Characterization of polymeric microcapsules containing a low molecular weight peptide for controlled release

Microscopy and Microanalysis

Volumn 19, Issue 1, 2013, Pages 213-226

  Moore, Keith ^a   Amos, Jennifer ^b   Davis, Jeffrey ^d   Gourdie, Robert ^c   Potts, Jay D ^a,d  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b University of Illinois at Urbana Champaign   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

connexin 43; electrohydrodynamics; electrospraying; gap junctions; Key words microencapsulation; poly l lysine; poly l ornithine; sodium alginate; zonula occludins

Indexed keywords

ALGINIC ACID; DRUG CARRIER; GLUCURONIC ACID; HEXURONIC ACID; PEPTIDE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BIOMIMETICS; CHEMISTRY; DELAYED RELEASE FORMULATION; MICROCAPSULE; MOLECULAR WEIGHT; PHASE CONTRAST MICROSCOPY; SCANNING ELECTRON MICROSCOPY;

ALGINATES; BIOMIMETICS; CAPSULES; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GLUCURONIC ACID; HEXURONIC ACIDS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, PHASE-CONTRAST; MOLECULAR WEIGHT; PEPTIDES;

EID: 84873370234     PISSN: 14319276     EISSN: 14358115     Source Type: Journal    
DOI: 10.1017/S143192761201389X     Document Type: Article

References (43)

