Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men

Endocrine Journal

Volumn 58, Issue 5, 2011, Pages 335-342

  Shiiya, Tomomi ^a   Ueno, Hiroaki ^a   Toshinai, Koji ^a   Kawagoe, Takashi ^a   Naito, Seiko ^b   Tobina, Takuro ^c   Nishida, Yuichiro ^d   Shindo, Munehiro ^b   Kangawa, Kenji ^e   Tanaka, Hiroaki ^b   Nakazato, Masamitsu ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b Junshin Junior College   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

^d SAGA UNIVERSITY   (Japan)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Adrenergic system; Des acyl ghrelin; Exercise; Ghrelin; Growth hormone

Indexed keywords

ADRENALIN; DES ACYL GHRELIN; DOPAMINE; GASTROINTESTINAL HORMONE; GHRELIN; GLUCOSE; GROWTH HORMONE; INSULIN; NORADRENALIN; UNCLASSIFIED DRUG;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; CONCENTRATION RESPONSE; CYCLING; DOPAMINE BLOOD LEVEL; EXERCISE INTENSITY; EXERCISE TEST; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; MALE; METABOLIC PARAMETERS; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; OXYGEN CONSUMPTION; STEADY STATE;

ADULT; BLOOD GLUCOSE; DOPAMINE; EPINEPHRINE; EXERCISE; EXERCISE TEST; GHRELIN; HUMAN GROWTH HORMONE; HUMANS; INSULIN; MALE; NOREPINEPHRINE; STOMACH;

EID: 79958029456     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K11E-021     Document Type: Article

