Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: A meta-analysis

International Journal of Sport Nutrition and Exercise Metabolism

Volumn 23, Issue 1, 2013, Pages 73-82

  Pelletier, Denis M ^a   Lacerte, Guillaume ^b   Goulet, Eric D B ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b NONE

Author keywords

Aerobic capacity; Ergogenic aids; Exercise capacity; Flavonoids; Sports supplements

Indexed keywords

PLACEBO; QUERCETIN;

AEROBIC CAPACITY; AEROBIC EXERCISE; ATHLETE; ATTENTION; DIET SUPPLEMENTATION; ENDURANCE; EXERCISE; EXERCISE TEST; EXHAUSTION; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; REVIEW; TRAINING; TREATMENT DURATION;

ANTIOXIDANTS; ATHLETIC PERFORMANCE; DIETARY SUPPLEMENTS; EXERCISE; HUMANS; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; QUERCETIN; SPORTS;

EID: 84873385953     PISSN: 1526484X     EISSN: 15432742     Source Type: Journal    
DOI: 10.1123/ijsnem.23.1.73     Document Type: Review

References (42)

1. Abbey, E.L., & Rankin, J.W. (2011). Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation. International Journal of Sport Nutrition and Exercise Metabolism, 21 (2), 91-96. PubMed
2. Bigelman, K.A., Fan, E.H., Chapman, D.P., Freese, E.C., Trilk, J.L., & Cureton, K.J. (2010). Effects of six weeks of quercetin supplementation on physical performance in ROTC cadets. Military Medicine, 175 (10), 791-798. PubMed
3. Bischoff, S.C. (2008). Quercetin: Potentials in the prevention and therapy of disease. Current Opinion in Clinical Nutrition and Metabolic Care, 11, 733-740. PubMed doi:10.1097/MCO.0b013e32831394b8
4. Borenstein, M., Hedges, L.V., Higgins, J.P.T., & Rothstein, H.R. (2009). Introduction to meta-analysis. Hoboken, NJ: Wiley & Sons.
5. Cheuvront, S.N., Ely, B.R., Kenefick, R.W., Michniak-Kohn, B.B., Rood, J.C., & Sawka, M.N. (2009). No effect of nutritional adenosine receptor antagonists on exercise performance in the heat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 296 (2), R394-R401. PubMed doi:10.1152/ajpregu.90812.2008
6. Comalada, M., Camuesco, D., Sierra, S., Ballester, I., Xaus, J., Gálvez, J., & Zarzuelo, A. (2005). In vivo quercetin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. European Journal of Immunolog y, 35 (2), 584-592. PubMed doi:10.1002/eji.200425778
7. Coskun, O., Kanter, M., Korkmaz, A., & Oter, S. (2005). Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacological Research, 51 (2), 117-123. PubMed doi:10.1016/j.phrs.2004.06.002
8. Cureton, K.J., Tomporowski, P.D., Singhal, A., Pasley, J.D., Bigelman, K.A., Lambourne, K.,... Zhao, Q. (2009). Dietary quercetin supplementation is not ergogenic in untrained men. Journal of Applied Physiology, 107 (4), 1095-1104. PubMed doi:10.1152/japplphysiol.00234.2009
9. Davis, J.M., Carlstedt, J.C., Chen, S., Carmichael, M.D., & Murphy, E.A. (2010). The dietary flavonoid quercetin increases VO2max and endurance capacity. International Journal of Sport Nutrition and Exercise Metabolism, 20 (1), 56-62. PubMed
10. Davis, J.M., Murphy, E.A., & Carmichael, M.D. (2009). Effects of the dietary flavonoid quercetin upon performance and health. Current Sports Medicine Reports, 8 (4), 206-213. PubMed
11. Dean, S., Braakhuis, A., & Paton, C. (2009). The effects of EGCG on fat oxidation and endurance performance in male cyclists. International Journal of Sport Nutrition and Exercise Metabolism, 19 (6), 624-644. PubMed
