Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared alpha 2-adrenoceptor in the brain-gut axis of rats in the forced swimming test

Neuropharmacology

Volumn 67, Issue , 2013, Pages 318-325

  Xie, Ying ^a,d   Huang, Xi ^a,b   Hu, Sui Yu ^a   Qiu, Xin Jian ^a   Zhang, Ying Jin ^a   Ren, Ping ^a   Wang, Yang ^a   Ji, Hui ^a   Zhang, Chun Hu ^a   Xie, Wei Bin ^a   He, Juan ^a   Xie, Meng Zhou ^c   Huang, Hui Yong ^c   Liu, Zhao Qian ^b   Zhou, Hong Hao ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

^d Shenzhen Centre for Disease Prevention and Control   (China)

Author keywords

Alpha 2 adrenoceptor; Common mechanism; Depression; Gastrointestinal dysfunction; Ghrelin; Meranzin hydrate

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; FLUOXETINE; GHRELIN; MERANZIN HYDRATE; MOSAPRIDE; PRAZOSIN; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG STRUCTURE; FORCED SWIMMING TEST; GASTROINTESTINAL MOTILITY; HORMONE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; INTESTINE TRANSIT TIME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; STOMACH EMPTYING;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; COUMARINS; DEPRESSION; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; MALE; NEURAL PATHWAYS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SWIMMING;

EID: 84873397342     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.10.003     Document Type: Article

References (32)

1. C.B. Brink Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression Recent Pat. CNS Drug Discov. 1 2006 29 41
2. C.B. Brink Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies J. Neural Transm. 115 2008 117 125
3. T. Bungo Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick Brain Res. 826 1999 313 316
4. B.Y. De Winter Effect of inhibition of inducible nitric oxide synthase ans guanylyl cyclase on endotonin-induced delay in gastric emptying and intestinal transit in mice Shock 18 2002 125 131
5. B.Y. De Winter Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice Neurogastroent. Motil. 16 2004 439 446
6. G. Eisenhofer Production and metabolism of dopamine and norepinephrine in mesenteric organs and liver of swine Am. J. Physiol. 268 1995 G641 G649
7. G. Eisenhofer Mesenteric organ production, hepatic metabolism, and renal elimination of norepinephrine and its metabolites in humans J. Neurochem. 66 1996 1565 1573
8. S. Elsenbruch Are there alterations of neuroendocrine and cellular immune responses to nutrients in woman with irritable bowel syndrome Am. J. Gastroenterol. 99 2004 703 710
9. P. Forsythe Mood and gut feelings Brain Behav. Immun. 24 2010 9 16
10. L. Hein Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission Nature 402 1999 181 184
11. Hiroshi Hosoda, and Kenji Kangawa The autonomic nervous system regulates gastric ghrelin secretion in rats Regul. Peptides 146 2008 12 18
12. W. Huang Meranzin hydrate induces similar effect to Fructus Aurantii on intestinal motility through activation of H1 histamine receptors J. Gastrointest. Surg. 15 2011 87 96
13. A.N. James Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility Neurogastroent. Motil. 17 2005 76 82
14. Sun-Hee Kim Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression Life Sci. 76 2005 1279 1306
15. S.Y. Lee, and M.C. Park Perceived stressful life events, coping style, social support and depressive symptoms of the functional dyspepsia patients J. Korean Neuropsychiatr. Assoc. 39 2000 351 361
16. A. Martelli Pharmacodynamic hybrids coupling established cardiovascular mechanisms of action with additional nitric oxide releasing properties Curr. Pharm. Des. 15 2009 614 636
17. E.A. Mayer, and K. Tillisch The brain-gut axis in abdominal pain syndromes Annu. Rev. Med. 62 2011 381 396
18. T.D. O'Connell Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload J. Clin. Invest. 116 2006 1005 1015
19. L. Ohman, and M. Simren New insights into the pathogenesis and phathophysiology of irritable bowel syndrome Dig. Liver Dis. 39 2007 201 215
20. R.D. Porsolt Depression: a new model sensitive to antidepressant treatments Nature 266 1977 730 732
21. B.P. Ramos, and A.F. Arnsten Adrenergic pharmacology and cognition: focus on the prefrontal cortex Pharmacol. Ther. 113 2007 523 536
22. M. Roche Circuitry underlying regulation of the serotonergic system by swim stress J. Neurosci. 23 2003 970 977
23. B. Romos Alpha-2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals Learn. Mem. 13 2006 770 776
24. R. Seiler alpha- and beta-adrenergic receptor mechanisms in spontaneous contractile activity of rat ileal longitudinal smooth muscle J. Gastrointest. Surg. 9 2005 227 235
25. R. Seiler Role of selective alpha and beta adrenergic receptor mechanisms in rat jejunal longitudinal muscle contractility J. Gastrointest. Surg. 12 2008 1087 1093
26. Tomomi Shiiya Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men Endocr. J. 58 5 2011 335 342
27. T. Tachibaba Feeding increases 5-hydroxytryptamine and norepinephrine within the hypothalamus of chicks Comp. Biochem. Physiol. 130 2001 715 722
28. J. Tack Influence of ghrelin on gastric emptying and meal-related symptoms Alimentary. Pharm. Ther. 22 2005 847 853.C
29. M. Tschop Ghrelin induces adiposity in rodents Nature 407 2001 908 913
30. M. Tschop Circulating ghrelin levels are decreased in human obesity Diabetes 50 2001 707 709
31. Rongqian Wu Ghrelin inhibits sympathetic nervous activity in sepsis Am. J. Physiol. Endocrinol. Metab. 293 2007 E1697 E1702
32. Ying-jin Zhang Ferulic acid-induced anti-depression and prokinetics similar to Chaihu-Shugan-San via polypharmacology Brain Res. Bull. 86 2011 222 228