1. Arghya, P., Dominique, S. & Satya, P. (2010). Investigation on PEG integrated alginate-chitosan microcapsules for myocardial therapy using marrow stem cells genetically modified by recombinant baculovirus. Cardiovasc Eng Technol 1(2), 154-164
2. Bender, J., Friedman, H., Giurgiutiu, V.,Watson, C., Fitzmaurice, M. & Yost, M. (2006). The use of biomedical sensors to monitor capsule formation around soft tissue implants. Ann Plas Surg 56(1), 72-77
3. Casper, C.L., Yamaguchi, N., Kiick, K.L. & Rabolt, J.F. (2005). Functionalizing electrospun fibers with biologically relevant macromolecules. Biomacromolecules 6, 1998-2007
4. Chakraborty, S., Liao, I., Adler, A. & Leong, K. (2009). Electrohydrodynamics: A facile technique to fabricate drug delivery systems. Adv Drug Deliver Rev 61, 1043-1054
5. Chew, S.,Wen, J., Yim, E. & Leong, K. (2005). Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules 6, 2017-2024
6. Chew, S., Wen, Y., Dzenis, Y. & Leong, K. (2006). The role of electrospinning in the emerging field of nanomedicine. Current Pharm Design 12(36), 4751-4770
7. Choi, J., Leong, K. & Yoo, H. (2008). In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials 29, 587-596
8. Dashevsky, A. (1998). Protein loss by the microencapsulation of an enzyme (lactase) in alginate beads. Int J Pharm 161, 1-5
9. Draget, K., Ostgaard, K. & Smidsrod, O. (1989). Alginate-based solid media for plant tissue culture. Appl Microbiol Biotechnol 31(1), 79-83
10. Enayati, M., Chang, M.-W., Bragman, F., Edirisinghe, M. & Stride, E. (2011). Electrohydrodynamic preparation of particles, capsules, and bubbles for biomedical engineering applications. Colloid Surface A 382, 154-164
11. Ghatnekar, G., O'Quinn, M., Jourdan, L.J., Gurjarpadhy, A., Draughn, R. & Gourdie, R. (2009). Connexin43 carboxylterminal peptides reduce scar progenitor and promote regenerative healing following skin wounding. RegenMed 4(2), 205-223
12. Giurgiutiu, V., Friedman, H., Bender, J., Borg, T., Yost, M., Newcomb, W., Black, A., Bost, J. & Stewart, C. (2004). Electromechanical impedance sensor for in vivo monitoring the body reaction to implants. J Invest Surg 17(5), 257-270
13. Gombotz, W. & Wee, S.F. (1998). Protein release from alginate matrices. Adv Drug Deliv Rev 31, 267-285
14. Gray, C.J. & Dowsett, J. (1988). Retention of insulin in alginate gel beads. Biotechnol Bioeng 31, 607-612
15. Hunter, A., Barker, R., Zhu, C. & Gourdie, R. (2005). Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell 16, 5686-5698
16. Hwang, Y.K., Jeong, U. & Cho, E.C. (2008). Production of uniform-sized polymer core-shell microcapsules by coaxial electrospraying. Langmuir 24, 2446-2451
17. Katti, D.S., Robinson, K., Ko, F. & Laurencin, C. (2004). Bioresorbable nanofiber-based systems for wound healing and drug delivery: Optimization of fabrication parameters. J Biomed Mater Res B 70B, 286-296
18. Langer, G. & Yamate, G. (1969). Encapsulation of liquid and solid aerosol particles to form dry powders. Colloid Interface Sci 29, 450-455
19. Lin, J., Yu,W., Liu, X., Xie, H.,Wang,W. & Ma, X. (2008). In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells. J Biosci Bioeng 105(6), 660-665
20. Mbanaso, E.N. & Roscoe, D.H. (1982). Alginate: An alternative to agar in plant protoblast culture. Plant Sci Lett 25(1), 61-66
21. Mercade-Prieto, R., Nguyen, B., Allen, R., York, D., Preece, J., Goodwin, T. & Zhang, Z. (2011). Determination of the elastic properties of single microcapsules using micromanipulation and finite element modeling. Chem Eng Sci 66, 2042-2049
22. Murphy, J.A. (1980). Non-coating techniques to render biological specimens conductive. Scan Electron Microsc 1, 209-220
23. Norris, R.,Moreno-Rodriguez, R., Sugi, Y., Hoffman, S., Amos, J., Hart, M., Potts, J., Goodwin, R. & Markwald, R. (2008). Periostin regulates atrioventricular valve maturation. Dev Biol 316, 200-213
24. O'Quinn, M., Palatinus, J., Harris, B., Hewett, K. & Gourdie, R. (2011). A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circ Res 108, 704-715
25. Orive, G., Tam, S., Pedraz, J. & Halle, J. (2006). Biocompatibility of alginate poly-L-lysine microcapsules for cell therapy. Biomaterials 27, 3691-3700
26. Oviedo-Orta, E. & Evans,W. (2004). Gap junctions and connexinmediated communication in the immune system. Biochim Biophys Acta 1662, 102-112
27. Pham, Q., Sharma, U. & Mikos, A. (2006). Electrospinning of polymeric nanofibers for tissue engineering applications: A review. Tissue Eng 12(5), 1197-1211
28. Rhett, J.M., Ghatnekar, G.S., Palatinus, J.A., O'Quinn, M., Yost, M. & Gourdie, R. (2008). Novel therapies for scar reduction and regenerative healing of skin wounds. Trends Biotechnol 26(4), 173-180
29. Rhett, J.M., Jourdan, J. & Gourdie, R. (2011). Connexin 43 connnexon to gap junction transition is regulated by zonula occludins-1. Molec Biol Cell 22, 1516-1528
30. Rho, K., Jeong, L., Lee, G., Seo, B., Park, Y., Hong, S., Roh, S., Cho, J., Park, W. & Min, B. (2006). Electrospinning of collagen nanofibers: Effects on the behavior of normal human keratinocytes and early stage wound healing. Biomaterials 27, 1452-1461
31. Rutledge, G. & Fridrikh, S. (2007). Formation of fibers by electrospinning. Adv Drug Deliv Rev 59, 1384-1391
32. Takka, S. & Gurel, A. (2010). Evaluation of chitosan/alginate beads using experimental design: Formulation and in vitro characterization. AAPS PharmSciTech 11(1), 460-466
33. Tama, S.K., Bilodeau, S., Dusseault, J., Langlois, G., Hallé, J.P. & Yahia, L.H. (2011). Biocompatibility and physicochemical characteristics of alginate-polycation microcapsules. Acta Biomater 7, 1683-1692
34. Vandenberg, G.W., Drolet, C., Scott, S.L. & de la Nouë, J. (2001). Factors affecting protein release from alginate-chitosan coacervate microcapsules during production and gastric/intestinal simulation. J Control Release 77, 297-307
35. Vinkin, M., Decrock, E., Leybaert, L., Bultynck, G., Himpens, B., Vanhaecke, T. & Rogeirs, V. (2011). Non-channel functions of connexins in cell growth and cell death. Biochim Biophys Acta 8, 2002-2008
36. Wan, K., Chan, V. & Dillard, D. (2002). Constitutive equation for elastic indentation of a thin-walled bio-mimetic microcapsule by an atomic force microscope tip. Colloid Surfaces B 27, 241-248
37. Wu, Y., MacKay, J.A., McDaniel, J.R., Chilkoti, A. & Clark, R.L. (2009). Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules 10(1), 19-24
38. Xu, Y. & Hanna, M.A. (2007). Electrosprayed bovine serum albumin-loaded tripolyphosphate cross-linked chitosan capsules: Synthesis and characterization. J Microencapsulation 24, 143-151
39. Xu, Y., Skotak, M. & Hanna, M.A. (2006). Electrospray encapsulation of water-soluble protein with polylactide: Effects of formulations and process on morphology and particle size. Microencapsulation 23, 69-78
40. Zhang, W. & He, X. (2009). Encapsulation of living cells in small (;100 micrometer) alginate microcapsules by electrostatic spraying: A parametric study. J Biomechanical Eng 131, 074515-1-6
41. Zhang,W., Li, B.-G., Zhang, C., Xie, X.-H. & Tang, T.-T. (2008). Biocompatibility and membrane strength of C3H10T1/2 cellloaded alginate-based microcapsules. Cryotherapy 10(1), 90-97
42. Zhang,W., Yang, G., Zhang, A., Xu, L. & He, X. (2010). Preferential vitrification of water in small alginate microcapsules significantly augments cell cryopreservation by vitrification. Biomed Microdevices 12, 89-96
43. Zhao, Y., Shimizu, T., Nishihira, J., Koyama, Y., Kushibiki, T., Honda, A.,Watanabe, H., Abe, R., Tabata, Y. & Shimizu, H. (2005). Tissue regeneration using macrophage migration inhibitory factor-impregnated gelatin microbeads in cutaneous wounds. Am J Pathol 167(6), 1519-1529