References (47)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
2. Hashizume T, Horiuchi M, Tate N, Nonaka S, Kojima M, Hosoda H, Kangawa K (2003) Effects of ghrelin on growth hormone secretion from cultured adenohypo-physial cells in cattle. Endocr J 50: 289-295.
3. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S (2001) A role for ghrelin in the central regulation of feeding. Nature 409: 194-198.
4. Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407: 908-913.
5. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, Matsukura S (2002) Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87: 240-244.
6. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K, Matsukura S (2001) Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 281: 1220-1225.
7. Ueno H, Shiiya T, Mizuta M, Mondal SM, Nakazato M (2007) Plasma ghrelin concentrations in different clinical stages of diabetic complications and glycemic control in Japanese diabetics. Endocr J 54: 895-902.
8. Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, Heiman ML, Lehnert P, Fichter M, Tschop M (2001) Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 145: 669-673.
9. Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, Hosoda H, Shimizu W, Yamagishi M, Oya H, Koh H, Yutani C, Kangawa K (2001) Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors. Circulation 104: 2034-2038.
10. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50: 707-709.
11. Simonian HP, Kresge KM, Boden GH, Parkman HP (2005) Differential effects of sham feeding and meal ingestion on ghrelin and pancreatic polypeptide levels: evidence for vagal efferent stimulation mediating ghre-lin release. Neurogastroenterol Motil 17: 348-354.
12. Williams DL, Grill HJ, Cummings DE, Kaplan JM (2003) Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology 144: 5184-5187.
13. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M (2002) The role of the gastric afferent vagal nerve in ghrelin-in-duced feeding and growth hormone secretion in rats. Gastroenterology 123: 1120-1128.
14. Johnson NA, Stannard SR, Thompson MW (2004) Muscle triglyceride and glycogen in endurance exercise: implications for performance. Sports Med 34: 151-164.
15. Foster-Schubert KE, McTiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y, Tworoger SS, Cummings DE (2005) Human plasma ghrelin levels increase during a one-year exercise program. J Clin Endocrinol Metab 90: 820-825.
16. Leidy HJ, Gardner JK, Frye BR, Snook ML, Schuchert MK, Richard EL, Williams NI (2004) Circulating ghre-lin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women. J Clin Endocrinol Metab 89: 2659-2664.
17. Burns SF, Broom DR, Miyashita M, Mundy C, Stensel DJ (2007) A single session of treadmill running has no effect on plasma total ghrelin concentrations. J Sports Sci 25: 635-642.
18. Dall R, Kanaley J, Hansen TK, Moller N, Christiansen JS, Hosoda H, Kangawa K, Jorgensen JO (2002) Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-defcient patients. Eur J Endocrinol 147: 65-70.
19. Jurimae J, Hofmann P, Jurimae T, Palm R, Maestu J, Purge P, Sudi K, Rom K, von Duvillard SP (2007) Plasma ghrelin responses to acute sculling exercises in elite male rowers. Eur J Appl Physiol 99: 467-474.
20. Kraemer RR, Durand RJ, Acevedo EO, Johnson LG, Kraemer GR, Hebert EP, Castracane VD (2004) Rigorous running increases growth hormone and insulin-like growth factor-I without altering ghrelin. Exp Biol Med (Maywood) 229: 240-246.
21. Martins C, Morgan LM, Bloom SR, Robertson MD (2007) Effects of exercise on gut peptides, energy intake and appetite. J Endocrinol 193: 251-258.
22. Schmidt A, Maier C, Schaller G, Nowotny P, Bayerle-Eder M, Buranyi B, Luger A, Wolzt M (2004) Acute exercise has no effect on ghrelin plasma concentrations. Horm Metab Res 36: 174-177.
23. Kraemer RR, Castracane VD (2007) Exercise and humoral mediators of peripheral energy balance: ghre-lin and adiponectin. Exp Biol Med (Maywood) 232: 184-194.
24. Sartorio A, Morpurgo P, Cappiello V, Agosti F, Marazzi N, Giordani C, Rigamonti AE, Muller EE, Spada A (2008) Exercise-induced effects on growth hormone levels are associated with ghrelin changes only in presence of prolonged exercise bouts in male athletes. J Sports Med Phys Fitness 48: 97-101.
25. Toshinai K, Kawagoe T, Shimbara T, Tobina T, Nishida Y, Mondal MS, Yamaguchi H, Date Y, Tanaka H, Nakazato M (2007) Acute incremental exercise decreases plasma ghrelin level in healthy men. Horm Metab Res 39: 849-851.
26. Malkova D, McLaughlin R, Manthou E, Wallace AM, Nimmo MA (2008) Effect of moderate-intensity exercise session on preprandial and postprandial responses of circulating ghrelin and appetite. Horm Metab Res 40: 410-415.
27. Christ ER, Zehnder M, Boesch C, Trepp R, Mullis PE, Diem P, Decombaz J (2006) The effect of increased lipid intake on hormonal responses during aerobic exercise in endurance-trained men. Eur J Endocrinol 154: 397-403.
28. Erdmann J, Tahbaz R, Lippl F, Wagenpfeil S, Schusdziarra V (2007) Plasma ghrelin levels during exercise - effects of intensity and duration. Regul Pept 143: 127-135.
29. Jurimae J, Jurimae T, Purge P (2007) Plasma ghrelin is altered after maximal exercise in elite male rowers. Exp Biol Med (Maywood) 232: 904-909.
30. Kraemer RR, Durand RJ, Hollander DB, Tryniecki JL, Hebert EP, Castracane VD (2004) Ghrelin and other glucoregulatory hormone responses to eccentric and concentric muscle contractions. Endocrine 24: 93-98.
31. Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, Enomoto M, Ono F, Kangawa K (2004) Optimum collection and storage conditions for ghrelin measurements: octanoyl modifcation of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clin Chem 50: 1077-1080.
32. Akamizu T, Shinomiya T, Irako T, Fukunaga M, Nakai Y, Kangawa K (2005) Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab 90: 6-9.
33. Broom DR, Stensel DJ, Bishop NC, Burns SF, Miyashita M (2007) Exercise-induced suppression of acylated ghrelin in humans. J Appl Physiol 102: 2165-2171.
34. King JA, Miyashita M, Wasse LK, Stensel DJ (2010) Infuence of prolonged treadmill running on appetite, energy intake and circulating concentrations of acylated ghrelin. Appetite 54: 492-498.
35. King JA, Wasse LK, Broom DR, Stensel DJ (2010) Infuence of brisk walking on appetite, energy intake, and plasma acylated ghrelin. Med Sci Sports Exerc 42: 485-492.
36. Broglio F, Gottero C, Van Koetsveld P, Prodam F, Destefanis S, Benso A, Gauna C, Hofand L, Arvat E, van der Lely AJ, Ghigo E (2004) Acetylcholine regulates ghrelin secretion in humans. J Clin Endocrinol Metab 89: 2429-2433.
37. Maier C, Schaller G, Buranyi B, Nowotny P, Geyer G, Wolzt M, Luger A (2004) The cholinergic system controls ghrelin release and ghrelin-induced growth hormone release in humans. J Clin Endocrinol Metab 89: 4729-4733.
38. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719.
39. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992.
40. King NA, Burley VJ, Blundell JE (1994) Exercise-induced suppression of appetite: effects on food intake and implications for energy balance. Eur J Clin Nutr 48: 715-724.
41. Osada T, Katsumura T, Hamaoka T, Inoue S, Esaki K, Sakamoto A, Murase N, Kajiyama J, Shimomitsu T, Iwane H (1999) Reduced blood fow in abdominal viscera measured by Doppler ultrasound during one-legged knee extension. J Appl Physiol 86: 709-719.
42. Otte JA, Oostveen E, Geelkerken RH, Groeneveld AB, Kolkman JJ (2001) Exercise induces gastric ischemia in healthy volunteers: a tonometry study. J Appl Physiol 91: 866-871.
43. Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL (2008) Identifcation of the acyltransferase that octanoy-lates ghrelin, an appetite-stimulating peptide hormone. Cell 132: 387-396.
44. Yoshimoto A, Mori K, Sugawara A, Mukoyama M, Yahata K, Suganami T, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao K (2002) Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol 13: 2748-2752.
45. Godfrey RJ, Madgwick Z, Whyte GP (2003) The exercise-induced growth hormone response in athletes. Sports Med 33: 599-613.
46. Giustina A, Veldhuis JD (1998) Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19: 717-797.
47. Vestergaard ET, Dall R, Lange KH, Kjaer M, Christiansen JS, Jorgensen JO (2007) The ghrelin response to exercise before and after growth hormone administration. J Clin Endocrinol Metab 92: 297-303.