurosurgery 2004; 54: 150-155.
12. Luo Y, Kuo CC, Shen H, Chou J, Greig NH, Hoffer BJ et al. Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol 2009; 65: 520-530.
13. Felling RJ, Levison SW. Enhanced neurogenesis following stroke. J Neurosci Res 2003; 73: 277-283.
14. Borlongan CV, Hida H, Nishino H. Early assessment of motor dysfunctions aids in successful occlusion of the middle cerebral artery. Neuroreport 1998; 9: 3615-3621.
15. Chang CF, Morales M, Chou J, Chen HL, Hoffer BJ, Wang Y. Bone morphogenetic proteins are involved in fetal kidney tissue transplantation- induced neuroprotection in stroke rats. Neuropharmacology 2002; 43: 418-426.
16. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986; 17: 472-476.
17. Howard DB, Powers K, Wang Y, Harvey BK. Tropism and toxicity of adeno-associated viral vector serotypes 1, 2, 5, 6, 7, 8, 9 in rat neurons and glia in vitro. Virology 2008; 372: 24-34.
18. Lu L, Wang X, Wu P, Xu C, Zhao M, Morales M et al. Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. Biol Psychiatry 2009; 66: 137-145.
19. Meletis K, Wirta V, Hede SM, Nister M, Lundeberg J, Frisen J. p53 suppresses the self-renewal of adult neural stem cells. Development 2006; 133: 363-369.
20. Yonemori F, Yamaguchi T, Yamada H, Tamura A. Spatial cognitive performance after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1999; 19: 483-494.
21. Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, Lein P et al. Intravenous admininstration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats. Stroke 2003; 34: 558-564.
22. Ren J, Kaplan PL, Charette MF, Speller H. Finklestein SP. Time window of intracisternal osteogenic protein-1 in enhancing functional recovery after stroke. Neuropharmacology 2000; 39: 860-865.
23. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW. Very delayed infarction after mild focal cerebral ischemia: a role for apotosis. J Cereb Blood Flow Metab 1996; 16: 195-201.
24. Wang Y, Lin SZ, Chiou AL, Williams LR, Hoffer BJ. Glial cell line-derived neuro-trophic factor protects against ischemia-induced injury in the cerebral cortex. J Neurosci 1997; 17: 4341-4348.
25. Kastin AJ, Akerstrom V. Entry of CART into brain is rapid but not inhibited by excess CART or leptin. Am J Physiol 1999; 277: E901-E904.
26. Dhuria SV, Hanson LR, Frey WH. Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system. J Pharm Sci 2009; 98: 2501-2515.
27. Jiang Y, Wei N, Lu T, Zhu J, Xu G, Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 2011; 172: 398-405.
28. Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002; 8: 963-970.
29. Okano H, Sakaguchi M, Ohki K, Suzuki N, Sawamoto K. Regeneration of the central nervous system using endogenous repair mechanisms. J Neurochem 2007; 102: 1459-1465.
30. Chou J, Harvey BK, Chang CF, Shen H, Morales M, Wang Y. Neuroregenerative effects of BMP7 after stroke in rats. J Neurol Sci 2006; 240: 21-29.
31. Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O. Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats. Stroke 2006; 37: 2361-2367.
32. Chen J, Zhang C, Jiang H, Li Y, Zhang L, Robin A et al. Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab 2005; 25: 281-290.
33. Ramic M, Emerick AJ, Bollnow MR, O'Brien TE, Tsai SY, Kartje GL. Axonal plasticity is associated with motor recovery following amphetamine treatment combined with rehabilitation after brain injury in the adult rat. Brain Res 2006; 1111: 176-186.
34. Rasmussen RS, Overgaard K, Hildebrandt-Eriksen ES, Boysen G. D-amphetamine improves cognitive deficits and physical therapy promotes fine motor rehabilitation in a rat embolic stroke model. Acta Neurol Scand 2006; 113: 189-198.
35. Papadopoulos CM, Tsai SY, Guillen V, Ortega J, Kartje GL, Wolf WA. Motor recovery and axonal plasticity with short-term amphetamine after stroke. Stroke 2009; 40: 294-302.