12. Duarte, J., Galisteo, M., Ocete, M.A., Pérez-Vizcaino, F., Zarzuelo, A., & Tamargo, J. (2001). Effects of chronic quercetin treatment on hepatic oxidative status of spontaneously hypertensive rats. Molecular and Cellular Biochemistry, 221 (1-2), 155-160. PubMed doi:10.1023/A:1010956928584
13. Edwards, R.L., Lyon, T., Litwin, S.E., Rabovsky, A., Symons, J.D., & Jalili, T. (2007). Quercetin reduces blood pressure in hypertensive subjects. The Journal of Nutrition, 137, 2405-2411. PubMed
14. Follmann, D., Elliott, P., Suh, I., & Cutler, J. (1992). Variance imputation for overviews of clinical trials with continuous response. Journal of Clinical Epidemiology, 45 (7), 769-773. PubMed doi:10.1016/0895-4356(92)90054-Q
15. Ganio, M.S., Armstrong, L.E., Johnson, E.C., Klau, J.F., Ballard, K.D., Michniak-Kohn, B.,... Maresh, C.M. (2010). Effect of quercetin supplementation on maximal oxygen uptake in men and women. Journal of Sports Sciences, 28 (2), 201-208. PubMed doi:10.1080/02640410903428558
16. Harwood, M., Danielewska-Nikiel, B., Borzelleca, J.F., Flamm, G.W., Williams, G.M., & Lines, T.C. (2007). A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food and Chemical Toxicology, 45 (11), 2179-2205. PubMed doi:10.1016/j. fct.2007.05.015
17. Higgins, J.P., & Thompson, S.G. (2002). Quantifying heterogeneity in a meta-analysis. Statistics in Medicine, 21 (11), 1539-1558. PubMed doi:10.1002/sim.1186
18. Hopkins, W.G. (2002). Calculating likely (confidence) limits and likelihoods for true values (Excel spreadsheet). Retrieved from sportsci.org/resource/stats/xcl.xls
19. Hopkins, W.G. (2004). How to interpret changes in an athletic performance test. Sportscience, 8, 1-7.
20. Hopkins, W.G., Hawley, J.A., & Burke, L.M. (1999). Design and analysis of research on sport performance enhancement. Medicine and Science in Sports and Exercise, 31 (3), 472-485. PubMed doi:10.1097/00005768-199903000- 00018
21. Hopkins, W.G., & Hewson, D.J. (2001). Variability of competitive performance of distance runners. Medicine and Science in Sports and Exercise, 33 (9), 1588-1592. PubMed doi:10.1097/00005768-200109000-00023
22. Hopkins, W.G., Schabort, E.J., & Hawley, J.A. (2001). Reliability of power in physical performance tests. Sports Medicine (Auckland, N.Z.), 31 (3), 211-234. PubMed doi:10.2165/00007256-200131030-00005
23. Katch, V.L., Sady, S.S., & Freedson, P. (1982). Biological variability in maximum aerobic power. Medicine and Science in Sports and Exercise, 14 (1), 21-25. PubMed doi:10.1249/00005768-198201000-00004
24. Kressler, J., Millard-Stafford, M., & Warren, G.L. (2011). Quercetin and endurance exercise capacity: A systematic review and meta-analysis. Medicine and Science in Sports and Exercise, 43 (12), 2396-2404. PubMed doi:10.1249/MSS.0b013e31822495a7
25. Jin, F., Nieman, D.C., Shanely, R.A., Knab, A.M., Austin, M.D., & Sha, W. (2010). The variable plasma quercetin response to 12-week quercetin supplementation in humans. European Journal of Clinical Nutrition, 64 (7), 692-697. PubMed doi:10.1038/ejcn.2010.91
26. Lau, J., Ioannidis, J.P., Terrin, N., Schmid, C.H., & Olkin, I. (2006). The case of the misleading funnel plot. BMJ, 333 (7568), 597-600.
27. Lipsey, M.W., & Wilson, D.B. (2001). Practical meta-analysis. Thousand Oaks, CA: Sage.
28. Loke, W.M., Hodgson, J.M., Proudfoot, J.M., McKinley, A.J., Puddey, I.B., & Croft, K.D. (2008). Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. The American Journal of Clinical Nutrition, 88 (4), 1018-1025. PubMed
29. MacRae, H.S.H., & Mefferd, K.M. (2006). Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance. International Journal of Sport Nutrition and Exercise Metabolism, 16, 405-419. PubMed
30. McAnulty, S.R., McAnulty, L.S., Nieman, D.C., Quindry, J.C., Hosick, P.A., Hudson, M.H.,... Dibarnardi, A. (2008). Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Applied Physiology, Nutrition, and Metabolism, 33 (2), 254-262. PubMed doi:10.1139/H07-177
31. Morikawa, K., Nonaka, M., Narahara, M., Torii, I., Kawaguchi, K., Yoshikawa, T.,... Morikawa, S. (2003). Inhibitory effect of quercetin on carrageenan-induced inflammation in rats. Life Sciences, 74 (6), 709-721. PubMed doi:10.1016/j.lfs.2003.06.036
32. Nieman, D.C., Henson, D.A., Davis, J.M., Angela Murphy, E., Jenkins, D.P., Gross, S.J.,... Mayer, E.P. (2007). Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. Journal of Applied Physiology, 103 (5), 1728-1735. PubMed doi:10.1152/japplphysiol.00707.2007
33. Nieman, D.C., Henson, D.A., Davis, J.M., Dumke, C.L., Gross, S.J., Jenkins, D.P.,... Mayer, E.P. (2007). Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run. Journal of Interferon and Cytokine Research, 27 (12), 1003-1011.
34. Nieman, D.C., Henson, D.A., Maxwell, K.R., Williams, A.S., McAnulty, S.R., Jin, F.,... Lines, T.C. (2009). Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. Medicine and Science in Sports and Exercise, 41 (7), 1467-1475. PubMed doi:10.1249/MSS.0b013e318199491f
35. Nieman, D.C., Williams, A.S., Shanely, R.A., Jin, F., McAnulty, S.R., Triplett, N.T.,... Henson, D.A. (2010). Quercetin's influence on exercise performance and muscle mitochondrial biogenesis. Medicine and Science in Sports and Exercise, 42 (2), 338-345. PubMed doi:10.1249/MSS.0b013e3181b18fa3
36. Paton, C., & Hopkins, W. (2006). Variation in performance of elite cyclists from race to race. European Journal of Sport Science, 6, 25-31. doi:10.1080/17461390500422796
37. Quindry, J.C., McAnulty, S.R., Hudson, M.B., Hosick, P., Dumke, C., McAnulty, L.S.,... Nieman, D. (2008). Oral quercetin supplementation and blood oxidative capacity in response to ultramarathon competition. International Journal of Sport Nutrition and Exercise Metabolism, 18 (6), 601-616. PubMed
38. Raastad, T., Høstmark, A.T., & Strømme, S.B. (1997). Omega-3 fatty acid supplementation does not improve maximal aerobic power, anaerobic threshold and running performance in well-trained soccer players. Scandinavian Journal of Medicine & Science in Sports, 7 (1), 25-31. PubMed
39. Rivera, L., Morón, R., Sánchez, M., Zarzuelo, A., & Galisteo, M. (2008). Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring, Md.), 16 (9), 2081-2087. PubMed doi:10.1038/oby.2008.315
40. Sánchez, M., Galisteo, M., Vera, R., Villar, I.C., Zarzuelo, A., Tamargo, J.,... Duarte, J. (2006). Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. Journal of Hypertension, 24 (1), 75-84. PubMed doi:10.1097/01.hjh.0000198029.22472.d9
41. Shanely, R.A., Knab, A.M., Nieman, D.C., Jin, F., McAnulty, S.R., & Landram, M.J. (2010). Quercetin supplementation does not alter antioxidant status in humans. Free Radical Research, 44 (2), 224-231. PubMed doi:10.3109/10715760903407293
42. Yfanti, C., Akerström, T., Nielsen, S., Nielsen, A.R., Mounier, R., Mortensen, O.H.,... Pedersen, B.K. (2010). Antioxidant supplementation does not alter endurance training adaptation. Medicine and Science in Sports and Exercise, 42 (7), 1388-1395. PubMed